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| 1 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 2 | ConservativeapproachinPeutz-JeghersSyndrome:Single-balloon enteroscopyandsmallbowelpolypectomy显示文摘AIM: To assess the usefulness of the balloon assisted enteroscopy in preventing surgical intervention in pa-tients with Peutz-Jeghers syndrome (PJS) having a small bowel large polyps. METHODS: Seven consecutive asymptomatic pts(age 15-38 years) with PJS have been collected; six under-went polypectomy using single balloon enteroscopy(Olympus SIF Q180) with antegrade approach using push and pull technique. SBE system consists of the SIF-Q180 enteroscope, an overtube balloon control unit(OBCU Olympus Balloon Control Unit) and a dispos-able silicone splinting tube with balloon(ST-SB1). All procedures were performed under general anesthesia. Previously all pts received wireless capsule endos-copy(WCE). Prophylactic polypectomy was reservedmainly in pts who had polyps > 15 mm in diameter. The balloon is inflated and deflated by a balloon control unit with a safety pressure setting range from-6.0 kPa to +5.4 kPa. Informed consent has been obtained from pts or parents for each procedure.RESULTS: Six pts underwent polypectomy of small bowel polyps; in 5 pts a large polyp > 15 mm(range 20-50 mm in diameter) was resected; in 1 patient with WCE negative, SBE was performed for previous surgi-cal resection of gastrointestinal stromal tumors. In 2 pts endoscopic clips were placed due to a polypectomy. No surgical complication have been reported. SBE with resection of small bowel large polyps in PJS pts was useful to avoid gastrointestinal bleeding and emergency laparotomy due to intestinal intussuscep-tions. No gastrointestinal tumors were found in sub-sequent enteroscopic surveillance in all seven pts. In order surveillance, all pts received WCE, upper en-doscopy, ileocolonoscopy every 2 years. No pts had extraintestinal malignant lesions. SBE was performed when WCE was positive for significant polyps(> 15 mm).CONCLUSION: The effective of prophylactic polyp-ectomy of small bowel large polyps(> 15 mm) could be the first line treatment for conservative approach in management of PJS patients. | Torroni F Romeo E Rea F De Angelis P Foschia F Faraci S Federici di Abriola G Contini AC Caldaro T Dall’Oglio L | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 7 |
| 3 | l -Carnitine: An adequate supplement for a multi-targeted anti-wasting therapy in cancer显示文摘 | Sílvia Busquets Roberto Serpe Míriam Toledo Angélica Betancourt Enrica Marmonti Marcel Orpí Fabrizio Pin Eva Capdevila Clelia Madeddu Francisco J. López-Soriano Giovanni Mantovani Antonio Macciò Josep M. Argilés | 2012 | Clinical Nutrition2012，，6： | 2 |
| 4 | Strategic Response to Institutional in Llences on Information Systems Outsourcing显示文摘 | Ang S Cummings L | 1997 | Organization Science1997，8，3： | 1 |
| 5 | Reliability andvalidity of the adapted Greek version of Scoliosis ResearchSociety-22(SRS-22)Questionnaire显示文摘 | Antonarakos PD Katranitsa L Angelis L | 2009 | Scoliosis2009，4，： | 1 |
| 6 | Gundersen flaps inthe management of ocular surface disease in an Asian pop- ulation 显示文摘 | LIM L S HOW A C ANG L P | 2009 | Conea2009，28，7： | 1 |
| 7 | The Effects of Taxes on the Relative Valuation of Dividends and Capital Gains:Evidence from Dual-Class British Investment Trusts显示文摘 | ANG J S BLACKWELL D W MEGGINSON W L | | 0，，： | 1 |
| 8 | The effect of acute hyperglycemia on QTc duration in healthy man显示文摘 | Marfella R Nappo F De Angelis L | | 0，，： | 1 |
| 9 | Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel显示文摘 | Ang L Palakodeti V Khalid A Tsimikas S Idrees Z Tran P | 2008 | J Am Coll Cardiol2008，52，： | 1 |
| 10 | Measuring environmental per- formance under different environmental DEA technologies 显示文摘 | ZHOU P ANG B W POH K L | 2008 | En- ergy Economics2008，30，1： | 1 |
| 11 | Thermal and Mechanical Analysis of Delamination in GaN-Based Light-Emitting Diode Packages 显示文摘 | H U J Z YANG L Q HW ANG W J | 2006 | J Crystal Growth2006，288，1： | 1 |
| 12 | Spinal muscular atrophy genotyping by gene dosage using multiple ligation-dependent probe amplification 显示文摘 | Scarciolla O Stuppia L De Angelis M V at al | 2006 | Neurogenetics2006，7，4： | 1 |
| 13 | Critical review of comparative-acute toxicity data on freshwater fish显示文摘 | Vitozzi L De Angelis G A | 1991 | Aquat Toxicol1991，19，3： | 1 |
| 14 | Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel 显示文摘 | ANG L PALAKODETI V KHALID A | 2008 | J Am Coll Cardiol2008，52，7： | 1 |
| 15 | Ramipril improves oxida-tive stress-related vascular endothelial dysfunction in db/dbmice显示文摘 | LIANG W TAN CY ANG L | 2008 | J Physiol Sci2008，58，6： | 1 |
| 16 | Gas chromatographicmass spectrometric determination of levodropropizine plasma levels in healthy volunteers显示文摘 | Zaratin P De Angelis L Cattabeni F | 1988 | Arzneimittelforschung1988，38，8： | 1 |
| 17 | A survey of data envelop-ment analysis in energy and environmental studies显示文摘 | ZHOU P ANG B W POH K L | 2008 | Euro-pean Journal of Operational Research2008，189，1： | 1 |
| 18 | Regression analysis on ionic liquid pretreatment of sugarcane bagasse and assessment of structural changes 显示文摘 | Yoon L W Ang T N Ngoh G C Chua A S M | 2012 | Biomass andBioenergy2012，36，： | 1 |
| 19 | Molecular interaction between COP1 and HY5 defines a regulatory switch for light control of Arabidopsis development显示文摘 | ANG L H CHATTOPADHYAY S WEI Ning | 1998 | Mol Cell1998，1，2： | 1 |
| 20 | The effect of acute hyperglycemia on QTc duration in healthy man显示文摘 | Nappo F De Angelis L | 2000 | Diabetologia2000，43，5： | 1 |
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