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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | Micro-Raman studies on DLC coatings 显示文摘 | Irmer G Annett D R | 2005 | Advanced Engineering Materials2005，8，： | 1 |
| 3 | p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-γ or FMLP stimulation显示文摘 | Jiafan Q Annette G | 1998 | J Immunol1998，160，： | 1 |
| 4 | Organochlorine exposure and risk of breast cancer显示文摘 | Annette P H Philippe G Torben J | 1998 | Lancet1998，352，： | 1 |
| 5 | Mesenchymal stem cells for the treatment of neurodegenerative disease显示文摘 | Joyce N Annett G Wirthlin L | 2010 | Re- gen Med2010，5，6： | 1 |
| 6 | An ethics core curriculum for Australasian medical schools, A Working Group, on behalf of the Association of Teachers of Ethics and Law in Australian and New Zealand Medical Schools (ATEAM) 显示文摘 | ANNETTE J B LYNN H G EDWINA F V | 2001 | MJA2001，，175： | 1 |
| 7 | Thermal denaturation and coagulation of whey proteins: effect of sugars显示文摘 | GARRETT J M STAIRS R A ANNETT R G | 1988 | Journal of Dairy Science1988，71，： | 1 |
| 8 | Mesenchymal stem cells for the treatment of neurodegenerative disease显示文摘 | Joyce N Annett G Wirthlin L | | 0，，06： | 1 |
| 9 | In vitro activities of terbinafine in combination with fluconazole,itraconazole,voriconazole,and posaconazole against clinical isolates of Candida glabrata with decreased susceptibility to azole显示文摘 | Perea S Gonzalez G Annette W | 2002 | J Clin Microbiol2002，40，： | 1 |
| 10 | Deletion of the gene encoding p60 in Listeria monocytogenes leads to abnormal cell division and loss of actin-based motility显示文摘 | SABINE P ANNETTE K M IVAYLO G | 2003 | Infect Immun2003，71，6： | 1 |
| 11 | Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction显示文摘 | Marc W. Merx Simone Gorressen Annette M. Sandt Miriam M. Cortese-Krott Jan Ohlig Manuel Stern Tienush Rassaf Axel G?decke Mark T. Gladwin Malte Kelm | 2014 | Basic Research in Cardiology2014，，： | 1 |
| 12 | YB-1:oncoprotein,prognosticmarker and therapeutic target?显示文摘 | Annette L Cristin G Adele GW | 2013 | Biochem J2013，449，1： | 1 |
| 13 | A 10 -year incidence survey of respiratory cancer and a case control study within a co- hort of nickel mining and refining workers in New Caledonia显示文摘 | Marcel G Paquerette G Annette L | 1994 | Cancer Causes and Control1994，5，： | 1 |
| 14 | Coupling satellite images with surface measurements of bright sunshine hours to estimate daily solar irradiation on horizontal surface显示文摘 | Selmin Ener Rusen Annette Hammer Akinoglu B G | 2013 | Renewable Energy2013，55，7： | 1 |
| 15 | Listeria monocytogenes-infected human dendritic cells: uptake and host cell response 显示文摘 | ANNETTE K M IVAYLO G HANS-WERNER F | 2000 | Infect and immune2000，68，： | 1 |
| 16 | Molecular of analysis of endometrial tumorigenesis;importance of complex hy- perplasia regardless of atpia 显示文摘 | Taina T Annette G Weal M | 2009 | Clin cancer Res2009，15，18： | 1 |
| 17 | DNA Fingerprinting of Dairy Propionibacteria Strains by Pulsed -Field Gel Electrophoresis 显示文摘 | Michel G Antonio C Annette R | 1996 | Curr Microbiol1996，32，： | 1 |
| 18 | Mesenchymal stem cells for the treatment of neurodegenerative disease 显示文摘 | Joyce N Annett G Wirthlin L | 2010 | Regen Med2010，5，： | 1 |
| 19 | Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism显示文摘 | STAVROS K ANNETTE G MANFRED O | 2002 | Circulation2002，106，3： | 1 |
| 20 | Deletion of the Gene Encoding p60 in Listeria monocytogenes leads to abnormal cell division and loss of actin-based motility显示文摘 | SABINE P ANNETTE K M IVAYLO G | 2003 | Infect Immun2003，71，6： | 1 |
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