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| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | Synthe- sis and electrochemical characterizations of amorphous manganese oxide and single walled carbon nanotube composites as supercapacitor electrode materials 显示文摘 | SUBRAMANIAN V ZHU H W WEI B Q | 2006 | Electrochem Commun2006，8，5： | 1 |
| 3 | 14-3-3 proteins:structure,function,and regulation显示文摘 | Fu H Subramanian R R and Masters S C | 2000 | Annu Rev Pharmacol Toxicol2000，40，： | 1 |
| 4 | Experimental stroke induces massive, rapid activation of the peripheral im- mune system显示文摘 | Offner H Subramanian S Parker SM | 2006 | Journal of Cerebral Blood Flow and Metabo- lism2006，26，5： | 1 |
| 5 | OverQoS:Offering internet QoS using overlays显示文摘 | Subramanian L Stoica I Balakrishnan H | 2003 | ACM SIGCOMM Computer Communications Review2003，33，1： | 1 |
| 6 | Wet grinding characteristics of soybean for soymilk extraction显示文摘 | Vishwanathan K H Singh V Subramanian R | 2011 | Journal of Food Engineering2011，106，1： | 1 |
| 7 | Optical and photocatalytie properties of heavily F-doped Sn02 nanocrystals by a novel single-source precursor approach显示文摘 | Portier J Choy J H Subramanian M A | | 0，，07： | 1 |
| 8 | Synthesis and electrochemical characterizations of amorphous manganese oxide and single walled carbon nanotube composites as supercapacitor electrode materials 显示文摘 | SUBRAMANIAN V ZHU H W WEI B Q | 2006 | Electrochem Commun2006，8，5： | 1 |
| 9 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 10 | Bio-modulation of galena and sphalerite surfaces using Thiobacillus thiooxidans显示文摘 | SANTHIYA D SUBRAMANIAN S NATARAJAN K A RAO K H FORSSBERG K S E | 2001 | International Journal of Minerals Processing2001，62，： | 1 |
| 11 | Preparation of tetramethyl ammonium hydroxide by electrolysis显示文摘 | Subramanian G S Udupa H V K | 1971 | Denki Kagaku Oyobi Kogyo Butsuri Kagaku,1971，39，3： | 1 |
| 12 | Innate lymphoid cells responding to IL-33 mediate airway-hyperreaetivity independent of adaptive immunity显示文摘 | Kim H Chang gJ Subramanian S | 2012 | J Allergy Clin Immunol2012，129，1： | 1 |
| 13 | Hydrothermal synthesis and pseudocapacitance properties of MnO2 nanostructures显示文摘 | Subramanian V Zhu H W Vajtai R | 2005 | Journal of Physical Chemistry B2005，109，20： | 1 |
| 14 | 显示文摘 | Subramanian V Zhu H W Wei B Q | 2006 | Journal of Power Sources2006，159，： | 1 |
| 15 | FeAl-TiC and FeAl-WC composites-melt infiltration processing,microstructure and mechanical properties显示文摘 | SCHNEIBEL J H | 1998 | Materials Science and Engineering1998，244，： | 1 |
| 16 | Synthesis and flocculation performance of graft and random eopolymer mierogels of aerylamide and diallyldimethylammonium chloride 显示文摘 | Subramanian R Zhu S Pehon R H | 1999 | Colloid Polym Sei1999，，277： | 1 |
| 17 | GSEA-P:a desktop application for gene set enrichment analysis显示文摘 | Subramanian A Kuehn H Gould J | 2007 | Bioinformatics2007，23，23： | 1 |
| 18 | Minimurn interference channel assignment in multi-radio wireless mesh networks显示文摘 | Subramanian A P Gupta H Das S R | 2008 | IEEE Transaction on Mobile Computing2008，11，7： | 1 |
| 19 | FeAl-TiC cermets-melt infiltration processing and mechanical properties显示文摘 | SCHNEIBEl J H | 1997 | Materials Science and Engineering1997，，： | 1 |
| 20 | Functional Conservation of 14-3-3 Isoforms in Inhibiting Bad-induced Apoptosis 显示文摘 | SUBRAMANIAN RR MASTERS SC ZHANG H | 2001 | Exp Cell Res (S0014-4827)2001，271，1： | 1 |
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