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| 1 | 肛裂临床诊治指南(第三次修订)显示文摘“美国结直肠外科医师协会(American Societyof ColonandRectal Surgeons.ASCRS)”(协会)致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高,给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成员组成。该委员会的建立是为了引领国际结直肠和肛门疾病诊治的发展,以建立具有循证医学证据的临床诊疗指南。指南是涵盖性的,非指令性的,目的是为临床决策提供信息,而非具体的治疗方法。指南适用于所有相关的医护人员以及希望得到相应指南中疾病的相关诊治信息的患者。 | Farshid Araghizadeh ~ Robin Boushey Sridhar Chalasani George Chang Robert Cima Gary Dunn Daniel Feingold Philip Fleshner Daniel Geisler Jill Genua Sharon Gregorcyk Daniel Herzig Andreas Kaiser Ravin Kumar David Larson Steven Mills John Monson P. Terry Phang Feza Remzi David Rivadeneira Howard Ross Peter Senatore Elin Sigurdson Thomas Stahl Scott Steele Scott Strong Charles Tement Judith Trudel Madhulika Varnna Martin Weiser 丁义江(译) 皇甫少华(译) 丁曙晴(译) | 2013 | 中华胃肠外科杂志2013，16，7： | 70 |
| 2 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 3 | Gut bless you:The microbiota-gut-brain axis in irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a common clinical label for medically unexplained gastrointestinal symptoms,recently described as a disturbance of the microbiota-gut-brain axis.Despite decades of research,the pathophysiology of this highly heterogeneous disorder remains elusive.However,a dramatic change in the understanding of the underlying pathophysiological mechanisms surfaced when the importance of gut microbiota protruded the scientific picture.Are we getting any closer to understanding IBS’etiology,or are we drowning in unspecific,conflicting data because we possess limited tools to unravel the cluster of secrets our gut microbiota is concealing?In this comprehensive review we are discussing some of the major important features of IBS and their interaction with gut microbiota,clinical microbiota-altering treatment such as the low FODMAP diet and fecal microbiota transplantation,neuroimaging and methods in microbiota analyses,and current and future challenges with big data analysis in IBS. | Eline Margrete Randulff Hillestad Aina van der Meeren Bharat Halandur Nagaraja Ben RenéBjørsvik Noman Haleem Alfonso Benitez-Paez Yolanda Sanz Trygve Hausken Gülen Arslan Lied Arvid Lundervold Birgitte Berentsen | 2022 | World Journal of Gastroenterology2022，28，4： | 15 |
| 4 | Modelling Hydrological Consequences of Climate Change—Progress and Challenges显示文摘The simulation of hydrological consequences of climate change has received increasing attention fromthe hydrology and land-surface modelling communities. There have been many studies of climate-changeeffects on hydrology and water resources which usually consist of three steps: (1) use of general circulationmodels (GCMs) to provide future global climate scenarios under the effect of increasing greenhouse gases,(2) use of downscaling techniques (both nested regional climate models, RCMs, and statistical methods)for 'downscaling' the GCM output to the scales compatible with hydrological models, and (3) use ofhydrologic models to simulate the effects of climate change on hydrological regimes at various scales.Great progress has been achieved in all three steps during the past few years, however, large uncertaintiesstill exist in every stage of such study. This paper first reviews the present achievements in this field andthen discusses the challenges for future studies of the hydrological impacts of climate change. | Chong-yu XU Elin WIDEN Sven HALLDIN | 2005 | Advances in Atmospheric Sciences2005，22，6： | 14 |
| 5 | Acute compartment syndrome of the thigh following hip replacement by anterior approach in a patient using oral anticoagulants显示文摘Acute compartment syndrome(ACS) of the thigh following primary total hip arthroplasty(THA) is a highly uncommon complication and has not yet been reported before with regards to the anterior approach through the anterior supine interval. We present a case of a 69-year-old male patient with a history of stroke, who developed ACS of the thigh after elective THA while using therapeutic low molecular weight heparin as bridging for regular oral anticoagulation. ACS pathogenesis, diagnostic tools, treatment and relevant literature are discussed. The patient's ACS was recognized in time and treated by operative decompression with fasciotomy of the anterior compartment. Follow-up did not show any neurological deficit or soft-tissue damage. | Dirk Pieter Hogerzeil Imraan Muradin Eline W Zwitser Joris A Jansen | 2017 | World Journal of Orthopedics2017，8，12： | 8 |
| 6 | Six-year outcomes in neovascular age-related macular degeneration with ranibizumab显示文摘● AIM: To evaluate the outcomes of ≥6y ranibizumab therapy in neovascular age-related macular degeneration(AMD).● METHODS: HELIX was a retrospective, observational effeciveness study using medical records of patients treated in three clinics in Belgium. Patients had neovascular AMD and were initially treated with intravitreal ranibizumab(0.5 mg) between November 1, 2007 and October 31, 2008, had ≥6y of data available, and were treated on an ongoing, as-needed basis. Outcomes included best-corrected visual acuity(BCVA) and central retinal thickness(CRT).● RESULTS: The sample consisted of 88 eyes from 69 patients. Mean age was 76.4±6.5y, most patients were female(62.3%). Most eyes(62.5%) were treatment-naive, 33 previously treated eyes had received predominantly other anti-vascular endothelial growth factor agents and verteporfin. Mean baseline BCVA was 57.4±12.7 ETDRS letters and CRT was 292±86 μm. On average, patients received 20.6±11.9 ranibizumab injections over the ≥6y. Intervals between injections were on average 12.7±16.1wk. Mean change in BCVA from baseline to last observation for the sample was less than one letter(-0.9±17.3 letters), with an average loss of-3.2±15.6 letters in previously treated eyes versus a gain of 0.6±18.4 letters in treatment-na?ve eyes. When considering a loss of <15 letters over 6y as stabilization of disease, 75.9% of all eyes showed a positive(improvement or stabilization) outcome. Mean change in CRT from baseline to last observation for the sample was-26.9±148.4 μm with the greatest reduction observed in treatment-naive eyes.● CONCLUSION: This retrospective study of 69 neovascular AMD patients treated for ≥6y with ranibizumab demonstrates long-term visual stabilization. In light of the natural evolution of the disease, these data confirm that ranibizumab is effective long-term under real-world conditions of heterogeneity of patients, clinicians, and centers. | Julie Jacob Heidi Brié Anita Leys Laurent Levecq Filip Mevgaerts Kris Denhaerynck Stefaan Vancayzeele Eline Van Craeyveld Ivo Abraham Karen MacDonald | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 5 |
| 7 | Adult female syphilis prevalence,congenital syphilis case incidence and adverse birth outcomes,Mongolia 2000e2016:Estimates using the Spectrum STI tool显示文摘Introduction:Mongolia's health ministry prioritizes control of Sexually Transmitted Infections,including syphilis screening and treatment in antenatal care(ANC).Methods:Adult syphilis prevalence trends were fitted using the Spectrum-STI estimation tool,using data from ANC surveys and routine screening over 1997e2016.Estimates were combined with programmatic data to estimate numbers of treated and untreated pregnant women with syphilis and associated incidence congenital syphilis(CS)and CS-attributable adverse birth outcomes(ABO),which we compared with CS case reports.Results:Syphilis prevalence in pregnant women was estimated at 1.7%in 2000 and 3.0%in 2016.We estimated 652 CS cases,of which 410 ABO,in 2016.Far larger,annually increasing numbers of CS cases and ABO were estimated to have been prevented:1654 cases,of which 789 ABO in 2016thanks to increasing coverages of ANC(99%in 2016),ANC-based screening(97%in 2016)and treatment of women diagnosed(81%in 2016).The 42 CS cases reported nationally over 2016(liveborn infants only)represented 27%of liveborn infants with clinical CS,but only 7%of estimated CS cases among women found syphilis-infected in ANC,and 6%of all estimated CS cases including those born to women with undiagnosed syphilis.Discussion/Conclusion:Mongolia's ANC-based syphilis screening program is reducing CS,but maternal prevalence remains high.To eliminate CS(target:<50 cases per 100,000 live births),Mongolia should strengthen ANC services,limiting losses during referral for treatment,and under-diagnosis of CS including still-births and neonatal deaths,and expand syphilis screening and prevention programs. | Erdenetungalag Enkhbat Eline L.Korenromp Jugderjav Badrakh Setsen Zayasaikhan Purevsuren Baya Enkhjargal Orgiokhuu Narantuya Jadambaa Sergelen Munkhbaatar Delgermaa Khishigjargal Narantuya Khad Guy Mahiane Naoko Ishikawa Davaalkham Jagdagsuren Melanie M.Taylor | 2018 | Infectious Disease Modelling2018，3，1： | 4 |
| 8 | LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2显示文摘(HP1 ) Heterochromatin 蛋白质 1 是染色质结构和功能的一个主要管理者。在动物,与 HP1 交往的蛋白质的网络主要与组成的 heterochromatin 由 H3K9me3 标记被联系。HP1 身体上与 SNF2 染色质 remodeler ATRX 的通常认为的 ortholog ?交往,它在哺乳动物控制 histone 变体 H3.3 的免职。在这研究,我们证明 ATRX 的 Arabidopsis thaliana ortholog ?参予 H3.3 免职并且在植物拥有特定的保存领域。我们发现象 HP1 (LHP1 ) 蛋白质一样的那植物通过在陆地植物明确地演变的领域与 ATRX 交往 ? 祖先。在 Arabidopsis 的 ATRX 功能的损失影响 PRC2 (POLYCOMB 压抑的建筑群 2 ) 控制的基因的一个有限子集的表示,包括 flowering 时间管理者 FLC。在 flowering 时间的规定的 ATRX 的函数要求新奇交往 LHP1 领域和 ATRX SNF2 helicase 域的 ATPase 活动。一起拿,这些结果建议不同进化小径在植物在哺乳动物和它的对应物 LHP1 导致了在 ATRX 和 HP1 之间的相互作用,导致 transcriptional 的不同模式规定。 | Haifeng Wang Danhua Jiang Elin Axelsson Zdravko J. Lorkovic Sean Montgomery Sarah Holec Bas J.G.E. Pieters Abbas H.K. AI Temimi Jasmin Mecinovic Frederic Berger | 2018 | Molecular Plant2018，11，8： | 3 |
| 9 | Bone remodeling effect of a chitosan and calcium phosphate-based composite显示文摘Chitosan is a biocompatible polymer that has been widely studied for tissue engineering purposes.The aim of this research was to assess bone regenerative properties of an injectable chitosan and calcium phosphate-based composite and identify optimal degree of deacetylation(%DDA)of the chitosan polymer.Drill holes were generated on the left side of a mandible in Sprague-Dawley rats,and the hole was either left empty or filled with the implant.The animals were sacrificed at several time points after surgery(7–22 days)and bone was investigated using micro-CT and histology.No significant new bone formation was observed in the implants themselves at any time points.However,substantial new bone formation was observed in the rat mandible further away from the drill hole.Morphological changes indicating bone formation were found in specimens explanted on Day 7 in animals that received implant.Similar bone formation pattern was seen in control animals with an empty drill hole at later time points but not to the same extent.A second experiment was performed to examine if the%DDA of the chitosan polymer influenced the bone remodeling response.The results suggest that chitosan polymers with%DDA between 50 and 70%enhance the natural bone remodeling mechanism. | Lilja Kjalarsdottir Arna Dyrfjord Atli Dagbjartsson Elin H.Laxdal Gissur Orlygsson Johannes Gislason Jon M.Einarsson Chuen-How Ng Halldor Jonsson Jr | 2019 | Regenerative Biomaterials2019，6，4： | 3 |
| 10 | Positron emission tomography to assess hypoxia and perfusion in lung cancer显示文摘In lung cancer, tumor hypoxia is a characteristic feature, which is associated with a poor prognosis and resistance to both radiation therapy and chemotherapy. As the development of tumor hypoxia is associated with decreased perfusion, perfusion measurements provide more insight into the relation between hypoxia and perfusion in malignant tumors. Positron emission tomography(PET) is a highly sensitive nuclear imaging technique that is suited for non-invasive in vivo monitoring of dynamic processes including hypoxia and its associated parameter perfusion. The PET technique enables quantitative assessment of hypoxia and perfusion in tumors. To this end, consecutive PET scans can be performed in one scan session. Using different hypoxia tracers, PET imaging may provide insight into the prognostic significance of hypoxia and perfusion in lung cancer. In addition, PET studies may play an important role in various stages of personalized medicine, as these may help to select patients for specifictreatments including radiation therapy, hypoxia modifying therapies, and antiangiogenic strategies. In addition, specific PET tracers can be applied for monitoring therapy. The present review provides an overview of the clinical applications of PET to measure hypoxia and perfusion in lung cancer. Available PET tracers and their characteristics as well as the applications of combined hypoxia and perfusion PET imaging are discussed. | Eline E Verwer Ronald Boellaard Astrid AM van der Veldt | 2014 | World Journal of Clinical Oncology2014，5，5： | 3 |
| 11 | Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth显示文摘 | Alexander Pietras Amanda M. Katz Elin J. Ekstr?m Boyoung Wee John J. Halliday Kenneth L. Pitter Jillian L. Werbeck Nduka M. Amankulor Jason T. Huse Eric C. Holland | 2014 | Cell Stem Cell2014，，3： | 3 |
| 12 | A longitudinal cohort study on quality of life in stroke patients and their partners: R estore4 S troke C ohort显示文摘 | Maria L. Mierlo Caroline M. Heugten Marcel W. M. Post Eline Lindeman Paul L. M. Kort Johanna M.A. Visser‐Meily | 2014 | Int J Stroke2014，，1： | 2 |
| 13 | Accuracy of Determining Nodal Negativity in Colorectal Cancer on the Basis of the Number of Nodes Retrieved on Resection显示文摘 | Natalie E. Joseph MD Elin R. Sigurdson MD PhD Alexandra L. Hanlon PhD Hao Wang MS Robert J. Mayer MD John S. MacDonald MD Paul J. Catalano ScD Daniel G. Haller MD | 2003 | Annals of Surgical Oncology2003，，3： | 2 |
| 14 | Effects of flow cytometry analysis on morphology and viability of fragile phytoplankton显示文摘 | ELIN M H TERRY L C CLARICE M Y | 1987 | Applied and Environmental Microbiology1987，53，11： | 1 |
| 15 | Reliability analysis of reinforced concrete columns exposed to fire显示文摘 | Christopher D. Eamon Elin Jensen | 2013 | Fire Safety Journal2013，，： | 1 |
| 16 | Perceived control of asthma andquality of life among adults with asthma显示文摘 | Katz PP Y elin EH Eisner MD | 2002 | Ann Allergy Asthma Im-munol2002，89，3： | 1 |
| 17 | Thirty-Year Experience With the Arterial Switch Operation显示文摘 | Shirin Lalezari Eline F. Bruggemans Nico A. Blom Mark G. Hazekamp | 2011 | The Annals of Thoracic Surgery2011，，3： | 1 |
| 18 | Evaluating and improving orphan drug regulations in Europe:A Delphi policy study显示文摘 | Eline P David C Steven S | 2012 | Health Policy2012，108，108： | 1 |
| 19 | Applicat ion of AFLP,RAPD and ISSR markers to genetic mapping of European and Japanese larch显示文摘 | Arcade A F Ans elin P Faivre Rampant | 2000 | Theor Appl Genet2000，100，： | 1 |
| 20 | Rapamyein prevents mesenteric neo-angiogenesis and reduces splanchnic blood flow in portal hypertensive mice 显示文摘 | ANJA M G ELINE V HANS V V | 2008 | Hepatol Res2008，38，： | 1 |
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