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| 1 | A randomized controlled trial of omega-3 fatty acids in dry eye syndrome显示文摘AIM:To evaluate the role of dietary supplementation of omega-3 fatty acids in dry eye syndrome.METHODS:A prospective,interventional,placebo controlled,double blind randomized trial was done at two referral eye centers.Two hundred and sixty-four eyes of patients with dry eye were randomized to receive one capsule(500mg)two times a day containing 325mg EPA and 175mg DHA for 3 months(omega-3 group).The omega-3 group was compared to a group of patients(n=254)who received a placebo(placebo group).There were 4 patient visits(at baseline,1 month,2 months and3 months).On each visit,recording of corrected distance visual acuity(CDVA),slit lamp examination and questionnaire based symptom evaluation and scoring was done.A symptomatic score of 0-6 was mild,6.1-12moderate and 12.1-18 severe dry eye.Response to intervention was monitored by routine tear function tests like Schirmer I test,tear film break-up time(TBUT),Rose Bengal staining and most notably,conjunctival impression cytology.RESULTS:Sixty-five percent of patients in the omega-3group and 33%of patients in placebo group had significant improvement in symptoms at 3 months(P=0.005).There was a significant change in both Schirmer's test value and TBUT values in the omega-3group(P<0.001),both comparisons.However,there was a larger drift in TBUT values in omega-3 than the placebo group,in comparison to Schirmer's test values.The mean TBUT score was 2.54±2.34 in the omega-3group and 0.13±0.16 in placebo group,respectively.The mean reduction in symptom score in omega-3 group was 2.02±0.96 as compared to 0.48±0.22 in placebogroup(P<0.001).Despite a slight increase mean score,the Schirmer scores did not correlate well with symptomatic improvement.CONCLUSION:Omega-3 fatty acids have a definite role for dry eye syndrome.The benefit seems to be more marked in conditions such as blepharitis and meibomian gland disease.The role of omega fatty acids in tear production and secretion needs further evaluation. | Rahul Bhargava Prachi Kumar Manjushrii Kumar Namrata Mehra Anurag Mishra | 2013 | International Journal of Ophthalmology(English edition)2013，6，6： | 14 |
| 2 | Post-infectious irritable bowel syndrome:Mechanistic insights into chronic disturbances following enteric infection显示文摘Irritable bowel syndrome(IBS)is a commonly encountered chronic functional gastrointestinal(GI)disorder.Approximately 10%of IBS patients can trace the onset of their symptoms to a previous a bout of infectious dysentery.The appearance of new IBS symptoms following an infectious event is defined as post-infectiousIBS.Indeed,with the World Health Organization estimating between 2 and 4 billion cases annually,infectious diarrheal disease represents an incredible international healthcare burden.Additionally,compounding evidence suggests many commonly encountered enteropathogens as unique triggers behind IBS symptom generation and underlying pathophysiological features.A growing body of work provides evidence supporting a role for pathogen-mediated modifications in the resident intestinal microbiota,epithelial barrier integrity,effector cell functions,and innate and adaptive immune features,all proposed physiological manifestations that can underlie GI abnormalities in IBS.Enteric pathogens must employ a vast array of machinery to evade host protective immune mechanisms,and illicit successful infections.Consequently,the impact of infectious events on host physiology can be multidimensional in terms of anatomical location,functional scope,and duration.This review offers a unique discussion of the mechanisms employed by many commonly encountered enteric pathogens that cause acute disease,but may also lead to the establishment of chronic GI dysfunction compatible with IBS. | Jennifer K Beatty Amol Bhargava Andre G Buret | 2014 | World Journal of Gastroenterology2014，20，14： | 12 |
| 3 | Determination of blast-induced ground vibration equations for rocks using mechanical and geological properties显示文摘In the recent decades,effects of blast loads on natural and man-made structures have gained considerable attention due to increase in threat from various man-made activities.Site-specific empirical relationships for calculation of blast-induced vibration parameters like peak particle velocity(PPV) and peak particle displacement(PPD) are commonly used for estimation of blast loads in design.However,these relationships are not able to consider the variation in rock parameters and uncertainty of in situ conditions.In this paper,a total of 1089 published blast data of various researchers in different rock sites have been collected and used to propose generalized empirical model for PPV by considering the effects of rock parameters like unit weight,rock quality designation(RQD),geological strength index(GSI),and uniaxial compressive strength(UCS).The proposed PPV model has a good correlation coefficient and hence it can be directly used in prediction of blast-induced vibrations in rocks.Standard errors and coefficient of correlations of the predicted blast-induced vibration parameters are obtained with respect to the observed field data.The proposed empirical model for PPV has also been compared with the empirical models available for blast vibrations predictions given by other researchers and found to be in good agreement with specific cases. | Ranjan Kumar Deepankar Choudhury Kapilesh Bhargava | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，3： | 11 |
| 4 | Hepatic Hemangioendothelioma: An update显示文摘Primary epithelioid hemangioendotheliomas of the liver(EHL)are rare tumors with a low incidence.The molecular background of EHL is still under investigation,with WWTR1-CAMPTA1 mutation may function as a tumor marker.Commonly,this tumor is misdiagnosed with angiosarcoma,cholangiocarcinomas,metastatic carcinoma,and hepatocellular carcinoma(sclerosing variant).Characteristic features on imaging modalities such as ultrasound,computed tomography,magnetic resonance imaging and positron emission tomography/computed tomography guide in diagnosis and staging.The“halo sign”and the“lollipop sign”on computed tomography and magnetic resonance imaging are described in the literature.Currently,there are no standardized guidelines for treating EHL with treatment options are broad including:chemotherapy,ablation,surgery and liver transplantation with inconsistent results. | Mayur Virarkar Mohammed Saleh Radwan Diab Melissa Taggart Peeyush Bhargava Priya Bhosale | 2020 | World Journal of Gastrointestinal Oncology2020，12，3： | 8 |
| 5 | Phacoemulsification versus small incision cataract surgery in patients with uveitis显示文摘AIM: To compare the safety and efficacy of phacoemulsification and small incision cataract surgery(SICS) in patients with uveitic cataract.·METHODS: In a prospective, randomized multi-centric study, consecutive patients with uveitic cataract were randomized to receive phacoemulsification or manual SICS by either of two surgeons well versed with both the techniques. A minimum inflammation free period of 3mo(defined as less than 5 cells per high power field in anterior chamber) was a pre-requisite for eligibility for surgery. Superior scleral tunnel incisions were used for both techniques. Improvement in visual acuity post-operatively was the primary outcome measure and the rate of post-operative complications and surgical time were secondary outcome measures, respectively. Means of groups were compared using t-tests. One way analysis of variance(ANOVA) was used when there were more than two groups. Chi-square tests were used for proportions. Kaplan Meyer survival analysis was done and means for survival time was estimated at 95%confidence interval(CI). A P value of <0.05 was considered statistically significant.·RESULTS: One hundred and twenty-six of 139 patients(90.6%) completed the 6-month follow-up. Seven patients were lost in follow up and another six excluded due to either follow-up less than six months(n=1) or inability implant an intraocular lens(IOL) because of insufficient capsular support following posterior capsule rupture(n=5). There was significant improvement in vision after both the procedures(paired t-test; P <0.001). On first postoperative day, uncorrected distance visual acuity(UDVA) was 20/63 or better in 31(47%)patients in Phaco group and 26(43.3%) patients in SICS group(P=0.384). The mean surgically inducedastigmatism(SIA) was 0.86 ±0.34 dioptres(D) in the phacoemulsification group and 1.16 ±0.28 D in SICS group. The difference between the groups was significant(t-test, P =0.002). At 6mo, corrected distance visual acuity(CDVA) was 20/60 or better in 60(90.9%) patients in Phaco group and 53(88.3%) in the manual SICS group(P =0.478). The mean surgical time was significantly shorter in the manual SICS group(10.8±2.9 versus 13.2±2.6min)(P <0.001). Oral prednisolone, 1 mg/kg body weight was given 7d prior to surgery, continued post-operatively and tapered according to the inflammatory response over 4-6wk in patients with previously documented macular edema, recurrent uveitis, chronic anterior uveitis and intermediate uveitis. Rate of complications like macular edema(Chi-square, P =0.459),persistent uveitis(Chi-square, P =0.289) and posterior capsule opacification(Chi-square, P =0.474) were comparable between both the groups.·CONCLUSION: Manual SICS and phacoemulsification do not differ significantly in complication rates and final CDVA outcomes. However, manual SICS is significantly faster. It may be the preferred technique in settings where surgical volume is high and access to phacoemulsification is limited, such as in eye camps. It may also be the appropriate technique for uveitic cataract under such circumstances. | Rahul Bhargava Prachi Kumar Shiv Kumar Sharma Manoj Kumar Avinash Kaur | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 8 |
| 6 | The role of human papillomavirus in nongenital cancers显示文摘 | Dan P. Zandberg Ranjana Bhargava Simon Badin Kevin J. Cullen | 2012 | CA: A Cancer Journal for Clinicians2012，，1： | 3 |
| 7 | Evaluation of Traditional Indian Antidiabetic Medicinal Plants for Human Pancreatic Amylase Inhibitory Effect In Vitro显示文摘 | Sudha Ponnusamy Remya Ravindran Smita Zinjarde Shobha Bhargava Ameeta Ravi Kumar | 2010 | Evidence-Based Complementary and Alternative Medicine2010，，： | 3 |
| 8 | Effect of Chlorophytum Borivilianum Santapau and Fernandes on Sexual Dysfunction in Hyperglycemic Male Rats显示文摘Objective:To investigate the effects of Chlorophytum borivilianum(CB) on sexual dysfunction, loss of body weight,and lack of libido in hyperglycemic rats induced with streptozotocin or alloxan.Methods: Wistar strain male albino rats were divided into five groups of six animals each:the control group(2% polyvinylpyrollidone solution),the streptozotocin control group(50 mg/kg),the alloxan control group(100 mg/kg), the streptozotocin + CB treated group(200 mg/kg),and the alloxan + CB treated group(200 mg/kg... | Mayank Thakur Shilpi Bhargava Werner Praznik Renate Loeppert Vinod K Dixit | 2009 | Chinese Journal of Integrative Medicine2009，15，6： | 3 |
| 9 | 失速点上湿压缩对于跨音速压气机转子性能的影响(英文)显示文摘In order to study the effects of wet compression on a transonic compressor,a full 3-D steady numerical simulation was carried out under varying conditions.Different injected water flow rates and droplet diameters were considered.The effect of wet compression on the shock,separated flow,pressure ratio,and efficiency was investigated.Additionally,the effect of wet compression on the tip clearance when the compressor runs in the near-stall and stall situations was emphasized.Analysis of the results shows that the range of stable operation is extended,and that the pressure ratio and inlet air flow rate are also increased at the near-stall point.In addition,it seems that there is an optimum size of the droplet diameter. | 杨怀丰 郑群 罗铭聪 孙兰昕 Rakesh Bhargava | 2011 | Journal of Marine Science and Application2011，10，1： | 3 |
| 10 | On Timing Offset Estimation for OFDM Systems显示文摘 | Minn H Zeng M Bhargava V K | | 0，，： | 2 |
| 11 | Phase-II Study of Gemcitabine and Cisplatin in Patients with Metastatic Biliary and Gallbladder Cancer显示文摘 | Jeffrey A. Meyerhardt Andrew X. Zhu Keith Stuart David P. Ryan Lawrence Blaszkowsky Nicole Lehman Craig C. Earle Matthew H. Kulke Pankaj Bhargava Charles S. Fuchs | 2008 | Digestive Diseases and Sciences2008，，2： | 2 |
| 12 | 放射性核素标记单克隆抗体显示文摘目前,分子医学中一个最迫切的问题是运送为能中和或修补分子缺陷而专门设计的药物到达指定的靶组织,以加强疗效,减少药物对其它组织的毒性反应.单克隆抗体作为一种分子载体,正日益受到人们的重视.适当的放射性核素和使用更简便、更好的标记方法是达到这一目的的重要步骤. | Bhargava KK Acharya SA 秦岚 | 1990 | 国外医学(放射医学核医学分册)1990，14，1： | 2 |
| 13 | Approaches for enhanced phytoextraction of heavy metals显示文摘 | Atul Bhargava Francisco F. Carmona Meenakshi Bhargava Shilpi Srivastava | 2012 | Journal of Environmental Management2012，，： | 2 |
| 14 | Physico-chemical changes in a-C: H by MeV He ion irradiation显示文摘 | Paterson M J Orrman-Rossiter K G Bhargava S | 1994 | J Appl Phys1994，75，2： | 2 |
| 15 | Plasma B-Type Natriuretic Peptide Levels and Recurrent Arrhythmia After Successful Ablation of Lone Atrial Fibrillation显示文摘 | Ayman A. Hussein Walid I. Saliba David O. Martin Mazyar Shadman Mohamed Kanj Mandeep Bhargava Thomas Dresing Mina Chung Thomas Callahan Bryan Baranowski Patrick Tchou Bruce D. Lindsay Andrea Natale Oussama M. Wazni | 2011 | Circulation2011，，19： | 2 |
| 16 | Cavernous hemangioma of testis with acute testicular infarction: a case report显示文摘 | Gharpure KJ Ahmed YB Bhargava MK | 1985 | Indinan J Cancer1985，22，1： | 1 |
| 17 | A study of platelet aggregation, thromboxane A2 and prostacyclin in central aortic and coronary sinus blood in ischemic heart disease显示文摘 | Bhargava B Chandra N | 1994 | Indian Heart J1994，46，4： | 1 |
| 18 | Analytical model for time to covet cracking in RC structures due to rebar corrosion显示文摘 | BHARGAVA K GHOSH A K MORI Y | 2006 | Nuclear Engineering and Design2006，，236： | 1 |
| 19 | Removal of chromium from synthetic plating waste by zero-valent iron and sulfate-reducing bacteria显示文摘 | Guha S Bhargava P | 2005 | Water Environ Res2005，77，4： | 1 |
| 20 | On Timing Offset Estimation for OFDM Systems显示文摘 | MINN H ZENG M BHARGAVA V K | 2000 | IEEE Commun Lett2000，4，： | 1 |
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