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| 1 | A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome显示文摘AIM:To test the efficacy of a proprietary nutraceutical combination in reducing insulin resistance associated with the metabolic syndrome(MetS).METHODS:Sixty-four patients with MetS followed at a tertiary outpatient clinic were randomly assigned to receive either placebo or a proprietary nutraceutical combination(AP)consisting of berberine,policosanol and red yeast rice,in a prospective,double-blind,placebo-controlled study.Evaluations were performed at baseline and after 18 wk of treatment.The homeostasis model assessment of insulin resistance(HOMAIR)index was the primary outcome measure.Secondary endpoints included lipid panel,blood glucose and insulin fasting,after a standard mixed meal and after an oral glucose tolerance test(OGTT),ow-mediated dilation(FMD),and waist circumference.RESULTS:Fifty nine patients completed the study,2 withdrew because of adverse effects.After 18 wk there was a signif icant reduction in the HOMA-IR index in the AP group compared with placebo(ΔHOMA respectively-0.6 ± 1.2 vs 0.4 ± 1.9;P < 0.05).Total and low density lipoprotein cholesterol also significantly decreased in the treatment arm compared with placebo(Δlow density lipoprotein cholesterol-0.82 ± 0.68 vs-0.13 ± 0.55 mmol/L;P < 0.001),while triglycerides,high density lipoprotein cholesterol,and the OGTT were not affected.In addition,there were significant reductions in blood glucose and insulin after the standard mixed meal,as well as an increase in FMD(ΔFMD 1.9 ± 4.2 vs 0 ± 1.9 %;P < 0.05)and a significant reduction in arterial systolic blood pressure in the AP arm.CONCLUSION:This short-term study shows that AP has relevant beneficial effects on insulin resistance and many other components of MetS. | Flora Affuso Valentina Mercurio Antonio Ruvolo Concetta Pirozzi Filomena Micillo Guido Carlomagno Fabrizia Grieco Serafino Fazio | 2012 | World Journal of Cardiology2012，4，3： | 7 |
| 2 | Efficacy and safety of valsartan plus hydroclorothiazide for high blood pressure显示文摘AIM:To evaluate efficacy and tolerability of the combination valsartan plus hydrochlorothiazide(160 mg and 25 mg daily,respectively) in young-middle aged males with high-normal blood pressure(BP) or firstdegree arterial hypertension with evidence of target organ damage.METHODS:Twenty males with high-normal BP or first-degree hypertension associated with left ventricular concentric remodeling and/or increased aortic stiffness were enrolled.BP at rest and during exercise,and echocardiographic parameters of the left ventricle(LV),were evaluated at baseline and after 3 mo of treatment.The effects of treatment on aortic stiffness,metabolic parameters,renal and erectile function were also assessed.RESULTS:BP was significantly reduced by treatment both at rest(P < 0.001) and during exercise(P < 0.001),and 85% of patients achieved BP normalization(< 130/85 mmHg).Doppler echocardiography showed a significant reduction of LV mass(P < 0.005).LV hypertrophy was identified in 70% of subjects at baseline and in 5% after 3 mo of treatment.The ratio of early(E) to late(A) trans-mitral diastolic flow velocity increased,(P < 0.05),the relative wall thickness decreased(P < 0.05) and the left ventricular relaxation time shortened(P < 0.005).The left atrial diameter(P < 0.05) and the aortic diameter(P < 0.05) and stiffness(P < 0.005) also decreased.CONCLUSION:The full-dose combination of valsartan plus hydrochlorothiazide produced optimal BP control with regression of target organ damage,already after 3 mo,without relevant side effects. | Antonio Ruvolo Valentina Mercurio Valeria Fazio Guido Carlomagno Teresa Russo Flora Affuso Serafino Fazio | 2010 | World Journal of Cardiology2010，2，5： | 4 |
| 3 | POINT: Efficacy of adding mitral valve restrictive annuloplasty to coronary artery bypass grafting in patients with moderate ischemic mitral valve regurgitation: A randomized trial显示文摘 | Khalil Fattouch Francesco Guccione Roberta Sampognaro Gaetano Panzarella Egle Corrado Emiliano Navarra Davide Calvaruso Giovanni Ruvolo | 2009 | The Journal of Thoracic and Cardiovascular Surgery2009，，2： | 2 |
| 4 | Ancient single origin for Malagasy primates 显示文摘 | Yoder A D Cartmill M Ruvolo M | 1996 | Proc Natl Acad Sci USA1996，93，： | 2 |
| 5 | The Tre2(USP6)oncogene is a hominoid-specific gene显示文摘 | Paulding CA Ruvolo M Haber DA | 2003 | Proc Nail Acad Sci USA2003，100，5： | 1 |
| 6 | Genetic sex identification in orangutans 显示文摘 | Steiper M Ruvolo M | 2003 | AuthropolAnz2003，51，1： | 1 |
| 7 | Lower apoptosis rate in human cumulus cells after administration of recombinant luteinizing hormone to women undergoing ovarian stimulation for in vitro fertilization procedures显示文摘 | Ruvolo G Bosco L Pane A | 2007 | Fertil Steril2007，87，3： | 1 |
| 8 | Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases显示文摘 | Deng X Ruvolo P Carr B | 2000 | Proc Natl Acad Sci USA2000，97，4： | 1 |
| 9 | Effect of normothermic versus hypothermic cardiopulmonary bypass on cytokine production and platelet function显示文摘 | Speziale G Ferroni P Ruvolo G | 2000 | J Cardiovasc Surg (Torino)2000，41，6： | 1 |
| 10 | Phosphorylation of Bcl-2 and reg-ulation of apoptosis显示文摘 | Ruvolo P P Deng X May W S | | 0，，4： | 1 |
| 11 | Flow capacity of inferior epigastric artery in composite arterial gafts显示文摘 | Speziale G Speziali G Ruvolo G | 1999 | J Cardiovasc Surg(Torino)1999，40，6： | 1 |
| 12 | Lower apoptosis rate in human cumulus cells after administration of recobinant luteinizing hormone to women undergoing ovarian stimulation for in vitro fertilization procedures显示文摘 | Ruvolo G Bodco L Pane A | 2007 | Fertil Steril2007，87，3： | 1 |
| 13 | Phosphorylation of Bcl2 and regulation of apoptosis显示文摘 | Ruvolo P P Deng X May W S | 2001 | Leukemia2001，15，4： | 1 |
| 14 | Oncoplastic surgery for the treatment of breast cancer 显示文摘 | Colombo G Dellacasa I Ruvolo V | 2009 | Minerva Ginecol2009，61，5： | 1 |
| 15 | Intracellular signal transduction pathways activated by ceramide and its metabolites 显示文摘 | Ruvolo PP | 2003 | Pharmacol Res2003，47，5： | 1 |
| 16 | Intracellular signal transduction pathways activated by ceramide and its metabohtes 显示文摘 | Ruvolo PP | 2003 | Pharmacol Res2003，47，5： | 1 |
| 17 | A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function显示文摘 | Ruvolo PP Clark W Mumby M | 2002 | J Biol Chem2002，277，22： | 1 |
| 18 | Hybridization cross-reactivity within homologous gene families on glass cDNA microarrays显示文摘 | Evertsz E M Au-Young J Ruvolo M W | 2001 | Biotechniques2001，31，： | 1 |
| 19 | Phosphorylation of Bcl2 and regulation of apoptosis 显示文摘 | Ruvolo PP Deng X May WS | 2001 | Leukemia2001，15，4： | 1 |
| 20 | Apoptosis repressor with caspase recruitment domain modulates second mitochondrial‐derived activator of caspases mimetic‐induced cell death through BIRC 2/ MAP 3K14 signalling in acute myeloid leukaemia显示文摘 | Po Y. Mak Duncan H. Mak Vivian Ruvolo Rodrigo Jacamo Steven M. Kornblau Hagop Kantarjian Michael Andreeff Bing Z. Carter | 2014 | Br J Haematol2014，，： | 1 |
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