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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet2010，，9726： | 4 |
| 3 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | 2010 (9726)2010，，9726： | 3 |
| 4 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet . 2010 (9726)2010，，： | 2 |
| 5 | Leaf respiration of show gum in light and dark interaction between temperature and irradiance 显示文摘 | ATKIN O K EVANS J R BALL M C | 2000 | Plant Physiology2000，122，： | 1 |
| 6 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 7 | A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis显示文摘 | JONKER Johan W MYOUNG SUH Jae ATKINS Annette R | | 0，，7398： | 1 |
| 8 | The epidemiology of chronic kidney disease显示文摘 | Atkins R C | 2005 | Kidney lnt2005，67，94： | 1 |
| 9 | Targeting of tumor associated antigens in renal cell carcinoma using proteome-based analysis and their clinical significance显示文摘 | Kellner R Lichtenfels R Atkins D | 2002 | Proteomics2002，2，12： | 1 |
| 10 | Antizyme expression: A subversion of triplet decoding, which is remarkably conserved by evolution is a sensor for an autoregulatory circuit显示文摘 | Ivanov I P Gesteland R F Atkins J F | 2000 | Nucleic Acids Res2000，，28： | 1 |
| 11 | TGF - 13 in the context of an inflammatory cytokine milieu supports de novo differentia- tion ofiL- 17 producing T cells显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，5： | 1 |
| 12 | Information consensus in mul- tivehicle cooperative control: Collective group behavior through lo- cal interaction 显示文摘 | WRen R W Beard E M Atkins | 2007 | IEEE Control Systems Magazine2007，27，2： | 1 |
| 13 | Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses显示文摘 | Lichtenfels R Kellner R Atkins D | 2003 | Biochim Biophys Acta2003，1646，12： | 1 |
| 14 | TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，2： | 1 |
| 15 | Chronic kidney disease as a global public health problem:approaches and initiatives-a position statement from Kidney Disease Improving Global Outcomes显示文摘 | Levey AS Atkins R Coresh J | 2007 | Kidney Int2007，72，3： | 1 |
| 16 | TGF - beta in the context of an infla - mmatory cytokine milieu sup- ports de novo differentiation of IL - 17 - producing T cells 显示文摘 | Veldhoen M Hocking R J Atkins C J | 2006 | Immunity2006，24，2： | 1 |
| 17 | Information consensus in multivehicle cooperative control 显示文摘 | REN W BEARD R W ATKINS E M | 2007 | IEEE Control Systems Maga- zine2007，27，2： | 1 |
| 18 | Periodic versus 'can-order' policies for coordinated muki-item inventory systems显示文摘 | Atkins D R Iyogun P O | 1988 | Management Science1988，34，： | 1 |
| 19 | Effect of peripherally administered leptin antagonist on whole-body metabolism, and bone microarchitecture and biomechanical properties in mouse显示文摘 | SOLOMON G ATKINS A SHAHAR R | 2014 | Am J Physiol Endocrinol Metab2014，306，1： | 1 |
| 20 | Joint optimization of maintenance and inventory policies for a simple system显示文摘 | Armstrong M J Atkins D R | 1996 | IIE Transactions1996，28，5： | 1 |
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