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| 1 | CaMKII in cerebral ischemia显示文摘神经原上的 Ischemic 侮辱触发引起 Ca 导致 neuronal 房间死亡(excitotoxicity ) 的 2+ 超载的过多的、病理学的 glutamate 版本。Ca 2+/calmodulin (凸轮) 依赖者蛋白质 kinase II (CaMKII ) 是位于 neuronal 粘性下面并且学习的生理的有刺激性的 glutamate 信号的一个主要调停人。Glutamate 刺激在 T286 触发 CaMKII 的 autophosphorylation,使 kinase 成为 “ 的一个过程; autonomous”(从 Ca 2+ 刺激的部分活跃的独立人士) 并且那为 synaptic 的形式被要求粘性。最近的研究为侮辱以后的 neuroprotection 作为潜在的药目标也建议了自治 CaMKII 活动,在在 neuronal 文化的 glutamate 侮辱以后并且在在 vivo 的焦点的服的局部缺血以后。然而, CaMKII 和凸轮 kinase 家庭的另外的成员在 neuronal 死亡和幸存的规定被含有。这里,我们在 excitotoxicity 和服的局部缺血讨论过去的调查结果和凸轮 kinase 功能的可能的机制,与 CaMKII 和它的规定的一个焦点。 | Steven J COULTRAP Rebekah S VEST Nicole M ASHPOLE Andy HUDMON K Ulrich BAYEF | 2011 | Acta Pharmacologica Sinica2011，32，7： | 6 |
| 2 | Advances in cirrhosis: Optimizing the management of hepatic encephalopathy显示文摘Hepatic encephalopathy(HE) is a major complication of cirrhosis resulting in significant socioeconomic burden, morbidity, and mortality. HE can be further subdivided into covert HE(CHE) and overt HE(OHE). CHE is a subclinical, less severe manifestation of HE and requires psychometric testing for diagnosis. Due to the time consuming screening process and lack of standardized diagnostic criteria, CHE is frequently underdiagnosed despite its recognized role as a precursor to OHE. Screening for CHE with the availability of the Stroop test has provided a pragmatic method to promptly diagnose CHE. Management of acute OHE involves institution of lactulose, the preferred first-line therapy. In addition, prompt recognition and treatment of precipitating factors is critical as it may result in complete resolution of acute episodes of OHE. Treatment goals include improvement of daily functioning, evaluation for liver transplantation, and prevention of OHE recurrence. For secondary prophylaxis, intolerance to indefinite lactulose therapy may lead to non-adherence and has been identified as a precipitating factor for recurrent OHE. Rifaximin is an effective add-on therapy to lactulose for treatment and prevention of recurrent OHE. Recent studies have demonstrated comparable efficacy of probiotic therapy to lactulose use in both primary prophylaxis and secondary prophylaxis. | Andy Liu Ryan B Perumpail Radhika Kumari Zobair M Younossi Robert J Wong Aijaz Ahmed | 2015 | World Journal of Hepatology2015，7，29： | 3 |
| 3 | High-perfomance HT-ACMs for automotive molded and extruded applications显示文摘 | Andy A Paul M John M | 2007 | Rubber World2007，237，1： | 1 |
| 4 | Quality assurance of rapid on site evaluation of CT guided fine-needle aspiration cytology of lung nodules显示文摘 | Bak M Hidv6gi J Andi J | 2013 | Orv Hetil2013，154，1： | 1 |
| 5 | Ice-slurry production using direct contact heat transfer显示文摘 | Wijeysundera N E Hawlader M N A Andy C W B | 2004 | International Journal of Refrigeration2004，27，5： | 1 |
| 6 | Distributed snapshots: Determining global states of distributed systems显示文摘 | CI-/ANDY K M LAMPORT L | 1985 | ACM Transactions on Com- puter Systems1985，3，1： | 1 |
| 7 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 8 | Challenges of evolvable hardware: past, present and the path to a promising future显示文摘 | Pauline C Haddow Andy M Tyrrell | 2011 | Genetic Programming and Evolvable Machines2011，12，3： | 1 |
| 9 | High-temperature vibration damping of thermal barrier coating materials 显示文摘 | Andi M Limarga | 2007 | Surf Coat Techn2007，202，47： | 1 |
| 10 | Complex Business Models:Managing Strategic Paradoxes Simultaneously显示文摘 | Smith W K Andy B Tushman M L | 2010 | Long Range Plan-ning2010，43，： | 1 |
| 11 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 12 | Dynamic cluster formation using level set methods显示文摘 | Yip Andy M Ding Chris Chan Tony F | 2006 | IEEE Trans on Pattern Analysis and Machine Intelligence2006，28，6： | 1 |
| 13 | The use of rapid prototype templates in reconstructive head & neck surgery 显示文摘 | Tohamy A M A Andi K A | 2012 | British Journal of Oral and Maxillofacial Surgery2012，50，1： | 1 |
| 14 | Cadmium Exposure and All-Cause and Cardiovascular Mortality in the U.S. General Population显示文摘 | Tellez-Plaza Maria Navas-Acien Ana Menke Andy Crainiceanu Ciprian M Pastor-Barriuso Roberto Guallar Eliseo | 2012 | EN2012，，7： | 1 |
| 15 | Modeling of the effect of Al 2 O 3 interlayer on residual stress due to oxide scale in thermal barrier coatings显示文摘 | Andi M Limarga Sujanto Widjaja Tick Hon Yip Lay Kuan Teh | 2002 | Surface & Coatings Technology2002，，1： | 1 |
| 16 | Modeling of the effect of Al2O3 interlayer on residual stress due to oxide scale in thermal barrier coatings显示文摘 | Andi M Limarga Sujanto Widjaja Tick Hon Yip | 2002 | Surface and Coatings Technology2002，153，： | 1 |
| 17 | High-performance HT-ACMs for automotive molded and extruded applications显示文摘 | Andy A Paul M John M | 2007 | Rubber World2007，237，1： | 1 |
| 18 | Diagnosing customer loyalty drivers显示文摘 | MICHAEL J R ROBERT R ANDY M | 1999 | Marketing Research1999，11，2： | 1 |
| 19 | 早期将抗生素由静脉转为口服治疗严重社区获得性肺炎:多中心随机试验显示文摘目的比较早期由静脉转换成口服抗生素与常规静脉使用7天抗生素治疗严重社区获得性肺炎(CAP)的疗效。设计多中心随机对照试验。地点荷兰5家教学医院和2所大学的医学中心。参加者非 ICU 住院的严重 CAP 患者302例,其中265例满足研究要求。干预静脉抗生素治疗3天,病情稳定后换成口服抗生素,或静脉使用抗生素治疗7天。主要评价结果临床治愈和住院天数。结果 302例患者被随机分组(平均年龄69.5岁,标准差14.0),肺炎严重度评分平均112.7(26.0)。37例患者因为提前3天退出而未纳入分析,对其余265例患者进行分析研究。第28天的死亡率在干预组是4%,对照组是6%(平均差2%,95%可信区间-3%~8%)。临床治愈率在干预组是83%,对照组是85%(2%;-7%~10%)。与对照组相比,干预组患者静脉治疗时间为3.4天[3.6(1.5)比7.0(2.0)天;2.8~3.9],患者住院天数减少1.9天[9.6(5.0)比11.5(4.9)天;0.6~3.2]。结论早期将抗生素由静脉应用转换成口服治疗严重 CAP 是安全的,并且可以减少住院时间2天。试验注册号临床试验 NCT00273676。 | Jan Jelrik Oosterheert Marc J M Bonten Margriet M E Schneider Erik Buskens Jan-Willem J Lammers Willem M N Hustinx Mark H H Kramer Jan M Prins Peter H Th J Slee Karin Kaasjager Andy I M Hoepelman 王伟巍(译) 童朝辉(校) | 2007 | 英国医学杂志中文版2007，10，2： | 1 |
| 20 | Green tea consumption en- hances survival of epithelial ovarian cancer E 显示文摘 | Zhang M Andy HL Colin WB | 2004 | Int J Cancer2004，112，3： | 1 |
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