|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia显示文摘AIM:To determine the expression of neurokinin-1receptor(NK-1R),phosphorylated epidermal growth factor receptor(p EGFR),cyclooxygenase-2(Cox-2),and vitamin D receptor(VDR)in normal,inflammatory bowel disease(IBD),and colorectal neoplasia tissues from Puerto Ricans.METHODS:Tissues from patients with IBD,colitisassociated colorectal cancer(CAC),sporadic dysplasia,and sporadic colorectal cancer(CRC),as well as normal controls,were identified at several centers in Puerto Rico.Archival formalin-fixed,paraffin-embedded tissues were de-identified and processed by immunohistochemistry for NK-1R,p EGFR,Cox-2,and VDR.Pictures of representative areas of each tissues diagnosis were taken and scored by three observers using a4-point scale that assessed intensity of staining.Tissues with CAC were further analyzed by photographing representative areas of IBD and the different grades of dysplasia,in addition to the areas of cancer,within each tissue.Differences in the average age between the five patient groups were assessed with one-way analysis of variance and Tukey-Kramer multiple comparisons test.The mean scores for normal tissues and tissues with IBD,dysplasia,CRC,and CAC were calculatedand statistically compared using one-way analysis of variance and Dunnett’s multiple comparisons test.Correlations between protein expression patterns were analyzed with the Pearson’s product-moment correlation coefficient.Data are presented as mean±SE.RESULTS:On average,patients with IBD were younger(34.60±5.81)than normal(63.20±6.13,P<0.01),sporadic dysplasia(68.80±4.42,P<0.01),sporadic cancer(74.80±4.91,P<0.001),and CAC(57.50±5.11,P<0.05)patients.NK-1R in cancer tissue(sporadic CRC,1.73±0.34;CAC,1.57±0.53)and sporadic dysplasia(2.00±0.45)were higher than in normal tissues(0.73±0.19).p EGFR was significantly increased in sporadic CRC(1.53±0.43)and CAC(2.25±0.47)when compared to normal tissue(0.07±0.25,P<0.05,P<0.001,respectively).Cox-2 was significantly increased in sporadic colorectal cancer(2.20±0.23 vs 0.80±0.37 for normal tissues,P<0.05).In comparison to normal(2.80±0.13)and CAC(2.50±0.33)tissues,VDR was significantly decreased in sporadic dysplasia(0.00±0.00,P<0.001 vs normal,P<0.001 vs CAC)and sporadic CRC(0.47±0.23,P<0.001 vs normal,P<0.001 vs CAC).VDR levels negatively correlated with NK-1R(r=-0.48)and p EGFR(r=-0.56)in normal,IBD,sporadic dysplasia and sporadic CRC tissue,but not in CAC.CONCLUSION:Immunohistochemical NK-1R and p EGFR positivity with VDR negativity can be used to identify areas of sporadic colorectal neoplasia.VDR immunoreactivity can distinguish CAC from sporadic cancer. | Raymond A Isidro Myrella L Cruz Angel A Isidro Axel Baez Axel Arroyo William A González-Marqués Carmen González-Keelan Esther A Torres Caroline B Appleyard | 2015 | World Journal of Gastroenterology2015，21，6： | 7 |
| 2 | Nickel ferrite spinel as catalyst precursor in the dry reforming of methane:Synthesis,characterization and catalytic properties显示文摘Dry reforming of methane by CO2 using nickel ferrite as precursor of catalysts was investigated.Nickel ferrite crystalline particles were prepared by coprecipitation of nitrates with NaOH or ammonia followed by calcination,or by hydrothermal synthesis without calcination step.The textural and structural properties were determined by a number of analysis methods,including X-ray diffraction (XRD),Raman spectroscopy and X-ray photoelectron spectroscopy (XPS),among which X-ray diffraction (XRD) was at room and variable temperatures.All synthesized oxides showed the presence of micro or nanoparticles of NiFe2O4 inverse spinel,but Fe2O3 (hematite) was also present when ammonia was used for coprecipitation.The reducibility by hydrogen was studied by temperature-programmed reduction (TPR) and in situ XRD,which showed the influence of the preparation method.The surface area (BET),particle size (Rietveld refinement),as well as surface Ni/Fe atomic ratio (XPS) and the behavior upon reduction varied according to the synthesis method.The catalytic reactivity was investigated using isopropanol decomposition to determine the acid/base properties.The catalytic performance of methane reforming with CO2 was measured with and without the pre-treatment of catalysts under H2 in 650-800 C range.The catalytic conversions of methane and CO2 were quite low but they increased when the catalysts were pre-reduced.A significant contribution of reverse water gas shift reaction accounted for the low values of H2 /CO ratio.No coking was observed as shown by the reoxidation step performed after the catalytic reactions.The possible formation of nickel-iron alloy observed during the study of reducibility by hydrogen was invoked to account for the catalytic behavior. | Rafik Benrabaa Hamza Boukhlouf Axel Lfberg Annick Rubbens Rose-Nelle Vannier Elisabeth Bordes-Richard Akila Barama | 2012 | Journal of Natural Gas Chemistry2012，21，5： | 5 |
| 3 | Chronic intestinal failure and short bowel syndrome in Crohn’s disease显示文摘Chronic intestinal failure(CIF)is a rare but feared complication of Crohn’s disease.Depending on the remaining length of the small intestine,the affected intestinal segment,and the residual bowel function,CIF can result in a wide spectrum of symptoms,from single micronutrient malabsorption to complete intestinal failure.Management of CIF has improved significantly in recent years.Advances in home-based parenteral nutrition,in particular,have translated into increased survival and improved quality of life.Nevertheless,60%of patients are permanently reliant on parenteral nutrition.Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy.The outcomes of patients with CIF could be greatly improved by more effective prevention,understanding,and treatment.In complex cases,the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation,nutritional support,and an improved quality of life.Here,we summarize current literature on CIF and short bowel syndrome,encompassing epidemiology,pathophysiology,and advances in surgical and medical management,and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease. | Aysegül Aksan Karima Farrag Irina Blumenstein Oliver Schröder Axel U Dignass Jürgen Stein | 2021 | World Journal of Gastroenterology2021，27，24： | 4 |
| 4 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 5 | Major outer membrane proteins of Brucella spp.: past, present and future显示文摘 | Axel Cloeckaert Nieves Vizca??no Jean-Yves Paquet Raúl A Bowden Philip H Elzer | 2002 | Veterinary Microbiology2002，，1： | 2 |
| 6 | A Novel Multigene Family May Encode Odorant Receptors: a Molecular Basis for Odor Recognition显示文摘 | Buck L Axel R | 1991 | Cell1991，65，： | 1 |
| 7 | Cerebral blood flow determination by rapid-sequence computed tomography:A theoretical analysis显示文摘 | | 1980 | Radiology1980，137，1： | 1 |
| 8 | Adaptive Call Admission Control for QoS/Revenue Optimization in CDMA Cellular Networks显示文摘 | Christoph L Marco L Axel T | 2004 | Wireless Networks2004，10，4： | 1 |
| 9 | A novel multigene family may encode odorant receptors: a molecular basis for odor recognition显示文摘 | Buck L Axel R | 1991 | Cell1991，65，： | 1 |
| 10 | Cerebral blood flow determination by rapid-sequence computed tomography theoretical analysis显示文摘 | Axel L | 1980 | Radiology1980，137，3： | 1 |
| 11 | Cerebral blood flow determination by rapid-sequence computed tomography:theoretical analysis显示文摘 | Axel L | 1980 | Radiology1980，137，3： | 1 |
| 12 | Three-dimensional motion and deformation in the heart wall: estimation from spatial modulation of magnetization-a model based approach显示文摘 | Young AA Axel L | 1992 | Radiology1992，185，1： | 1 |
| 13 | Cerebral blood flow determination by rapid sequence computed tomography显示文摘 | Axel L | 1980 | Radiology1980，137，3： | 1 |
| 14 | Major outer membrane proteins of Brucella spp.: past, present and future显示文摘 | Axel Cloeckaert Nieves Vizca??no Jean-Yves Paquet Raúl A Bowden Philip H Elzer | 2002 | Veterinary Microbiology2002，，1： | 1 |
| 15 | Cerebral blood flow determination by rapid sequence computed tomography : theoretical analysis 显示文摘 | Axel L | 1980 | Radiolology1980，137，30： | 1 |
| 16 | MR imaging of motion with spatial modulation of magnetization 显示文摘 | Axel L Dougherty L | 1989 | Radiology1989，171，： | 1 |
| 17 | Dry eyes or mouth-an epidemiological study in Swedish adults,with special reference to primary Sjogren's syndrome显示文摘 | Jacobsson L T Axell T E Hansen B U | 1989 | J Autoimmun1989，2，4： | 1 |
| 18 | Cerebral blood flow determination by rapid-sequence computed tomography显示文摘 | Axel L | 1980 | Radiology1980，137，3： | 1 |
| 19 | Quality assurance methods and phantoms for magnetic resonance imaging:report of AAPM nuclear magnetic resonance显示文摘 | Price R_K Axel L Morgan T | 1990 | MEDICAL PHYSICS1990，17，2： | 1 |
| 20 | Cerebral Blood Flow Determination by Rapid Sequence Computed Tomography:Theoretical Analysis显示文摘 | Axel L | 1980 | Radiology1980，137，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员