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| 1 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 2 | 英格兰和威尔士地区儿童恶性肿瘤与高压输电线距离的关系:一项病例-对照研究显示文摘目的 确定英格兰和威尔士地区儿童白血病及其他癌症发病率是否与其出生时家庭地址与高压电线的距离存在关系。设计 病例-对照研究。设置 癌症登记处和国家电力供应网的记录。对象1962-1995年,英格兰和威尔士地区出生的0-14岁的29081名癌症患儿中包括9700名白血病患儿。对照组依照性别、大致相同的出生日期、出生登记处等予以个体匹配。并不强求积极参与。主要结果测定 儿童出生时的家庭地址与当时最近的高架高压输电线问的距离(以下有时简称为距离)。结果 与生活在距输电线超过600米的儿童相比,距输电线200米之内的儿童患白血病的相对危险度为1.69(95%可信区间为1.13-2.53);200-600米间的发病相对危险度为1.23(1.02-1.49)。白血病发病风险与输电线相互距离的倒数存在显著相关性(P〈0.01)。毗邻输电线未发现增加儿童其他癌症的额外发病风险。结论 儿童白血病发病风险与出生时家庭地址距高压电线的远近存在相关关系,且风险程度超出了以往研究的预期。在英格兰和威尔士地区,出生时生活在距离高压输电线600米内的白血病患儿约占4%。如果这种相关是偶然的,那么在该地区约1%的儿童白血病是由于高压输电线导致的,尽管这种估计在统计学上具有相当的不确定性。没有其他可接受的生物学机制来解释这些流行病学结果;事实上这种联系可能源于偶然或混杂。 | Gerald Draper Tim Vincent Mary E Kroll John Swanson 李勇 | 2005 | 英国医学杂志中文版2005，8，6： | 4 |
| 3 | Perforator-Based Flaps for Low Posterior Midline Defects显示文摘 | Stephen S. Kroll Lome Rosenfield Stephen J. Kroll | 1988 | Plastic and Reconstructive Surgery1988，，4： | 2 |
| 4 | Multicenter evaluation of the Roche NT-proBNP assay and comparison to the Biosite Triage BNP assay显示文摘 | Kiang-Teck J. Yeo Alan H.B. Wu Fred S. Apple Martin H. Kroll Robert H. Christenson Kent B. Lewandrowski Frank A. Sedor Anthony W. Butch | 2003 | Clinica Chimica Acta2003，，1： | 2 |
| 5 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 6 | Si-C-N三元系统的新陶瓷相显示文摘固体化学合成的氮化物较其他氧化物研究相对较少,然而过去20年来,该研究领域得到重视。超硬 C3N4相所类似的碳氮化物目前已获得深入研究,相比较而言,Si-C-N化合物的研究依旧比较少。在大气条件下首先合成的三元晶体相为Si(NCN)2和 Si2C2(NCN)。本文回顾了近年来采用高温高压反应工艺合成C-N二元和 Si-C-N三元系材料的研究现状。这类新型材料因具有一些独特的性能,如高硬度、磁性、光电性能,而具有重大研究前景。 | RIEDEL Ralf HORVATH-BORDON Elisabeta KLEEBE Hans-Joachim KROLL Peter MIEHE Gerhard van AKEN Peter A LAUTERBACH Stefan | 2007 | 硅酸盐学报2007，35，8： | 2 |
| 7 | Modelling and simulation of fixtures during grinding显示文摘The complex workpiece-fixture behaviour during machining is an essential component of the fixture development process.In detail,the forces acting on fixture components have to be analysed.A method for the prediction of the reaction forces due to process and clamping loads is presented in this article.At the beginning,detailed information about the workpiece-fixture behaviour during the process is determined by a complex finite element model.Secondly,the reduction of the number of elements leads to a smaller model with less computation time,validated and used for the variation of process parameters.Finally,an analytical description is developed based on the combination of both results.With the help of the empiric equation it is possible to predict the reaction forces and the dependency on several process parameters.This method has been validated by modelling shape grinding of a nozzle guide vane. | Matthias KLAERNER Juergen LEOPOLD Lothar KROLL | 2009 | Science China(Technological Sciences)2009，52，7： | 2 |
| 8 | 研究生涯:美国研究人员所需的信息支持显示文摘2010年7月,OCLC研究部发布了最新的报告,该报告对美国研究人员在工作之中所需的各类信息支持情况进行了访谈。访谈对象主要是来自康奈尔大学、俄亥俄州立大学、范德比尔特大学和华盛顿大学的研究员、研究员助理、研究生、基金会以及其他与研究工作有关的行政人员等。 | Susan Kroll(著) Rick Forsman (著) 徐静(编译) | 2010 | 图书情报工作动态2010，，8： | 2 |
| 9 | Memory and language skills in simultaneous interpreters: The role of expertise and language proficiency显示文摘 | Ingrid K. Christoffels Annette M.B. de Groot Judith F. Kroll | 2005 | Journal of Memory and Language2005，，3： | 2 |
| 10 | Delayed spontaneous reversibility of left bundle branch block in non-ischemic cardiomyopathy: a case report显示文摘Left bundle branch block(LBBB)causes a delay in left ventricular contraction with an unsynchronized ventricular systole.LBBB is an independent determinant of morbi-mortality mainly when associated with cardiomyopathy and left ventricular dysfunction.[1] LBBB due to non-ischemic cardiomyopathy is considered non-reversible.Such irreversibility occurs because LBBB and cardiomyopathy act in a synergic manner in order to maintain both situations.However,there are a few reports in the literature showing that some patients have had an improvement in cardiac function with normalization of QRS and have experienced a reverse remodelling with pharmacological therapy only.[2–4] | Marcus VH Carvalho Priscila C Kroll Vinicius N Carvalho | 2020 | Journal of Geriatric Cardiology2020，17，3： | 2 |
| 11 | Total sacretomy and Galvestont rod reconstruction for malignant neoplasns显示文摘 | Gokaslan ZL Romsdahl MM Kroll SS | 1997 | J Neurosurg1997，87，5： | 1 |
| 12 | Reconstruction and the radiated breast:is there a role for implants?显示文摘 | Evans GR Schusterman MA Kroll SS | 1995 | Plast Reconstr Surg1995，96，5： | 1 |
| 13 | Evaluation of the extent of nonlinearity in reportable range studies显示文摘 | Kroll M H Prastgaard J Michaliszyn E | 2000 | Arch Pathol Lab Med2000，124，： | 1 |
| 14 | Upconversion dynamics in Er3+:doped Yag显示文摘 | Xu H L Kroll S | 2005 | Journal of Luminescence2005，111，3： | 1 |
| 15 | Complications in aphakic eyes after vitreous loss显示文摘 | Kroll P Busse H Berg P | 1981 | Ann ophthalmol1981，13，： | 1 |
| 16 | Category Interference in Translation and Picture Naming: Evidence for Asymmetric Connections Between Bilingual Memory Representations显示文摘 | Kroll J F Stewart E | 1994 | Journal of Memory and Language1994，33，： | 1 |
| 17 | Enzymatically induced posterior vitreous detachment in poliferative diabetic vitreoretinopathy显示文摘 | Hesse L Kroll P | 1999 | Klin Monatsbl Augenheilkd1999，214，2： | 1 |
| 18 | Identification and preliminary characterization of white sturgeon ( Acipensertransmontanus) vitellogenin mRNA 显示文摘 | Bidwell C A Kroll K J Severud E | 1991 | Gen Corap Endcrinol1991，83，3： | 1 |
| 19 | Binding of selected phe-nolic compounds to proteins 显示文摘 | Rawel H M’Meidtner K Kroll J | 2005 | J Agric Food Chem2005，53，42： | 1 |
| 20 | Choice of flap and incidence of free flap success显示文摘 | Kroll SS Schusterman MA Reece GP | 1996 | Plast Reconstr Surg1996，98，： | 1 |
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