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| 1 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 2 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 3 | Expression of Tissue Factor in High-Grade Carotid Artery Stenosis: Association With Plaque Destabilization显示文摘 | Sebastian Jander Matthias Sitzer Angélique Wendt Michael Schroeter Martin Buchkremer Mario Siebler Wolfram Müller Wilhelm Sandmann Guido Stoll | 2001 | Stroke: Journal of the American Heart Association2001，，4： | 3 |
| 4 | l -Carnitine: An adequate supplement for a multi-targeted anti-wasting therapy in cancer显示文摘 | Sílvia Busquets Roberto Serpe Míriam Toledo Angélica Betancourt Enrica Marmonti Marcel Orpí Fabrizio Pin Eva Capdevila Clelia Madeddu Francisco J. López-Soriano Giovanni Mantovani Antonio Macciò Josep M. Argilés | 2012 | Clinical Nutrition2012，，6： | 2 |
| 5 | A Study of Growth Mechanism of KDP and ADP Crystals by Means of Quantum Chemistry显示文摘 | Asakuma Y Li Q Ang H M | 2008 | Applied Surface Science2008，254，： | 1 |
| 6 | A Review of Synergistic Effect of Photocatalysis and Ozonation on Wastewater Treatment 显示文摘 | Agustina T E Ang H M Vareek V K | 2005 | J Photo- ehem Photobiol C2005，6，4： | 1 |
| 7 | Latent bioactive peptides in milk proteins: proteolytic activation and significance in dairy processing 显示文摘 | GOBBETTI M STEPANIAK M DE ANGELIS | 2002 | Critical Reviews in Food Science and Nutrition2002，42，3： | 1 |
| 8 | Skeletal muscle infarction in diabetes mellitus显示文摘 | Grigoriadis E Fam AG Starok M Ang LC | 2000 | J Rheumatol2000，27，4： | 1 |
| 9 | Removal of ammonium from greywater using natural zeolite 显示文摘 | Widiastuti N Wu H W Ang H M | 2011 | Desalination2011，277，13： | 1 |
| 10 | Characterization of non-starter lactic acid bacteria from Italian ewe cheeses based on phe- notypic, genotypic, and cell wall protein analyses显示文摘 | DE ANGELIS M CORSETTI A TOSTI N | 2001 | Applied and Envi- ronmental Microbiology2001，67，5： | 1 |
| 11 | Spinal muscular atrophy genotyping by gene dosage using multiple ligation-dependent probe amplification 显示文摘 | Scarciolla O Stuppia L De Angelis M V at al | 2006 | Neurogenetics2006，7，4： | 1 |
| 12 | Study of the effects of texture, pH, NaCI, and aw on the proteolytic and lipolytic activities of cheese-related lactic acid bacteria by quadratic respinse surface methodology 显示文摘 | GOBBETTI M LANCIOTTIR ANGELIS M D | 1999 | Enzyme and Microbial Technology1999，25，10： | 1 |
| 13 | Optimum dietary protein requirement of a Malaysian freshwater catfish,Mystus nemurus显示文摘 | Khan M S Ang K J Kohl H G | 1993 | Aquaculture1993，112，： | 1 |
| 14 | Influ- ence of surface treatments on the flexural properties of fiber posts显示文摘 | D'Arcangelo C D'Amario M Vadini M De Angelis F Caputi S | 2007 | J Endod2007，33，7： | 1 |
| 15 | Regression analysis on ionic liquid pretreatment of sugarcane bagasse and assessment of structural changes 显示文摘 | Yoon L W Ang T N Ngoh G C Chua A S M | 2012 | Biomass andBioenergy2012，36，： | 1 |
| 16 | Mutagenic and genotoxic effects of the atrazine herbicide in Oreochromis niloticus(Perciformes,Cichlidae)detected by the micronuclei test and the comet assay显示文摘 | Ventura B C de Angelis D F Marin-Morales M A | 2008 | Pestic Biochem Physiol2008，90，1： | 1 |
| 17 | 显示文摘 | Hor T S A Xu G Q | 1999 | Chem Mater1999，11，： | 1 |
| 18 | Nigral glutathione deficiency is not specific for idiopathic Parkinsen's disease 显示文摘 | Fitzmaurice PS Ang L Guttman M | 2003 | Mov Disord2003，18，： | 1 |
| 19 | CD151 protein expression predicts the clinical outcome of low-grade primary prostate cancer better than histologic grading: a new prognostic indicator? 显示文摘 | Ang J Lijovic M Ashman LK | 2004 | Cancer Epidemiol Biomarkers Prev2004，13，111： | 1 |
| 20 | Prognostic significance of recurrent chromosomal aberrations detected by comparative genomic hybridization in sporadic colorectal cancer显示文摘 | De Angelis P M Stokke T Beigi M | 2001 | Int J Colorectal Dis2001，16，1： | 1 |
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