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| 1 | Study on the removal of NO_x from simulated flue gas using acidic NaClO_2 solution显示文摘从模仿的烟道气体的 NOx 的移动上的学习在起泡的实验室规模被执行了用钠绿泥石的酸的答案的反应堆。实验在各种各样的 pH 和入口被执行在在 45 ° C 的 SO2 气体的缺席或存在的没有集中。没有氧化和 NO2 吸收上的 SO2 的效果非常被检验。钠绿泥石的氧化能力在不同 pH 被调查,是在 pH 的更好的氧化剂被发现不到 4。在酸的媒介,钠绿泥石分解了成 ClO2 气体,它被相信不象在 NO2 吸收一样参予氧化。用酸的钠绿泥石答案的貌似合理的 NOx 移动机制被要求了。大约 81% 的最大的 NOx 移动效率被完成了。 | Bal Rai Deshwal Si Hyun Lee Jong Hyeon Jung Byung Hyun Shon Hyung Keun Lee | 2008 | Journal of Environmental Sciences2008，20，1： | 39 |
| 2 | 不同年龄小儿穿孔性阑尾炎流行病学及临床表现差异分析显示文摘目的分析不同年龄段儿童急性穿孔性阑尾炎流行病学和临床表现的差异,为改进急性穿孔性阑尾炎的早期诊断提供理论依据。方法收集近20年本院收治的急性穿孔性阑尾炎患儿的临床资料。根据年龄分为新生儿及婴幼儿组(1d至3岁)、学龄前组(4~7岁)、小学年龄组(8~12岁)、青春期组(13~16岁)。统计穿孔性阑尾炎的性别比例和年龄分布。计算比较不同年龄段患儿的穿孔率。比较不同月份不同年龄段患儿穿孔性阑尾炎的发病情况。分析不同年龄段患儿穿孔性阑尾炎主要临床症状、体征、实验室及影像检查的差异。结果本院近20年共收治急性阑尾炎5859例,其中穿孔性阑尾炎1446例,男936例,女510例,男女比1.84:1,总穿孔率为24.68%。不同年龄段患儿阑尾炎穿孔率分别为:新生儿及婴幼儿组28.65%,学龄前组28.63%,小学年龄组22.64%,青春期组13.35%。穿孔性阑尾炎发病呈季节性分布,其中夏季7、8、9三个月发病率最高,而2、3、4三个月发病率最低。腹痛是各年龄组最常见症状,各年龄组发生率无明显差异(P〉0.05)。转移性右下腹痛仅出现于15.70%的患儿中,且随年龄增长发生率逐渐增加。发热、呕吐、厌食、腹泻等症状发生率随年龄增长逐渐降低,差异有统计学意义(P〈0.05)。而转移性右下腹痛和腹部压痛及肌紧张的发生率随年龄增长逐渐升高,差异有统计学意义(P〈0.01)。中性粒细胞比例新生儿及婴幼儿组低于小学年龄组和青春期组,C反应蛋白水平新生儿及婴幼儿组高于小学年龄组和青春期组,差异有统计学意义(P〈0.05)。腹部平片和B型超声显示青春期组肠梗阻征和肠壁增厚伴蠕动减少的发生率高于其他各组,B型超声和CT显示小学年龄组和青春期组阑尾粪石出现率高于新生儿及婴幼儿组和学龄前组,差异有统计学意义(P〈0.05)。结论阑尾炎穿孔率随年龄的变化而不同。穿孔性阑尾炎发病呈季节性分布。不同症状、体征在不同年龄组的发生率有显著差异。不同年龄组患儿中性粒细胞比例和C反应蛋白不同。部分影像学表现在不同年龄组患儿中出现率不等。 | 孙松 Bal Mukunda Basnet 郑珊 徐梦华 陈功 秦宏 | 2013 | 中华小儿外科杂志2013，34，11： | 35 |
| 3 | Achieving the best bowel preparation for colonoscopy显示文摘Bowel preparation is a core issue in colonoscopy,as it is closely related to the quality of the procedure.Patients often find that bowel preparation is the most unpleasant part of the examination.It is widely accepted that the quality of cleansing must be excellent to facilitate detecting neoplastic lesions.In spite of its importance and potential implications,until recently,bowel preparation has not been the subject of much study.The most commonly used agents are high-volume polyethylene glycol(PEG)electrolyte solution and sodium phosphate.There has been some confusion,even in published meta-analyses,regarding which of the two agents provides better cleansing.It is clear now that both PEG and sodium phosphate are effectivewhen administered with proper timing.Consequently,the timing of administration is recognized as one of the central factors to the quality of cleansing.The bowel preparation agent should be administered,at least in part,a few hours in advance of the colonoscopy.Several low volume agents are available,and either new or modified schedules with PEG that usually improve tolerance.Certain adjuvants can also be used to reduce the volume of PEG,or to improve the efficacy of other agents.Other factors apart from the choice of agent can improve the quality of bowel cleansing.For instance,the effect of diet before colonoscopy has not been completely clarified,but an exclusively liquid diet is probably not required,and a low-fiber diet may be preferable because it improves patient satisfaction and the quality of the procedure.Some patients,such as diabetics and persons with heart or kidney disease,require modified procedures and certain precautions.Bowel preparation for pediatric patients is also reviewed here.In such cases,PEG remains the most commonly used agent.As detecting neoplasia is not the main objective with these patients,less intensive preparation may suffice.Special considerations must be made for patients with inflammatory bowel disease,including safety and diagnostic issues,so that the most adequate agent is chosen.Identifying neoplasia is one of the main objectives of colonoscopy with these patients,and the target lesions are often almost invisible with white light endoscopy.Therefore excellent quality preparation is required to find these lesions and to apply advanced methods such as chromoendoscopy.Bowel preparation for patients with lower gastrointestinal bleeding represents a challenge,and the strategies available are also reviewed here. | Adolfo Parra-Blanco Alex Ruiz Manuel Alvarez-Lobos Ana Amorós Juan Cristóbal Gana Patricio Ibáez Akiko Ono Takahiro Fujii | 2014 | World Journal of Gastroenterology2014，20，47： | 37 |
| 4 | Boron in Plants: Deficiency and Toxicity显示文摘Boron (B) is an essential nutrient for normal growth of higher plants, and B availability in soil and irrigation water is an important determinant of agricultural production. To date, a primordial function of B is undoubtedly its structural role in the cell wall; however, there is increasing evidence for a possible role of B in other processes such as the maintenance of plasma membrane function and several metabolic pathways. In recent years, the knowledge of the molecular basis of B deficiency and toxicity responses in plants has advanced greatly. The aim of this review is to provide an update on recent findings related to these topics, which can contribute to a better understanding of the role of B in plants. | Juan J. Camacho-Cristóbal Jesús Rexach Agustín Gonzlez-Fontes | 2008 | Journal of Integrative Plant Biology2008，50，10： | 25 |
| 5 | 压水堆熔融物堆内滞留策略:历史回顾与研究展望显示文摘本文对广泛应用于第三代压水堆的严重事故缓解措施——熔融物堆内滞留(IVR)进行了历史回顾。IVR策略最早源自于第二代反应堆Lovissa VVER-440的改进设计,以应对堆芯熔化事故。随后,IVR策略被应用于许多新设计的反应堆,如西屋的AP1000、韩国的APR1400以及中国的先进压水堆CAP1400和华龙一号。对IVR策略有效性影响最大的因素分别为堆内堆芯熔化进程、熔融物加载于压力容器壁面的热流密度和压力容器外部冷却。对于堆芯熔化进程,过去人们一直仅关注压力容器下腔室内熔池的换热行为。但通过回顾与分析,本文认为堆内的其他现象,如堆芯的降级和迁移、碎片床的形成及其可冷却性以及熔池的动态形成过程等,可能也会对熔池的最终状态及其作用于下封头的热负荷产生影响。通过对相关研究的回顾,本文希望找出IVR策略的研究中有待完善的部分,并据目前发展水平提出未来IVR研究的需求。 | 马卫民 元一单 Bal Raj Sehgal | 2016 | Engineering2016，2，1： | 14 |
| 6 | BZS1, a B-box Protein, Promotes Photomorphogenesis Downstream of Both Brassinosteroid and Light Signaling Pathways显示文摘Photomorphogenesis 被多重发信号的小径控制,包括光和 brassinosteroid (BR ) 小径。发信号的 BR 激活 BZR1 抄写因素,它为在黑暗中压制 photomorphogenesis 被要求。我们识别了 BR 过分敏感的变异的 bzr11D 的 suppressor 并且把它称为 bzr11D suppressor1 主导(bzs1D ) 。bzs1D 变化被 B 盒子锌手指蛋白质 BZS1 的 overexpression 引起,它被 BZR1 transcriptionally 镇压。BZS1 的 Overexpression 在黑暗,在光的短胚轴,到 BR 处理的减少的敏感,和许多激活 BR 的基因的压抑中引起 de 青白化。由部分压制的合作抑制的 BZS1 击倒 BR 缺乏或感觉迟钝的异种的短胚轴显型。BZS1 是 BR 反应的一个否定管理者的这些结果支持。BZS1 overexpressors 对光的不同波长过分敏感, BZS1 的功能的损失减少植物敏感点亮并且部分压制组成的 photomorphogenesis 1 (cop1 ) 在黑暗中变异,在轻反应建议一个积极角色。BZS1 蛋白质在黑暗成年的 BZS1OX 植物并且在 cop1 异种的轻处理以后在增加的水平积累,并且 BZS1 在 vitro 与 COP1 交往,建议光调整通过调停 COP1 的 ubiquitination 和 proteasomal 降级的 BZS1。这些结果证明 BZS1 调停在 BR 和轻小径之间的串音。 | Xi-Ying Fan Yu Sun Dong-Mei Cao Ming-Yi Bal Xiao-Min Luo Hong-Juan Yang Chuang-Qi Wei Sheng-Wei Zhu Ying Sun Kang Chonga Zhi-Yong Wang | 2012 | Molecular Plant2012，5，3： | 12 |
| 7 | 横向磁场直线开关磁阻电机及其控制系统(英文)显示文摘研究了基于横向磁场直线开关磁阻电机(transverse flux linear switched reluctance motor,TFLSRM)、全数字控制器与新型位置传感器的直线电机驱动系统,建立了TFLSRM数学模型。新型位置传感器利用了TFLSRM次极边极形,无需在次极安装任何元件,改善了系统可靠性。为改善系统性能,在电流环进行了从牵引力到平均电流的非线性转换,在速度环采用离散时间趋近率控制。基于DSP设计了控制器,测试了新型位置传感器与所提驱动系统的动、静态性能。实验结果验证了新型位置传感器与TFLSRM驱动系统的优良性能。 | 葛宝明 赵楠 Aníbal T.de Almeida Fernando J.T.E.Ferreira | 2007 | 中国电机工程学报2007，27，33： | 11 |
| 8 | Primary duodenal neoplasms:A retrospective clinico-pathological analysis显示文摘AIM: To analyze the clinico-pathological spectrum of primary duodenal neoplasms. METHODS: A total of 55 primary duodenal neoplasms reported in the last 10 years after excluding ampullary and periampullary tumors were included in the study. Clinical details were noted and routine hematoxylin and eosin stained paraffin sections were studied for histological subtyping of the tumors. RESULTS: On histopathological examination primary duodenal neoplasms were categorized as: epithelial tumor in 27 cases (49.0%) including 10 cases of adenoma, 15 cases of adenocarcinoma, and 2 cases of Brunner gland adenoma; mesenchymal tumor in 9 cases (16.3%) consisting of 4 cases of gastrointestinal stromal tumor, 4 cases of smooth muscle tumor and I case of neurofibroma; lymphoproliferative tumor in 12 cases (21.8%), and neuroendocrine tumor in 7 cases (12.7%). CONCLUSION: Although non-ampullary/periampullary duodenal adenocarcinomas are rare, they constitute the largest group. Histopathological examination of primary duodenal tumors is important for correct histological subtyping. | Amanjit Bal Kusum Joshi Kim Vaiphei JD Wig | 2007 | World Journal of Gastroenterology2007，13，7： | 10 |
| 9 | Association of ezrin expression in intestinal and diffuse gastric carcinoma with clinicopathological parameters and tumor type显示文摘AIM: To investigate the correlation between ezrin expression and types of gastric carcinoma and clinicopathological variables. METHODS: We examined ezrin protein expression in 75 gastric carcinoma (53 intestinal types of adenocarcinoma, 22 diffuse types of carcinoma) tissues by immunohistochemistry. The results were compared with clinicopathological parameters such as tumor type, grade of tumor, clinical stage, presence of metastatic lymph node, and depth of invasion. RESULTS: Ezrin immunostaining was positive in 43 cases (81.1%) of intestinal type and in 9 (40.9%) cases of diffuse type adenocarcinomas (P < 0.001). In gastric carcinomas, the expression of ezrin protein correlated with the status of H pylori and survival. There was no correlation between expression of ezrin with TNM stage and histological grade of gastric carcinomas (P > 0.05). CONCLUSION: The low expression of ezrin implicates the loss of adhesion in diffuse carcinomas. Furthermore, overexpression of ezrin in carcinomas with H pylori infection may be a genuine specific pathway in which H pylori may cause/initiate gastric carcinoma. | Nebil Bal Sedat Yildirim Tarik Z Nursal Filiz Bolat Fazilet Kayaseluk | 2007 | World Journal of Gastroenterology2007，13，27： | 9 |
| 10 | Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development显示文摘Chronic obstructive pulmonary disease(COPD) significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork(COSYCONET) study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA(miRNA) profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance(two-tailed unpaired t-test adjusted for multiple testing P < 0.05), including members of the miR-320 family. The identified mi RNAs regulate different cancer-related pathways including the MAPK pathway(P = 2.3 x 10^(-5)). We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer. | Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart Meese Robert Bals | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 9 |
| 11 | 电力系统电流互感器饱和特性的柔性神经网络补偿法显示文摘电流互感器(CT)由于饱和使得副边电流变形,进而导致保护与测量应用中的许多问题。为此,提出一种补偿CT饱和特性的方法,以改善其测量性能。所提算法基于具有2个可变参数的sigmoid函数,构建了新型柔性神经网络,以估算CT励磁电流。实时地将估算所得励磁电流与扭曲的副边测量电流相加,即得补偿后原边电流。在学习过程中,所建补偿器的各柔性神经元柔性地改变其形状以适应各自的角色,高度柔性特点增强了网络学习能力,不但可减少网络节点数,而且可减少迭代学习时间。仿真研究中,应用一个900:5A的CT测试所提出的补偿器,测试时考虑了CT原边电流不同直流分量、CT剩磁大小与CT负载特性的影响。仿真结果验证了所提补偿方法的高精度,而且不受CT负载特性、CT剩磁情况及原边电流直流成分的影响。 | 葛宝明 Aníbal T.de Almeida Fernando J.T.E.Ferreira | 2006 | 中国电机工程学报2006，26，16： | 8 |
| 12 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 13 | Long-term rotational stability and visual outcomes of a single-piece hydrophilic acrylic toric IOL:a 1.5-year follow-up显示文摘AIM:To evaluate the rotational stability and visual outcomes of a single-piece hydrophilic acrylic toric intraocular lenses(IOL) over a 1.5-year follow-up period.Data from the 6-month follow-up study have been previously reported.METHODS:Forty eyes of 26 cataract patients(mean age:72.8±7.9y) with pre-existing corneal astigmatism of 1.0 to 2.6 D were enrolled in the study.Mean axial length was 23.17±0.88 mm.Main outcome measures after implantation of the Torica-a A IOL(Human Optics) were IOL rotational stability,subjective refraction,astigmatism correction,uncorrected and corrected distance visual acuity(UDVA,CDVA).RESULTS:There was no significant change in the parameters evaluated between the 6-month and 1.5-year follow-ups.At last visit,mean absolute IOL rotation(objective method) was 1.81°±1.87°(range 0.00° to 7.20°) with 78.6% of eyes having IOL rotation <3°,92.9% of eyes <5° and 100% of eyes <8°.No patient required secondary IOL repositioning during the course of the study.Mean residual refractive cylinder was-0.60±0.40 D.There was a significant reduction in the magnitude of the J0 vector postoperatively(P<0.0001) with a mean absolute change of 0.76±0.40 D.The mean J45 vector was close to zero preoperatively and postoperatively and didn't change significantly(P=0.28).Mean monocular UDVA and CDVA was 0.09±0.12 log MAR and-0.01±0.12 log MAR,respectively.No treatment with Nd:YAG laser was required.CONCLUSION:The Torica-a A IOL shows good and stable visual performance and rotational stability over a 1.5-year follow-up period. | Balázs Gyongyossy Paul Jirak Ulrich Schonherr | 2017 | International Journal of Ophthalmology(English edition)2017，10，4： | 7 |
| 14 | Non-alcoholic fatty liver disease may not be a severe disease at presentation among Asian Indians显示文摘瞄准:与非含酒精的脂肝疾病(NAFLD ) 评估病人的临床、生物化学的侧面并且在表示估计他们的组织学的严厉。方法:介绍给所有印度的肝诊所的连续病人与提起的 transaminases 医学科学(AIIMS ) 开创到乘正常的上面的限制的至少 1.5,并且组织学地证实的非酒精的脂肝疾病被包括。或谁有重要白酒吸入或另外的肝疾病的积极标记的病人正在服知道生产脂肝的药被排除。这个组的临床、生物化学、组织学的侧面被学习。结果:有 NAFLD 的 51 个病人形成了学习人口。他们的中部的年龄和 BMI 是 34 (17-58 ) 年并且 26.7 (21.3-32.5 ) kg/m (2 ) 分别地并且(90.1%) 46 是男性。病人的多数有温和发炎,也分级 1 [32 (63%)] 或等级 2 [16 (31%)] 并且仅仅 3 (6%) 病人们有严重(等级 3 ) 发炎。23 (45%) , 19 (37%) , 8 (16%) 并且 1 (2%) 病人有 0, 1, 2 和 3 纤维变性分别地在索引活体检视和没有上有的舞台肝硬化。在 univariate 分析上,甘油三酸酯铺平超过 150 mg %( 或 = 7.1;95% CI:1.6-31.5, P = 0.002 ) 并且著名计算机生产厂商 / 中高音 ratio>1 (或 = 14.3;95% CI:1.4-678.5, P = 0.008 ) 与发炎的高等级被联系,任何一个都没与先进纤维变性被联系。在上多变量逻辑回归分析, hypertriglyceridemia >150 mg% 是独立地与发炎的高等级的存在联系的唯一的因素(或 = 1.6;95% CI:1.3-22.7, P = 0.02 ) ,当任何一个都没与先进纤维变性被联系时。甘油三酸酯层次与煽动性的等级断然相关(r = 0.412;P = 0.003 ) 。结论:在诺思印第安人病人的 NAFLD 是年轻超重男性,其中大多数是抵抗的胰岛素的疾病,他们趋于在表示有温和组织学的疾病。 | Kaushal Madan Yogesh Batra S Datta Gupta Bal Chander K D Anand Rajan M S Tewatia S K Panda S K Acharya | 2006 | World Journal of Gastroenterology2006，12，21： | 7 |
| 15 | Genetic polymorphism in CD14 gene, a co-receptor of TLR4 associated with non-alcoholic fatty liver disease显示文摘AIM To evaluate the pathogenic role of toll-like receptor(TLR) gene polymorphisms in patients with nonalcoholic fatty liver disease(NAFLD).METHODS Two hundred and fifty subjects(NAFLD = 200, healthy volunteers = 50) underwent polymerase chain reaction and restriction fragment length polymorphism to assess one polymorphism in the toll-like receptor 2(TLR2) gene(A753G), two polymorphisms in the TLR4 gene(TLR4 Asp299 Gly and Thr399 Ile allele), and two polymorphisms in the cluster of differentiation 14(CD14)(C-159 T and C-550T) gene, a co-receptor of TLR4. Association of TLR gene polymorphisms with NAFLD and its severity was evaluated by genetic models of association.RESULTS On both multiplicative and recessive models of gene polymorphism association, there was significant association of CD14 C(-159) T polymorphism with NAFLD; patients with TT genotype had a 2.6 fold increased risk of developing NAFLD in comparison to CC genotype. There was no association of TLR2 Arg753 Gln, TLR4 Asp299 Gly, Thr399 Ile, and CD14 C(-550) T polymorphisms with NAFLD. None of the TLR gene polymorphisms had an association with histological severity of NAFLD.CONCLUSION Patients with CD14 C(-159) T gene polymorphism, a co-receptor of TLR4, have an increased risk of NAFLD development. | Shweta Kapil Ajay Duseja Bal Krishan Sharma Bhupesh Singla Anuradha Chakraborti Ashim Das Pallab Ray Radha K Dhiman Yogesh Chawla | 2016 | World Journal of Gastroenterology2016，22，42： | 7 |
| 16 | A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone显示文摘Transforming growth factor-β(TGF-β)and bone morphogenetic protein(BMP)play important roles in bone metabolism.Smad ubiquitination regulatory factors(Smurfs)regulate TGF-β/BMP signaling via ubiquitination,resulting in degradation of signaling molecules to prevent excessive activation of TGF-β/BMP signaling.Though Smurf2 has been shown to negatively regulate TGF-β/Smad signaling,its involvement in BMP/Smad signaling in bone metabolism has not been thoroughly investigated.In the present study,we sought to evaluate the role of Smurf2 in BMP/Smad signaling in bone metabolism.Absorbable collagen sponges containing 3μg of recombinant human BMP2(rhBMP2)were implanted in the dorsal muscle pouches of wild type(WT)and Smurf2−/−mice.The rhBMP2-induced ectopic bone in Smurf2−/−mice showed greater bone mass,higher mineral apposition and bone formation rates,and greater osteoblast numbers than the ectopic bone in WT mice.In WT mice,the ectopic bone consisted of a thin discontinuous outer cortical shell and scant inner trabecular bone.In contrast,in Smurf2−/−mice,the induced bone consisted of a thick,continuous outer cortical shell and abundant inner trabecular bone.Additionally,rhBMP2-stimulated bone marrow stromal cells(BMSCs)from Smurf2−/−mice showed increased osteogenic differentiation.Smurf2 induced the ubiquitination of Smad1/5.BMP/Smad signaling was enhanced in Smurf2−/−BMSCs stimulated with rhBMP2,and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs.These findings demonstrate that Smurf2 negatively regulates BMP/Smad signaling,thereby identifying a new regulatory mechanism in bone metabolism. | Junichi Kushioka Takashi Kaito Rintaro Okada Hiroyuki Ishiguro Zeynep Bal Joe Kodama Ryota Chijimatsu Melanie Pye Masahiro Narimatsu Jeffrey LWrana Yasumichi Inoue Hiroko Ninomiya Shin Yamamoto Takashi Saitou Hideki Yoshikawa Takeshi Imamura | 2020 | Bone Research2020，8，4： | 6 |
| 17 | Acute abdomen in pregnancy due to isolated Fallopian tube torsion: The laparoscopic treatment of a rare case显示文摘In the last years, operative laparoscopy became a standard approach in gynaecology and general surgery. Even in pregnancy its use is becoming more widely accepted. In fact, it offers advantages similar to those in no pregnant women, associated with good maternal and fetal outcomes. Around 0.2% of pregnant women require abdominal surgery. The most common indications of laparoscopy in pregnancy are cholelithiasis complications, appendicitis, persistent ovarian cyst and adnexal torsion. Authors describe a very rare case of acute abdomen due to isolated Fallopian tube torsion in a 24 th weeks pregnant woman, managed by laparoscopic salpingectomy. | Zacharoula Sidiropoulou António Setúbal | 2014 | World Journal of Clinical Cases2014，2，11： | 5 |
| 18 | Predictors of fifty days in-hospital mortality in decompensated cirrhosis patients with spontaneous bacterial peritonitis显示文摘AIM: To determine the predictors of 50 d in-hospital mortality in decompensated cirrhosis patients with spontaneous bacterial peritonitis(SBP).METHODS: Two hundred and eighteen patients admitted to an intensive care unit in a tertiary care hospital between June 2013 and June 2014 with the diagnosis of SBP(during hospitalization) and cirrhosis were retrospectively analysed. SBP was diagnosed by abdominal paracentesis in the presence of polymorphonuclear cell count ≥ 250 cells/mm3 in the peritoneal fluid. Student's t test, multivariate logistic regression, cox proportional hazard ratio(HR), receiver operating characteristics(ROC) curves and Kaplan-Meier survival analysis were utilized for statistical analysis. Predictive abilities of several variables identified by multivariate analysis were compared using the area under ROC curve. P < 0.05 were considered statistical significant. RESULTS: The 50 d in-hospital mortality rate attributable to SBP is 43.11%(n = 94). Median survival duration for those who died was 9 d. In univariate analysis acute kidney injury(AKI), hepatic encephalopathy, septic shock, serum bilirubin, international normalized ratio, aspartate transaminase, and model for end-stage liver disease- sodium(MELD-Na) were significantly associated with in- hospital mortality in patients with SBP(P ≤ 0.001). Multivariate coxproportional regression analysis showed AKI(HR = 2.16, 95%CI: 1.36-3.42, P = 0.001) septic shock(HR = 1.73, 95%CI: 1.05-2.83, P = 0.029) MELD-Na(HR = 1.06, 95%CI: 1.02-1.09, P ≤ 0.001) was significantly associated with 50 d in-hospital mortality. The prognostic accuracy for AKI, MELD-Na and septic shock was 77%, 74% and 71% respectively associated with 50 d inhospital mortality in SBP patients.CONCLUSION: AKI, MELD-Na and septic shock were predictors of 50 d in-hospital mortality in decompensated cirrhosis patients with SBP. | Chinmaya Kumar Bal Ripu Daman Vikram Bhatia | 2016 | World Journal of Hepatology2016，8，12： | 5 |
| 19 | 纳米多孔二氧化钛电极辅助光电化学降解乙酰氨基酚及伐昔洛韦(英文)显示文摘作为一类具有较高生物活性的物质,药物及个人护理品对环境的污染引起人们越来越多的关注.对乙酰氨基酚和伐昔洛韦是两种使用广泛的药物,由于其潜在的对人类健康和生态安全的威胁而逐渐成为研究热点.而电化学辅助光氧化技术因其具备能够高效处理难降解化学品的优点而得到广泛使用.本文合成了纳米多孔二氧化钛电极,研究了电化学还原处理对纳米多孔二氧化钛电极辅助光电化学降解对乙酰氨基酚和伐昔洛韦的影响.使用扫描电镜和色散谱技术对合成的纳米多孔二氧化钛电极的形态和元素组成进行了表征.循环伏安法、莫特-肖特基曲线、紫外-可见分光光度计和总有机碳分析仪被用来研究对乙酰氨基酚和伐昔洛韦的光电化学降解过程.结果显示,对乙酰氨基酚和伐昔洛韦的光化学降解和电化学降解过程非常缓慢,在研究的时间范围内其浓度未见明显变化,因此可以忽略不计.但是对乙酰氨基酚和伐昔洛韦的光电化学降解速度比较快,与未经处理的纳米多孔二氧化钛电极相比,经过电化学还原处理的电极可以使对乙酰氨基酚和伐昔洛韦的光电化学降解分别提高86.96%和53.12%.这可能是由于在电化学还原处理过程中生成了Ti(3+),Ti^(2+)和氧空位以及导电性的提高.还研究了温度对对乙酰氨基酚和伐昔洛韦光电化学降解的影响,随着温度升高,对乙酰氨基酚和伐昔洛韦的光电化学降解速率增大. | 谢国红 常欣 Bal Ram Adhikari Sapanbir S.Thind 陈爱成 | 2016 | Chinese Journal of Catalysis2016，37，7： | 5 |
| 20 | Recurrent ischemic stroke as an initial manifestation of an concealed pancreatic adenocarcinoma: Trousseau's syndrome显示文摘在稀罕例子,摸可以 preceed 癌症的诊断并且是 malignancy.Cerebral 梗塞主要复杂化淋巴瘤,癌,和稳固的肿瘤的位于 \O 下面的第一条临床的证据。恶意相关的 thromboembolism 能介绍同样尖锐的服的梗塞, nonbacterial thrombotic 心内膜炎和迁移的 thrombophlebitis。它通常被归因于一个癌症相关的 hypercoagulable 时期,长期的 dissemiated intravascular coagulopathy (DIC ) ,或肿瘤栓塞。我们从 undiagnosed 报导了 malignancy-releated thromboembolism 的一个案例在由于长期的 DIC 与周期性的 ischemic 击介绍了的一个 54 岁的人的胰腺的腺癌。尽管有 anticoagulation therapy.This 大小写的适当机构,他死于内在的恶意强调服的梗塞可以是 undiagnosed 癌症的第一表明。如果有实验室或临床的证据,与 DIC 联系,有未知病原学的服的梗塞的病人应该为一个恶意的过程被调查。在有 thromboembolic 疾病的癌症病人的 anticoagulation 的最佳的方法(晒) 仍然保持不清楚。 | Semih Giray Feyzi Birol Sarica Zulfikar Arlier Nebil Bal | 2011 | Chinese Medical Journal2011，，4： | 4 |
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