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| 1 | Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy显示文摘This review summarizes the current state of knowledge regarding the role of endothelial dysfunction in the pathogenesis of early and delayed intestinal radiation toxicity and discusses various endothelial-oriented interventions aimed at reducing the risk of radiation enteropathy. Studies published in the biomedical literature during the past four decades and cited in PubMed, as well as clinical and laboratory data from our own research program are reviewed. The risk of injury to normal tissues limits the cancer cure rates that can be achieved with radiation therapy. During treatment of abdominal and pelvic tumors, the intestine is frequently a major dose-limiting factor. Microvascular injury is a prominent feature of both early (inflammatory), as well as delayed (fibroproliferative) radiation injuries in the intestine and in many other normal tissues. Evidence from our and other laboratories suggests that endothelial dysfunction, notably a deficiency of endothelial thrombomodulin, plays a key role in the pathogenesis of these radiation responses. Deficient levels of thrombomodulin cause loss of vascular thromboresistance, excessive activation of cellular thrombin receptors by thrombin, and insufficient activation of protein C, a plasma protein with anticoagulant, anti-inflammatory, and cytoprotective properties. These changes are presumed to be critically involved in many aspects of early intestinal radiation toxicity and may sustain the fi broproliferative processes that lead to delayed intestinal dysfunction, fi brosis, and clinical complications. In conclusion, injury of vascular endothelium is important in the pathogenesis of the intestinal radiation response. Endothelial-oriented interventions are appealing strategies to prevent or treat normal tissue toxicity associated with radiation treatment of cancer. | Junru Wang Marian Boerma Qiang Fu Martin Hauer-Jensen | 2007 | World Journal of Gastroenterology2007，13，22： | 20 |
| 2 | Improving the outcomes in oncological colorectal surgery显示文摘During the last several decades,colorectal cancer surgery has experienced some major perioperative improvements.Preoperative risk-assessment of nutrition,frailty,and sarcopenia followed by interventions for patient optimization or an adapted surgical strategy,contributed to improved postoperative outcomes.Enhanced recovery programs or fast-track surgery also resulted in reduced length of hospital stay and overall complications without affecting patient safety.After an initially indecisive start due to uncertainty about oncological safety,the most significant improvement in intraoperative care was the introduction of laparoscopy.Laparoscopic surgery for colon and rectal cancer is associated with better short-term outcomes,whereas long-term outcomes regarding survival and recurrence rates are comparable.Nevertheless,long-term results in rectal surgery remain to be seen.Early recognition of anastomotic leakage remains a challenge,though multiple improvements have allowed better management of this complication. | Jeroen LA van Vugt Kostan W Reisinger Joep PM Derikx Djamila Boerma Jan HMB Stoot | 2014 | World Journal of Gastroenterology2014，20，35： | 13 |
| 3 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
| 4 | Systematic review of cystic duct closure techniques in relation to prevention of bile duct leakage after laparoscopic cholecystectomy显示文摘AIM To study the effect of different techniques of cystic duct closure on bile leakage after laparoscopic cholecystectomy(LC) for biliary disease.METHODS A systematic search of MEDLINE, Cochrane and EMBASE was performed. Rate of cystic duct leakage(CDL) was the primary outcome. Risk of bias was evaluated. Odds ratios were analyzed for comparison of techniques and pooled event rates for non-comparative analyses. Pooled event rates were compared for each of included techniques.RESULTS Out of 1491 articles, 38 studies were included. A total of 47491 patients were included, of which 38683(81.5%)underwent cystic duct closure with non-locking(metal)clips. All studies were of low-moderate methodological quality. Only two studies reported separate data on uncomplicated and complicated gallbladder disease. For overall CDL, an odds ratio of 0.4(95%CI: 0.06-2.48)was found for harmonic energy vs clip closure and an odds ratio of 0.17(95%CI: 0.03-0.93) for locking vs non-locking clips. Pooled CDL rate was around 1% for harmonic energy and metal clips, and 0% for locking clips and ligatures. CONCLUSION Based on available evidence it is not possible to either recommend or discourage any of the techniques for cystic duct closure during LC with respects to CDL,although data point out a slight preference for locking clips and ligatures vs other techniques. No separate recommendation can be made for complicated gallbladder disease. | Aafke H van Dijk Stijn van Roessel Philip R de Reuver Djamila Boerma Marja A Boermeester Sandra C Donkervoort | 2018 | World Journal of Gastrointestinal Surgery2018，10，6： | 3 |
| 5 | Space radiation and cardiovascular disease risk显示文摘Future long-distance space missions will be associated with significant exposures to ionizing radiation,and the health risks of these radiation exposures during manned missions need to be assessed. Recent Earth-based epidemiological studies in survivors of atomic bombs and after occupational and medical low dose radiation exposures have indicated that the cardiovascular system may be more sensitive to ionizing radiation than was previously thought. This has raised the concern of a cardiovascular disease risk from exposure to space radiation during long-distance space travel. Groundbased studies with animal and cell culture models play an important role in estimating health risks from space radiation exposure. Charged particle space radiation has dense ionization characteristics and may induce unique biological responses,appropriate simulation of the space radiation environment and careful consideration of the choice of the experimental model are critical. Recent studies have addressed cardiovascular effects of space radiation using such models and provided first results that aid in estimating cardiovascular disease risk,and several other studies are ongoing. Moreover,astronauts could potentially be administered pharmacological countermeasures against adverse effects of space radiation,and research is focused on the development of such compounds. Because the cardiovascular response to space radiation has not yet been clearly defined,the identification of potential pharmacological countermeasures against cardiovascular effects is still in its infancy. | Marjan Boerma Gregory A Nelson Vijayalakshmi Sridharan Xiao-Wen Mao Igor Koturbash Martin Hauer-Jensen | 2015 | World Journal of Cardiology2015，7，12： | 2 |
| 6 | Early Laparoscopic Cholecystectomy Improves Outcomes After Endoscopic Sphincterotomy for Choledochocystolithiasis显示文摘 | Jan Siert K. Reinders Annemarie Goud Robin Timmer Philip M. Kruyt Ben J.M. Witteman Niels Smakman Ronald Breumelhof Sandra C. Donkervoort Jeroen M. Jansen Joos Heisterkamp Marina Grubben Bert van Ramshorst Djamila Boerma | 2010 | Gastroenterology2010，，7： | 2 |
| 7 | Staged multidisciplinary step‐up management for necrotizing pancreatitis显示文摘 | D. W. da Costa D. Boerma H. C. van Santvoort K. D. Horvath J. Werner C. R. Carter T. L. Bollen H. G. Gooszen M. G. Besselink O. J. Bakker | 2014 | Br J Surg2014，，1： | 2 |
| 8 | Long-term resuits of laparoscopic adjustable gastric banding in patients lost to follow-up 显示文摘 | te Riele WW Boerma D Wiezer M J | 2010 | Br J Surg2010，97，10： | 1 |
| 9 | A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque de- velopment 显示文摘 | Boerma M Forsberg L Van Zeijl L | 1999 | J Intern Med1999，246，2： | 1 |
| 10 | Towards an oncological resection of gall bladder cancer review,61 refs 显示文摘 | Boerma EJ | 1994 | European journal of surgical oncology1994，20，： | 1 |
| 11 | Wait-and-see policy or lapamscopic cholecystectomy after endoscopic sphincterotomy for bile-duct stones:a randomized trial显示文摘 | Boerma D Rauws EA Keulemans YC | 2002 | Lancet2002，360，9335： | 1 |
| 12 | Genotype effects on pro-liferative embryogenesis and plant regeneration of soybean显示文摘 | Bailey M A Boerma H R Parrott W A | 1993 | InVitro Cellular & Developmental Biology-Plant1993，29，： | 1 |
| 13 | Prognostic role of indoleamine 2,3-dioxygenase in endometrial carcinoma显示文摘 | DE JONG R A KEMA I P BOERMA A | 2012 | Gynecolc Oncol2012，126，3： | 1 |
| 14 | Global and regional causes of death 显示文摘 | Mathers C D Boerma T Ma Fat D | 2009 | Br Med Bu112009，92，： | 1 |
| 15 | Molecular mapping and confirmation of QTLs associated with oleic acid content in N003350 soybean显示文摘 | Monteros M J Burton J W Boerma H R | 2008 | Crop Science2008，48，： | 1 |
| 16 | Effects of nitroglycerin on sublingual mieroeircu --latory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: A double-- blind randomized placebo controlled trial显示文摘 | Boerma E C Koopmans M Konijn A | 2010 | Crit Care Med2010，38，1： | 1 |
| 17 | Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-eoen- zyme A reductase inhibition 显示文摘 | Boerma M Burton GR Wang J | 2006 | Blood Coagul Fibrinolysis2006，17，3： | 1 |
| 18 | The Netherlands:Health system review显示文摘 | Sch fer W Kroneman M Boerma W van den Berg M Westert G Devill é W and van Ginneken E | | 0，，01： | 1 |
| 19 | National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys显示文摘 | Mascarenhas MN Flaxman SR Boerma T | 2012 | PLoS Med2012，9，10： | 1 |
| 20 | Changes in bone mineral density,body composition,and lipid metabolism during growth hormone (GH) treatment in children with GH deficiency显示文摘 | Boot AM Engels MAMJ Boerma GJM | 1997 | J Clin Endocrinol Metab1997，82，8： | 1 |
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