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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | 本地混合菌群微生物氧化难处理含金硫化精矿(英文)显示文摘采用含铁氧化菌和硫氧化菌的混合嗜中温菌群浸出阿根廷Andacollo矿的含金硫化浮选精矿。实验在摇瓶中进行,矿浆浓度为10%,采用pH 1.8的含亚铁离子的基础盐溶液作为介质。采用不同的方法对浸出液的pH值、氧化还原电位、亚铁离子和总金属浓度进行测定。结果表明,该种混合菌能够很好地还原浸出该难处理金矿,金的回收率可达91.6%,同时,铜和锌的浸出率也较高。动力学研究表明金属的溶解符合收缩核模型。其中,铜的溶解速率受生成产物层的扩散控制,而锌的溶解没有明显的控制步骤。 | N. MARCHEVSKY M. M. BARROSO QUIROGA A. GIAVENO E. DONATI | 2017 | Transactions of Nonferrous Metals Society of China2017，27，5： | 3 |
| 3 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 4 | Surgical Management of Early-Stage Hepatocellular Carcinoma: Resection or Transplantation?显示文摘 | Emily C. Bellavance Kimberly M. Lumpkins Gilles Mentha Hugo P. Marques Lorenzo Capussotti Carlo Pulitano Pietro Majno Paulo Mira Laura Rubbia-Brandt Alessandro Ferrero Luca Aldrighetti Steven Cunningham Nadia Russolillo Benjamin Philosophe Eduardo Barroso | 2008 | Journal of Gastrointestinal Surgery2008，，10： | 2 |
| 5 | Hormone abuse in sports: the antidoping perspective显示文摘自从古老的时间起,不道德运动员试图通过做物质的使用获得不公平的竞争优势。做在运动禁止的物质和方法的一张表每年被世界做反的机构(WADA ) 出版。如果它完成至少二个下列标准,一种物质或方法可能在表被包括:提高运动性能;代表风险到运动员的健康;或违背运动的精神。这张表,常常更新了象做趋势一样在药品的工业反映新开发,枚举禁止进出竞争的药类型和方法。在包括的物质之中是 steroidal 和肽荷尔蒙和他们的调节的人,兴奋剂, glucocorticosteroids, β2-agonists,利尿剂和掩盖的代理人,麻醉剂,和 cannabinoids。血做,捣弄,做的注入,和基因是在表上显示的禁止的方法的例子。从所有这些,荷尔蒙迄今为止组成做实验室的反报导的不利分析调查结果的最高的数字。尽管到日期大多数由于 anabolism 的类固醇,分子的生物学技术的来临使 recombinant 成为了容易地可得到的肽荷尔蒙。这些物质逐渐地正在改变做趋势的风景。象 erythropoietin (EPO ) 一样的肽荷尔蒙,人的生长荷尔蒙(hGH ) ,胰岛素,和像胰岛素的生长因素(IGF-I ) 我被假定广泛地为性能被虐待改进。而且,因为有对他们的察觉合适的技术的少量,肽荷尔蒙对不诚实的运动员更加有吸引力。这文章愿望概述是的荷尔蒙的使用在运动做物质,当他们代表紧迫的挑战到对做的当前的战斗,主要集中于肽荷尔蒙。当新做,荷尔蒙和荷尔蒙调节的人被药品的工业正在开发,它能出现物质,也被讨论。 | Osquel Barroso Irene Mazzoni Olivier Rabin | 2008 | Asian Journal of Andrology2008，10，3： | 2 |
| 6 | The aryl hydrocarbon receptor and the gut–brain axis显示文摘The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor initially identified as the receptor for dioxin.Almost half a century after its discovery,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and disease.In this review,we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases. | Andreia Barroso João Vitor Mahler Pedro Henrique Fonseca-Castro Francisco J.Quintana | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 7 | A regionalized IO-model to value seasonal recreational ecosystem services in a mountain National Park in Spain显示文摘Recreational Ecosystem Services(RES)are among the most frequently evaluated ecosystem services.RES are seen as a major opportunity for sustainable development in areas of high ecological value resulting from the presence of emblematic species,habitats or scenery,often integrated in conservation areas,in particular in mountain areas affected by depopulation,rising environmental risks and poverty.Economically,the assessment of RES has been based on Contingent Valuation and Choice Experiments,methods with limitations related to their subjectivity.Alternatively,Input-Output(IO)models provide a very accurate and effective way of valuation of RES with regional information regarding interindustry transactions.Whilst data on nature tourist expenditure may be only available annually,tourism inflows have a strong seasonal behavior,which impacts the profitability of several local economic activities.In this paper,we firstly constructed a novel regionalized IO-model based on Cross-Industry Location Quotients using employment data and,secondly,based on Monte Carlo simulation,we estimated nature tourist expenditure monthly using data on nature tourism inflows.This method allowed for a more precise RES evaluation,estimating direct,indirect and induced monthly economic impacts of nature-based tourism.The method was applied to the Ordesa and Monte Perdido(OMP)National Park in the Spanish Pyrenees.To estimate the average tourist expenditure,we collected and analyzed spending on commerce,hospitality and restaurants,leisure,and transport of 385 visitors.Results suggest that using a regionalized IO model leads to a considerable reduction of over-estimation of the economic impact of tourist expenditure estimated by conventional methods.Taking into consideration the direct,indirect and induced effects of tourist expenditure in 2016-2018,the total annual output effect in the OMP National Park amounted to€208.8 million,while the total income effect amounted to€86.29 million.Also,a total of 2,429 jobs were created which indicates that for each thousand annual visitors to the National Park,3.8 jobs are created in the surrounding area.Overall,the proposed methodology can be easily applied to the remaining National Parks in Spain or other regions in the world,making it a valuable tool to estimate the value of RES in areas affects by strong seasonality,to set priorities and support regional policies for mountain sustainable development. | Víctor MARTIN BARROSO Mónica de CASTRO-PARDO Pascual FERNÁNDEZ MARTÍNEZ João C.AZEVEDO | 2022 | Journal of Mountain Science2022，19，1： | 2 |
| 8 | Foveal thickness reduction after anti-vascular endothelial growth factor treatment in chronic diabetic macular edema显示文摘AIM:To report foveal thickness reduction in eyes with resolution of macular edema and recovery of a foveal depression after one-year of anti-vascular endothelial growth factor(anti-VEGF) therapy for center-involving diabetic macular edema(DME).METHODS:Foveal thickness was assessed with optical coherence tomography to determine the central subfield foveal thickness(CSFT) and macular volume in 42 eyes with DME(CSFT>275 μm). Evaluations also included measurement of best-corrected visual acuity(BCVA), and were performed at baseline, and upon foveal depression recovery achieved after 12 monthly intravitreal injections of either 1.5 mg/0.06 mL bevacizumab(n=21) or 0.5 mg/0.05 mL ranibizumab(n=21). Data was compared to 42 eyes of normally sighted, non-diabetic, healthy individuals with similar age, gender and race distributions.RESULTS:Mean baseline BCVA was 0.59±0.04 and 0.32± 0.03 log MAR(P<0.001) after treatment and resolution of DME, with all, but 3 eyes, showing BCVA improvement. Mean CSFT before treatment was 422.0±20.0 μm, and after treatment, decreased to 241.6±4.6 μm(P<0.001), which is significantly thinner than CSFT found in control subjects(272.0±3.4 μm; P<0.001). Moreover, in 33/42 DM eyes(79%), CSTF was thinner than the matched control eye. Macular volume showed comparable results, but with lower differences between groups(control:8.5±0.4 mm^3; DME:8.2±1.0 mm^3; P=0.0267).CONCLUSION:DME eyes show significantly lower foveal thickness than matched controls after DME resolution achieved with one-year anti-VEGF therapy. Further investigation into the reasonsfor this presumable retinal atrophy using fluorescein angiography and functional parameters as well as establishing possible predictors is warranted. This finding should be considered during the treatment of DME. | Gabriel Willmann Antonio Brunno Nepomuceno Katharina Messias Leticia Barroso Ingrid U.Scott André Messias Rodrigo Jorge | 2017 | International Journal of Ophthalmology(English edition)2017，10，5： | 2 |
| 9 | Ultrasound-assisted extraction of soy isoflavones显示文摘 | Mauricio A. Rostagno Miguel Palma Carmelo G. Barroso | 2003 | Journal of Chromatography A2003，，2： | 2 |
| 10 | Laboratory investigation of flow rate through composite liners consisting of a geomembrane, a GCL and a soil liner显示文摘 | Barroso M Touze-Fohz N Maubeuge K | 2006 | Geotextiles and Geomembranes2006，，24： | 1 |
| 11 | High FSH:LH ratio and low LH levels in basal cycle day3:impact on follicular development and IVF outcome显示文摘 | Barroso G Oehninger S Kolm MP | 2001 | J Assist Reprod Genet2001，18，9： | 1 |
| 12 | Web search for a planet: The Google cluster architecture显示文摘 | Luiz Andr?Barroso Jeffrey Dean Urs H(o)lzle | 2003 | IEEE Computer Society2003，11，： | 1 |
| 13 | Market power assessment and mitigation in hydrothermal systems显示文摘 | KELMAN R AUGUSTO L BARROSO N | 2001 | IEEE Transactions on Power Systems2001，16，3： | 1 |
| 14 | Factors affecting secondary metabolite production in plants: Volatile components and essential oils 显示文摘 | Figueiredo A C Barroso J G Pedro L G | 2008 | Flavour Fragr J2008，23，4： | 1 |
| 15 | Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insu- lin secretion显示文摘 | Gonzalez- Barroso MM Giurgea I Bouillaud F | 2008 | PLuS One2008，3，12： | 1 |
| 16 | Design facts in the axial monotron显示文摘 | Barroso J J | 2000 | IEEE Transactions on Plasma Science2000，28，3： | 1 |
| 17 | Web search for a planet: The Google cluster architecture显示文摘 | Barroso L A Dean J Holzle U | 2003 | IEEE Micro2003，23，2： | 1 |
| 18 | Do inflammatory markers add predictive information of death beyond that provided by age and comorbidity in chronic renal failure patients显示文摘 | Caravaca F Martin MV Barroso S | 2006 | Nephrel Dial Transplant2006，21，： | 1 |
| 19 | Determination of benzo pyrene in total particulate matter of virginia and black tobacco smoke by HPLC with fluorimetric detection 显示文摘 | Kayali M N Rubio- Barroso S | 1995 | J Liquid Chromatography1995，18，8： | 1 |
| 20 | Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension 显示文摘 | Barroso I Gurnell M Crowley VE | 1999 | Nature1999，402，6764： | 1 |
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