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| 1 | Neuroprotective effects of meloxicam on transient brain ischemia in rats:the two faces of anti-inflammatory treatments显示文摘The inflammato ry response plays an important role in neuroprotection and regeneration after ischemic insult.The use of non-ste roidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects.In this context,the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stro ke,but its ability to inhibit both cyclooxygenase isoforms(1 and 2) could be a promising strategy to modulate postischemic inflammation.This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats,measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area.We show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia.Moreover,meloxicam treatment modulated glial scar reactivity,which matched with an increase in axonal sprouting.However,this treatment decreased the formation of neuronal progenitor cells.This study discusses the dual role of anti-inflammatory treatments after stro ke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies. | Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez JoséManuel Gonzalo-Orden Arsenio Fernández-López | 2023 | Neural Regeneration Research2023，18，9： | 3 |
| 2 | Neuroprotection by salubrinal treatment in global cerebral ischemia显示文摘Most common cerebrovascular accidents(CVAs)result from the occlusion of a blood vessel and are called ischemic stroke.The interruption of the blood flow reduces the oxygen and glucose levels in the neural parenchyma,which in turn decreases the energy of the cells and compromises their homeostasis.This condition has to be reverted for cell survival.One of the homeostatic processes impaired by cerebral ischemia is protein folding in | Berta Anuncibay-Soto María Santos-Galdiano Arsenio Fernández-López | 2016 | Neural Regeneration Research2016，11，11： | 2 |
| 3 | Necroptosis in global cerebral ischemia: a role for endoplasmic reticulum stress显示文摘Necroptosis has been reported in the last years as a type of regulated cell death that can be ignited by a number of specific death receptors,such as FAS,tumor necrosis factor receptor 1(TNFR1),or pathogen recognition receptors.This cell death subroutine is involved in the response to stress and in homeostatic functions,such as the maintenance of adult T-cell balance(Galluzzi et al.,2018).Dead receptor activation leads to the recruitment of protein complexes that act as nodes of signaling that can elicit different pathways driving to death or survival,depending on the cell conditions. | Enrique Font-Belmonte Paloma González-Rodríguez Arsenio Fernández-López | 2020 | Neural Regeneration Research2020，15，3： | 2 |
| 4 | A survey on energy efficient for the future Internet 显示文摘 | Sliva T Arsenio A | 2013 | Computer and Communication Engineering2013，2，5： | 1 |
| 5 | Multiple human papil lomavirus infection and high grade cervical intraepithelial neopla sia among women with cytological diagnosis of atypical squamous cells of undetermined significance or low grade squamous intraepi theliallesions显示文摘 | Arsenio S Barbara DB Barbara G etal | 2009 | GynecolOncol2009，113，1： | 1 |
| 6 | Validation of an immunolo~c diagnostic kit for in- fectious vaginitis by Triehomonas vaginalis, Candida spp, and Gard- nerella vaginalis显示文摘 | Arsenio Betancourt Bravo Lilian sanchcz Miarnda Octavio Fernan- dez Lima | 2009 | Diagnostic Microbiology and Infectious Dis- ease2009，63，3： | 1 |
| 7 | Vaccinia virus KIL and CTL inhibit antiviral activities induced by type I interferons 显示文摘 | Meng X Jiang C Arsenio J | 2009 | J Virol2009，83，10： | 1 |
| 8 | Varieties of childhood bullying: Values, emotion processes, and social competence 显示文摘 | Arsenio W F Lemerise E A | 2001 | Social Development2001，10，： | 1 |
| 9 | Effects of Hoechst 33342 staining and ultraviolet irradiation on mitochondrial distribution and DNA copy number in porcine oocytes and preimplantation embryos显示文摘 | Maria Antonia Gil Carolina Maside Cristina Cuello Inmaculada Parrilla Juan Maria Vazquez Jordi Roca Emilio Arsenio Martinez | 2012 | Mol. Reprod. Dev2012，，9： | 1 |
| 10 | Pain management for orthropldeieprocedures显示文摘 | Nalini V Arsenio B Raymond S | 2006 | Pain Manag2006，，9： | 1 |
| 11 | Dynamin participates in focal extracellular matrix radiation by invasive cells显示文摘 | Massimiliano B Arsenio P Galina B | 2003 | Mol Biol Cell2003，14，10： | 1 |
| 12 | Effectiveness of long-term treatmerit with pantethine in patients with dyalipidemia显示文摘 | Arsenio L Boddria P Magnati G | 1986 | Clin Ther1986，8，5： | 1 |
| 13 | Improving the efficiency of sperm technologies in pigs:the value of deep intrauterine insemination 显示文摘 | Juan Maria Vazquez Emilio Arsenio Martinez Jordi Roca et a/ | 2005 | Theriogenology2005，63，： | 1 |
| 14 | Effects of Hoechst 33342 staining and ultraviolet irradiation on mitochondrial distribution and DNA copy number in porcine oocytes and preimplantation embryos显示文摘 | Maria Antonia Gil Carolina Maside Cristina Cuello Inmaculada Parrilla Juan Maria Vazquez Jordi Roca Emilio Arsenio Martinez | 2012 | Mol Reprod Dev2012，，9： | 1 |
| 15 | Combining anti-inflammatory and unfolding protein responses to fight stroke显示文摘This perspective shows an attempt to obtain synergy effects to fight ischemic stroke by combining agents acting on two different homeostatic mechanisms:inflammation and unfolded protein response (Anuncibay-Soto et al.,2018).Different pharmacological approaches have been assayed to alleviate cerebrovascular accident (stroke), which represents one of the most devastating diseases in the elderly. | Berta Anuncibay-Soto Enrique Font-Belmonte Arsenio Fernández-López | 2019 | Neural Regeneration Research2019，14，3： | 1 |
| 16 | The influence of exercise intensity on the power spectrum of heart rate variability显示文摘 | Renza Perini Claudio Orizio Giuseppe Baselli Sergio Cerutti Arsenio Veicsteinas | 1990 | European Journal of Applied Physiology and Occupational Physiology (-)1990，，1： | 1 |
| 17 | Azurin-like protein blocks invasion of toxoplasma gondii through potential interactions with parasite surface antigen SAGI显示文摘 | Arunasalam N Arsenio MF Anita C | 2008 | Antimicrobial Agents and Chemotherapy2008，52，2： | 1 |
| 18 | Vaccinia virus E3suppresses expression of diverse cytokines through inhibitionof the PKR,NF-kappaB,and IRF3pathways显示文摘 | Myskiw C Arsenio J van Bruggen R | 2009 | J Virol2009，83，13： | 1 |
| 19 | PROGNOSTIC MARKERS IN BLADDER CANCER: A CONTEMPORARY REVIEW OF THE LITERATURE显示文摘 | JOHN P. STEIN GARY D. GROSSFELD DAVID A. GINSBERG DAVID ESRIG JOHN A. FREEMAN ARSENIO J. FIGUEROA DONALD G. SKINNER RICHARD J. COTE | 1998 | The Journal of Urology1998，，3： | 1 |
| 20 | Separation of fifteen quinolones by high performance liquid chromatography:Application to pharmaceuticals and ofloxacin determination in urine显示文摘 | Florentina Canada-Canada Anunciación Espinosa-Mansilla Arsenio Munoz de la Pena | 2007 | Journal of Separation Science2007，30，9： | 1 |
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