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| 1 | MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma显示文摘AIM: To investigate the expressions of MUC1 and MUC5AC in intrahepatic cholangiocarcinoma (ICC). Association of expressions of mucins MUC1 and MUC5AC with clinical findings, metastasis, and survival of the liver fluke-associated ICC patients was determined.METHODS: The expressions of MUC1 and MUC5AC mucins were examined by immunohistochemical staining in 87cases of histologically-proven ICC. The expressions of mucins in relationship between clinicopathological significance and prognosis of the patients were evaluated.RESULTS: Fifty-two patients (60%) exhibited both MUC1 and MUC5AC expressions, whereas 31% expressed either MUC1or MUC5AC, and 9% expressed neither. High MUC1immunoreactivity displayed a significant correlation with tumor progression as reflected by vascular invasion (P<0.001),whereas high expression of MUC5AC significantly correlated with neural invasion (P = 0.022) and advanced ICC stage (P = 0.008). Patients with high expression of MUC1 had a significantly shorter survival (P = 0.0002). According to multivariate analyses, MUC1 reactivity (P = 0.026),histological grading and stage of tumor represented the least probability of survival.CONCLUSION: MUC1 is overexpressed in liver flukeassociated cholangiocarcinoma and relates to vascular invasion and poor prognosis, whereas MUC5AC mucin is neoexpressed and relates to neural invasion and advanced ICC stage. High MUC1 expression in tumor may be useful for predicting the poor outcome of ICC patients. | Chanchai Boonla Banchob Sripa Peti Thuwajit Ubon Cha-On Anucha Puapairoj Masanao Miwa Sopit Wongkham | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 2 | Establishment and characterization of an opisthorchiasis-associated cholangiocarcinoma cell line (KKU-100)显示文摘AIM To establish and dharacterize a nev cholangiocarcinoma cell line from a patient living in the Opisthorchis viverrini (O. viverrini) endemic area of Northeast Thailand.METHODS: Fresh liver biopsy and bile specimens were obtained from a 65-year-old Thai woman with cholangiocarcinoma of the porta hepatis. After digestion, the cells were cultured in Ham's F12 media. The established cell line was then characterized for growth kinetics, cell morphology, imm unocytochemistry and cytogenetics. Tumorigenicity of the cell line was determined by heterotransplanting in nude mice. RESULTS: The primary tumor was a poorly differentiated tubular adenocarcinoma. Examination of the bile revealed malignant cells with O. viverrini eggs. The cholangiocarcinoma cell line KKU-100 was established 4 mo after the primary culture-population doubling time was 72 h. KKU-100 possesses compact and polygonal-shapedepithelial cells. Immunocytochemically, this cell line exhibited cytokeratin, EMA, CEA, and CA125, but not α-fetoprotein (AFP), CA19-9, desmin, c-met, or p53. Such protein expressions parallel those of the primary tumor. Cytogenetic analysis identified aneuploidy karyotypes with a modal chromosome number of 78 and marked chromosomal structural changes. Inoculation of KKU-100 cells into nude mice produced a transplantable, poorly differentiated aden-ocarcinoma, similar to the original tumor.CONCLUSION: KKJ-100 is the first egg-proven, Opisthorchis- associated cholangiocarcinoma cell line, which should prove useful for further investigations of the tumor biology of this cancer. | Banchob Sripa Saman Leungwattanawanit Takayuki Nitta Chaisiri Wongkham Vajarabhongsa Bhudhisawasdi Anucha Puapairoj Chongrak Sripa Masanao Miwa | 2005 | World Journal of Gastroenterology2005，11，22： | 4 |
| 3 | Intravenous transplantation of mouse embryonic stem cells attenuates demyelination in an ICR outbred mouse model of demyelinating diseases显示文摘Induction of demyelination in the central nervous system(CNS) of experimental mice using cuprizone is widely used as an animal model for studying the pathogenesis and treatment of demyelination. However, different mouse strains used result in different pathological outcomes. Moreover, because current medicinal treatments are not always effective in multiple sclerosis patients, so the study of exogenous cell transplantation in an animal model is of great importance. The aims of the present study were to establish an alternative ICR outbred mouse model for studying demyelination and to evaluate the effects of intravenous cell transplantation in the present developed mouse model. Two sets of experiments were conducted. Firstly, ICR outbred and BALB/c inbred mice were fed with 0.2% cuprizone for 6 consecutive weeks; then demyelinating scores determined by luxol fast blue stain or immunolabeling with CNPase were evaluated. Secondly, attenuation of demyelination in ICR mice by intravenous injection of m ES cells was studied. Scores for demyelination in the brains of ICR mice receiving cell injection(m ES cells-injected group) and vehicle(sham-inoculated group) were assessed and compared. The results showed that cuprizone significantly induced demyelination in the cerebral cortex and corpus callosum of both ICR and BALB/c mice. Additionally, intravenous transplantation of m ES cells potentially attenuated demyelination in ICR mice compared with sham-inoculated groups. The present study is among the earliest reports to describe the cuprizone-induced demyelination in ICR outbred mice. Although it remains unclear whether m ES cells or trophic effects from m ES cells are the cause of enhanced remyelination, the results of the present study may shed some light on exogenous cell therapy in central nervous system demyelinating diseases. | Kidsadagon Pringproa Anucha Sathanawongs Chananthida Khamphilai Sarocha Sukkarinprom Apichart Oranratnachai | 2016 | Neural Regeneration Research2016，11，10： | 2 |
| 4 | Polymorphism of glutathione S -transferase Omega gene and risk of cancer显示文摘 | Sujan Babu Marahatta Phaibul Punyarit Vajarabhongsa Bhudisawasdi Anucha Paupairoj Sopit Wongkham Songsak Petmitr | 2005 | Cancer Letters2005，，2： | 1 |
| 5 | Successful treatment of disseminated methicillin- resistant Staphylococcus aureus with fcsfomycin, cefoperazone/sulbactam and rifampin followed by fusidic acid and rifampin显示文摘 | Anucha A Mundy LM | 2007 | Int J Infect Dis2007，11，3： | 1 |
| 6 | A muhifaceted inter- vention to reduce pandrug-resistant aeinetobacter baumannii coloni- zation and infection in 3 intensive care units in a thai tertiary care center: a 3-year study 显示文摘 | Anucha A Uayporn P Kanokporn T | 2008 | Clin Infect Dis2008，47，6： | 1 |
| 7 | Leaching behavior of CRT funnel glass显示文摘 | Masaru Yamashita Anucha Wannagon Sachiko Matsumoto Tomoko Akai Hajime Sugita Yukari Imoto Takeshi Komai Hirofumi Sakanakura | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 8 | Systematic layout planning to assist plant layout : Casestudy pulley factory 显示文摘 | WATANAPA ANUCHA | 2011 | Applied Mechan- ics and Materials2011，110，116： | 1 |
| 9 | Characterization of Li-Zn-Fe crystalline phases in low temperature ceramic glaze显示文摘 | Anucha Wannagon Sitthisak Prasanphan Samunya Sanguanpak | 2013 | Journal of the European Ceramic Society2013，33，： | 1 |
| 10 | Ventilator-associated pneumonia in extremely preterm neonates in a neonatal intensive care unit : characteristics, risk factors, and outcomes 显示文摘 | Anucha Apisarnthanarak Galit Holzmann-Pazgal Aaron Hamvas | 2003 | Pediatrics2003，112，6： | 1 |
| 11 | Phase,microstmcture and ferroelectric properties of new complex-structured ferroelectric ceramics in the PZT-SBN system显示文摘 | ORAPIM Namsara ANUCHA Watcharapasom SUKANDA Jiansirisomboon | 2013 | Ceram Int2013，39，1： | 1 |
| 12 | Influence of shielding gas on aluminum alloy 5083 in gas tungsten arc welding显示文摘 | Prachya P Anucha W | 2012 | Procedia Engineering2012，29，： | 1 |
| 13 | Molecular Characterization and Epidemiology of Extended - spectrum - β - lactamase -producing Escherichia Coli and Klebsiella Pneumoniae Isolates Causing Health Care- associated Infection in Thailand, Where the CTX- M Family is Endemic 显示文摘 | Pattarachai K Anucha A Chaitat L | 2008 | Antimicrobial Agents and Chemotherapy2008，52，8： | 1 |
| 14 | EFFECT OF QUAIL LITTER BIOCHAR ON PRODUCTIVITY OF FOUR NEW PHYSIC NUT VARIETIES PLANTED IN CADMIUM-CONTAMINATED SOIL显示文摘 | Suppadit Tawadchai Kitikoon Viroj Phubphol Anucha | 2012 | Chilean Journal of Agricuhural Research2012，72，1： | 1 |
| 15 | Influence of ferric oxide on the crystallization of ferrite anorthite and Hematite phases at low temperature ceramic glaze显示文摘 | Supakorn Silakate Anucha Wannagon Apinon Nuntiya | 2015 | Journal of the European Ceramic Society2015，35，7： | 1 |
| 16 | Characterization of Li–Zn–Fe crystalline phases in low temperature ceramic glaze显示文摘 | Anucha Wannagon Sitthisak Prasanphan Samunya Sanguanpak | 2013 | Journal of the European Ceramic Society2013，，4： | 1 |
| 17 | International Nosocomial Infection Control Consortiu (INICC) report, data summary of 43 countries for 2007-2012. Device-associated module显示文摘 | Víctor Daniel Rosenthal Dennis George Maki Yatin Mehta Hakan Leblebicioglu Ziad Ahmed Memish Haifaa Hassan Al-Mousa Hanan Balkhy Bijie Hu Carlos Alvarez-Moreno Eduardo Alexandrino Medeiros Anucha Apisarnthanarak Lul Raka Luis E. Cuellar Altaf Ahmed Joseph | 2014 | AJIC: American Journal of Infection Control2014，，： | 1 |
| 18 | Nonjudicious Dispensing of Antibiotics by Drug Stores in Pratumthani,Thailand显示文摘 | Anucha A Jeeraluk T Korakot T | 2008 | Infection Control and Hospital Epidemiology2008，29，6： | 1 |
| 19 | Influence of shiehling gas on aluminum alloy 5083 in gas tungsten arc welding显示文摘 | Prachya Peasura Anucha Watanapa | 2012 | Proccdia Engineering2012，29，： | 1 |
| 20 | Nonjudicious Dispensing ofAntibiotics by Drug Stores in Pratumthani,Thailand显示文摘 | Anucha A Jeeraluk T Korakot T | 2008 | InfectionControl and Hospital Epidemiology2008，29，6： | 1 |
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