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| 1 | Pathogenesis of hepatocarcinogenesis in non-cirrhotic nonalcoholic fatty liver disease:Potential mechanistic pathways显示文摘Although hepatocellular carcinoma(HCC) primarily arises in the background of liver cirrhosis,the development of HCC in nonalcoholic fatty liver disease(NAFLD) without cirrhosis is increasingly recognized. The pathogenesis of NAFLD associated non-cirrhotic HCC is distinct from that of cirrhotic HCC because the metabolic syndrome(MS) along with obesity and insulin resistance(IR) underlie several unique mechanisms that promote tumorigenesis. IR associated with MS,NAFLD,and type 2 diabetes mellitus lead to the release of multiple pro-inflammatory cytokines,including tumor necrosis factor alpha,interleukin-6,leptin and resistin,as well as decreased amounts of adiponectin. These processes favor the development of hepatic steatosis and inflammation within the liver,which precede HCC development. Nevertheless,further investigation is necessary to elucidate the determinants for development of HCC in patients with NAFLD in the absence of cirrhosis. | Ryan B Perumpail Andy Liu Robert J Wong Aijaz Ahmed Stephen A Harrison | 2015 | World Journal of Hepatology2015，7，22： | 6 |
| 2 | Advances in alcoholic liver disease:An update on alcoholic hepatitis显示文摘Alcoholic hepatitis is a pro-inflammatory chronic liver disease that is associated with high short-term morbidity and mortality(25%-35% in one month) in the setting of chronic alcohol use. Histopathology is notable for micro- and macrovesicular steatosis, acute inflammation with neutrophil infiltration, hepatocellular necrosis, perivenular and perisinusoidal fibrosis, and Mallory hyaline bodies found in ballooned hepatocytes. Other findings include the characteristic eosinophilic fibrillar material(Mallory's hyaline bodies) found in ballooned hepatocytes. The presence of focal intense lobular infiltration of neutrophils is what typically distinguishes alcoholic hepatitis from other forms of hepatitis, in which the inflammatory infiltrate is primarily composed of mononuclear cells. Management consists of a multidisciplinary approach including alcohol cessation, fluid and electrolyte correction, treatment of alcohol withdrawal, and pharmacological therapy based on the severity of the disease. Pharmacological treatment for severe alcoholic hepatitis, as defined by Maddrey's discriminant factor ≥ 32, consists of either prednisolone or pentoxifylline for a period of four weeks. The body of evidence for corticosteroids has been greater than pentoxifylline, although there are higher risks of complications. Recently head-to-head trials between corticosteroids and pentoxifylline have been performed, which again suggests that corticosteroids should strongly be considered over pentoxifylline. | Randy Liang Andy Liu Ryan B Perumpail Robert J Wong Aijaz Ahmed | 2015 | World Journal of Gastroenterology2015，21，42： | 5 |
| 3 | Advances in cirrhosis: Optimizing the management of hepatic encephalopathy显示文摘Hepatic encephalopathy(HE) is a major complication of cirrhosis resulting in significant socioeconomic burden, morbidity, and mortality. HE can be further subdivided into covert HE(CHE) and overt HE(OHE). CHE is a subclinical, less severe manifestation of HE and requires psychometric testing for diagnosis. Due to the time consuming screening process and lack of standardized diagnostic criteria, CHE is frequently underdiagnosed despite its recognized role as a precursor to OHE. Screening for CHE with the availability of the Stroop test has provided a pragmatic method to promptly diagnose CHE. Management of acute OHE involves institution of lactulose, the preferred first-line therapy. In addition, prompt recognition and treatment of precipitating factors is critical as it may result in complete resolution of acute episodes of OHE. Treatment goals include improvement of daily functioning, evaluation for liver transplantation, and prevention of OHE recurrence. For secondary prophylaxis, intolerance to indefinite lactulose therapy may lead to non-adherence and has been identified as a precipitating factor for recurrent OHE. Rifaximin is an effective add-on therapy to lactulose for treatment and prevention of recurrent OHE. Recent studies have demonstrated comparable efficacy of probiotic therapy to lactulose use in both primary prophylaxis and secondary prophylaxis. | Andy Liu Ryan B Perumpail Radhika Kumari Zobair M Younossi Robert J Wong Aijaz Ahmed | 2015 | World Journal of Hepatology2015，7，29： | 3 |
| 4 | A stochastic programming approach to electric energy procurement for large consumers显示文摘 | Miguel C Andy B P Antonio J C | 2007 | IEEE Trans On Power Systems2007，22，2： | 1 |
| 5 | Ice-slurry production using direct contact heat transfer显示文摘 | Wijeysundera N E Hawlader M N A Andy C W B | 2004 | International Journal of Refrigeration2004，27，5： | 1 |
| 6 | Electrical impedance tomography system based on active electrodes显示文摘 | Pascal O G Andy A Josef B | 2012 | Physiol Meas2012，33，5： | 1 |
| 7 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 8 | The forces that shape organizational performance measurement systems:An interdisciplinary review显示文摘 | DANNIEL B WAGGONER ANDY D NELLY MIKE P KENNERLEY | 1999 | International Journal of production economics1999，，8： | 1 |
| 9 | Complex Business Models:Managing Strategic Paradoxes Simultaneously显示文摘 | Smith W K Andy B Tushman M L | 2010 | Long Range Plan-ning2010，43，： | 1 |
| 10 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 11 | Rapid and simple protein-stability screens:application to membrane proteins显示文摘 | Andrew P Yeh Andy McMillan Michael H B Stowell | 2006 | Acta Cryst2006，62，： | 1 |
| 12 | Attention-deficit/hyperactivity disorder in preschool children:An investigation of validation based on visual attention performance显示文摘 | Mini T Xuemei S Andy B | 2009 | J Child Adolesc Psychopharmacol2009，19，2： | 1 |
| 13 | The effects of tympanic membrance intubation on middle ear resonant frequency in children 显示文摘 | ANDY J B WALTER B G | 1998 | J Speech Language Path Aud1998，22，1： | 1 |
| 14 | Adaptive robust optimization for the security constrained unit commiment problem显示文摘 | Dimitris B Eugene L Sun Xu Andy | 2013 | IEEE Transaction on Power Systems2013，28，1： | 1 |
| 15 | Long-term clinical outcome and left ventricular lead position in cardiac resynchronization therapy 显示文摘 | Mads B Andi E Jens C | 2009 | Europace2009，11，： | 1 |
| 16 | Influence of tail shape on tadpole swimming performance显示文摘 | ANDY S M | 2000 | The Journal of Experimental Biology2000，203，： | 1 |
| 17 | The effect of acrylamide-co-vi- nylpyrrolidinone copolymer on the depressionof talc in mixed nickel mineral flotation 显示文摘 | Andy L James W Anton B | 2011 | Minerals Engineering2011，24，： | 1 |
| 18 | Glutamates 78 and 122 in the active site of saccharopine dehydrogenase contribute to reac- tant binding and modulate the basicity of the acid-base catalysts 显示文摘 | EKANAYAKE D K ANDI B BOBYK K D | 2010 | J Biol Chem2010，285，20： | 1 |
| 19 | The studies of statistics in homology显示文摘 | Iobel A Andy B | 1998 | Bioin-formatics1998，14，4： | 1 |
| 20 | Randomised controlled trial of an automated,interactive telephone intervention to improve type 2 diabetes self-management(Telephone-Linked Care Diabetes Project):Study protocol显示文摘 | Dominique B Brian OL andy C | | 0，，： | 1 |
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