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| 1 | 国际教育信息化2013地平线报告(高等教育版)显示文摘国际新媒体联盟(New Media Consortium,简称NMC)所发布的年度地平线报告已经成为全球范围内教育信息化发展的显示器与风向标。2012年10月,北京开放大学与美国新媒体联盟签署协议,授权北京开放大学作为其在中国发行其年度报告中文版的唯一官方机构。本期学报正式刊出的2013年度地平线报告显示,未来五年内影响高等教育的六大技术为:大规模开放网络课程、平板电脑、游戏和游戏化、学习分析技术、3D打印技术、可穿戴技术。这些新技术对于我们生活中的沟通交流、获取信息、社会交往、日常学习等方面正在产生重大而深远的影响。希望本报告能够有助于国内同行及时了解国际范围内教育信息化的发展趋势、新技术应用,为促进信息技术更有效地提高教学质量服务提供有益借鉴。新媒体联盟总裁莱瑞博士(Larry Johnson)专门写信祝贺2013年度地平线报告(中文版)刊出:'北京开放大学与新媒体联盟的合作已使成千上万的中国教育界同行有机会围绕教育技术及其在大学和中小学课堂应用问题参与全球对话。北京开放大学以其在教育技术、在线学习的实践探索及开展的国际合作等方面取得的业绩成为国际地平线项目有价值的合作者。你们为地平线专题研究做出了贡献,还承担了地平线报告(中文版)的翻译出版。借助你们的帮助,许多国外同行开始了解信息技术如何在中国这一人口大国的大学和中小学得到应用;同时,也使中国教育界了解世界各国同行正在开展的信息化实践探索。' | Johnson L. AdamsBecker S. Cummins M. Estrada V. Freeman A. Ludgate H. 张铁道 殷丙山 殷蕾 白晓晶 | 2013 | 北京广播电视大学学报2013，，2： | 50 |
| 2 | 2013地平线报告高等教育版(上)显示文摘美国新媒体联盟地平线报告系列是一项鉴别和描述未来五年内对全球教育产生巨大影响的新兴技术的综合性研究,旨在帮助教育领导者、政策制订者和教师们理解新兴技术,以及技术对教学和研究产生的潜在影响。自2004年以来地平线报告每年发布一次,均在全球范围内引起反响。2013地平线报告高等教育版于今年2月发布,该报告立足高等教育机构的现状,以全球化视角展望2013-2018未来五年间的技术发展和应用前景,包括大规模开放在线课程、平板电脑、游戏与游戏化、学习分析、3D打印、可穿戴技术等六项新兴技术,并概括了影响高等教育发展的六大趋势和高等教育面临的六大挑战。 | (美)NMC地平线项目 龚志武 吴迪 陈阳键 苏宏 王寒冰 Johnson L. Adams Becker S. Cummins M. Estrada V. Freeman A. Ludgate H. | 2013 | 广州广播电视大学学报2013，13，2： | 24 |
| 3 | Effect of particle shape and size on flow properties of lactose powders显示文摘The shape and size of particles are understood to affect the bulk behaviour of powders, though there are but few studies that present quantitative information on the relationship between particle shape and the flow properties of powder. This is due in part to the lack of techniques for rapidly determining both particle shape and the range of flow characteristics that describe the response of powders to the stress and shear experienced during their processing. This study presents data that quantifies the influence of particle shape/size of three different lactose powders on their respective flow and bulk characteristics. Two of the samples differ in size but have similar shapes; the third sample is more spherical but similar in size to one of the other two samples. The results demonstrate that in addition to particle size, particle shape significantly affect the flow characteristics of a powder over a wide range of stress conditions. | Xiaowei Fu Deborah Huck Lisa Makein Brian Armstrong Ulf Willen Tim Freeman | 2012 | Particuology2012，10，2： | 22 |
| 4 | 新媒体联盟2016地平线报告高等教育版显示文摘《2016地平线报告高等教育版》沿用以往讨论趋势和挑战的三元维度展开,即政策,领导力和实践,确定了18项未来五年极有可能影响高等教育变革的关键趋势、重大挑战和重要的技术进展。关键趋势中,长期趋势包括:推进创新文化、反思高校运作;中期趋势包括:学习空间的重构、转向深度学习;近期趋势包括:对测量学习持续关注、混合学习设计的广泛应用。就制约高等教育领域技术应用的挑战而言,正式与非正式学习的融合、数字素养的提升被认为是可解决的挑战,教育模式的竞争、个性化学习是艰巨的挑战,而平衡线上和线下生活、保持教育的切合性则是棘手的挑战。未来1-5年内,自带设备、学习分析和自适应学习、增强现实和虚拟现实、创客空间、情感计算、机器人技术将对高等教育产生重要影响。 | NMC地平线项目 苏宏 陈阳键 吴迪 龚志武 项荣健 Johnson L. Adams Becker S. Cummins M. Estrada V. Freeman A. Hall C. | 2016 | 广州广播电视大学学报2016，16，2： | 23 |
| 5 | Celiac disease:Prevalence,diagnosis,pathogenesis and treatment显示文摘Celiac disease(CD) is one of the most common diseases,resulting from both environmental(gluten) and genetic factors [human leukocyte antigen(HLA) and nonHLA genes].The prevalence of CD has been estimated to approximate 0.5%-1% in different parts of the world.However,the population with diabetes,autoimmune disorder or relatives of CD individuals have even higher risk for the development of CD,at least in part,because of shared HLA typing.Gliadin gains access to the basal surface of the epithelium,and interact directly with the immune system,via both trans-and para-cellular routes.From a diagnostic perspective,symptoms may be viewed as either 'typical' or 'atypical'.In both positive serological screening results suggestive of CD,should lead to small bowel biopsy followed by a favourable clinical and serological response to the gluten-free diet(GFD) to confirm the diagnosis.Positive anti-tissue transglutaminase antibody or antiendomysial antibody during the clinical course helps to confirm the diagnosis of CD because of their over 99% specificities when small bowel villous atrophy is present on biopsy.Currently,the only treatment available for CD individuals is a strict life-long GFD.A greater understanding of the pathogenesis of CD allows alternative future CD treatments to hydrolyse toxic gliadin peptide,prevent toxic gliadin peptide absorption,blockage of selective deamidation of specific glutamine residues by tissue,restore immune tolerance towards gluten,modulation of immune response to dietary gliadin,and restoration of intestinal architecture. | Naiyana Gujral Hugh J Freeman Alan BR Thomson | 2012 | World Journal of Gastroenterology2012，18，42： | 19 |
| 6 | 新《劳动合同法》如何影响农民工的劳动权益?显示文摘2008年1月1日新《劳动合同法》正式生效,该法明确规定企业应该与工人(包括农民工)签订书面劳动合同,增强了对工人的劳动保护,加大了对违法企业的惩处力度。本文采用新法生效前后对珠三角农民工开展的调研数据,利用农民工第一次签订书面合同的回顾信息,分析法律实施对农民工劳动关系以及社会保险覆盖的影响。实证结果表明,新《劳动合同法》的施行提高了农民工的书面合同签订率,进一步提升了农民工的社会保险覆盖率,降低了拖欠农民工工资的发生率,与此同时,农民工工作企业的工会覆盖率也有所上升。 | 李小瑛 Richard Freeman | 2014 | 劳动经济研究2014，2，3： | 19 |
| 7 | 基于嗅觉神经网络采用时间序列的电子鼻模式分类方法显示文摘从传感器阵列响应曲线中提取有效特征是传统人工神经网络在电子鼻模式识别应用中的第一步.文中提出将传感器阵列时间序列信号直接输入到一种具有丰富动力学特性的嗅觉神经网络中进行模式分类的方法.该方法不仅在仿生角度上使电子鼻进一步模拟了生物嗅觉系统信息处理过程,而且与以前所用的特征提取加神经网络的方法相比,在6种有机挥发物的分类识别中表现得更佳. | 傅均 李光 Walter J. Freeman | 2007 | 传感技术学报2007，20，9： | 16 |
| 8 | Adult eosinophilic gastroenteritis and hypereosinophilic syndromes显示文摘Eosinophilic gastroenteritis (EGE) in the adult is a distinctive pathologically-based disorder characterized by an eosinophil-predominant mucosal inflammatory process. Most often,the disorder is detected during endoscopic investigation for abdominal pain or diarrhea. Other causes of gastric and intestinal mucosal eosinophilia require exclusion,including parasitic infections and drug-induced causes. Occasionally,the muscle wall or serosal surface may be involved. EGE appears to be more readily recognized,in large part,due to an evolution in the imaging methods used to evaluate abdominal pain and diarrhea,in particular,endoscopic imaging and mucosal biopsies. Def inition of EGE,however,may be diffi cult,as the normal ranges of eosinophil numbers in normal and abnormal gastric and intestinal mucosa are not well standardized. Also,the eosinophilic inflammatory process may be either patchy or diffuse and the detection of the eosinophilic infiltrates may vary depending on the method of biopsy fixation. Treatment has traditionally focused on resolution of symptoms,and,in some instances,eosinophil quantification in pre-treatment and post-treatment biopsies. Future evaluation and treatment of EGE may depend on precise serological biomarkers to aid in defi nition of the long-term natural history of the disorder and its response to pharmacological or biological forms of therapy. | Hugh James Freeman | 2008 | World Journal of Gastroenterology2008，14，44： | 14 |
| 9 | Intestinal lymphangiectasia in adults显示文摘Intestinal lymphangiectasia in the adult may be characterized as a disorder with dilated intestinal lacteals causing loss of lymph into the lumen of the small intestine and resultant hypoproteinemia, hypogamma-globulinemia, hypoalbuminemia and reduced number of circulating lymphocytes or lymphopenia. Most often, intestinal lymphangiectasia has been recorded in children, often in neonates, usually with other congenital abnormalities but initial def inition in adults including the elderly has become increasingly more common. Shared clinical features with the pediatric population such as bilateral lower limb edema, sometimes with lymphedema, pleural effusion and chylous ascites may occur but these reflect the severe end of the clinical spectrum. In some, diarrhea occurs with steatorrhea along with increased fecal loss of protein, reflected in increased fe- cal alpha-1-antitrypsin levels, while others may present with iron def iciency anemia, sometimes associated with occult small intestinal bleeding. Most lymphangiectasia in adults detected in recent years, however, appears to have few or no clinical features of malabsorption. Diagnosis remains dependent on endoscopic changes confirmed by small bowel biopsy showing histological evidence of intestinal lymphangiectasia. In some, video capsule endoscopy and enteroscopy have revealed moreextensive changes along the length of the small intes- tine. A critical diagnostic element in adults with lym- phangiectasia is the exclusion of entities (e.g. malignancies including lymphoma) that might lead to obstruction of the lymphatic system and 'secondary' changes in the small bowel biopsy. In addition, occult infectious (e.g. Whipple's disease from Tropheryma whipplei) or in? am- matory disorders (e.g. Crohn's disease) may also present with profound changes in intestinal permeability and protein-losing enteropathy that also require exclusion. Conversely, rare B-cell type lymphomas have also been described even decades following initial diagnosis of intestinal lymphangiectasia. Treatment has been historically def ined to include a low fat diet with medium-chain triglyceride supplementation that leads to portal venous rather than lacteal uptake. A number of other pharma- cological measures have been reported or proposed but these are largely anecdotal. Finally, rare reports of localized surgical resection of involved areas of small intestine have been described but follow-up in these cases is often limited. 2011 Baishideng. All rights reserved. | Hugh James Freeman Michael Nimmo | 2011 | World Journal of Gastrointestinal Oncology2011，3，2： | 13 |
| 10 | 消毒副产物三氯甲烷与膀胱癌的关系显示文摘氯化消毒(chlorination)是饮用水加工过程中使用最广泛的消毒方式。然而,氯化消毒过程中可产生对健康有害的物质一消毒副产物(disinfection byproducs,DBPs)。消毒副产物主要包括三卤甲烷(trihalomethanes,THMs)、卤代乙酸(haloacefic acids,HAAs)、卤代乙腈(haloaceton itriles,HAN)等。毒理学研究显示DBPs具有遗传毒性、致突变性、细胞毒性、生殖发育毒性和致癌性。膀胱癌是指发生在膀胱黏膜上的恶性肿瘤。 | 李园园 Beane Freeman L E Cantor K P Baris D | 2017 | 环境卫生学杂志2017，7，5： | 10 |
| 11 | “Melanosis” in the small and large intestine显示文摘Deposition of pigment in the intestinal mucosa is commonly observed by the endoscopist, especially within the colon, and particularly during investigations for constipation. Pigment may also be detected in the small intestine. Although labeled as melanosis, electron microscopy and X-ray analytical methods have provided evidence that this pigment is not melanin at all, but lipofuscin. Often, herbal remedies or anthracene containing laxatives are often historically implicated, and experimental studies in both humans and animal models have also confirmed the intimate relationship with these pharmacological or pseudo-pharmacological remedies. The appearance of melanosis coli during colonoscopy is largely due to pigment granule deposition in macrophages located in the colonic mucosa. The pigment intensity is not uniform, being more intense in the cecum and proximal colon compared to the distal colon. Possibly, this reflects higher luminal concentrations of an offending agent in the proximal compared to distal colon, differential absorption along the length of the colon, or finally, differences in macrophage distribution within the colon. Mucosal lymphoid aggregates normally display a distinct absence of pigment producing a 'starry sky' appearance, especially in the rectosigmoid region. Interestingly, some focal, usually sessile, colonic mucosal neoplastic lesions, rather than submucosal lesions, may be better appreciated as pigment deposition may be absent or limited. If detected, removal and further histopathologic analysis of the polyp may be facilitated. | Hugh James Freeman | 2008 | World Journal of Gastroenterology2008，14，27： | 10 |
| 12 | 普瑞巴林治疗糖尿病周围神经痛的疗效、安全性和耐受性显示文摘目的:通过分析7项普瑞巴林治疗糖尿病周围神经病(DPN)的临床研究,评估普瑞巴林在其有效剂量范围内的疗效、安全性和耐受性;评估每日两次给药(BID)和每日三次给药(TID)的疗效差异; | Roy Freeman Edith Durso-Decruz Birol Emir | 2011 | 中国新药杂志2011，20，6： | 10 |
| 13 | Natural history and long-term clinical course of Crohn's disease显示文摘Crohn’s disease is a chronic inflammatory disease process involving different sites in the gastrointestinal tract.Occasionally,so-called metastatic disease occurs in extra-intestinal sites.Granulomatous inflammation may be detected in endoscopic biopsies or resected tissues.Genetic,epigenetic and environmental factors appear to play a role.Multiple susceptibility genes have been described in both familial and non-familial forms while the disease is phenotypically heterogeneous with a female predominance.The disorder occurs over a broad age spectrum,from early childhood to late adulthood.More than 80%are diagnosed before age 40 years usually with terminal ileal and colonic involvement.Pediatric-onset disease is more severe and more extensive,usually with a higher chance of upper gastrointestinal tract disease,compared to adult-onset disease.Long-term studies have shown that the disorder may evolve with time into more complex disease with stricture formation and penetrating disease complications(i.e.,fistula,abscess).Although prolonged remission may occur,discrete periods of symptomatic disease may re-appear over many decades suggesting recurrence or re-activation of this inflammatory process.Eventual development of a cure will likely depend on identification of an etiologic cause and a fundamental understanding of its pathogenesis.Until now,treatment has focused on removing risk factors,particularly cigarette smoking,and improving symptoms.In clinical trials,clinical remission is largely defined as improved numerical and endoscopic indices for'mucosal healing'.'Deep remission'is a conceptual,more'extended'goal that may or may not alter the long-term natural history of the disease in selected patients,albeit at a significant risk for treatment complications,including serious and unusual opportunistic infections. | Hugh James Freeman | 2014 | World Journal of Gastroenterology2014，20，1： | 10 |
| 14 | Cosmic-ray exposure age of Martian meteorite GRV 99027显示文摘We have determined the concentrations of 10Be and 26Al in GRV 99027 recovered by the 16th Chinese Antarctic expedition team, which are 14.1 ± 0.6 dpm/kg and 67.5 ± 3.4 dpm/kg, respectively. From the concentration of 10Be, we calculate a cosmic-ray exposure age of 4.4 ± 0.6 Ma for GRV 99027. The concentration of 26Al is too high compared to the 10Be exposure age, indicating extra production from solar ray. The exposure ages, petrologic and geochemical characteristics of mantle-derived Martian meteorites GRV 99027, LEW 88516, Y-793605, NWA 1950 and ALHA77005 are very similar, suggesting that these meteorites most probably were ejected from Mars in the same impact event. | D. FABEL R. BROWN S. FREEMAN | 2007 | Science China Earth Sciences2007，50，10： | 8 |
| 15 | Diabetes inhibits corneal epithelial cell migration and tight junction formation in mice and human via increasing ROS and impairing Akt signaling显示文摘Corneal wounds usually heal quickly;but diabetic patients have more fragile corneas and experience delayed and painful healing. In the present study, we compared the healing capacity of corneal epithelial cells (CECs) between normal and diabetic conditions and the potential mechanisms. Primary murine CEC derived from wild-type and diabetic (db/db) mice, as well as primary human CEC were prepared. Human CEC were exposed to high glucose (30 mM) to mimic diabetic conditions. Cell migration and proliferation were assessed using Scratch test and MTT assays, respectively. Reactive oxygen species (ROS) production in the cells was measured using dichlorofluorescein reagent. Western blot was used to evaluate the expression levels of Akt. Transepithelial electrical resistance (TEER) and zonula occludens-1 (ZO-1) expression were used to determine tight junction integrity. We found that the diabetic CEC displayed significantly slower cell proliferation and migration compared with the normal CEC from both mice and humans. Furthermore, ROS production was markedly increased in CEC grown under diabetic conditions. Treatment with an antioxidant N-acetyl cysteine (NAC, 100 μM) significantly decreased ROS production and increased wound healing in diabetic CEC. Barrier function was significantly reduced in both diabetic mouse and human CEC, while NAC treatment mitigated these effects. We further showed that Akt signaling was impaired in diabetic CEC, which was partially improved by NAC treatment. These results show that diabetic conditions lead to delayed wound-healing capacity of CEC and impaired tight junction formation in both mice and human. Increased ROS production and inhibited Akt signaling may contribute to this outcome, implicating these as potential targets for treating corneal wounds in diabetic patients. | Qi-wei Jiang Denis Kaili Jonaye Freeman Chong-yang Lei Bing-chuan Geng Tao Tan Jian-feng He Zhi Shi Jian-jie Ma Yan-hong Luo Heather Chandler Hua Zhu | 2019 | Acta Pharmacologica Sinica2019，40，9： | 8 |
| 16 | Early stage colon cancer显示文摘Evidence has now accumulated that colonoscopy and removal of polyps,especially during screening and surveillance programs,is effective in overall risk reduction for colon cancer.After resection of malignant pedunculated colon polyps or early stage colon cancers,long-term repeated surveillance programs can also lead to detection and removal of asymptomatic high risk advanced adenomas and new early stage metachronous cancers.Early stage colon cancer can be defined as disease that appears to have been completely resected with no subsequent evidence of involvement of adjacent organs,lymph nodes or distant sites.This differs from the clinical setting of an apparent'curative'resection later pathologically upstaged following detection of malignant cells extending into adjacent organs,peritoneum,lymph nodes or other distant sites,including liver.This highly selected early stage colon cancer group remains at high risk for subsequent colon polyps and metachronous colon cancer.Precise staging is important,not only for assessing the need for adjuvant chemotherapy,but also for patient selection for continued surveillance.With advanced stages of colon cancer and a more guarded outlook,repeated surveillance should be limited.In future,novel imaging technologies(e.g.,confocal endomicroscopy),coupled with increased pathological recognition of high risk markers for lymph node involvement(e.g.,'tumor budding')should lead to improved staging and clinical care. | Hugh James Freeman | 2013 | World Journal of Gastroenterology2013，19，46： | 8 |
| 17 | 中国就业政策的国际视角显示文摘针对中国就业政策制定和劳动力市场制度建设中的一些关键性问题,本文有针对性地概述了劳动经济学理论的一系列最新发展,介绍了其他国家就业政策的相关经验;建议中国在借鉴有关国际经验和教训的前提下,因地制宜地制定自己的就业政策,并推动劳动力市场制度建设。本文集中讨论以下问题:经济增长与就业、如何更好地推进城乡就业转移、宏观经济的再平衡对就业的影响、促进服务业发展的措施、大学毕业生就业、提高普通劳动者的技能、制度和市场之间适当的平衡、如何规制集体性组织和劳动争议、如何规制劳动力市场结果以及如何应对非正规就业等。 | 蔡昉 Richard Freeman Adrian Wood | 2014 | 劳动经济研究2014，2，5： | 8 |
| 18 | 2,8-二氨基-10-甲氧基-5,10-二氢磷杂吖嗪-10-氧化物的合成、诱变性及应用性能研究显示文摘10 羟基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 1)经酰氯化、甲基化得到 10 甲氧基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 2 ) ,2经硝化得到 10 甲氧基 2 ,8 二硝基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 3 ,62 %) .3在Pd/C (w =0 .0 5 )存在下 ,用氢气还原为 2 ,8 二氨基 10 甲氧基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 4 ,71%) ,考察了Pd/C (w =0 0 5 )用量对氢化还原反应的影响 .经过Salmonella/mammalianmicrosomeassay测试 ,4表现为非诱变性 ,用 4与乙酰J 酸作用得到新型双偶氮酸性染料 ( 5 ) .5对羊毛和丝绸分别在 2 %与 3 %色度下浸染都得到黑色染样 ,考察了 5的上染曲线 ,并对染样进行了测色研究 ,发现该染料属于酸性蓝黑染料 ,其黑度优于目前市场上流行的酸性黑 10B . | 尹志刚 熊卫东 赵德丰 FREEMAN Harold S.c | 2004 | 化学学报2004，62，10： | 7 |
| 19 | Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis显示文摘Fundic gland polyps are now commonly recognized during endoscopy. These polyps are benign, often multiple and usually detected in the gastric body and fundus. In the past, these polyps were sometimes associated with familial adenomatous polyposis. In recent years, it has become evident that increasing numbers of these polyps are being detected during endoscopic studies, particularly in patients treated with proton pump inhibitors for prolonged periods. In some, dysplastic changes in these polyps have also been reported. Recent studies have suggested that there may be no increase in risk of colon cancer with long-term proton pump inhibitor therapy. While temporarily reassuring, ongoing vigilance, particularly in those genetically predisposed to colon cancer, is still warranted. | Hugh James Freeman | 2008 | World Journal of Gastroenterology2008，14，9： | 7 |
| 20 | In-situ cosmogenic ^(36)Cl denudation rates of carbonates in Guizhou karst area显示文摘This study quantifies surface denudation of carbonate rocks by the first application of in-situ cosmogenic36Cl in China. Concentrations of natural Cl and in-situ cosmogenic36Cl in bare carbonates from Guizhou karst areas were measured with isotope dilution by accelerator mass spectrometer. The Cl concentration varied from 16 to 206 ppm. The 36Cl concentrations were in range of (0.8-2.4)106 atom g-1 , resulting in total denudation rates of 20-50 mm ka-1 that averaged over a 104-105 a timescale. The 36Cl-denudation rates showed roughly a negative correlation with the local mean temperature. This preliminary observation may suggest the variations of proportions of chemical weathering and physical erosion in denudation process, depending upon local climatic conditions. | XU Sheng LIU CongQiang FREEMAN Stewart LANG YunChao SCHNABEL Christoph TU ChengLong WILCKEN Klaus ZHAO ZhiQi | 2013 | Chinese Science Bulletin2013，58，20： | 7 |
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