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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 3 | Influence of Biochars on Nitrous Oxide Emission and Nitrogen Leaching from Two Contrasting Soils显示文摘 | Singh Bhupinder Pal Hatton Blake J Singh Balwant Cowie Annette L Kathuria Amrit | 2010 | Journal of Environmental Quality2010，，4： | 4 |
| 4 | Influence of Biochars on Nitrous Oxide Emission and Nitrogen Leaching from Two Contrasting Soils显示文摘 | Singh Bhupinder Pal Hatton Blake J Singh Balwant Cowie Annette L Kathuria Amrit | 2010 | Journal of Environmental Quality2010，，4： | 2 |
| 5 | Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake显示文摘Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit quality.Actinidia chinensis var.deliciosa‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is unclear.In this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit DM.During fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate supply.We showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate limited.Enhanced glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after anthesis.Transcipt analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate supply.At standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch degradation.When carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase genes.We conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited. | Simona Nardozza Helen L Boldingh Mark W Wohlers Andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C Richardson | 2017 | Horticulture Research2017，4，1： | 2 |
| 6 | Mixed-species plantations of Eucalyptus with nitrogen-fixing trees:A review显示文摘 | Forrester J B Annette L C | 2006 | Forest Ecology and Management2006，233，： | 1 |
| 7 | Ovarian malignant mixed müllerian tumors treated with platinum-based chemotherapy显示文摘 | Charles L Elvio GS | 1995 | Obstet Gynecol1995，85，： | 1 |
| 8 | Oxidation of^6-to^5 by peroxomonosulfate in strong and weak acid solutions,an example of zero-order kinetics显示文摘 | Annette L N Robert C B Geoffrey A L | 1998 | J Chem Soc Dalton Trans1998，，5： | 1 |
| 9 | Characterization of Damaged Skin by Imedance Spec- troscopy: Mechanical Damage 显示文摘 | White Erick A Orazem Mark E Bunge Annette L | 2013 | Pharmaceutical Research2013，30，8： | 1 |
| 10 | Cognitive existential coupletherapy for newly diagnosed prostate cancer patients and their part-ners:A descriptive pilot study显示文摘 | Collins A L Bloch S Annette F | 2011 | Psycho-oncology2011，10，2： | 1 |
| 11 | Production of hepatic outflow block and ascites with an ameroid constrictor 显示文摘 | Sweat E R Musieant M E Annetts D L | 1966 | Surg Forum1966，17，： | 1 |
| 12 | Mesenchymal stem cells for the treatment of neurodegenerative disease显示文摘 | Joyce N Annett G Wirthlin L | 2010 | Re- gen Med2010，5，6： | 1 |
| 13 | Mesenchymal stem cells for the treatment of neurodegenerative disease显示文摘 | Joyce N Annett G Wirthlin L | | 0，，06： | 1 |
| 14 | Shift - work and cardiovascular disease显示文摘 | Annette L | 2010 | Eur J Epidemiol2010，，25： | 1 |
| 15 | YB-1:oncoprotein,prognosticmarker and therapeutic target?显示文摘 | Annette L Cristin G Adele GW | 2013 | Biochem J2013，449，1： | 1 |
| 16 | Integrating Point-to-Point Videoconfer- encing into Professional Development of Rural Elementary School Science Teachers 显示文摘 | L Annette D Dickerson | 2006 | Contemporary Issues in Technology and Teacher Education2006，，4： | 1 |
| 17 | A 10 -year incidence survey of respiratory cancer and a case control study within a co- hort of nickel mining and refining workers in New Caledonia显示文摘 | Marcel G Paquerette G Annette L | 1994 | Cancer Causes and Control1994，5，： | 1 |
| 18 | Acquiring new knowledge: The role of retaining human capital in acquisitions of high teeh firms 显示文摘 | Annette L L Michael D | 2000 | Journal of High Technology Management Research2000，11，2： | 1 |
| 19 | Associations of blood biomarkers with glomerular filtration rate in patients with TIA and stroke: population-based study显示文摘Background and purpose Non-traditional risk factors such as chronic inflammation,oxidative stress and thrombogenic factors are believed to contribute to the excess stroke risk in chronic kidney disease(CKD)by triggering vascular injury and endothelial dysfunction.We aimed to determine how well a panel of biomarkers representative of these factors would correlate with estimated glomerular filtration rate(eGFR)in patients with recent transient ischaemic attack(TIA)or stroke.We also investigated whether eGFR would confound previously reported associations between biomarkers and mortality.Methods We studied a panel of 16 blood biomarkers related to inflammation,thrombosis,atherogenesis and cardiac or neuronal cell damage in TIA or ischaemic stroke in a population-based study(Oxford Vascular Study).Biomarker levels were log-transformed and correlated with eGFR,adjusted for age.Cox proportional hazard models were used for survival analysis.Results Among 1297 patients with TIA or stroke,52.7%(n=684)of patients had CKD(eGFR<60 mL/min/1.73 m^(2)).There was a moderate correlation between log-eGFR and the log-transformed soluble tumour necrosis factor receptor-1(R^(2)=0.21),attenuating with adjustment for age(R^(2)=0.12).There were moderate-to strong correlations with markers of cardiac injury,N-terminal pro-brain natriuretic peptide and heart-type fatty acid binding protein(hFABP,R2=0.14 and 0.34,respectively).The strongest correlation after adjustment for age was between hFABP and eGFR(R^(2)=0.20).Adjusting for eGFR did not impact any biomarker associations with mortality.Conclusions Correlations between biomarkers related to inflammation and thrombosis with renal dysfunction in the setting of cerebrovascular events were generally modest after adjustment for age,suggesting that putative risk factors such as chronic inflammation or coagulopathy are unlikely to be important stroke mechanisms in patients with CKD. | Dearbhla M.Kelly Linxin Li Annette I Burgess Deborah L Poole Julia M Duerden Peter M.Rothwell | 2021 | Stroke & Vascular Neurology2021，6，1： | 1 |
| 20 | Mesenchymal stem cells for the treatment of neurodegenerative disease 显示文摘 | Joyce N Annett G Wirthlin L | 2010 | Regen Med2010，5，： | 1 |
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