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| 1 | Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro显示文摘Sertoli 房间紧密的连接(TJ ) 是血睾丸障碍的关键部件,在它扣押开发在生精的小管以内经历精子发生的细菌房间的地方。神经质地调整的 claudin-11 是在不孕涉及障碍功能和它的鼠科的猛烈结果的批评 transmembrane 蛋白质。我们试图估计份量上到 TJ 功能的 claudin-11 的贡献的意义在 vitro,使用调停 siRNA 的基因 silencing。我们也进行了 occludin 的贡献的分析, TJ 的另一内在的 transmembrane 蛋白质。claudin-11 或 occludin 的 Silencing 在一个不成熟的老鼠 Sertoli 房间文化模型用 siRNA 被进行。Transepithelial 电的抵抗被用来在整个文化估计份量上 TJ 功能。在 siRNA 处理以后的二天,房间为对 mRNA 的 RT-PCR 评价为连接蛋白质或 lyzed 的 immunocytochemical 本地化被修理表示。claudin-11, occludin,或两个的 Silencing 在 55% 的 TJ 功能导致了重要减少(P <0.01 ) , 51%(P <0.01 ) ,并且 62%(P <0.01 ) 分别地。数据在到 Sertoli 房间 TJ 的指向的蛋白质的本地化是有在 mRNA 表示和显著减小的重要减少的伴随物。我们提供 claudin-11 显著地贡献的量的证据(P <0.01 ) 到 Sertoli 房间 TJ 在 vitro 工作。有趣地, occludin,神经质地在不孕被调整然而并非含有直到迟了的成人生活,也是一重要(P <0.01 ) 贡献者到障碍功能。我们的数据与一致在清楚地为这些表明一个角色的 vivo 研究,在维持正常 TJ 障碍的蛋白质组织并且工作。 | Mark J McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G Stanton | 2016 | Asian Journal of Andrology2016，18，4： | 7 |
| 2 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 3 | Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies显示文摘 | Andrew G Renehan Margaret Tyson Matthias Egger Richard F Heller Marcel Zwahlen | 2008 | The Lancet2008，，9612： | 2 |
| 4 | Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies显示文摘 | Andrew G Renehan Margaret Tyson Matthias Egger Richard F Heller Marcel Zwahlen | 2008 | The Lancet . 2008 (9612)2008，，： | 2 |
| 5 | Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies显示文摘 | Andrew G Renehan Margaret Tyson Matthias Egger Richard F Heller Marcel Zwahlen | 2008 | 2008 (9612)2008，，9612： | 2 |
| 6 | Rock/ fluid interactions of carbonated brines in a sandstone reservoir Pembina Cardium, Alberta, Canada显示文摘 | Sayegh S G Krause F F Girard Marcel | 1990 | SPE Formation Evaluation1990，5，4： | 1 |
| 7 | Paul alivisatos semiconductor nanocrystals as fluorescent biological labels显示文摘 | Marcel Bruchez Jr Mario M Peter G Shimon W | 1998 | Science1998，281，： | 1 |
| 8 | Semiconductor nanocrystals as fluorescent biological labels显示文摘 | MARCEL B J MARIO M PETER G | 1998 | Science1998，281，： | 1 |
| 9 | Commensal bacteria do translocate across the intestinal barrier in surgical patients 显示文摘 | Bala S John M Marcel G | 2007 | Clin Nutr2007，26，2： | 1 |
| 10 | Semiconductor Nanocrystals as Fluorescent Biological Labels显示文摘 | Marcel BJ Mario M Peter G | 1998 | Science1998，281，： | 1 |
| 11 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 12 | Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells显示文摘 | Jo'zefa W G Marieta G Marcel H | 2005 | Mol Cancer Ther2005，4，1： | 1 |
| 13 | In vivo effects of human recombinant TGF-β on bone turnover in normal mice显示文摘 | Marcellic Yates K Mundy G | 1996 | J Bone Miner Res1996，，5： | 1 |
| 14 | Apolipoprotein A-I:structure-functionrelationships显示文摘 | FRANK P G MARCEL Y L | | 0，，06： | 1 |
| 15 | Experience with methyl salicylate affects behavioural responses of a predatory mite to blends of herbivore-induced plant volatiles 显示文摘 | Jetske G de Boer Marcel Dicke | 2004 | Entomologia Experimentalis et Applicata2004，110，2： | 1 |
| 16 | Direct torque control of an inductor machine using a three-level inverter and fuzzy logic 显示文摘 | Toro Xavier del Calls Salvador Jayne Marcel G | 2004 | IEEE Transactions on Industrial Electronics2004，，2： | 1 |
| 17 | Derivatives of erythropoietin that are tissue protective but not erythropoietic显示文摘 | Marcel L Pietro G Giovanni G | 2004 | Science2004，305，5681： | 1 |
| 18 | High diversity of genes for nonhost resistance of barley to heterologous rust fungi显示文摘 | Jafary H Albertazzi G Marcel T C | 2008 | Genetics2008，178，： | 1 |
| 19 | Semiconductor nanocrystals as fluorescent biological labels显示文摘 | Marcel B J Mario M Pater G | 1998 | Science1998，281，： | 1 |
| 20 | Activation of the 55kDa TNF receptor is necessary and sufficient for TNF-induced liver failure,hepatocyte apotosis,andnitite release显示文摘 | MARCEL L FLORIAN G SAINE J | 1995 | J Immunol1995，154，： | 1 |
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