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| 1 | Red pigment production by Penicillium purpurogenum GH2 is influenced by pH and temperature显示文摘The combined effects of pH and temperature on red pigment production and fungal morphology were evaluated in a submerged culture of Penicillium purpurogenum GH2, using Czapek-Dox media with D-xylose as a carbon source. An experimental design with a factorial fix was used: three pH values (5, 7, and 9) and two temperature levels (24 and 34 °C) were evaluated. The highest production of red pigment (2.46 g/L) was reached with a pH value of 5 and a temperature of 24 °C. Biomass and red pigment production were not directly associated. This study demon- strates that P. purpurogenum GH2 produces a pigment of potential interest to the food industry. It also shows the feasibility of producing and obtaining natural water-soluble pigments for potential use in food industries. A strong combined effect (p<0.05) of pH and temperature was associated with maximal red pigment production (2.46 g/L). | Alejandro MéNDEZ Catalina PéREZ Julio Cesar MONTAéZ Gabriela MARTíNEZ Cristóbal Noé AGUILAR | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，12： | 4 |
| 2 | Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production. | Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi | 2014 | World Journal of Gastroenterology2014，20，27： | 4 |
| 3 | Nutritional Status,Sarcopenia and the Importance of Prehabilitation of Gastrointestinal Tumor Patients:a Surgical Point of View显示文摘Background Surgery may be the field of healthcare where malnutrition and sarcopenia have their greatest impact on patient morbidity and mortality.However,there are limited data on the nutritional status of surgical patients and the effects of prehabilitation on the outcomes of surgery.Methods A prospective analysis was conducted on all patients surgically-treated for malignant gastrointestinal tumors at St.John Hospital during a two-year period.The patient’s gender,age,body weight,height,BMI and weight loss were registered,then a risk score was determined by the MUST survey.Measurement of the triceps and thigh skin-fold thickness and the circumference of the upper arm and thigh were done to calculate muscle area and muscle index,respectively.The body composition was assessed using an OMRON-BF511 device.Muscle function was evaluated based on hand clamping force measurement and activity tests.Patients who were diagnosed as being at-risk received preoperative prehabilitation,which included physiotherapy and nutritional therapy.Results A total of 231 patients(133 males/98 females)were analyzed.They had a mean age of 68.9 years(18~98).Seventy-four patients(32%)lost weight,with an average loss of 7 kilograms(3~15 kg).Anthropometric data showed an average upper-arm circumference of 27.4 cm(14.3~38.1)and thigh circumference of 44.7 cm(19.3~60.1),so the median muscle index was 1.29.The mean BMI was 26,which is above normal,and the elevated BMI was consistent documented in each patient subgroup stratified by age and tumor type.A body composition analysis was performed for 75 patients(44 male/31 female),who had a median age of 68(37~88 y).The average BMI of these patients was 25.7 y and their average MUST score was 1.12.The total body fat percentage(of the total body mass)was 29.5%,total muscle was 30.1%and visceral fat was 10%.Thirty patients(40%)had sarcopenia,with a mean BMI of 28.7,fat comprising 34.2%of the body mass,visceral-fat 11%,and muscle 27.1%,and their median MUST score was 1.23.Patients who received preoperative training(physiotherapy)showed improvements in physical function ranging from 12%~33%.Conclusion Gastrointestinal tumor patients have a higher than normal BMI regardless of age or tumor type.Patients with sarcopenia show measurable improvement after two weeks of prehabilitation. | Péter Lukovich Ákos Nagy Bianka Barok Borbála Csiba Ram Rokka Balázs Pőcze | 2020 | Journal of Nutritional Oncology2020，5，3： | 2 |
| 4 | Muscle oxygen uptake and energy turnover during dynamic exercise at different contraction frequencies in humans显示文摘 | Ferguson RA Bal D Krustrup P | | 0，，1： | 1 |
| 5 | Bamboo shoot processing: food quality and safety aspect (a review)显示文摘 | SATYA S BAL L M SINGHAL P | 2010 | Trends in Food Science&Technology2010，21，4： | 1 |
| 6 | Design,synthesis and biological evaluation of novel non-nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties显示文摘 | SRIRAM D BAL T R YOGEESWARI P | 2004 | Bioorganic&Medicinal Chemistry2004，12，22： | 1 |
| 7 | Multi- metal binding site of serum albumin 显示文摘 | BAL W CHRISTODOULOU J SADLER P J | 1998 | J Inorg Bio- chem1998，70，： | 1 |
| 8 | Bamboo shoot: a potential source of food security显示文摘 | SATYA S SINGHAL P BAL L M | 2012 | Mediterranean Journal of Nutritionand Metabolism2012，5，1： | 1 |
| 9 | Psychological contract breach and job attitudes:A meta-analysis of age as a moderator 显示文摘 | Bal P M De Lange A H Jansen P G W Der Velde M E G V | 2008 | Journal of Vocational Behavior2008，72，1： | 1 |
| 10 | Thermoluminescent dosimetry of the select seed 125I interstitial brachytherapy seed显示文摘 | An G Bal D Kar P | | 0，，05： | 1 |
| 11 | Bamboo shoot processing:food quality and safety aspect(a review)显示文摘 | Satya S Bal LM Singhal P Naik SN | | 0，，04： | 1 |
| 12 | C1-C2 posterior fixation: are 4 screws better than 2 ? 显示文摘 | Vergara P Bal J S Hickman C A | 2012 | Neurosurgery2012，71，1： | 1 |
| 13 | Bamboo shoot processing:food quality and safety aspect:a review显示文摘 | SANTOSH S BAL L M SINGHAL P | | 0，，04： | 1 |
| 14 | Von Hippel-Lindau syndrome: demonstration of entire disease spectrum with (68) Ga-DOTANOC PET-CT显示文摘 | Sharma P Dhull VS Bal C | 2014 | Korean J Radiol2014，15，1： | 1 |
| 15 | Saponins from Chenopo-dium album 显示文摘 | LAVAUD C VOUTQUENNE L BAL P | 2000 | Fitoterapia2000，71，： | 1 |
| 16 | Application of small interfering RNA(si RNA)for modulation of airway epithelial gene expression显示文摘 | Platz J Pinkenburg O Beisswenger C Püchner A Damm T Bals R | 2005 | Oligonucleotides2005，15，2： | 1 |
| 17 | An amputa-tion-specific protocol architecture for wireless micro sensor net-works显示文摘 | Heinzelman W B Chandrakasan A P Bal Krishnan H | 2002 | IEEE Transactions on Wireless Communications2002，，1： | 1 |
| 18 | Biological identifications through DNA barcodes显示文摘 | Hebert P D N Cywimska A Bal S L | 2003 | Biological Sciences/The Royal Society2003，270，1512： | 1 |
| 19 | Standardization of the quantification of iron concentration in the liver by magnetic resonance imaging显示文摘 | Alústiza J M Emparanzab J I Aldazábal P | | 0，，2： | 1 |
| 20 | Protecting groups in organic synthesis, part 8 : Conversion of aldehydes in-to geminal diacetates显示文摘 | Kochhar K S Bal B S Deshpande R P | 1983 | J Org Chem1983，48，17： | 1 |
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