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| 1 | Therapeutic potential of targeting the renin angiotensin system in portal hypertension显示文摘Portal hypertension is responsible for the bulk of the morbidity and mortality in patients with cirrhosis.Drug therapy to reduce portal pressure involves targeting two vascular beds.The first approach is to reduce intra hepatic vascular tone induced by the activity of powerful vasocontrictors such as angiotensin Ⅱ,endothelin-1 and the sympathetic system and mediated via contraction of perisinusoidal myofibroblasts and pervascular smooth muscle cells.The second approach is to reduce mesenteric and portal blood flow.Non-selective b-blockers are widely used and have been shown to prolong patient survival and reduce oesophageal variceal bleeding in advanced cirrhosis.However many patients are unable to tolerate these drugs and they are ineffective in a significant proportion of patients.Unfortunately there are no other drug therapies that have proven efficacy in the treatment of portal hypertension and prevention of variceal bleeding.This review briefly outlines current therapeutic approaches to themanagement of portal hypertension,and the evidence supporting the role of the renin angiotensin system(RAS) and the use of RAS blockers in this condition.It will also outline recent advances in RAS research that could lead to the development of new treatments focusing in particular on the recently discovered 'alternate axis' of the RAS. | Chandana B Herath Josephine A Grace Peter W Angus | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 9 |
| 2 | Hepatopulmonary syndrome: Update on recent advances in pathophysiology, investigation, and treatment显示文摘 | Josephine A Grace Peter W Angus | 2013 | J Gastroenterol Hepatol2013，，2： | 2 |
| 3 | Genetic algorithms for reliability-based optimization of water distribution systems显示文摘 | Bryan A Tolson Holger R Maierl Angus R Simpson | 2005 | Journal of Water Resources and Management2005，26，6： | 1 |
| 4 | Parents' needs following identification of childhood hearing loss 显示文摘 | Fitzpatrick E Angus D Durieux-Smith A | 2008 | Am J Audiol2008，17，1： | 1 |
| 5 | Cooperation and competition in pathogenic bacteria显示文摘 | ASHLEIGH S G STUART A W ANGUS B | 2004 | Letters to Nature2004，430，10： | 1 |
| 6 | Soil water extraction by dryland crops, annual pastures, and lucerne in south-eastern Australia 显示文摘 | Angus J F Stapper M Van Herwaarden A F | 2001 | Australian Journal of Agricultural Research2001，52，2： | 1 |
| 7 | Genetic algorithms for reliability2based optimization of waterdistribution systems 显示文摘 | Bryan A Tolson Holger R Maierl Angus R Simp son | 2004 | Journal of Water Resources andM anagem ent2004，，： | 1 |
| 8 | RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients:a cohort analysis显示文摘 | Hoste EA Clermont G Kersten A Venkataraman R Angus DC De Bacquer D | | 0，，： | 1 |
| 9 | The potential of NIR spectroscopy to predict nitrogen mineralization in rice soils显示文摘 | Russelll C A Angus J F Batten G D | 2002 | Plant and Soil2002，247，： | 1 |
| 10 | Biofumigation:isothiocynates released from Brassica roots inhibit growth of the take-all fungus显示文摘 | Angus J F Gardner P A Kirkegaard J A | 1994 | Plant and Soil1994，162，： | 1 |
| 11 | Increasing water use and water use efficiency in dry land wheat 显示文摘 | Angus J F Van Herwaarden A F | 2001 | Agronomy Journal2001，93，： | 1 |
| 12 | A randomized, double-blind, 24-week study comparing the efficacy and tolerability of mirtazapine and paroxetine in depressed patients in pri mary care显示文摘 | Wade A Crawford GM Angus M | 2003 | Int Clin Psyehopharmaeol2003，18，3： | 1 |
| 13 | Increasing water use and water use efficiency in dryland wheat显示文摘 | Angus J F Van Herwaarden A F | 2001 | Agronomy Journal2001，93，5： | 1 |
| 14 | Electronic effects of sodium in epitaxial CuIn1-xGaxSe2 显示文摘 | Schroeder David J Rockett Angus A | 1997 | J Appl Phys1997，82，： | 1 |
| 15 | Increase water use and water use efficiency in dryland wheat显示文摘 | Angus J F Herwarden A F | 2001 | Agron J2001，93，： | 1 |
| 16 | Lay- er-by-layer engineered capsules and their applications 显示文摘 | ANGUS P R J CHRISTINA C ALEXANDRA S A | 2006 | Curr Opin Colloidln2006，11，4： | 1 |
| 17 | Effects of sleep posture on upper airway stability in patients with obstructive sleep apnea显示文摘 | NEILL A M ANGUS S M SAJKOV D | 1997 | Am J Respir Crit Care Med1997，155，： | 1 |
| 18 | The management of intrauterine synechiae显示文摘 | Angus JMT Jason A A Rebecca D | | Current Opinion in Obstetrics and Gynecology0，，： | 1 |
| 19 | Articular constraint, handedness, and directional asymmetry in the human second metacarpal 显示文摘 | Lazenby Richard A Cooper David ML Angus Sarah et a! | 2008 | Journal of Human Evolution2008，54，6： | 1 |
| 20 | Increasing water use and water use efficiency in dryland wheat显示文摘 | Angus J F A F van Herwaarden | 2001 | Agronomy Journal2001，93，： | 1 |
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