|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Timely reperfusion for ST-segment elevation myocardial infarction:Effect of direct transfer to primary angioplasty on time delays and clinical outcomes显示文摘Primary percutaneous coronary intervention(PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction(STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the benefit of selecting this therapeutic option. Several strategies have been proposed to decrease the temporal delays to deliver PPCI. Among them,prehospital diagnosis and direct transfer to the cath lab,by-passing the emergency department of hospitals,has emerged as anattractive way of diminishing delays. The purpose of this review is to address the effect of direct transfer on time delays and clinical events of patients with STEMI treated by PPCI. | Rodrigo Estévez-Loureiro ángela López-Sainz Armo Pérez de Prado Carlos Cuellas Ramón Calvio Santos Norberto Alonso-Orcajo Jorge Salgado Fernández Jose Manuel Vázquez-Rodríguez Maria López-Benito Felipe Fernández-Vázquez | 2014 | World Journal of Cardiology2014，6，6： | 6 |
| 3 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 4 | Operative Versus Nonoperative Treatment for Stage 0 Distal Rectal Cancer Following Chemoradiation Therapy: Long-term Results显示文摘 | Angelita Habr-Gama Rodrigo Oliva Perez Wladimir Nadalin Jorge Sabbaga Ulysses Ribeiro Afonso Henrique Silva e Sousa Fábio Guilherme Campos Desidério Roberto Kiss Joaquim Gama-Rodrigues | 2004 | Annals of Surgery2004，，4： | 2 |
| 5 | Foveal thickness reduction after anti-vascular endothelial growth factor treatment in chronic diabetic macular edema显示文摘AIM:To report foveal thickness reduction in eyes with resolution of macular edema and recovery of a foveal depression after one-year of anti-vascular endothelial growth factor(anti-VEGF) therapy for center-involving diabetic macular edema(DME).METHODS:Foveal thickness was assessed with optical coherence tomography to determine the central subfield foveal thickness(CSFT) and macular volume in 42 eyes with DME(CSFT>275 μm). Evaluations also included measurement of best-corrected visual acuity(BCVA), and were performed at baseline, and upon foveal depression recovery achieved after 12 monthly intravitreal injections of either 1.5 mg/0.06 mL bevacizumab(n=21) or 0.5 mg/0.05 mL ranibizumab(n=21). Data was compared to 42 eyes of normally sighted, non-diabetic, healthy individuals with similar age, gender and race distributions.RESULTS:Mean baseline BCVA was 0.59±0.04 and 0.32± 0.03 log MAR(P<0.001) after treatment and resolution of DME, with all, but 3 eyes, showing BCVA improvement. Mean CSFT before treatment was 422.0±20.0 μm, and after treatment, decreased to 241.6±4.6 μm(P<0.001), which is significantly thinner than CSFT found in control subjects(272.0±3.4 μm; P<0.001). Moreover, in 33/42 DM eyes(79%), CSTF was thinner than the matched control eye. Macular volume showed comparable results, but with lower differences between groups(control:8.5±0.4 mm^3; DME:8.2±1.0 mm^3; P=0.0267).CONCLUSION:DME eyes show significantly lower foveal thickness than matched controls after DME resolution achieved with one-year anti-VEGF therapy. Further investigation into the reasonsfor this presumable retinal atrophy using fluorescein angiography and functional parameters as well as establishing possible predictors is warranted. This finding should be considered during the treatment of DME. | Gabriel Willmann Antonio Brunno Nepomuceno Katharina Messias Leticia Barroso Ingrid U.Scott André Messias Rodrigo Jorge | 2017 | International Journal of Ophthalmology(English edition)2017，10，5： | 2 |
| 6 | Intravitreal Bevacizumab for Diabetic Macular Edema Associated With Severe Capillary Loss: One-Year Results of a Pilot Study显示文摘 | Marco Bonini-Filho Rogério A. Costa Daniela Calucci Rodrigo Jorge Luiz A.S. Melo Ingrid U. Scott | 2009 | American Journal of Ophthalmology2009，，6： | 1 |
| 7 | Meningococcal disease, a clinical and epidemiological review显示文摘Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Africa. In Brazil, it is endemic with occasional outbreaks, epidemics and sporadic cases occurring throughout the year, especially in the winter. The major epidemics of the disease occurred in Brazil in the 70's caused by serogroups A and C. Serogroups B, C and Y represent the majority of cases in Europe, the Americas and Australia. However, there has been a growing increase in serogroup W in some areas. The pathogen transmission happens for respiratory route(droplets) and clinically can lead to meningitis and sepsis(meningococcemia). The treatment is made with antimicrobial and supportive care. For successful prevention, we have some measures like vaccination, chemoprophylaxis and droplets' precautions. In this review, we have described and clarify clinical features of the disease caused by N. meningitidis regarding its relevance for healthcare professionals. | Rodrigo Siqueira Batista Andreia Patricia Gomes Jorge Luiz Dutra Gazineo Paulo Sergio Balbino Miguel Luiz Alberto Santana Lisa Oliveira Mauro Geller | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 1 |
| 8 | Mesenchymal stem cells can be obtained from the human saphena vein显示文摘 | Dimas T. Covas Carlos E. Piccinato Maristela D. Orellana Jorge L.C. Siufi Wilson A. Silva Rodrigo Proto-Siqueira Edgar G. Rizzatti Luciano Neder Ane R.L. Silva Vanderson Rocha Marco A. Zago | 2005 | Experimental Cell Research2005，，2： | 1 |
| 9 | Protein synthesis, PKA, and MAP kinase are differentially involved in short- and long-term memory in rats显示文摘 | Jo?o Quevedo M?nica R.M. Vianna Márcio Rodrigo Martins Tatiana Barichello Jorge H. Medina Rafael Roesler Ivan Izquierdo | 2004 | Behavioural Brain Research2004，，2： | 1 |
| 10 | Minimal loss reconfiguration using genetic algorithms with restricted population and addressed operators real application显示文摘 | Jorge M Rodrigo Lopez Dario M | 2006 | IEEE Trans on Power Systems2006，21，2： | 1 |
| 11 | Operative Versus Nonoperative Treatment for Stage 0 Distal Rectal Cancer Following Chemoradiation Therapy: Long-term Results显示文摘 | Angelita Habr-Gama Rodrigo Oliva Perez Wladimir Nadalin Jorge Sabbaga Ulysses Ribeiro Afonso Henrique Silva e Sousa Fábio Guilherme Campos Desidério Roberto Kiss Joaquim Gama-Rodrigues | 2004 | Annals of Surgery2004，，4： | 1 |
| 12 | Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cells显示文摘 | Rodrigo A Panepucci Jorge LC | 2004 | Stem Cells2004，22，： | 1 |
| 13 | Intravitreal bevacizumab (Avastin) associated with the regression of subretinal neovascularization in idiopathic juxtafoveolar retinal telangiectasis显示文摘 | Rodrigo Jorge Rogério A. Costa Daniela Calucci Ingrid U. Scott | 2006 | Graefe’s Archive for Clinical and Experimental Ophthalmology2006，，7： | 1 |
| 14 | Memantine is a useful drug to prevent the spatial and non- spatial memory deficits induced by methamphetamine in rats 显示文摘 | Jorge Camarasa Teresa Rodrigo David Pubill | 2010 | Pharmacol Res2010，62，5： | 1 |
| 15 | Omega-3 fatty acids and blood pressure显示文摘 | Cabo Jorge Alonso Rodrigo Mata Pedro | 2012 | British Journal of Nutrition2012，，2： | 1 |
| 16 | HIPPOCRATES®project:A proof of concept of a collaborative program for hepatitis C virus micro-elimination in a prison setting显示文摘BACKGROUND In the last few years we have witnessed a revolution in the treatment of hepatitis C virus(HCV)infection.With the introduction of direct-acting antiviral agents(DAAs),sustained virological response(SVR)is achieved in more than 95%of the patients.The focus is now being turned to the global targets set by the World Health Organization,with the aim of achieving HCV elimination by 2030.Prison inmates constitute one of the high-risk groups,and receive treatment less frequently due to several barriers in access to health care.AIM To describe the management and follow-up of a cohort of HCV monoinfected patients treated with DAA in the prison setting,where tertial referral liver center specialists locally provide,on-site assessment and treatment for the prisoners.METHODS A prospective observational study was conducted from April 2017 to March 2020,which included all HCV monoinfected prison inmates in the largest Northern Portugal prison.Demographic,clinical,and laboratory data,as well as transient elastography measurements,were collected onsite by the medical team and prospectively recorded.Patients were treated with DAA according to international guidelines.The primary endpoint was SVR at post-treatment week 12.RESULTS There were 98 monoinfected HCV male inmates(mean age,42.7±8.6 years)included in the analysis.Injecting drugs or tattooing were reported in 74.5%,with 38.8%of the latter being done in prison.Alcohol consumption of more than 30 g/d was referred in 69.4%.The most prevalent genotype was 1a(54.1%),followed by 3(27.6%),4(9.2%)and 1b(6.1%).Pretreatment fibrosis degree was mild-tomoderate(F0-F2)in 77.6%and severe in 22.4%(F3-F4).Treatment regimens chosen were:45.9%elbasvir/grazoprevir,29.6%sofosbuvir/velpatasvir,and 12.2%sofosbuvir/ledispavir and glecaprevir/pibrentasvir.No major adverse events were observed.SVR at post-treatment week 12 was 99%.CONCLUSION In a population considered to be both hard-to-access and a cornerstone for HCV elimination,the onsite evaluation and treatment of HCV-infected prisoners,achieved an exceptional highly effective success rate.This type of collaborative program should be considered to be expanded,to support hepatitis C elimination efforts. | Rui Gaspar Rodrigo Liberal Jorge Tavares Rui Morgado Guilherme Macedo | 2020 | World Journal of Hepatology2020，12，12： | 1 |
| 17 | A simple score to predict early death in adult cancer patients with bloodstream infections显示文摘 | Eduardo Velasco Rodrigo D. Portugal Jorge I.F. Salluh | 2009 | Journal of Infection2009，，： | 1 |
| 18 | Mean platelet volume predict patency of the infarc-related artery before mechanical reperfusion and short-term mortality in patients with ST-segment elevation myocardial in farction undergoing primary percutaneous coronary intervention显示文摘 | Rodrigo EL Jorge SF Raquel MR | 2009 | Thrombosis Res2009，124，： | 1 |
| 19 | 希望是一剂良药——请大胆去用吧显示文摘只要当过患者,或者当过陪患者看病的家属,每个人都会意识到医患关系的重要性。这种关系的核心是患者需要知道问题在哪里,要得到理解,要看到希望。尽管大家都知道希望是战胜任何疾病的基础,但是在给予希望的过程中,临床医生的作用却依赖于个人的经历和本能,并且被认为仅仅是一种独特的“医学技巧”。然而,实际上,希望是一个很实用的治疗手段,就像其他治疗手段一样,可以进行优化。 | Rodrigo A Bressan Eduardo Iacoponi Jorge Candido de Assis Sukhi S Shergill 任倩(译) | 2018 | 英国医学杂志中文版2018，21，10： | 1 |
| 20 | Robust Autonomous Stair Climbing by a Tracked Robot Using Accelerometer Sensors 显示文摘 | Jorge Ferraz Rodrigo Ventura | 2009 | Mobile Robotics2009，5，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员