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| 1 | 国际生物样本库和网络系统:成功因素和主要预算方案显示文摘概述了分布在欧洲、北美、澳大利亚以及亚洲的16个最大的生物样本库与生物样本信息网络在人类生物样本收集、分发,以及资金的科学运转等方面所采用的方法。这些生物样本库的运转和经济模式取决于他们所在国家和研究所的医学和研究宗旨。生物样本库模式的成功运作取决于各种因素,包括明确的目标,可靠的经营计划,以及具有严格质量控制和操作规范的生物样本收集。 | Jim Vaught Andrea Kelly Robert Hewitt 孙孟红 倪淑娟 杜祥 | 2011 | 医学与哲学(A)2011，32，7： | 8 |
| 2 | Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth显示文摘 | Michael Quante Shui Ping Tu Hiroyuki Tomita Tamas Gonda Sophie S.W. Wang Shigeo Takashi Gwang Ho Baik Wataru Shibata Bethany DiPrete Kelly S. Betz Richard Friedman Andrea Varro Benjamin Tycko Timothy C. Wang | 2011 | Cancer Cell2011，，2： | 4 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Gastroschisis: what is the average gestational age of spontaneous delivery?显示文摘 | Andrea Y. Lausman Jacob C. Langer Melissa Tai P. Gareth R. Seaward Rory C. Windrim Edmond N. Kelly Greg Ryan | 2007 | Journal of Pediatric Surgery2007，，11： | 1 |
| 5 | Protein-sensitive hypoglycemia without leucine sensitivity in hyperinsulinism caused by K ATP channel mutations显示文摘 | Shannon H. Fourtner Charles A. Stanley Andrea Kelly | 2006 | The Journal of Pediatrics2006，，1： | 1 |
| 6 | Muscle Coactivation Before and After the Impact Phase of Running Following Isokinetic Fatigue显示文摘 | ELEFTHERIOS KELLIS ANDREAS ZAFEIRIDIS IOAN- NIS G | 2011 | J Athl Training2011，46，1： | 1 |
| 7 | Results of the PROspective MInnesota Study of ECHO/TDI in Cardiac Resynchronization Therapy (PROMISE-CRT) Study显示文摘 | Alan J. Bank Christopher L. Kaufman Aaron S. Kelly Kevin V. Burns Stuart W. Adler Tom S. Rector Steven R. Goldsmith Maria-Teresa P. Olivari Chuen Tang Linda Nelson Andrea Metzig | 2009 | Journal of Cardiac Failure2009，，： | 1 |
| 8 | Optimal investment in a tax increment financing district显示文摘 | Kieran P. Donaghy Andrea Kelly Elson Gerrit J. Knaap | 1999 | The Annals of Regional Science1999，，3： | 1 |
| 9 | VERNAUZATION1 Modulates Root System Architecture in Wheat and Barley显示文摘 | Kai P. Voss-Fels Hannah Robinson Stephen R. Mudge Cecile Richard Saul Newman Benjamin Wittkop Andreas Stahl Wolfgang Friedt Matthias Frisch lulian Gabur Anika Miller-Cooper Bradley C. Campbell Alison Kelly Glen Fox Jack Christopher Mandy Christopher Karine Chenu Jerome Franckowiak Emma S. Mace Andrew K. Borrell Howard Eagles David R. Jordan Jose R. Botella Graeme Hammer lan D. Godwin Ben Trevaskis Rod J. Snowdon Lee T. Hickey | 2018 | Molecular Plant2018，11，1： | 1 |
| 10 | Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort显示文摘BACKGROUND Non-invasive assessment of non-alcoholic steatohepatitis(NASH)is increasing in desirability due to the invasive nature and costs associated with the current form of assessment;liver biopsy.Quantitative multiparametric magnetic resonance imaging(mpMRI)to measure liver fat(proton density fat fraction)and fibroinflammatory disease[iron-corrected T1(cT1)],as well as elastography techniques[vibration-controlled transient elastography(VCTE)liver stiffness measure],magnetic resonance elastography(MRE)and 2D Shear-Wave elastography(SWE)to measure stiffness and fat(controlled attenuated parameter,CAP)are emerging alternatives which could be utilised as safe surrogates to liver biopsy.AIM To evaluate the agreement of non-invasive imaging modalities with liver biopsy,and their subsequent diagnostic accuracy for identifying NASH patients.METHODS From January 2019 to February 2020,Japanese patients suspected of NASH were recruited onto a prospective,observational study and were screened using noninvasive imaging techniques;mpMRI with LiverMultiScan®,VCTE,MRE and 2DSWE.Patients were subsequently biopsied,and samples were scored by three independent pathologists.The diagnostic performances of the non-invasive imaging modalities were assessed using area under receiver operating characteristic curve(AUC)with the median of the histology scores as the gold standard diagnoses.Concordance between all three independent pathologists was further explored using Krippendorff’s alpha(a)from weighted kappa statistics.RESULTS N=145 patients with mean age of 60(SD:13 years.),39%females,and 40%with body mass index≥30 kg/m2 were included in the analysis.For identifying patients with NASH,MR liver fat and cT1 were the strongest performing individual measures(AUC:0.80 and 0.75 respectively),and the mpMRI metrics combined(cT1 and MR liver fat)were the overall best non-invasive test(AUC:0.83).For identifying fibrosis≥1,MRE performed best(AUC:0.97),compared to VCTE-liver stiffness measure(AUC:0.94)and 2D-SWE(AUC:0.94).For assessment of steatosis≥1,MR liver fat was the best performing non-invasive test(AUC:0.92),compared to controlled attenuated parameter(AUC:0.75).Assessment of the agreement between pathologists showed that concordance was best for steatosis(a=0.58),moderate for ballooning(a=0.40)and fibrosis(a=0.40),and worst for lobular inflammation(a=0.11).CONCLUSION Quantitative mpMRI is an effective alternative to liver biopsy for diagnosing NASH and non-alcoholic fatty liver,and thus may offer clinical utility in patient management. | Kento Imajo Louise Tetlow Andrea Dennis Elizabeth Shumbayawonda Sofia Mouchti Timothy J Kendall Eve Fryer Shogi Yamanaka Yasushi Honda Takaomi Kessoku Yuji Ogawa Masato Yoneda Satoru Saito Catherine Kelly Matt D Kelly Rajarshi Banerjee Atsushi Nakajima | 2021 | World Journal of Gastroenterology2021，27，7： | 1 |
| 11 | Molecular basis of cellular localization of poly C binding protein 1 in neuronal cells显示文摘 | Andrea M Berry A Kelly E | 2006 | Biochem Biophys Res Commun2006，49，4： | 1 |
| 12 | Fucoidans and fucoidanases—focus on techniques for molecular structure elucidation and modification of marine polysaccharides显示文摘 | Andrea Désirée Holtkamp Svenja Kelly Roland Ulber Siegmund Lang | 2009 | Applied Microbiology and Biotechnology2009，，1： | 1 |
| 13 | Pipeline of drugs for related diseases: tuberculosis显示文摘 | Kelly E. Dooley Eric L. Nuermberger Andreas H. Diacon | 2013 | Current Opinion in HIV and AIDS2013，，6： | 1 |
| 14 | Discussion of some‘knowns’and some‘unknowns’about the tumour suppressor p53显示文摘Activation of the tumour suppressor p53 upon cellular stress can induce a number of different cellular processes?The diverse actions of these processes are critical for the protective function of p53 in preventing the development of cancer.However,it is still not fully understood which process(es)activated by p53 is/are critical for tumour suppression and how this might differ depending on the type of cells undergoing neoplastic transformstion and the nature of the drivers of oncogenesis.Moreover,it is not clear why upon activation of p53 some cells undergo cell cycle arrest and senescence whereas others die by apoptosis.Here we discuss some of the cellular processes that are crucial for p53-mediated tumour suppression and the factors that could impact cell fate upon p53 activation.Finally,we describe therapies aimed either at activating wild-type p53 or at changing the behaviour of mutant p53 to unleash tumour growth suppressive processes for therapeutic benefit in malignant disease. | Elizabeth Lieschke Zilu Wang Gemma L Kelly Andreas Strasser | 2019 | Journal of Molecular Cell Biology2019，11，3： | 1 |
| 15 | Prostaglandin E2 represses interleukin 1 beta-induced inflammatory mediator output from pregnant humanmy ometrial cells through the EP2 and EP4 receptors显示文摘 | Mosher Andrea A Rainey Kelly J Giembycz Mark A | 2012 | Biol Reprod2012，87，1： | 1 |
| 16 | Fucoidans and fucoidanases—focus on techniques for molecular structure elucidation and modification of marine polysaccharides显示文摘 | Andrea Désirée Holtkamp Svenja Kelly Roland Ulber Siegmund Lang | 2009 | Applied Microbiology and Biotechnology2009，，1： | 1 |
| 17 | The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat显示文摘 | Laura Kelly Belinda Grehan Andrea Della Chiesa Shane M. O’Mara Eric Downer George Sahyoun Karen A. Massey Anna Nicolaou Marina A. Lynch | 2011 | Neurobiology of Aging2011，，： | 1 |
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