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| 1 | Evaluation of fully covered self-expanding metal stents in benign biliary strictures and bile leaks显示文摘AIM: To investigate the use of fully covered metal stents in benign biliary strictures (BBS) and bile leaks. METHODS: We studied 17 patients, at Harbor-UCLA Medical center (Los Angeles), with BBS (n=12) and bile leaks (n=5) from July 2007 to February 2012 that had received placement of fully covered self-expanding metal stents (FCSEMs). Fourteen patients had endoscopic placement of VIABIL (Conmed, Utica, New York, United States) stents and three had Wallflex (Boston Scientific, Mass) stents. FCSEMS were 8 mm or 10 mm in diameter and 4 cm to 10 cm in length. Patients were followed at regular intervals to evaluate for symptoms and liver function tests. FCSEMS were removed after 4 or more weeks. Resolution of BBS and leak was documented cholangiographically following stent removal. Stent patency can be defined as adequate bile and contrast flow from the stent and into the ampulla during endoscopic retrograde cholangiopancreatography (ERCP) without clinical signs and/or symptoms of biliary obstruction. Criterion for bile leak resolution at ERCP is defined as absence of contrast extravasation from the common bile duct, cystic duct remanent, or gall blad-der fossa. Rate of complications such as migration, and instent occlusion were recorded. Failure of endoscopic therapy was defined as persistent biliary stenosis or continuous biliary leakage after 12 mo of stent placement. RESULTS: All 17 patients underwent successful FC- SEMS placement and removal. Etiologies of BBS included: cholecystectomies (n=8), cholelithiasis (n=2), hepatic artery compression (n=1), pancreatitis (n=2), and Whipple procedure (n=1). All bile leaks occurred following cholecystectomy. The anatomic location of BBS varied: distal common bile duct (n=7), common hepatic duct (n=1), hepaticojejunal anastomosis (n=2), right intrahepatic duct (n=1), and choledochoduo-denal anastomatic junction (n=1). All bile leaks were found to be at the cystic duct. Twelve of 17 patients had failed prior stent placement or exchange. Resolution of the biliary strictures and bile leaks was achieved in 16 of 17 patients (94%). The overall median stent time was 63 d (range 27-251 d). The median stent time for the BBS group and bile leak group was 62 ± 58 d (range 27-199 d) and 92 ± 81 d (range 48-251 d), respectively. All 17 patients underwent successful FCSEMS removal. Long term follow-up was obtained for a median of 575 d (range 28-1435 d). Complications occurred in 5 of 17 patients (29%) and included: migration (n=2), stent clogging (n=1), cholangitis (n=1), and sepsis with hepatic abscess (n=1). CONCLUSION: Placement of fully covered self-expanding metal stents may be used in the management of benign biliary strictures and bile leaks with a low rate of complications. | David Lalezari Inder Singh Sofiya Reicher Viktor Ernst Eysselein | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 8 |
| 2 | Alkaloids of Papaver orientale L显示文摘 | Shafiee A Lalezari I Assadi F | 1997 | Pharmacol Sci1997，7，7： | 1 |
| 3 | Evaluating acti- vated carbons for removing low concentrations of taste and odour producing organics 显示文摘 | Lalezary S Pirbazari M McGuire M J | 1986 | JAWWA1986，78，11： | 1 |
| 4 | Oxidation of five earthy musty taste and odor compounds 显示文摘 | Lalezary S | 1986 | AWWA1986，78，3： | 1 |
| 5 | Safety, efficacy, and pharmacokinetics of TBR-652, a CCR5/CCR2 antagonist, in HIV-l-infected, treatment-experienced, CCR5 antagonistnaive subjects 显示文摘 | Lalezari J Gathe J Brinson C | 2011 | JAequir Immune Defie Syndr2011，57，2： | 1 |
| 6 | Suppression of T-cell-mediated immuneresponses by sodium cyanate显示文摘 | NEHLSEN S L LALEZARI P | 1977 | Transplant Proc1977，9，1： | 1 |
| 7 | Thirty-Year Experience With the Arterial Switch Operation显示文摘 | Shirin Lalezari Eline F. Bruggemans Nico A. Blom Mark G. Hazekamp | 2011 | The Annals of Thoracic Surgery2011，，3： | 1 |
| 8 | 1,2, 3- Selenadiazolyl-1,3,4-oxadiazole, 1,2,3-Thiadiazolyl-1,3,4- oxadiazole and 5-( 1,2,3-Thiadiazolyl ) -S-triazolo - 1,3,4-thiadiazole 显示文摘 | SHAFIEE A LALEZARI I MIRRASHED M | 1977 | J Heterocyclic Chem1977，14，： | 1 |
| 9 | Oxidation of five earthy-musty taste and odor compounds显示文摘 | Lalezary S Pirbazari M McGuire M J | 1986 | J AWWA1986，78，3： | 1 |
| 10 | Enfuvirtide,an HIV-1 fusion inhibitor,for drug-resistant HIV infection in North and South America显示文摘 | LALEZARI JP HENRY K HEARN M | 2003 | N Engl J Med2003，348，22： | 1 |
| 11 | All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection: ALLY-3 Phase III Study 显示文摘 | Nelson DR Cooper JN Lalezari JP | 2015 | Hematology2015，61，： | 1 |
| 12 | Combined analysis of06-methylguanine-DNA methyltransferase protein expres-sion and promoter methylation provides optimized prognos-tication of glioblastoma outcome显示文摘 | Lalezari S Chou AP Tran A | 2013 | Neuro Oncol2013，15，： | 1 |
| 13 | Positive results with autologous transplant of ZFN-modified CD4 T-cells:a step toward a practical,functional cure for HIV显示文摘 | Jay Lalezari R Mitsuyasu S Deeks | 2011 | AIDS Patient Care STDS2011，25，11： | 1 |
| 14 | A randomized, double-blind, placebo-controlled assessment of BMS:936558, a fully humanmonoclonal antibody to programmed death-1 (PD- 1 ), in patients with chronic hepatitis C virus infection 显示文摘 | Gardiner D Lalezari J Lawitz E | 2013 | PLoS One2013，8，63： | 1 |
| 15 | Oxidation of five earthy- musty taste and odor compounds 显示文摘 | Lalezary S Pirbazari M McGuire M J | 1986 | J AWWA1986，78，3： | 1 |
| 16 | Evaluating activated carbons for removing low concentrations of taste-and-odour producing organics 显示文摘 | LALEZARY S PIRBAZARI M MCGUIRE M | 1986 | Journal of the American Water Works Association1986，78，11： | 1 |
| 17 | Oxidation of five earthy-musty taste and odor compounds显示文摘 | LALEZARY S PIRBAZARI M MCGUIRE M J | 1986 | Journal of American Water Works Association1986，78，3： | 1 |
| 18 | Oxidation of five earthy- musty taste and odor compounds 显示文摘 | LALEZARY S PIRBAZARI M MCGUIRE M J | 1986 | Journal of the American Water Works Association1986，78，3： | 1 |
| 19 | Synthesis and pharmacological activity of dialkylaminoalkyl esters of benzilic acids containing fluorine or trifluoromethyl groups 显示文摘 | Lalezari I Hatefi M Khoyi MA | 1971 | J Med Chem1971，14，11： | 1 |
| 20 | T-1249 retains potent antiretroviral activity in patients who had experienced virological failure while on an enfuvirtide-containing treatment regimen显示文摘 | LALEZARI JP BELLOS NC SATHASIVAM K | 2005 | J Infect Dis2005，191，7： | 1 |
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