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53篇 您的检索式:作者名="Arkwright"
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1Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes显示文摘Fas/CD95 表面受体调停各种各样的房间的快速的死亡打字,包括有为触发 autoimmunity 的潜力的 autoreactive T 房间。这里,我们表明那的船边交货的现在的新奇方面定义一种“社会”的尺寸到导致受体的 apoptosis。船边交货刺激很快导致在附近的 T 房间之间的广泛的膜 nanotube 形成。这极其依赖于 Rho GTPases 然而并非在 caspase 激活上。包括活跃 caspases 的膜和 cytosolic 元素的双向转移能被观察经由这些 nanotubes 发生。Nanotube 形成和死亡信号的细胞间的交换在从有在船边交货受体的自体免疫的 lymphoproliferative 症候群 harbouring 变化的病人的 T 淋巴细胞是有缺点的。我们断定调停 nanotube 的交换组成扩充在附近的 T 房间之间发信号的死亡的繁殖的细胞间的通讯的一种新奇形式。Peter D Arkwright Francesca Luchetti Julien Tour Charlotte Roberts Rahna Ayub Ana P Morales Jose J Rodriguez Andrew Gilmore Barbara Canonico Stefano Papa Mauro Degli Esposti 2010Cell Research2010,20,1:4
2儿童湿疹和哮喘对双亲睡眠和身心健康的影响:一项前瞻性比较研究显示文摘Background: The psychological impact of childhood atopic eczema on parents and carers is poorly quantified. Objectives: To compare the impact of caring for a child with atopic eczema vs. asthma on parents’sleep and well-being. Methods: Ninety two parents of 55 children who had moderate to severe atopic eczema or asthma took part in this prospective, questionnaire based study. It was conducted at regional eczema and asthma outpatient clinics within a U.K. tertiary paediatric hospital. The main outcome measures were the number and duration of parents’sleep disturbances, as well as their anxiety and depression scores. Results: Mothers caring for children with atopic eczema lost a median of 39 min of sleep per night and fathers lost 45 min sleep per night. This compared with a median of 0 min sleep lost by parents who had children with asthma (P < 0.001). These differences were independent of the age of the children, and whether the child came from a single-parent or two-parent family. There was a direct correlation between the severity of sleep disturbance and the level of maternal anxiety (rho = 0.58; P = 0.002) and depression (rho = 0.73; P < 0.001), as well as the level of paternal anxiety (rho = 0.59; P = 0.01). Conclusions: Compared with looking after a child with chronic asthma, caring for a child with chronic atopic eczema was associated with greater parental sleep disturbances. Disruption to parental sleep correlated with anxiety levels and, in the case of mothers, depression scores.Moore K. David T.J. Murray C.S. P.D. Arkwright 李政霄 2006世界核心医学期刊文摘(皮肤病学分册)2006,2,6:2
3The Pressor Effect of Moderate Alcohol Consumption in Man: A Search for Mechanisms显示文摘PETER D. ARKWRIGHT LAWRENCE J. BEILIN ROBERT VANDONGEN IAN A. ROUSE CLAIRE LALOR 1982Circulation1982,,3:2
4The effect of sacral nerve stimulation on distal colonic motility in patients with faecal incontinence 显示文摘Patton V Wiklendt L Arkwright JW 2013Br J Surg2013,100,:1
5Pancolonic motor response to subsensory and suprasensory sacral nervestimulation in patients with slow-transit constipation 显示文摘Dinning PG Hunt LM Arkwright JW 2012British J Surg2012,99,:1
6Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to receptor blockade with eternacept显示文摘Arkwright PD McDermott MF Houston SM 2002Clin Exp Immunol2002,130,30:1
7Atopic dermatitis is associated with a lowproducer transforming growth factor beta (1)cytokine genotype显示文摘 Chase JM Babbage S 2001J Allergy Clin Immunol2001,108,:1
8Deterministic control of thin film thickness in physical vapor deposition systems using a multi-aperture mask 显示文摘Arkwright J Underhill I Pereira N 2005Optics Express(S 1094-4087)2005,13,7:1
9Atopicdermatitis is associated with a low-producer transforminggrowth factor beta(1)cytokine genotype显示文摘Arkwright PD Chase JM Babbage S 2001J Allergy ClinImmunol2001,108,2:1
10Design of a high-sensor count fibre optic manometry catheter for in-vivo colonic diagnostics显示文摘Arkwright JW Underhil ID Maunder SA 0,,25:1
11Manage- ment of difficult - to - treat atopic dermatitis 显示文摘Arkwright P D Motala C Subramanian H 2013J Allergy Clin Immunol Pract2013,1,2:1
12The effect of sacral nerve stimulation on distal colonic motility in patients with fecal incontinence显示文摘Patton V Wiklendt L Arkwright JW 2013Br J Surg2013,100,7:1
13TGF-beta(1)geno-type and accelerated decline in lung function of patients with cystic fibrosis显示文摘Arkwright PD Laurie S Super M 2000Thorax2000,55,6:1
14Intradermal administration of a killed Mycobacterium vaccae suspension (SRL172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease显示文摘Arkwright P D David T J 2001J Allergy Clin Immunol2001,107,:1
15Infantile nephrotic syndrome and atopy显示文摘Arkwright PD Clark G 1996Pediatr Nephrol1996,10,:1
16The effect of sacral nerve stimulation on distal colonic motility in patients with faecal incontinence显示文摘Patton V Wiklendt L Arkwright JW 2013Br J Surg2013,100,7:1
17Atopic eczema is associated with delayed maturation of the antibody response to pneumococcal vaccine显示文摘Arkwright PD Patel L Moran A Haeney MR Ewing CI David TJ 2000Clin Exp Immunol2000,122,1:1
18Pancolonic motor response to subsensory and suprasensory sacral nerve stimulation in patients with slow-transit constipation显示文摘Dinning PC Hunt LM Arkwright JW 2012Br J Surg2012,99,7:1
19Anti-CD20 or anti-IgE therapy for severe chronic autoimmune urticaria 显示文摘Arkwright PD 2009J Allergy Clin Immunol2009,123,2:1
20TGF -βgenotype and accelerated decline in lung function of patients with cystic fibrosis 显示文摘Arkwright PD Laurie S Super M 2000Thorax2000,55,:1
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