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| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 3 | Change de- tection from remotely sensed images: from pixel-based to object- based approaches 显示文摘 | Masroor Hussain Dongmei Chen Angela Cheng | 2013 | ISPRS Journal of Photogrammetry and Re- mote Sensing2013，80，： | 1 |
| 4 | Orlistat 显示文摘 | Nina N Wong Angela Cheng Lai | 2000 | Heart Disease2000，2，： | 1 |
| 5 | Genotype-Phenotype Correlations in Attenuated Adenomatous Polyposis Coli显示文摘 | Claudio Soravia Terri Berk Lisa Madlensky Angela Mitri Hong Cheng Steven Gallinger Zane Cohen Bharati Bapat | 1998 | The American Journal of Human Genetics1998，，6： | 1 |
| 6 | Change detection from remotely sensed images: From pixel-based to object-based approaches显示文摘 | Masroor Hussain Dongmei Chen Angela Cheng Hui Wei David Stanley | 2013 | ISPRS Journal of Photogrammetry and Remote Sensing2013，，： | 1 |
| 7 | Metabolic and Adipokine Profile of Chinese Patients With Nonalcoholic Fatty Liver Disease显示文摘 | Vincent Wai–Sun Wong Alex Yui Hui Steven Woon–Choy Tsang Joyce Lai–Yee Chan Ada Mei–Ling Tse Kui–Fat Chan Wing–Yee So Angela Yuen–Shan Cheng Wing–Fung Ng Grace Lai–Hung Wong Joseph Jao–Yiu Sung Henry Lik–Yuen Chan | 2006 | Clinical Gastroenterology and Hepatology2006，，9： | 1 |
| 8 | Anti‐VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models显示文摘 | Mallika Singh Suzana S Couto William F Forrest Anthony Lima Jason H Cheng Rafael Molina Jason E Long Patricia Hamilton Angela McNutt Ian Kasman Michelle A Nannini Hani Bou Reslan Tim C Cao Calvin CK Ho Kai H Barck Richard AD Carano Oded Foreman Jeffrey Ea | 2012 | J Pathol2012，，4： | 1 |
| 9 | 用无细胞真皮基质包裹全部假体治疗包膜挛缩:一项新技术显示文摘背景与目的包膜挛缩是乳房再造术的常见并发症,其受累患者比例为2.8%~15.9%。已有应用无细胞真皮基质治疗包膜挛缩的报道,其复发率为6.3%,但这个比例仅限于假体局部覆盖者。笔者报道一种应用无细胞真皮基质完整覆盖假体来治疗及预防包膜挛缩的新的手术技术。方法将乳房假体以无细胞真皮基质完全包裹并置入,手术由同一医师施行,对此类患者进行图表评估鉴定。记录患者的人口统计学信息、放射治疗或包膜挛缩病史、治疗前及治疗后并发症。结果对11例患者(16只乳房)进行鉴定。患者平均年龄(52.3±6.9)岁,平均体质量指数(23.6±4.4)kg/m。4例患者(5只乳房)有包膜挛缩病史,之前经包囊切除术及更换假体治疗。10例患者为新出现的Ⅲ级(n=2)和Ⅳ级(n=8)包膜挛缩的矫治,l例患者为预防包膜挛缩。无细胞真皮基质的平均尺寸为144~256eIll,平均(229.8±46.5)cm。随访2.4~18.8个月,平均9.2个月。1例患者(1只乳房)出现感染而需要取出假体。无一例患者出现包膜挛缩复发。结论通过无细胞真皮基质包裹可成功治疗包膜挛缩。该技术可作为当前治疗顽固性包膜挛缩(标准疗法下的早期复发或顽固复发)有用的附加技术。(循证医学证据等级:疗法,Ⅳ级) | Angela Cheng Chrisovalantis Lakhiani Michel Saint-Cyr 魏峰(译) 高景恒(译) 张晨(译) | 2014 | 中国美容整形外科杂志2014，25，2： | 0 |
| 10 | Crowdsourcing in health and medical research:a systematic review显示文摘Background:Crowdsourcing is used increasingly in health and medical research.Crowdsourcing is the process of aggregating crowd wisdom to solve a problem.The purpose of this systematic review is to summarize quantitative evidence on crowdsourcing to improve health.Methods:We followed Cochrane systematic review guidance and systematically searched seven databases up to September 4th 2019.Studies were included if they reported on crowdsourcing and related to health or medicine.Studies were excluded if recruitment was the only use of crowdsourcing.We determined the level of evidence associated with review findings using the GRADE approach.Results:We screened 3508 citations,accessed 362 articles,and included 188 studies.Ninety-six studies examined effectiveness,127 examined feasibility,and 37 examined cost.The most common purposes were to evaluate surgical skills(17 studies),to create sexual health messages(seven studies),and to provide layperson cardiopulmonary resuscitation(CPR)out-of-hospital(six studies).Seventeen observational studies used crowdsourcing to evaluate surgical skills,finding that crowdsourcing evaluation was as effective as expert evaluation(low quality).Four studies used a challenge contest to solicit human immunodeficiency virus(HIV)testing promotion materials and increase HIV testing rates(moderate quality),and two of the four studies found this approach saved money.Three studies suggested that an interactive technology system increased rates of layperson initiated CPR out-ofhospital(moderate quality).However,studies analyzing crowdsourcing to evaluate surgical skills and laypersoninitiated CPR were only from high-income countries.Five studies examined crowdsourcing to inform artificial intelligence projects,most often related to annotation of medical data.Crowdsourcing was evaluated using different outcomes,limiting the extent to which studies could be pooled.Conclusions:Crowdsourcing has been used to improve health in many settings.Although crowdsourcing is effective at improving behavioral outcomes,more research is needed to understand effects on clinical outcomes and costs.More research is needed on crowdsourcing as a tool to develop artificial intelligence systems in medicine. | Cheng Wang Larry Han Gabriella Stein Suzanne Day Cedric Bien-Gund Allison Mathews Jason JOng Pei-Zhen Zhao Shu-Fang Wei Jennifer Walker Roger Chou Amy Lee Angela Chen Barry Bayus Joseph D.Tucker | 2020 | Infectious Diseases of Poverty2020，9，1： | 0 |
| 11 | 转移过程对CVD生长的石墨烯质量的影响显示文摘利用化学气象沉淀法(CVD)在金属衬底上生长的石墨烯制备电子器件需要先把石墨烯转移到绝缘基底上,转移过程对器件制备的成功率和性能的均匀性有重要影响.转移过程中导致的石墨烯破损和金属生长基底残余颗粒污染受到普遍重视,然而由金属基底腐蚀液导致的石墨烯表面污染还没有引起足够的重视.本文利用拉曼光谱和X射线光电子能谱(XPS)证明了转移过程中金属基底腐蚀液会在石墨烯表面引入污染,利用我们发展的'改良的RCA(radio corporation of America)清洗(modified RCA clean)'转移工艺能够有效地去除这种污染.这对提高后续制备的电子器件的性能有重要意义. | 梁学磊 李伟 CHENG GuangJun CALIZO Irene HACKER Christina A HIGHT WALKER Angela R RICHTER Curt A 彭练矛 | 2014 | 科学通报2014，59，33： | 0 |
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