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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Refining Soil Organic Matter Determination by Loss-on-Ignition显示文摘Wet oxidation procedure,i.e.,Walkley-Black (WB) method,is a routine,relatively accurate,and popular method for the determination of soil organic matter (SOM) but it is time-consuming,costly and also has a high potential to cause environmental pollution because of disposal of chromium and strong acids used in this analysis.Therefore,loss-on-ignition (LOI) procedure,a simple and cheap method for SOM estimation,which also avoids chromic acid wastes,deserves more attention.The aims of this research were to study the statistical relationships between SOM determined with the LOI (SOMLOI) and WB (SOMWB) methods to compare the spatial variability of SOM in two major plains,Shahrekord and Koohrang plains,of Chaharmahal-va-Bakhtiari Province,Iran.Fifty surface soil samples (0-25 cm) were randomly collected in each plain to determine SOM using the WB method and the LOI procedure at 300,360,400,500 and 550 ℃ for 2 h.The samples covered wide ranges of soil texture and calcium carbonate equivalent (CCE).The general linear form of the regression equation was calculated to estimate SOM LOI from SOM obtained by the WB method for both overall samples and individual plains.Forty soil samples were also randomly selected to compare the SOM and CCE before and after ignition at each temperature.Overall accuracy of the continuous maps generated for the LOI and WB methods was considered to determine the accordance of two procedures.Results showed a significant positive linear relationship between SOM LOI and SOM WB.Coefficients of determination (R2) of the equations for individual plains were higher than that of the overall equation.Coefficients of determination and line slopes decreased and root mean square error (RMSE) increased with increasing ignition temperature,which may be due to the mineral structural water loss and destruction of carbonates at higher temperatures.A temperature around 360 ℃ was identified as optimum as it burnt most organic carbon,destroyed less inorganic carbon,caused less clay structural water loss,and used less electrical energy.Although the trends of SOM in the kriged maps by the two procedures accorded well,low overall accuracy was observed for the maps obtained by the two methods.While not suitable for determination where high accuracy is required,determination of organic carbon through LOI is likely suitable for exploratory soil surveys where rough estimation of organic matter is required. | M.H.SALEHI O.HASHEMI BENI H.BEIGI HARCHEGANI I.ESFANDIARPOUR BORUJENI H.R.MOTAGHIAN | 2011 | Pedosphere2011，21，4： | 14 |
| 3 | Genetic Diversity Analysis of Wild Tea Plants in Yunnan Province Using EST-SSR Markers显示文摘In this study,27 pairs of EST-SSR primers were employed to analyze the genetic diversity and genetic relationship of 100 wild tea plant germplasm resources and 22 cultivars. according to the results,a total of 88 polymorphic bands were amplified with 27 pairs of primers; the variation of effective alleles accounted for 69. 01%; a total of 183 genotypes were detected,with a variation range of 4- 11; averagely 6. 78 genotypes were amplified with each primer pair; Shannon index( I) of 27 primer pairs ranged from 0. 32 to 1. 35,with an average of 0. 88; the observed heterozygosity(0. 52) was basically consistent with the expected heterozygosity(0. 52); the average polymorphism heterozygosity was 0. 48,which was very close to 0. 50; the average Nei's index was 0. 51,which was higher than0. 50; the average polymorphism information content( PIC) was 0. 52,which was higher than 0. 50,indicating high genetic diversity among wild tea germplasm resources in Yunnan Province. According to the clustering results,based on geographical origins and genetic backgrounds,122 materials were clustered into 14 categories. Dendrogram based on Nei's genetic distance revealed complex genetic relationships among wild tea germplasm resources in Yunnan Province. This study provided certain reference for subsequent preservation,development and research of wild tea germplasm resources in China. | Meng ZHOU Youyong LI Xuemei SUN Jiajin WANG Jin XIE Hao CHENG Yungang WANG Benying LIU | 2015 | Agricultural Biotechnology2015，4，1： | 4 |
| 4 | Photosynthesis and biochemical responses to elevated O_3 in Plantago major and Sonchus oleraceus growing in a lowland habitat of northern China显示文摘A field experiment was carried out to compare the responses to ozone(O_3) in two common herbaceous plant species, Plantago major L. and Sonchus oleraceus L., by building open-top growth chambers in situ to simulate O_3stress(+ O_3, 85 ± 5 ppb, 9 hr/day for 30 days) in a lowland habitat in Inner Mongolia, Northern China. Responses to O_3 of gas exchange,chlorophyll a fluorescence, leaf pigment content, antioxidant capability, soluble protein content, membrane lipid peroxidation and dark respiration(R_d) were analyzed. Results showed that elevated O_3 exposure significantly reduced the light-saturated net photosynthesis(P_(Nsat)), stomatal conductance(g_s) and transpiration rate(E) in both species. Although non-significant interactive effect between species and O_3 on P_(Nsat) was analyzed, the reduction in P_(Nsat) in S. oleraceus might be due primarily to the higher fraction of close PSII reaction centers and impaired activities of plant mesophyll cells as evidences by decreased maximum efficiency of PSII photochemistry after dark adapted state(F_v/F_m) and unchanged intercellular CO_2concentration(C_i). Besides, biochemical analysis showed that S. oleraceus had lower antioxidant ability compared to P. major. As a result, S. oleraceus was damaged to the larger extent in terms of lipid peroxidation and visible O_3 injury, indicating that S. oleraceus was more sensitive to O_3 than P. major. Our results indicated that wild herbaceous plant species growing in a lowland habitat in sandy grassland were sensitive to O_3 stress and S. oleraceus can be considered as one of the bio-indicators for high O_3 concentration in semi-arid grassland of northern China. | Benying Su Meihua Zhou Hong Xu Xiujie Zhang Yonggeng Li Hua Su Bao Xiang | 2017 | Journal of Environmental Sciences2017，29，3： | 4 |
| 5 | Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study显示文摘 | Jean-Fran?ois Bosset Gilles Calais Laurent Mineur Philippe Maingon Suzana Stojanovic-Rundic René-Jean Bensadoun Etienne Bardet Alexander Beny Jean-Claude Ollier Michel Bolla Dominique Marchal Jean-Luc Van Laethem Vincent Klein Jordi Giralt Pierre Clavère | 2014 | Lancet Oncology2014，，2： | 2 |
| 6 | Medial temporal lobe abnormalities in pediatric unipolar depression显示文摘 | Sheila C. Caetano Manoela Fonseca John P. Hatch Rene L. Olvera Mark Nicoletti Kristina Hunter Beny Lafer Steven R. Pliszka Jair C. Soares | 2007 | Neuroscience Letters2007，，3： | 2 |
| 7 | validity measure for Fuzzy Clustering显示文摘 | XIE X BENI G A | 1991 | IEEE Transactions on Pattern Analysis and Machine Intelligence1991，13，8： | 2 |
| 8 | Studies on unfolding energy spectra of neutrons using maximumlikelihood expectation–maximization method显示文摘Energy spectra of neutrons are important for identification of unknown neutron sources and for determination of the equivalent dose. Although standard energy spectra of neutrons are available in some situations, e.g., for some radiotherapy treatment machines, they are unknown in other cases, e.g., for photoneutrons created in radiotherapy rooms and neutrons generated in nuclear reactors. In situations where neutron energy spectra need to be determined, unfolding the required neutron energy spectra using the Bonner sphere spectrometer (BSS) and nested neutron spectrometer (NNS) has been found promising. However, without any prior knowledge on the spectra, the unfolding process has remained a tedious task. In this work, a standalone numerical tool named ‘‘NRUunfold’’ was developed which could satisfactorily unfold neutron spectra for BSS or NNS, or any other systems using similar detection methodology. A generic and versatile algorithm based on maximum-likelihood expectation– maximization method was developed and benchmarked against the widely used STAY’SL algorithm which was based on the least squares method. The present method could output decent results in the absence of precisely calculated initial guess, although it was also remarked that employment of exceptionally bizarre initial spectra could lead to some unreasonable output spectra. The neutron count rates computed using the manufacturer’s response functions were used for sensitivity studies. The present NRUunfold code could be useful for neutron energy spectrum unfolding for BSS or NNS applications in the absence of a precisely calculated initial guess. | Mehrdad Shahmohammadi Beni D.Krstic D.Nikezic K.N.Yu | 2019 | Nuclear Science and Techniques2019，30，9： | 2 |
| 9 | Analysis of Differences in Biochemical Components Between Yunnan and Kenya Tea Tree Varieties显示文摘With 16 Yunnan tea tree varieties and 5 Kenya tea tree varieties as test materials,the differences in biochemical components between Yunnan and Kenya tea tree varieties were compared and analyzed.The results showed that the coefficients of variation of tea polyphenols,amino acids,caffeine,water extract,gallic acid(GA),catechin(C),epicatechin(EC),epicatechin gallate(ECG),epigallocatechin(EGC),epigallocatechin gallate(EGCG)and total catechins in Yunnan tea tree varieties were greater than those in Kenyan tea trees.The contents of tea polyphenols,amino acids,caffeine,water extract,C,EC,EGC,EGCG and total catechins in Yunnan tea tree varieties had no significant differences from those in Kenyan tea trees varieties(P>0.05),while there were significant differences in the contents of GA and ECG between Yunnan tea tree varieties and Kenya tea tree varieties(P<0.05).Therefore,it could be predicted that GA and ECG might be one of the main characteristics of the differences in biochemical components between Yunnan tea tree varieties and Kenyan tea tree varieties.The cluster analysis results showed that when the genetic distance was 15,the 21 tested tea varieties could be divided into three groups with obvious biochemical differences. | Shengmei YANG Youyong LI Zhifen DUAN Yunxiu BAO Weiqiong SHANG Benying LIU Yichun TANG | 2020 | Agricultural Biotechnology2020，9，4： | 2 |
| 10 | CHADS 2 and CHA 2 DS 2 -VASc Scores in the Prediction of Clinical Outcomes in Patients With Atrial Fibrillation After Catheter Ablation显示文摘 | Tze-Fan Chao Yenn-Jiang Lin Hsuan-Ming Tsao Chin-Feng Tsai Wei-Shiang Lin Shih-Lin Chang Li-Wei Lo Yu-Feng Hu Ta-Chuan Tuan Kazuyoshi Suenari Cheng-Hung Li Beny Hartono Hung-Yu Chang Kibos Ambrose Tsu-Juey Wu Shih-Ann Chen | 2011 | Journal of the American College of Cardiology2011，，23： | 2 |
| 11 | A validity measure for fuzzy clustering显示文摘 | Xie X L Beni G | 1991 | IEEE Transactions on Pattern Analysis and Machine Intelligence1991，13，8： | 1 |
| 12 | Hip arthroplasty for salvage of failed treatment of intertrochanteric hip fractures显示文摘 | Haidukenych GJ Beny DJ | 2003 | J Bone Joint Surg(Am)2003，85，5： | 1 |
| 13 | A validity measure for fuzzy clustering显示文摘 | Xie X L Beni G | 1991 | IEEE Transactions Pattern Analysis and Machine Intelligence1991，13，8： | 1 |
| 14 | A least biased fuzzy clustering method显示文摘 | Beni C Liu X M | 1992 | IEEE PAMI1992，14，9： | 1 |
| 15 | A validity measure for fuzzy clustering 显示文摘 | XIE Xuan-li Beni G | 1991 | IEEE Transactions on Pattern Analysis and Machine Intelligence1991，13，8： | 1 |
| 16 | Myelin-,reactive glia-,and scar-derived CNS axon growth inhibitors:expression,receptor signaling,and correlation with axon regeneration显示文摘 | Sandvig A Beny M Barxett LB | 2004 | Glia2004，46，3： | 1 |
| 17 | Myelin-,reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration显示文摘 | Sandvig A Beny M Barxett LB | 2004 | Glia2004，46，3： | 1 |
| 18 | Intracellular cAMP: the 'switch' that trigt's on 'spontaneous transient outward currents' generation in fresh- ly isolated myocytes from thoracic aorta显示文摘 | Hayoz S Beny JL Bychkov R | 2007 | Am J Physiol Cell Physiol2007，292，4： | 1 |
| 19 | Investiga- tion of grain refinement in A1/A1203/B4C nano-composite produced by ARB 显示文摘 | Akbari Beni H Alizadeh M Ghaffari M | 2014 | Composites Part B: Engineering2014，58，： | 1 |
| 20 | Melatonin -induced neuroprotection after closed head injury is associated with increased brain antioxidants and attenuated late -phase activation of NF-κB and AP-1显示文摘 | Beni S M Kohen R Reiter R S | 2003 | FASEB J2003，10，： | 1 |
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