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| 1 | A novel m6A reader Prrc2a controls oligodendroglial specification and myelination显示文摘While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2A), which controls oligodendrocyte specification and myelination. Nestin-Cre-mediated knockout of Prrc2a induces significant hypomyelination, decreased lifespan, as well as locomotive and cognitive defects in a mouse model. Further analyses reveal that Prrc2a is involved in oligodendrocyte progenitor cells (OPCs) proliferation and oligodendrocyte fate determination. Accordingly, oligodendroglial-lineage specific deletion of Prrc2a causes a similar phenotype of Nestin-Cre-mediated deletion. Combining transcriptome-wide RNA-seq, m6A-RIP-seq and Prrc2a RIP-seq analysis, we find that Olig2 is a critical downstream target gene of Prrc2a in oligodendrocyte development. Furthermore, Prrc2a stabilizes Olig2 mRNA through binding to a consensus GGACU motif in the Olig2 CDS (coding sequence) in an m6A-dependent manner. Interestingly, we also find that the m6A demethylase, Fto, erases the m6A modification of Olig2 mRNA and promotes its degradation. Together, our results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m6A reader. These findings suggest a new avenue for the development of therapeutic strategies for hypomyelination-related neurological diseases. | Rong Wu Ang Li Baofa Sun Jian-Guang Sun Jinhua Zhang Ting Zhang Yusheng Chen Yujie Xiao Yuhao Gao Qingyang Zhang Jun Ma Xin Yang Yajin Liao Wei-Yi Lai Xiaolong Qi Shukun Wang Yousheng Shu Hai-Lin Wang Fengchao Wang Yun-Gui Yang Zengqiang Yuan | 2019 | Cell Research2019，29，1： | 32 |
| 2 | Contrast-enhanced ultrasonography assessment of gastric cancer response to neoadjuvant chemotherapy显示文摘AIM:To quantitatively assess the ability of double contrast-enhanced ultrasound(DCUS) to detect tumor early response to pre-operative chemotherapy.METHODS:Forty-three patients with gastric cancer treated with neoadjuvant chemotherapy followed by curative resection between September 2011 and February 2012 were analyzed.Pre-operative chemotherapy regimens of fluorouracil + oxaliplatin or S-1 + oxaliplatin were administered in 2-4 cycles over 6-12 wk periods.All patients underwent contrast-enhanced computed tomography(CT) scan and DCUS before and after two courses of pre-operative chemotherapy.The therapeutic response was assessed by CT using the response evaluation criteria in solid tumors(RECIST 1.1) criteria.Tumor area was assessed by DCUS as enhanced appearance of gastric carcinoma due to tumor vascularity during the contrast phase as compared to the normal gastric wall.Histopathologic analysis was carried out according to the Mandard tumor regression grade criteria and used as the reference standard.Receiver operating characteristic(ROC) analysis was used to evaluate the efficacy of DCUS parameters in differentiating histopathological responders from non-responders.RESULTS:The study population consisted of 32 men and 11 women,with mean age of 59.7 ± 11.4 years.Neither age,sex,histologic type,tumor site,T stage,nor N stage was associated with pathological response.The responders had significantly smaller mean tumor size than the non-responders(15.7 ± 7.4 cm vs 33.3 ± 14.1 cm,P < 0.01).According to Mandard's criteria,27 patients were classified as responders,with 11(40.7%) showing decreased tumor size by DCUS.In contrast,only three(18.8%) of the 16 non-responders showed decreased tumor size by DCUS(P < 0.01).The area under the ROC curve was 0.64,with a 95%CI of 0.46-0.81.The effects of several cut-off points on diagnostic parameters were calculated in the ROC curve analysis.By maximizing Youden's index(sensitivity + specificity-1),the best cut-off point for distinguishing responders from non-responders was determined,which had optimal sensitivity of 62.9% and specificity of 56.3%.Using this cut-off point,the positive and negative predictive values of DCUS for distinguishing responders from non-responders were 70.8% and 47.4%,respectively.The overall accuracy of DCUS for therapeutic response assessment was 60.5%,slightly higher than the 53.5% for CT response assessment with RECIST criteria(P = 0.663).Although the advantage was not statistically significant,likely due to the small number of cases assessed.DCUS was able to identify decreased perfusion in responders who showed no morphological change by CT imaging,which can be occluded by such treatment effects as fibrosis and edema.CONCLUSION:DCUS may represent an innovative tool for more accurately predicting histopathological response to neoadjuvant chemotherapy before surgical resection in patients with locally-advanced gastric cancer. | Jian Ang Liang Hu Pin-Tong Huang Jin-Xiu Wu Ling-Na Huang Chun-Hui Cao Yi-Xiong Zheng Li Chen | 2012 | World Journal of Gastroenterology2012，18，47： | 18 |
| 3 | Seismic fragility analysis of highway bridges considering multi-dimensional performance limit state显示文摘Fragility analysis for highway bridges has become increasingly important in the risk assessment of highway transportation networks exposed to seismic hazards. This study introduces a methodology to calculate fragility that considers multi-dimensional performance limit state parameters and makes a first attempt to develop fragility curves for a multi-span continuous (MSC) concrete girder bridge considering two performance limit state parameters: column ductility and transverse deformation in the abutments. The main purpose of this paper is to show that the performance limit states, which are compared with the seismic response parameters in the calculation of fragility, should be properly modeled as randomly interdependent variables instead of deterministic quantities. The sensitivity of fragility curves is also investigated when the dependency between the limit states is different. The results indicate that the proposed method can be used to describe the vulnerable behavior of bridges which are sensitive to multiple response parameters and that the fragility information generated by this method will be more reliable and likely to be implemented into transportation network loss estimation. | Wang, Qi'ang Wu, Ziyan Liu, Shukui | 2012 | Earthquake Engineering and Engineering Vibration2012，11，2： | 16 |
| 4 | Observation of atmospheric nitrous acid with DOAS in Beijing, China显示文摘Measurements of nitrous acid(HONO) and nitrogen dioxide(NO2) in Beijing City have been performed by means of a developed differential optical absorption spectroscopy(DOAS) system based on photodiode array(PDA), during the autumn of 2004. HONO and NO2 were simultaneously identified by their characteristic absorption bands in the spectral region between 337 nm and 372 nm with high sensibility and time resolution. The concentrations of HONO exhibit obviously diurnal variation with a nocturnal maximum and a daytime minimum. The highest HONO value up to 11.8 ?滋g/m3 was observed during the night of 2/3 September. Possible sources of the observed HONO were discussed. Good correlation to NO2 indicates that NO2 is a main source component. The measurement also shows direct emission of HONO is an important source in strongly polluted urban area. | QIN Min XIE Pin-hua LIU Wen-qing LI Ang DOU Ke FANG Wu LIU Jian-guo ZHANG Wei-jun | 2006 | Journal of Environmental Sciences2006，18，1： | 15 |
| 5 | MicroRNA changes of bone marrow-derived mesenchymal stem cells differentiated into neuronal-like cells by Schwann cell-conditioned medium显示文摘Bone marrow-derived mesenchymal stem cells differentiate into neurons under the induction of Schwann cells. However, key microRNAs and related pathways for differentiation remain unclear. This study screened and identified differentially expressed microRNAs in bone marrow- derived mesenchymal stem cells induced by Schwann cell-conditioned medium, and explored targets and related pathways involved in their differentiation into neuronal-like cells. Primary bone marrow-derived mesenchymal stem cells were isolated from femoral and tibial bones, while primary Schwann cells were isolated from bilateral saphenous nerves. Bone marrow-derived mesenchymal stem cells were cultured in unconditioned (control group) and Schwann cell-conditioned medium (bone marrow-derived mesenchymal stem cell + Schwann cell group). Neuronal differentiation of bone marrow-derived mesenchymal stem cells induced by Schwann cell-conditioned medium was observed by time-lapse imaging. Upon induction, the morphology of bone marrow-derived mesencaymal stem cells changed into a neural shape with neurites. Results of quantitative reverse transcription-polymerase chain reaction revealed that nestin mRNA expression was upregulated from 1 to 3 days and downregulated from 3 to 7 days in the bone marrow-derived mesenchymal stem cell + Schwann cell group. Compared with the control group, microtubule-associated protein 2 mRNA expression gradually increased from 1 to 7 days in the bone marrow-derived mesenchymal stem cell + Schwann cell group. After 7 days of induction, microRNA analysis iden:ified 83 significantly differentially expressed microRNAs between the two groups. Gene Ontology analysis indicated enrichment of microRNA target genes for neuronal projection development, regulation of axonogenesis, and positive regulation of cell proliferation. Kyoto Encyclopedia of Genes and Genomes pathway analysis demonstrated that Hippo, Wnt, transforming growth factor-beta, and Hedgehog signaling pathv/ays were potentially associated with neural differentiation of bone marrow-derived mesenchymal stem cells. This study, which carried out successful microRNA analysis of neuronal-like cells differentiated from bone marrow-derived mesenchymal stem cells by Schwann cell induction, revealed key microRNAs and pathways involved in neural differentiation of bone marrow-derived mesenchymal stem cells. All protocols were approved by the Animal Ethics Committee of Institute of Radiation Medicine, Chinese Academy of Medical Sciences on March 12, 2017 (approval number: DWLI-20170311). | Zhi-Jian Wei Bao-You Fan Yang Liu Han Ding Hao-Shuai Tang Da-Yu Pan Jia-Xiao Shi Peng-Yuan Zheng Hong-Yu Shi Heng Wu Ang Li Shi-Qing Feng | 2019 | Neural Regeneration Research2019，14，8： | 13 |
| 6 | TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells显示文摘免疫疗法和化疗的联合为癌症的某些类型的治疗被认为是一条有希望的途径。然而,内在的机制需要充分被调查为癌症 chemoimmunotherapy 指导更有效的协议的设计。联系危险的分子的模式(阻尼) 能激活有免疫力的房间,是众所周知的,包括树枝状的房间(DC ) ,经由像使用费的受体(TLR ) ;然而,在有免疫力的反应的激活免除化学对待药的肿瘤房间的阻尼的角色需要进一步被阐明。这里,我们发现那 colorectal 与 oxaliplatin (OXA ) 对待的癌症(CRC ) 房间或 5 氟尿嘧啶(5-Fu ) 释放了高活动性的组盒子 1 的高水平(HMGB1 ) 和热吃惊蛋白质 70 (HSP70 ) 。在 OXA/5-Fu 治疗以后,也展出的 CRC 病人的 sera 增加了 HMGB1 和 HSP70 的层次,哪个是著名阻尼。与 OXA/5-Fu 对待的垂死的 CRC 房间的上层清液支持了老鼠和人的 DC 成熟,与 HLA 医生, CD80 和 CD86 表示和 IL-1β 的改进的 upregulation;, TNF-α, MIP-1α, MIP-1β, RANTES 和 IP-10 生产。由 DC 组成的疫苗与导致的化学上强调的 CRC 房间的上层清液搏动了更重要的 IFN-γ在 vitro 并且在 vivo 生产 Th1 反应。然而,化学上强调的 CRC 房间的上层清液没能在 TLR4 缺乏的 DC 导致 phenotypic 成熟和 cytokine 生产,显示在导致阻尼的 DC 成熟和激活的 TLR4 的一个必要角色。而且,有化学上强调的 CRC 房间的上层清液的 pulsing 高效地没导致 IFN-γ在 TLR4 缺乏的 DC 生产 Th1 反应。一起,这些结果证明免除化学上强调的癌症房间的阻尼能经由 TLR4 激活 DC 并且提高反肿瘤 T 房间有免疫力的回答的正式就职,描出一条临床上相关的免疫助手小径由阻尼被触发。 | Hongliang Fang Bing Ang Xinyun Xu Xiaohui Huang Yanfeng Wu Yanping Sun Wenying Wang Nan Li Xuetao Cao Tao Wan | 2014 | Cellular & Molecular Immunology2014，11，2： | 11 |
| 7 | Schroth exercises improve health-related quality of life and radiographic parameters in adolescent idiopathic scoliosis patients显示文摘Background:Finding an optimal treatment strategy for adolescent idiopathic scoliosis(AIS)patients remains challenging because of its intrinsic complexity.For mild to moderate scoliosis patients with lower skeletal growth potential(Risser 3-5),most clinicians agree with observation treatment;however,the curve progression that occurs during puberty,the adolescent period,and even in adulthood,remains a challenging issue for clinicians.The aim of the study is to investigate the efficacy of Schroth exercise in AIS patients with lower skeletal growth potential(Risser 3-5)and moderate scoliosis(Cobb angle 20°-40°).Methods:From 2015 to 2017,data of 64 patients diagnosed with AIS in Peking University Third Hospital were reviewed.Forty-three patients underwent Schroth exercise were classified as Schroth group,and 21 patients underwent observation were classified as observation group.Outcomes were measured by health-related quality of life(HRQOL)and radiographic parameters.HRQOL was assessed using the visual analog scale(VAS)scores for back,Scoliosis Research Society-22(SRS-22)patient questionnaire.Radiographic spinopelvic parameters were obtained from anteroposterior and lateral X-rays.The pre-treatment and post-treatment HRQOL and radiographic parameters were tested to validate Schroth exercise efficacy.The inter-rater reliability of the radiographic parameters was tested using the interclass correlation coefficient(ICC).The pairedt test was used to examine HRQOL and radiographic parameters.Clinical relevance between C2-C7 sagittal vertical axis(SVA)and thoracic kyphosis was analyzed using Spearman correlation.Results:In Schroth group,VAS back score,SRS-22 pain,and SRS-22 self-image domain were significantly improved from pre-treatment 3.0±0.8,3.6±0.5,and 3.5±0.7 to post-treatment 1.6±0.6(t=5.578,P=0.013),4.0±0.3(t=-3.918,P=0.001),and 3.7±0.4(t=-6.468,P<0.001),respectively.No significant improvements of SRS-22 function domain(t=-2.825,P=0.088)and mental health domain(t=-3.174,P=0.061)were observed.The mean Cobb angle decreased from 28.9±5.5°to 26.3±5.2°at the final follow-up,despite no statistical significance was observed(t=1.853,P=0.102).The mean C2-C7 SVA value decreased from 21.7±8.4 mm to 17.0±8.0 mm(t=-1.224P=0.049)and mean T1 tilt decreased from 4.9±4.2°to 3.5±3.1°(t=2.913,P=0.011).No significant improvement of radiographic parameters and HRQOL were observed in observation group.Conclusions:For AIS patients with a Risser 3-5 and a Cobb angle 20°-40°,Schroth exercises improved HRQOL and halted curve progression during the follow-up period.Both cervical spine alignment and shoulder balance were also significantly improved after Schroth exercises.We recommend Schroth exercises for patients with AIS. | Ang Gao Jun-Yu Li Rui Shao Tong-Xuan Wu Yong-Qiang Wang Xiao-Guang Liu Miao Yu | 2021 | Chinese Medical Journal2021，，21： | 10 |
| 8 | Duloxetine versus placebo in the treatment of patients with generalized anxiety disorder in China显示文摘背景 Duloxetine 在试图估计功效的美国和 elsewhere.This 学习为概括焦虑混乱(荡者)的治疗被同意, tolerability ,并且在有 GAD.Methods 的中国病人的 duloxetine 的安全这9地点研究与至少中等严重的荡者和 Sheehan 残疾规模( SDS )与 duloxetine 60-120 mg 或与 placebo.Patients 由双窗帘治疗组成了 15 个星期全球工作缺陷总数分数 12 在这研究被包括。在那个点,为 nonresponders ,剂量为留下被增加到 120 mg 主要功效措施是的 8 weeks.The 医院焦虑和消沉规模焦虑 subscale 分数上的端点的从基线的吝啬的变化( HADS --一) .Secondary 功效措施包括了哈密尔顿焦虑等级规模( HAMA ), SDS ,和疼痛 measures.Safety 和 tolerability 是 assessed.Results 基线特征没在这些题目( n=210 )的治疗 groups.Mean 年龄之间显著地不同是 37.6 | WU Wen-yuan WANG Gang Susan G Ball Durisala Desaiah ANG Qiu-qing | 2011 | Chinese Medical Journal2011，，20： | 8 |
| 9 | Progresses in Sustainable Recycling Technology of Spent Lithium-Ion Batteries显示文摘The number of lithium-ion batteries(LIBs)is steadily increasing in order to meet the ever-growing demand for sustainable energy and a high quality of life for humankind.At the same time,the resulting large number of LIB waste certainly poses safety hazards if it is not properly disposed of and will seriously harm the environment due to its inherent toxicity due to the use of toxic substances.Moreover,the consumption of many scarce precious metal resources is behind the mass production of batteries.In the light of severe environmental,resources,safety and recycling problems,recycling spent LIBs have become an essential urgently needed action to achieve sustainable social development.This review therefore critically analyses the value and the need for recycling of spent LIBs from a variety of resources and the environment.A range of existing technologies for recycling and reusing spent LIBs,such as pretreatment,pyrometallurgy,hydrometallurgy,and direct recycled methods,is subsequently summarized exclusively.In addition,the benefits and problems of the methods described above are analyzed in detail.It also introduces recycling progress of other LIB components,such as anodes,separators,and electrolytes,as well as the high-value cathode.Finally,the prospects for recycling LIBs are addressed in four ways(government,users,battery manufacturers,and recyclers).This review should contribute to the development of the recycling of used LIBs,particularly in support of industrialization and recycling processes. | Kaidi Du Edison Huixiang Ang Xinglong Wu Yichun Liu | 2022 | Energy & Environmental Materials2022，5，4： | 7 |
| 10 | Express,on of the novel adipokine ClqTNF-related protein 4 (CTRP4) suppresses colitis and colitis- associated colorectal cancer in mice显示文摘 | Yang Luo Xiaotong Wu Zhuang Ma Weifeng Tan Lanlan Wang Daxiang Na Guoying Zhang Ang Yin He Huang Dan Xia Yingmei Zhang Xueying Shi Lu Wang | 2016 | Cellular & Molecular Immunology2016，13，5： | 6 |
| 11 | Variation of temporal and spatial patterns of NO_2 in Beijing using OMI and mobile DOAS显示文摘Control policies such as 'odd-and-even license plate rule' were implemented by the Chinese government to restrict traffic and suspend factory production in Beijing and neighboring cities during the Asia-Pacific Economic Cooperation summit. We use ozone monitoring instrument(OMI), mobile differential optical absorption spectroscopy(DOAS), and multi-axis differential optical absorption spectroscopy(MAX-DOAS) to measure the variation of the spatial and temporal patterns of NO2 column densities from October 24, 2014 to November 22, 2014. It is found that the NO2 column densities during the episode of control policies are significantly lower than those during other periods, and the emission flux of NO2 calculated by mobile DOAS is also lower than the results from other periods. Some daily low NO2 column densities occur with the northwest wind direction. We then compare the relationship between OMI and mobile DOAS NO2 column density observations, and the results of mobile DOAS are approximately 2.7 times larger than the OMI values. The largest discrepancy occurs in the northern part of Beijing city. In other parts, the two instruments have a better correlation coefficient(R2) of 0.61. The low NO2 column densities that occur during the episode of control policies are affected by the control policies as well as meteorological conditions. | Ang Li Jie Zhang Pinhua Xie Zhaokun Hu Jin Xu Fusheng Mou Fengcheng Wu Jianguo Liu Wenqing Liu | 2015 | Science China Chemistry2015，58，9： | 5 |
| 12 | Association between painful physical symptoms and clinical outcomes in Chinese patients with major depressive disorder:a three-month observational study显示文摘背景痛苦的物理症状( PPS )可以作为专业的一个部件介绍在中国病人的 .Their 效果一直不是的压抑的混乱( MDD ) investigated.This 分析在疾病严厉报导变化,治疗模式,在一个中国队的生活和结果的质量根据存在(PPS+)或痛苦的物理 symptoms.Methods 的缺席(PPS-),从来自中国的亚洲国家和区域的病人的大观察3月的研究的中国病人的亚群是 classi 49.56 (26.49 ) 为 PPS- 的 vs.16.60 (20.99 ) , P 0.01 ) ,更多被压抑(HAMD17,平均数(SD ) :25.32 (5.47 ) 为 PPS- 的 vs.23.33 (5.24 ) , P=0.002 ) 并且生活的有的更差的质量(EQ-5D 健康状态,平均数(SD ) :38.48 (22.38 ) 为 PPS- 的 vs.49.57 (18.54 ) , P 0.001 ).PPS+ 病人在压抑的症状严厉显示出更少的全面改进(HAMD17,从基线(95% CI ) 的变化:-17.38(-18.65,-16.12) vs.-19.20 (为 PPS- 的 -20.05,-18.35) , P=-0.032;CGI-S,从基线(95% CI ) 变化:-2.85(-3.11,-2.58) vs.-3.20 (为 PPS- 的 -3.38,-3.02) , P=0.044 ).Conclusions PPS 比与当抗抑郁剂被给时,比 PPS- 与更大的 MDD 严厉和更少的改进联系的亚洲 populations.PPS+were 的以前的研究相比期望是不太经常的。 | LI Hui-chun ZHANG Ming-yuan WANG Gang ZHANG Hong-geng ZHANG Hong-yan LIU Ying LI Ming ZHANG Cong-pei TANG Ji-sheng WU Wen-yuan Pritibha Singh Renee Elizabeth Granger Joel Raskin ANG Qiu-qing | 2010 | Chinese Medical Journal2010，，15： | 5 |
| 13 | Main issues in research and practice of environmental protection for water conservancy and hydropower projects in China显示文摘In this paper,we generally summarize the main issues in the operational period of water conservancy and hydropower projects in China over the past several decades.First,the adverse impacts of these projects since the technical guidelines were proposed in 2006 are analyzed.Then,combined with projects and experience from 2006 to 2014,the four main issues are summarized:(1) There exist many questions in the design and construction of fishways,which are useful for fish migration,and the migration effects are not as expected.(2) Temperature stratification affecting the downstream fish is the major impact of temperature,and alters fish spawning in the reproduction season.(3)Ecological base flow has been one of the primary questions of the last 30 years in China,the greatest related difficulty being quantification of the amount and flow process necessary to satisfy fish life history.(4) Fish habitat protection and restoration are popular topics in recent years with the development of river ecosystem restoration.Fish habitat loss due to the impacts of dam construction and habitat fragmentation has become more and more serious.These four issues are now the main difficulties in water project management,and interact with one another to bear combined effects on river ecosystems.The issues of eco-hydraulic consideration in the design period are the key factors.Finally,future priorities for research and practice of environmental protection for water conservancy and hydropower projects in China are proposed.The main purpose of this paper is to enhance the scientific research,monitoring,and assessment of operating effectiveness. | Ang Chen Miao Wu Kai-qi Chen Zhi-yu Sun Chen Shen Peng-yuan Wang | 2016 | Water Science and Engineering2016，9，4： | 5 |
| 14 | Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis显示文摘Signal transduction between different organs is crucial in the normal development of the human body. As an important medium for signal communication, exosomes can transfer important information, such as microRNAs(miRNAs), from donors to receptors.MiRNAs are known to fine-tune a variety of biological processes, including maxillofacial development; however, the underlying mechanism remains largely unknown. In the present study, transient apoptosis was found to be due to the expression of a miniature swine maxillofacial-specific miRNA, ssc-mir-133b. Upregulation of ssc-mir-133b resulted in robust apoptosis in primary dental mesenchymal cells in the maxillofacial region. Cell leukemia myeloid 1(Mcl-1) was verified as the functional target, which triggered further downstream activation of endogenous mitochondria-related apoptotic processes during tooth development.More importantly, mandible exosomes were responsible for the initial apoptosis signal. An animal study demonstrated that ectopic expression of ssc-mir-133 b resulted in failed tooth formation after 12 weeks of subcutaneous transplantation in nude mice. The tooth germ developed abnormally without the indispensable exosomal signals from the mandible. | Ye Li Xinxin Wang Jiali Ren Xiaoshan Wu Guoqing Li Zhipeng Fan Chunmei Zhang Ang Li Songlin Wang | 2018 | Bone Research2018，6，4： | 5 |
| 15 | Catalytic Metalloporphyrin Protects Against Paraquat Neurotoxicity in vivo显示文摘Objective To examine the neuroprotective effects of a novel manganese porphyrin, manganese (III) meso-tetrakis (N,N′-diethylimidazolium-2-yl) porphyrin (MnTDM), in the mouse model of Parkinson’s disease (PD) induced by paraquat (PQ). Methods Male C57BL / 6 mice were subcutaneously injected with either saline or PQ at 2-day intervals for a total of 10 doses, MnTDM was subcutaneously injected with the PQ 2 h before treatment. Performance on the pole and swim test were measured 7 days after the last injection and animals were sacrificed one day later. Levels of dopamine (DA) and its metabolites in the striatum were measured by high-performance liquid chromatography with an electrochemical detector (HPLC-ECD). Thiobarbituric acid (TBA) method was used to assay the lipid peroxidation product, malondialdehyde (MDA), and the number of tyrosine hydroxylase (TH) positive neurons was estimated using immunohistochemistry. Results Pretreatment with MnTDM significantly attenuated PQ-impaired behavioral performance, depleted dopamine content in striata, increased MDA, and dopaminergic neuron loss in the substantia nigra. Conclusions Oxidative stress plays an important role in PQ-induced neurotoxicity which can be potentially prevented by manganese porphyrin. These findings also propose a possible therapeutical strategy for neurodegenerative disorders associated with oxidative stress such as PD. | PING CHEN ZHEN CHEN ANG LI XIAO-CHU LOU XIAO-KANG WU CHUN-JUN ZHAO SHI-LONG WANG LI-PING LIANG | 2008 | Biomedical and Environmental Sciences2008，21，3： | 4 |
| 16 | Monolithic integration of MoS2-based visible detectors and GaN-based UV detectors显示文摘With the increasing demand for high integration and multi-color photodetection for both military and civilian applications, the research of multi-wavelength detectors has become a new research hotspot. However, current research has been mainly in visible dual-or multi-wavelength detectors, while integration of both visible light and ultraviolet(UV) dual-wavelength detectors has rarely been studied. In this work, large-scale and high-quality monolayer MoS2 was grown by the chemical vapor deposition method on transparent free-standing GaN substrate. Monolithic integration of MoS2-based visible detectors and GaN-based UV detectors was demonstrated using common semiconductor fabrication technologies such as photolithography, argon plasma etching, and metal deposition. High performance of a 280 nm and 405 nm dual-wavelength photodetector was realized.The responsivity of the UV detector reached 172.12 A/W, while that of the visible detector reached 17.5 A/W.Meanwhile, both photodetectors achieved high photocurrent gain, high external quantum efficiency, high normalized detection rate, and low noise equivalent power. Our study extends the future application of dual-wavelength detectors for image sensing and optical communication. | YOU WU ZHIWEN LI KAH-WEE ANG YUPING JIA ZHIMING SHI ZHI HUANG WENJIE YU XIAOJUAN SUN XINKE LIU DABING LI | 2019 | Photonics Research2019，7，10： | 4 |
| 17 | Joint frequency offset tracking and PAPR reduction algorithm in OFDM systems显示文摘This paper presents an algorithm that aims to reduce the peak-to-average power ratio(PAPR) of orthogonal frequency division multiplexing(OFDM) communication systems while maintaining frequency tracking.The algorithm achieves PAPR reduction by applying the complex conjugates of the data symbol obtained from the frequency domain to cancel the phase of the data symbol.A likelihood estimator is used to obtain the sub-carrier phase error due to the residual carrier frequency offset(RCFO) using the same complex conjugates as a pilot signal.Furthermore,a joint time and frequency domain multicarrier phase locked loop(MPLL) is developed to compensate additional frequency offset.Simulation results show that this algorithm is capable of reducing PAPR without impacting the frequency tracking performance. | Lijun Ge Yingxin Zhao Hong Wu Ning Xu Yu'ang Jin Wenqi Li | 2010 | Journal of Systems Engineering and Electronics2010，21，4： | 4 |
| 18 | Diagnostic Utility of Diffusion-weighted Magnetic Resonance Imaging in Differentiating Small Solid Renal Tumors (≤4 cm) at 3.0T Magnetic Resonance Imaging显示文摘 | Han-Mei Zhang Ying-Hua Wu Qi Gan Xiao Lyu Xiang-Lan Zhu Min Kuang Rong-Bo Liu Zi-Xing Huang ang Yuan Xi-Jiao Liu Bin Song | 2015 | Chinese Medical Journal2015，，11： | 4 |
| 19 | Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells显示文摘Background:Tooth is vital not only for a good smile,but also good health.Yet,we lose tooth regularly due to accidents or diseases.An ideal solution to this problem is to regenerate tooth with patients’own cells.Here we describe the generation of tooth-like structures from integration-free human urine induced pluripotent stem cells(ifhU-iPSCs).Results:We first differentiated ifhU-iPSCs to epithelial sheets,which were then recombined with E14.5 mouse dental mesenchymes.Tooth-like structures were recovered from these recombinants in 3 weeks with success rate up to 30%for 8 different iPSC lines,comparable to H1 hESC.We further detected that ifhU-iPSC derived epithelial sheets differentiated into enamel-secreting ameloblasts in the tooth-like structures,possessing physical properties such as elastic modulus and hardness found in the regular human tooth.Conclusion:Our results demonstrate that ifhU-iPSCs can be used to regenerate patient specific dental tissues or even tooth for further drug screening or regenerative therapies. | Jinglei Cai Yanmei Zhang Pengfei Liu Shubin Chen Xuan Wu Yuhua Sun Ang Li Ke Huang Rongping Luo Lihui Wang Ying Liu Ting Zhou Shicheng Wei Guangjin Pan Duanqing Pei | 2013 | Cell Regeneration2013，2，1： | 4 |
| 20 | Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells显示文摘Paraquat (PQ, 1,1'-dimethyl-4,4'-bipyridinium ) ,使用得广泛地的除草剂,为 Parkinson 的疾病的发展作为一个潜在的 etiologic 因素被建议了。在最近的年里,许多研究集中于 PQ neurotoxicity 的机制。在这研究,我们检验了锰( III )的 neuroprotective 效果 meso-tetrakis ( N , N'-diethylimidazolium )卟啉( MnTDM ),超级氧化物 dismutase/catalase 模仿,在在 1RB ( 3 )的 导致PQ 的氧化应力和 apoptosis 上一( 27 )( N27 )房间,一根 dopaminergic neuronal 房间线。结果显示 MnTDM 显著地稀释了房间生存能力,谷胱甘肽弄空,和反应的氧种类生产的导致 PQ 的损失。MnTDM 也改善了 apoptosis 的导致 PQ 的词法原子变化和 apoptosis 的增加的率。另外,我们的数据提供 MnTDM 压制了导致 PQ 的 caspase-3 劈开的直接证据,可能 PQ neurotoxicity 的一个关键事件。这些观察建议了那个氧化压力, apoptosis 在导致 PQ 的 neurotoxicity 被含有,这毒性能被 MnTDM 阻止。这些调查结果也为 Parkinson 与氧化应力联系的疾病和另外的混乱建议了一条新奇治疗学的途径。 | Ping Chen Ang Li Mengjie Zhang Meilan He Zhen Chen Xiaokang Wu Chunjun Zhao Shilong Wang Liping Liang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，2： | 4 |
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