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| 1 | Targeted therapies in metastatic gastric cancer: Current knowledge and future perspectives显示文摘Gastric cancer(GC)represents a leading cause of cancer related morbidity and mortality worldwide accounting for more than 1 million of newly diagnosed cases and thousands of deaths every year.In the last decade,the development of targeted therapies and the optimization of already available chemotherapeutic drugs has expanded the available treatment options for advanced GC and granted better survival expectations to the patients.At the same time,global efforts have been undertaken to investigate in detail the genomic and epigenomic heterogeneity of this disease,resulting in the identification of new specific and sensitive predictive and prognostic biomarkers and in innovative molecular classifications based on gene expression profiling.Nonetheless,several randomized studies aimed at exploring new innovative agents,such as immune checkpoint inhibitors,failed to demonstrate clinically meaningful survival advantages.Therefore,it is essential to further improve the molecular characterization of GC subgroups in order to provide researchers and medical oncologists with new tools for patients’selection and stratification in future clinical development programs and subsequent trials.The aim of the present manuscript is to provide a global overview of the recent molecular classifications from The Cancer Genome Atlas and the Asian Cancer Research Group and to present key promising developments in the field of immunotherapy and targeted therapies in metastatic GC. | Antonio Pellino Erika Riello Floriana Nappo Stefano Brignola Sabina Murgioni Selma Ahcene Djaballah Sara Lonardi Vittorina Zagonel Massimo Rugge Fotios Loupakis Matteo Fassan | 2019 | World Journal of Gastroenterology2019，25，38： | 9 |
| 2 | Right ventricular septal pacing: Safety and efficacy in a long term follow up显示文摘AIM: To evaluate the safety and efficacy of the permanent high interventricular septal pacing in a long term follow up, as alternative to right ventricular apical pacing. METHODS: We retrospectively evaluated:(1) 244 patients(74 ± 8 years; 169 men, 75 women) implanted with a single(132 pts) or dual chamber(112 pts) pacemaker(PM) with ventricular screw-in lead placed at the right ventricular high septal parahisian site(SEPTAL pacing);(2) 22 patients with permanent pacemaker and low percentage of pacing(< 20%)(NO pacing);(3) 33 patients with high percentage(> 80%) right ventricular apical pacing(RVA). All patients had a narrow spontaneous QRS(101 ± 14 ms). We evaluated New York Heart Association(NYHA) class, quality of life(Qo L), 6 min walking test(6MWT) and left ventricular function(end-diastolic volume, LV-EDV; end-systolic volume, LVESV; ejection fraction, LV-EF) with 2D-echocardiography. RESULTS: Pacing parameters were stable duringfollow up(21 mo/patient). In SEPTAL pacing group we observed an improvement in NYHA class, Qo L score and 6MWT. While LV-EDV didn't significantly increase(104 ± 40 m L vs 100 ± 37 m L; P = 0.35), LV-ESV slightly increased(55 ± 31 m L vs 49 ± 27 m L; P = 0.05) and LV-EF slightly decreased(49% ± 11% vs 53% ± 11%; P = 0.001) but never falling < 45%. In the RVA pacing control group we observed a worsening of NYHA class and an important reduction of LV-EF(from 56% ± 6% to 43% ± 9%, P < 0.0001).CONCLUSION: Right ventricular permanent high septal pacing is safe and effective in a long term follow up evaluation; it could be a good alternative to the conventional RVA pacing in order to avoid its deleterious effects. | Eraldo Occhetta Gianluca Quirino Lara Baduena Rosaria Nappo Chiara Cavallino Emanuela Facchini Paolo Pistelli Andrea Magnani Miriam Bortnik Gabriella Francalacci Gabriele Dell’Era Laura Plebani Paolo Marino | 2015 | World Journal of Cardiology2015，7，8： | 5 |
| 3 | Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans: Role of Oxidative Stress显示文摘 | Katherine Esposito Francesco Nappo Raffaele Marfella Giovanni Giugliano Francesco Giugliano Myriam Ciotola Lisa Quagliaro Antonio Ceriello Dario Giugliano | 2002 | Circulation: Journal of the American Heart Association2002，，16： | 3 |
| 4 | Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans:role of oxidative stress显示文摘 | Esposito K Nappo F Marfella R | 2002 | Circulation2002，106，16： | 1 |
| 5 | Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus显示文摘 | Giugliano D Nappo F | 2004 | Circulation2004，110，2： | 1 |
| 6 | Innflasmmatory cytokine concentrations are acutely increased by hyper glycemia in humans~ role of oxidative stress显示文摘 | Esposito K Nappo F Marfella R | 2002 | Circula tion2002，106，16： | 1 |
| 7 | The effect of acute hyperglycemia on QTc duration in healthy man显示文摘 | Marfella R Nappo F De Angelis L | | 0，，： | 1 |
| 8 | Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans role of oxidative stress显示文摘 | Esposito K Nappo F Maffella R | 2002 | Circulation2002，106，： | 1 |
| 9 | Inflammatory cytokine con- centrations are acutely increased by hyperglycemia in humans:role of oxidative stress 显示文摘 | Esposito K Nappo F Marfella R | 2002 | Circulation2002，106，16： | 1 |
| 10 | Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes显示文摘 | MARFELLA R ESPOSITO K NAPPO F | 2004 | Diabetes2004，53，9： | 1 |
| 11 | The effect of acute hyperglycemia on QTc duration in healthy man显示文摘 | Nappo F De Angelis L | 2000 | Diabetologia2000，43，5： | 1 |
| 12 | Inflammatory cytokine concentrations are acutely increased by hypeglycemia in human:role of oxidative stress显示文摘 | Esposito K Nappo F Marfella R | | 0，，16： | 1 |
| 13 | Inflammation cytokine concentrations are acutely increased by hyrperglycemia in human:Role of oxidative stress显示文摘 | ESPOSITO K NAPPO F MARFELL R | 2002 | Circulation2002，106，16： | 1 |
| 14 | Inflammatory cytokine concentrations are acutely increased by hyperglyce- mia in humans:role of oxidative stress 显示文摘 | ESPOSITO K NAPPO F MARFELLA R | 2002 | Circulation2002，106，16： | 1 |
| 15 | Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans :role of oxidative stress显示文摘 | Esposito K Nappo F Marfella R | 2002 | Circulation2002，106，16： | 1 |
| 16 | Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals显示文摘 | Nappo F Esposito K Cioffi M | 2002 | J Am Coll Cardiol2002，39，： | 1 |
| 17 | Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year显示文摘 | Ziccardi P Nappo F Giugliano G | 2002 | Circulalation2002，105，7： | 1 |
| 18 | Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year显示文摘 | ZICCARDI P NAPPO F GIUGLIANO G | 2002 | Circulation2002，105，7： | 1 |
| 19 | Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year显示文摘 | Ziccardi P Nappo F Giugliano G | 2002 | Circulation2002，105，7： | 1 |
| 20 | Regression of carotid atherosclerosis by control of morning blood pressure peak in newly diagnosed hypertensive patients 显示文摘 | Marfella R Sliniscalchi M Nappo F | 2005 | Am J Hypertension2005，18，3： | 1 |
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