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| 1 | Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang显示文摘Acute myeloid leukemia(AML) is characterized by the accumulation of circulating immature blasts that exhibit uncontrolled growth, lack the ability to undergo normal differentiation, and have decreased sensitivity to apoptosis. Accumulating evidence shows the bone marrow(BM) niche is critical to the maintenance and retention of hematopoietic stem cells(HSC), including leukemia stem cells(LSC), and an increasing number of studies have demonstrated that crosstalk between LSC and the stromal cells associated with this niche greatly influences leukemia initiation, progression, and response to therapy. Undeniably, stromal cells in the BM niche provide a sanctuary in which LSC can acquire a drug-resistant phenotype and thereby evade chemotherapyinduced death. Yin and Yang, the ancient Chinese philosophical concept, vividly portrays the intricate and dynamic interactions between LSC and the BM niche. In fact, LSC-induced microenvironmental reprogramming contributes significantly to leukemogenesis. Thus, identifying the critical signaling pathways involved in these interactions will contribute to target optimization and combinatorial drug treatment strategies to overcome acquired drug resistance and prevent relapse following therapy. In this review, we describe some of the critical signaling pathways mediating BM niche-LSC interaction, including SDF1/CXCL12, Wnt/β-catenin, VCAM/VLA-4/NF-κB, CD44, and hypoxia as a newly-recognized physical determinant of resistance, and outline therapeutic strategies for overcoming these resistance factors. | Hong-Sheng Zhou Bing Z.Carter Michael Andreeff | 2016 | Cancer Biology & Medicine2016，13，2： | 6 |
| 2 | The Participation of mesenchymal stem cells in tumor stroma formation and their application as tar geted-gene delivery vehicles显示文摘 | Hall B Andreeff M Marini F | 2007 | Handb Exp Pharmacol2007，，180： | 1 |
| 3 | BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells显示文摘 | Stephanie Beurlet Nader Omidvar Petra Gorombei Patricia Krief Carole Le Pogam Niclas Setterblad Pierre de la Grange Christophe Leboeuf Anne Janin Maria-Elena Noguera Florence Hervatin Laure Sarda-Mantel Marina Konopleva Michael Andreeff Andrea W. Tu Alice | 2013 | Blood2013，，16： | 1 |
| 4 | 1,25-dihydroxyvitamin D3enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53显示文摘 | Thompson T Andreeff M Studzinski GP | 2010 | Mol Cancer Ther2010，9，5： | 1 |
| 5 | The mitogen-activated protein kinase signaling module as a therapeutic target in hematologic malignancies显示文摘 | Milella M Kornblau SM Andreeff M | 2003 | Rev Clin Exp Hematol2003，7，2： | 1 |
| 6 | Inhibition of the phosphatidylinositol 3'-kinase-AKT path way induces apoptosis in pancreatic carcinoma cells in vitro and in vivo 显示文摘 | BONDAR V M SWEENEY-GOTSCH B ANDREEFF M | 2002 | Mol Cancer Ther2002，1，12： | 1 |
| 7 | Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA 显示文摘 | Andreeff M Darzynkiewicz Z Sharpless TK | 1980 | Blood1980，55，2： | 1 |
| 8 | Apoptosis repressor with caspase recruitment domain modulates second mitochondrial‐derived activator of caspases mimetic‐induced cell death through BIRC 2/ MAP 3K14 signalling in acute myeloid leukaemia显示文摘 | Po Y. Mak Duncan H. Mak Vivian Ruvolo Rodrigo Jacamo Steven M. Kornblau Hagop Kantarjian Michael Andreeff Bing Z. Carter | 2014 | Br J Haematol2014，，： | 1 |
| 9 | The Participation of mesenchymal stem cells in tumor stroma formation and their application as targeted- gene delivery vehicles 显示文摘 | Hall B Andreeff M Marini F | 2007 | Handb Exp Pharmacol2007，，180： | 1 |
| 10 | Discrimination of human leukemiasubtypes by flow cytometric analysis of cellular DNA and RNA显示文摘 | ANDREEFF M DARZYNKIEWICZ Z SHARPLESS TK | 1980 | Blood1980，55，： | 1 |
| 11 | The participation of mesenchymal stem cells in tumor stroma formation and their application as targeted-gene delivery vehicles 显示文摘 | Hall B Andreeff M Marini F | 2007 | Handbook of experimental pharmacology2007，52，180： | 1 |
| 12 | HOX expression pat- terns identify a common signature for favorable AML显示文摘 | Andreeff M Ruvolo V Gadgil S | 2008 | Leukemia2008，22，11： | 1 |
| 13 | Flow cytometry Clinical and research applications in hemotologic malignancies 显示文摘 | Huh YO Andreeff M | 1994 | Hematol/Oncol Clin north Am1994，8，4： | 1 |
| 14 | Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism 显示文摘 | Samudio I Fiegl M Andreeff M | 2009 | Cancer Res2009，69，6： | 1 |
| 15 | Cell survival kinetics in peripheral blood and bone marrow during total body irradiation for marrow transplantation显示文摘 | Andreeff M Li D | 1983 | Int J Radiat Oncol Biol Phys1983，9，6： | 1 |
| 16 | CD38 in hematopoietic malignancies显示文摘 | Konopleva M Rissling I Andreeff M | 2000 | Chem Immunol2000，75，： | 1 |
| 17 | Mesenchymal stem cells as delivery systems for cancer and leukemia gene therapy显示文摘 | ANDREEFF M STUDENY M DEMBINSKI J | 2004 | J Clin Oncol2004，22，14： | 1 |
| 18 | Investigational FMS-like tyrosine kinase 3 inhibitors in treatment of acute myeloid leukemia显示文摘 | Pemmaraju N Kantarjian H Andreeff M | 2014 | Expert Opin Investig Drugs2014，23，7： | 1 |
| 19 | hTERT promoter induces tumor- specific Bax gene expression and cell killing insyngenic mouse tumor model and prevents systemic toxicity 显示文摘 | Gu J Andreeff M Roth JA | 2002 | Gene Ther2002，9，1： | 1 |
| 20 | Flow cytometry clinical and research applications in hemotologic malignancies显示文摘 | Huh YO Andreeff M | 1994 | Hematol/Oncol Clin north Am1994，8，4： | 1 |
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