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| 1 | 胃癌预防亚太地区共识指南显示文摘背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(H.pylori)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。H.pylori感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。H.pylori筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行H.pylori筛查。H.pylori感染的一线治疗应遵循国家治疗指南。结论:高危人群中H.pylori筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。 | Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 | 2008 | 胃肠病学2008，13，4： | 37 |
| 2 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 3 | Association between Ambient Air Pollution and Outpatient Visits for Acute Bronchitis in a Chinese City显示文摘Objective To investigate the short-term association between outdoor air pollution and outpatient visits for acute bronchitis,which is a rare subject of research in the mainland of China.Methods A time-series analysis was conducted to examine the association of outdoor air pollutants with hospital outpatient visits in Shanghai by using two-year daily data(2010-2011).Results Outdoor air pollution was found to be associated with an increased risk of outpatient visits for acute bronchitis in Shanghai.The effect estimates of air pollutants varied with the lag structures of the concentrations of the pollutants.For lag06,a 10 μg/m3 increase in the concentrations of PM10,SO2,and NO2 corresponded to 0.94%(95% CI:0.83%,1.05%),11.12%(95% CI:10.76%,11.48%),and 4.84%(95% CI:4.49%,5.18%) increases in hospital visits for acute bronchitis,respectively.These associations appeared to be stronger in females(P<0.05).Between-age differences were significant for SO2(P<0.05),and between-season differences were also significant for SO2(P<0.05).Conclusion Our analyses have provided the first evidence that the current air pollution level in China has an effect on acute bronchitis and that the rationale for further limiting air pollution levels in Shanghai should be strengthened. | GUO Li Juan ZHAO Ang CHEN Ren Jie KAN Hai Dong KUANG Xing Ya | 2014 | Biomedical and Environmental Sciences2014，27，11： | 13 |
| 4 | Ambient Temperature and Outpatient Visits for Acute Exacerbation of Chronic Bronchitis in Shanghai: A Time Series Analysis显示文摘The association between ambient temperature and acute exacerbation of chronic bronchitis(AECB)was still unknown.Therefore,we performed an epidemiological study in a large hospital of Shanghai to explore the relationship about temperature and outpatient visit for AECB.We adopted a quasi-Poisson generalized additive models and distributed lag nonlinear models to estimate the accumulative effects of | HUANG Fang ZHAO Ang CHEN Ren Jie KAN Hai Dong KUANG Xing Ya | 2015 | Biomedical and Environmental Sciences2015，28，1： | 7 |
| 5 | Physicochemical properties and heavy metals leachability of fly ash from coal-fired power plant显示文摘The physicochemical properties of fly ash from two kinds of coal-fired power plants were studied. Three aspects were examined: the micro-morphology, the mineral composition and the content of heavy metals. The results show that the fly ash from plants using a circulating fluidized bed are more irregular particles, while the particles from the plants using a pulverized coal-fired boiler are mainly spherical in shape. Quartz and mullite are the main crystalline phases in the ash. Clearly, both the technology and the coal used by a power plant can influence the mineral composition of the ash. The mineral composition of fly ash from a circulating fluidized bed is more complex than that from a pulverized coal-fired boiler. The quantity of elements found in the fly ash is greater than that found in the bottom ash for the same plant. Heavy metals are likely to be enriched in the fly ash. Heavy metal leachability was studied using two leaching methods. The results indicate that most of the heavy metals that leached during either batch leaching or column leaching experiments did not exceed the related maximum concentration standards. But Ni concentrations in the leachates from both batch and column tests exceed the standard. The highest excess rates in both tests were 572% and 497%, which levels might threaten the environment. | Xiang Wei Han Baoping Zhou Dong Nzihou Ange | 2012 | International Journal of Mining Science and Technology2012，22，3： | 5 |
| 6 | Stable isotope analysis of water sources for Tamarix laxa in the mega-dunes of the Badain Jaran Desert, China显示文摘The complex interactions in desert ecosystems between functional types and environmental conditions could be reflected by plant water use patterns. However, the mechanisms underlying the water use patterns as well as the water sources of Tamarix laxa in the mega-dunes of the Badain Jaran Desert, China, remain unclear. This study investigated the water sources and water use patterns of T. laxa using the stable oxygen isotope method. The δ^(18)O values of xylem water, soil water in different layers(0–200 cm), rainwater, snow water, lake water, atmospheric water vapor, condensate water, and groundwater were measured. The sources of water used by T. laxa were determined using the IsoSource model. The results indicate that T. laxa mainly relies on soil water. At the beginning of the growing season(in May), the species is primarily dependent on water from the middle soil layer(60–120 cm) and deep soil layer(120–200 cm). However, it mainly absorbs water from the shallow soil layer(0–60 cm) as the rainy season commences. In September, water use of T. laxa reverts to the deep soil layer(120–200 cm). The water use patterns of T. laxa are closely linked with heavy precipitation events and soil water content. These findings reveal the drought resistance mechanisms of T. laxa and are of significance for screening species for ecological restoration. | ZHANG Jinhu WANG Nai'ang NIU Zhenmin SUN Jie DONG Chunyu ZHANG LyuLyu | 2018 | Journal of Arid Land2018，10，6： | 5 |
| 7 | A novel dense descriptor based on structure tensor voting for multi-modal image matching显示文摘Automatic and robust matching of multi-modal images can be challenging owing to the nonlinear intensity differences caused by radiometric variations among these images.To address this problem,a novel dense feature descriptor and improved similarity measure are proposed for enhancing the matching performance.The proposed descriptor is built on a voting scheme of structure tensor that can effectively capture the geometric structural properties of images.It is not only illumination and contrast invariant but also robust against the degradation caused by significant noise.Further,the similarity measure is improved to adapt to the reversal of orientation caused by the intensity inversion between multi-modal images.The proposed dense feature descriptor and improved similarity measure enable the development of a robust and practical templatematching algorithm for multi-modal images.We verify the proposed algorithm with a broad range of multi-modal images including optical,infrared,Synthetic Aperture Radar(SAR),digital surface model,and map data.The experimental results confirm its superiority to the state-of-the-art methods. | Jiazhen LU Maoqing HU Jing DONG Songlai HAN Ang SU | 2020 | Chinese Journal of Aeronautics2020，33，9： | 3 |
| 8 | Thermoresponsive Lignin-Reinforced Poly(Ionic Liquid)Hydrogel Wireless Strain Sensor显示文摘To meet critical requirements on flexible electronic devices,multifunctionalized flexible sensors with excellent electromechanical performance and temperature perception are required.Herein,lignin-reinforced thermoresponsive poly(ionic liquid)hydrogel is prepared through an ultrasound-assisted synthesized method.Benefitting from the electrostatic interaction between lignin and ionic liquid,the hydrogel displays high stretchability(over 1425%),excellent toughness(over 132 kPa),and impressive stress loading-unloading cyclic stability.The hydrogel strain sensor presents excellent electromechanical performance with a high gauge factor(1.37)and rapid response rate(198 ms),which lays the foundation for human body movement detection and smart input.Moreover,owing to the thermal-sensitive feature of poly(ionic liquid),the as-prepared hydrogel displays remarkable thermal response sensitivity(0.217℃^(-1))in body temperature range and low limit of detection,which can be applied as a body shell temperature indicator.Particularly,the hydrogel can detect dual stimuli of strain and temperature and identify each signal individually,showing the specific application in human-machine interaction and artificial intelligence.By integrating the hydrogel strain sensor into a wireless sensation system,remote motion capture and gesture identification is realized in real-time. | Xinyu Qu Ye Zhao Zi’ang Chen Siying Wang Yanfang Ren Qian Wang Jinjun Shao Wenjun Wang Xiaochen Dong | 2021 | Research2021，，1： | 3 |
| 9 | Paeonol Improves Lipopolysaccharide-induced Microcirculatory Disturbance in Rat Mesentery显示文摘Objective: To investigate the effect of paeonol on lipopolysaccheride(LPS)-induced rat mesenteric microcirculatory dysfunctions.Methods: Male Wistar rats were randomly distributed into 5 groups(n=6 in each): Sham group, LPS group, paeonol group, paeonol+LPS group, and LPS+paeonol group. Endotoximia model was conducted by continuous LPS infusion. Changes in mesenteric microcirculatory variables, including diameter of venule, velocity of red blood cells in venule, leukocyte adhesion, free radicals produced in venule and albumin leakage from venule, were observed through an inverted intravital microscope. Meanwhile, the expression of myeloperoxidase(MPO), CD18,intercellular adhesion molecule-1(ICAM-1), toll-like receptor 4(TLR4), nuclear factor-kappa B p65 subunit(NF-κB p65), activator protein-1(AP-1), and Jun N-terminal kinase(JNK) was assessed by Western blot.Results: After infusion of LPS, the number of leukocytes adherent to venular wall, the intensity of dihydrorhodamine 123(DHR)fluorescence in the venular walls, and albumin leakage from venules were significantly increased, whereas the red blood cell velocity in venule was decreased. All the manifestations were significantly reduced by pre-treatment and post-treatment with paeonol. Moreover, paeonol significantly attenuated the expression of MPO, CD18, ICAM-1, TLR4, NF-κB p65, AP-1 and JNK in rat mesentery after LPS.Conclusions: The results demonstrated that paeonol could protect from and ameliorate the microcirculation disturbance induced by LPS. | Lei Dong Ang Li Mei-Li Duan Kai Sun Yu-Ying Liu Ming-Xia Wang Chuan-She Wang Jing-Yu Fan Jing-Yan Han | 2015 | World Journal of Traditional Chinese Medicine2015，1，1： | 3 |
| 10 | Re-evaluation of the mechanical properties and creep resistance of commercial magnesium die-casting alloy AE44显示文摘This paper presents a re-evaluation of the room temperature mechanical properties and high temperature creep resistance of magnesium die-casting alloy AE44(Mg-4Al-4RE)in light of the influence of minor Mn addition.It is shown that the Mn-containing AE44 exhibits distinct age hardening response upon direct ageing(T5)due to the precipitation of nanoscale Al-Mn particles,as reported previously in a similar alloy.The T5 ageing leads to a significant improvement in strength with similar ductility.Consequently,the T5-aged AE44 has a remarkably better strength-ductility combination than most Mg die-casting alloys and even the Al die-casting alloy A380.Minor Mn addition is also shown to be critical for the creep resistance of AE44 whereas the influence of the RE constituent is not as significant as previously thought,which reaffirms that precipitation hardening of theα-Mg matrix is more important than grain boundary reinforcement by intermetallic phases for the creep resistance of die-cast Mg alloys.The findings in this work could provide new application perspectives for AE44,particularly in the automotive industry. | Suming Zhu Trevor B.Abbott Jian-Feng Nie Hua Qian Ang Dong Qiu Kazuhiro Nogita Mark A.Easton | 2021 | Journal of Magnesium and Alloys2021，9，5： | 2 |
| 11 | Emodin Improves Lipopolysaccharide‐Induced Microcirculatory Disturbance in Rat Mesentery显示文摘 | Ang Li Lei Dong Mei‐Li Duan Kai Sun Yu‐Ying Liu Ming‐Xia Wang Jing‐Na Deng Jing‐Yu Fan Bao‐En Wang Jing‐Yan Han | 2013 | Microcirculation2013，，7： | 2 |
| 12 | Surface pseudocapacitance of mesoporous Mo_(3)N_(2) nanowire anode toward reversible high-rate sodium-ion storage显示文摘Sodium-ion storage devices are highly desirable for large-scale energy storage applications owing to the wide availability of sodium resources and low cost.Transition metal nitrides(TMNs)are promising anode materials for sodium-ion storage,while their detailed reaction mechanism remains unexplored.Herein,we synthesize the mesoporous Mo3N2 nanowires(Meso-Mo_(3)N_(2)-NWs).The sodium-ion storage mechanism of Mo3N2 is systematically investigated through in-situ XRD,ex-situ experimental characterizations and detailed kinetics analysis.Briefly,the Mo_(3)N_(2) undergoes a surface pseudocapacitive redox charge storage process.Benefiting from the rapid surface redox reaction,the Meso-Mo_(3)N_(2)-NWs anode delivers high specific capacity(282 m Ah g^(-1) at 0.1 A g^(-1)),excellent rate capability(87 m Ah g^(-1) at 16 A g^(-1))and long cycling stability(a capacity retention of 78.6%after 800 cycles at 1 A g^(-1)).The present work highlights that the surface pseudocapacitive sodium-ion storage mechanism enables to overcome the sluggish sodium-ion diffusion process,which opens a new direction to design and synthesize high-rate sodiumion storage materials. | Yalong Jiang Jun Dong Shuangshuang Tan Qiulong Wei Fangyu Xiong Wei Yang Yuanhao Shen Qingxun Zhang Zi'ang Liu Qinyou An Liqiang Mai | 2021 | Journal of Energy Chemistry2021，30，4： | 2 |
| 13 | Zinc finger factor ZNF121 is a MYC-interacting protein functionally affecting MYC and cell proliferation in epithelial cells显示文摘MYC is a potent oncoprotein that modulates multiple cellular processes including proliferation,apoptosis, differentiation, stemness, senescence, and migration. Functioning primarily as a transcriptional factor, MYC interacts with a large number of proteins, and identification and characterization of MYC-interacting proteins are important for understanding how MYC functions. In this study, we used different systems to demonstrate that a novel zinc finger transcription factor, ZNF121, physically interacted with MYC, and the interaction involved their N-terminal regions. Overexpression of ZNF121 increased, while its knockdown decreased, the expression of MYC in multiple epithelial cell lines, and MYC had similar effects on ZNF121 expression. An expression correlation was also detectable in a panel of epithelial cell lines and a cohort of human breast cancer tissues. Functionally, knockdown of ZNF121 in several breast epithelial cell lines attenuated the expressions of MYC and its target genes(e.g., EGR1,CDC2, and nucleolin) and slowed cell proliferation, accompanied by cell cycle arrest in the G1 phase and expression alteration of cell cycle regulators(cyclin D1, p14 and p21). Analysis of publically available databases showed that ZNF121 expression is up-regulated in human breast cancer, and the up-regulation significantly associates with worse patient survival in the luminal A subtype of breast cancer. These findings establish ZNF121 as a MYC-interacting protein with functional effects on MYC and cell proliferation. | Ang Luoa Xuan Zhanga Liya Fua Zhengmao Zhua Jin-Tang Dong | 2016 | Journal of Genetics and Genomics2016，43，12： | 2 |
| 14 | Carbon‐based materials for all‐solid‐state zinc–air batteries显示文摘Solid‐state Zn–air batteries(ZABs)hold great potential for application in wearable and flexible electronics.However,further commercialization of current ZABs is still limited by the poor stability and low energy efficiency.It is,thus,crucial to develop efficient catalysts as well as optimize the solid electrolyte system to unveil potential of the ZAB technology.Due to the low cost and versatility in tailoring the structures and properties,carbon materials have been extensively used as the conductive substrates,catalytic air electrodes,and important components in the electrolytes for the solid‐state ZABs.Within this context,we discuss the challenges facing current solid‐state ZABs and summarize the strategies developed to modify properties of carbon‐based electrodes and electrolytes.We highlight the metal−organic framework/covalent organic framework‐based electrodes,heteroatom‐doped carbon,and the composites formed of carbon with metal oxides/sulfides/phosphides.We also briefly discuss the progress of graphene oxide‐based solid electrolyte. | Dan Yang Dong Chen Yu Jiang Edison Huixiang Ang Yuezhan Feng Xianhong Rui Yan Yu | 2021 | Carbon Energy2021，3，1： | 2 |
| 15 | Associations between PRF1 Ala91 Val polymorphism and risk of hemophagocytic lymphohistiocytosis: a meta-analysis based on 1366 subjects显示文摘Background Perforin(PRF1)gene mutation can cause the onset of hemophagocytic lymphohistiocytosis(HLH).It has reported that PRFl Ala91 Val polymorphism was related with HLH risk.In the meta-analysis,we aim to evaluate the association between PRF1 Ala91 Val polymorphism and HLH risk.Methods We accomplished a meta-analysis of six published case-control studies including 391 patients with HLH and 975 controls.We evaluated the quality of each study through Newcastle-Ottawa Scale(NOS).Data analysis was performed with Stata software.Results In general,all studies were of high quality(NOS score higher than 7).There were statistically significant between the PRFl Ala91 Val polymorphism and HLH risk though the pooled analysis[for Ala/Val vs.Ala/Ala:pooled odds ratio(OR)=3.22,95%confidence interval(Cl)1.08-9.56,P=0.035,random model;for Ala/Val+Val/Val vs.Ala/Ala:pooled OR=2.96,95%Cl 1.14-7.69,P=0.025,random model].Furthermore,sensitivity analysis also revealed a relationship between PRFl Ala91Val polymorphism and HLH risk(for Ala/Val vs.Ala/Ala:pooled OR=5.236,95%Cl 2.72-10.08,P<0.000,/2=12.1%,^heterogeneity=0-332;for Ala/Val+Val/Val vs.Ala/Ala,pooled OR=4.856,95%Cl 2.66-8.85,P<0.000,/2=5.9%,Pheterogeneity=0.373).Funnel plot and Egger’s test did not indicate obvious published bias(P=0.841 for Ala/Val vs.Ala/Ala;?=0.284 for Ala/Val+Val/Val vs.Ala/Ala).Conclusion This meta-analysis indicated that PRFl Ala91 Val polymorphism affects the factor for developing HLH and future studies of PRFl Ala91 Val on the onset of HLH will be guaranteed. | Guang-Hua Zhu Li-Ping Zhang Zhi-Gang Li Ang Wei Ying Yang Yu Tian Hong-Hao Ma Dong Wang Xiao-Xi Zhao Yun-Ze Zhao Na Li Wei Liu Tian-You Wang Rui Zhang | 2020 | World Journal of Pediatrics2020，16，6： | 2 |
| 16 | A supply chain network equilibrium model显示文摘 | NAGURNEY A DONG J ZH ANG D | | 0，，： | 1 |
| 17 | The effect of Na2S203 on RE-boronizing behavior of 45 carbon steel 显示文摘 | Wang Dong Zhao Hanyu Wu Ang | 2015 | Materials and Design2015，67，： | 1 |
| 18 | Room-Temperature NH3 Gas Sensor Based on Hydrothermally Grown ZnO Nanorods显示文摘 | Wei Ang Wang Zhao Pan Liu-Hua Li Wei-Wei Xiong Li Dong Xiao-Chen Huang Wei | 2011 | Chinese Physics Letters2011，，8： | 1 |
| 19 | Phase characterisation of metalenses显示文摘Metalenses have emerged as a new optical element or system in recent years,showing superior performance and abundant applications.However,the phase distribution of a metalens has not been measured directly up to now,hindering further quantitative evaluation of its performance.We have developed an interferometric imaging phase measurement system to measure the phase distribution of a metalens by taking only one photo of the interference pattern.Based on the measured phase distribution,we analyse the negative chromatic aberration effect of monochromatic metalenses and propose a feature size of metalenses.Different sensitivities of the phase response to wavelength between the Pancharatnam-Berry phase-based metalens and propagation phase-reliant metalens are directly observed in the experiment.Furthermore,through phase distribution analysis,it is found that the distance between the measured metalens and the brightest spot of focusing will deviate from the focal length when the metalens has a low nominal numerical aperture,even though the metalens is ideal without any fabrication error.We also use the measured phase distribution to quantitatively characterise the imaging performance of the metalens.Our phase measurement system will help not only designers optimise the designs of metalenses but also fabricants distinguish defects to improve the fabrication process,which will pave the way for metalenses in industrial applications. | Maoxiong Zhao Mu Ku Chen Ze-Peng Zhuang Yiwen Zhang Ang Chen Qinmiao Chen Wenzhe Liu Jiajun Wang Ze-Ming Chen Bo Wang Xiaohan Liu Haiwei Yin Shumin Xiao Lei Shi Jian-Wen Dong Jian Zi Din Ping Tsai | 2021 | Light(Science & Applications)2021，10，4： | 1 |
| 20 | Methyl jasmonate induces ganoderic acid biosynthesis in the basidiomycetous fungus Ganoderma lu cidum显示文摘 | Ang Ren Lei Qin Liang Shi Xin Dong Da Shuai Mu Yu Xiang Li Ming Wen Zhao | 2010 | Bioresource Technology2010，101，： | 1 |
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