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| 1 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 2 | Toxoplasma gondii : from animals to humans显示文摘 | Astrid M Tenter Anja R Heckeroth Louis M Weiss | 2000 | International Journal for Parasitology2000，，12： | 4 |
| 3 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 4 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 5 | 临床试验数据共享声明显示文摘国际医学期刊编辑委员会(ICMJE)认为,由于临床试验参与者处于研究风险之中,我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月,ICMJE发表了一项关于临床试验数据共享的提案,旨在帮助创造共享去标识个体患者数据的常态化环境。 | Darren B Taichman Peush Sahni Anja Pinborg Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Joyce Backus 季媛媛 | 2017 | 中国医院院长2017，13，16： | 2 |
| 6 | Inflammatory cytokines and the risk to develop type 2 diabetes:results of the prospective population-based european prospective investigation into cancer and nutrition (EPIC)-Potsdam study显示文摘 | JOACHIM S ANJA K MATTHIAS M | 2003 | Diabetes2003，52，3： | 1 |
| 7 | Nitrososphaera viennen- sis, an ammonia oxidizing archaeon from soil显示文摘 | Fourna M Michaela S Anja S etal | 2011 | Proceedings of the National Academy of Sciences2011，108，20： | 1 |
| 8 | Rapamyein prevents mesenteric neo-angiogenesis and reduces splanchnic blood flow in portal hypertensive mice 显示文摘 | ANJA M G ELINE V HANS V V | 2008 | Hepatol Res2008，38，： | 1 |
| 9 | Activation of flavonoid biosynthesis by solar radiation in bilberry (Vaccinium myrtillus L.) leaves显示文摘 | Laura Jaakola Kaisu M??tt?-Riihinen Sirpa K?renlampi Anja Hohtola | 2004 | Planta2004，，5： | 1 |
| 10 | A CFD study of fuel evaporation and related thermo-fluid dynamics in the inlet manifold, port and cylinder of the CFR octane engine 显示文摘 | Anja T Garetha F Chris M | 2012 | SAE International Journal of Fuels and Lubricants2012，，3： | 1 |
| 11 | Pilot study of non‐contrast‐enhanced MRI vs. ultrasound in renal transplant recipients with acquired cystic kidney disease: a prospective intra‐individual comparison显示文摘 | Anja S. Mühlfeld Christian Lange Gisela Kroll Jürgen Floege Gabriele A. Krombach Christiane Kuhl Frank Eitner Simone Schrading | 2013 | Clin Transplant2013，，6： | 1 |
| 12 | Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency 显示文摘 | Richard M A Anja R J Indra L B | 2005 | Annals of Clinical Microbiology and Antimicrobials2005，4，2： | 1 |
| 13 | Effect of exogenous fibrolytic enzymes on ruminal fermentation and nutrient digestion in dairy cows显示文摘 | Anja P Peter L Ulrich M | 2010 | Arch Anita Nutr2010，64，3： | 1 |
| 14 | Influence of acids, salt, sugars and hydrocolloids on the colour stability of anthocyanin rich black currant and elderberry concentrates显示文摘 | EVA M H ANJA H HEIKO S | 2006 | Eur Food Res Technol2006，223，： | 1 |
| 15 | Extracellular NAD + induces a rise in [Ca 2+ ] i in activated human monocytes via engagement of P2Y 1 and P2Y 11 receptors显示文摘 | Carina Klein Anja Grahnert Aliaa Abdelrahman Christa E. Müller Sunna Hauschildt | 2009 | Cell Calcium2009，，4： | 1 |
| 16 | Functional characterization of the lectin pathway of complement in human serum显示文摘 | Anja R Lee HB Jeric M | 2003 | Molecular Immunology2003，39，65： | 1 |
| 17 | PET/MRI of inflammation in myocardial infarction显示文摘 | Won Woo Lee Brett Marinelli Anja M | 2012 | J Am Coli Carciiol2012，59，2： | 1 |
| 18 | Effects of long - term use of video - communication technologies on the con- versational process 显示文摘 | VAN DER KLEIJ R PAASHUIS R M ANJA J J L | 2004 | Cognition Technology & Work2004，6，1： | 1 |
| 19 | Aiponectin and protegtion against type 2 diabetes mellitus 显示文摘 | Joachim S Anja K Matthias M | 2003 | Lancet2003，361，9358： | 1 |
| 20 | Integrating molecular information into treatment of childhood acute lymphoblastic leukemia—A perspective from the BFM Study Group显示文摘 | Martin Stanulla Gunnar Cario Barbara Meissner André Schrauder Anja M?ricke Hansj?rg Riehm Martin Schrappe | 2007 | Blood Cells Molecules and Diseases2007，，2： | 1 |
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