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| 1 | PHYSICAL SIMULATION OF INTERFACIAL CONDITIONS IN HOT FORMING OF STEELS显示文摘In the last few years,substantial experimental simulation and mumerical modelling hare been carried out in IMMPETUS to characterise the interfacial heat transfer and friction conditions during hot forging and rolling of steels. Emphasis has been placed on the influence of the oxide scale which forms on the steel workpiece. In the present paper, the experimental methods used for investigating interfacial heat transfer and friction conditions are described. Theses include hot flat rolling of steel slabs and hot axi- symmetric forging of steel cylinders and rings.Temperature measurements and computations demon- strate that for similar conditions, similar conditions, the effective interfacial heat transfer coefficients (IHTC) derived for hot rolling are significantly higher than those for forging, mainly due to the contribution of scale cracking during rolling. On the basis of experimental observations and numerical analysis,physical models for interfacial heat transfer in forging and rolling have been established. In addition, hot' sandwich' rolling and hot tensile tests with finite element modelling have been carried out to evaluate the hot ductility of the oxide scale.The results indicate that the defomation, cracking and decohesion behaviour of the oxide scale depend on deformation temperature, strain and relative strengths of the scale layer and scale - steel interface.Finaly, friction results from hot ring compression tests and from hot rolling with forward/backward slip measurements are reported. | Y. H. Li M. Krzyzanowski J. H. Beynon and C. M. Sellars IMMPETUS( Institute for Microstructural and Mechanical Process Engineering: The University of Sheffield, Sheffield SI 3JD, UK) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 8 |
| 2 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 3 | The reference genetic linkage map for the multinational Brassica rapa genome sequencing project显示文摘 | Su Ryun Choi Graham R. Teakle Prikshit Plaha Jeong Hee Kim Charlotte J. Allender Elena Beynon Zhong Yun Piao Pilar Soengas Tae Ho Han Graham J. King Guy C. Barker Paul Hand Derek J. Lydiate Jacqueline Batley David Edwards Dal Hoe Koo Jae Wook Bang Beom-Se | 2007 | Theoretical and Applied Genetics2007，，6： | 2 |
| 4 | An analysis of distributions of priority values from alternative comparison scales within AHP显示文摘 | Malcolm Beynon | 2002 | European Journal of Operational Research2002，，140： | 1 |
| 5 | Reducts within the variable precision rough sets model: a further investigation 显示文摘 | Beynon M | 2001 | European Journal of Operational Research2001，134，3： | 1 |
| 6 | Qualitative analysis of organic compounds by mass spectrometry 显示文摘 | Beynon J H | 1954 | Nature1954，174，5： | 1 |
| 7 | Endosonic appearances of normal colon and recrum显示文摘 | Beynon J Fog DM Temple LN | 1986 | Dis Colon Rectum1986，29，12： | 1 |
| 8 | The Dempster-Shafer theory of evidence: an alternative approach to multicriteria decision modeling 显示文摘 | M Beynon B Curry P Morgan | 2000 | Omega2000，28，： | 1 |
| 9 | Minimally invasive en- doscopic surgery for treatment of spontaneous intracerebral haematomas显示文摘 | Beynon C Schiebel P Basel J | 2015 | Neurosurg Rev2015，38，3： | 1 |
| 10 | Reducts within the variable precision rough set model: a further investigation显示文摘 | Beynon M | 2001 | European Journal of Operational Research2001，，134： | 1 |
| 11 | Reducts within the variable precision rough sets model: A further investigation显示文摘 | Beynon M | 2001 | European Journal of Operational Research2001，134，： | 1 |
| 12 | A Method of Aggregation in DS/AHP for Group Decision-Making with the Non-Equivalent Importance of Individuals in the Group显示文摘 | Beynon M J | 2005 | Computers and Operations Research2005，32，7： | 1 |
| 13 | Laparoscopic treatment of pelvic pain associated with minimal and mild endometriosis with use of the Helica Thermal Coagulator显示文摘 | Nardo LG Moustafa M Gareth Beynon DW | 2005 | Fertil Steril2005，83，3： | 1 |
| 14 | Erythrocyte complement receptor type 1 and interactions between immune complexes, neutrophils, and endothelium 显示文摘 | BEYNON H L DAVIES K A HASKARD D O | 1994 | J Imm1994，153，7： | 1 |
| 15 | Silencing mieroRNA-155 ameliorates experimental autoimmune encephalomyelitis显示文摘 | Murugaiyan G Beynon V Mittal A | 2011 | J Immunol2011，187，5： | 1 |
| 16 | Speech--evoked cortical potentials and speech recognition in cochlear implant users显示文摘 | Groenen PA Beynon AJ Snik AF | 2001 | Scand Audiol2001，30，： | 1 |
| 17 | Microstructure and wear resistance of pearlitic rail steels 显示文摘 | A J Perez- Unzueta J H Beynon | 1993 | Wear1993，，： | 1 |
| 18 | Incidence and characteristics of viral community-acquired pneumonia in adults显示文摘 | Jennings L C Anderson T P Beynon K A | 2008 | Thorax2008，63，1： | 1 |
| 19 | The Dempster-Shafer theory of evidence:An alternative approach tomulticriteria decision modeling显示文摘 | BEYNON M J BRUCE CURRY PETER MORGAN | 2000 | Omega2000，28，1： | 1 |
| 20 | Modelling Microstructure and Its Effects during Multipass Hot Rolling显示文摘 | Beynon J H Sellars C M | 1992 | ISIJ International1992，，3： | 1 |
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