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| 1 | Importance of gastrin in the pathogenesis and treatment of gastric tumors显示文摘In addition to regulating acid secretion, the gastric antral hormone gastrin regulates several important cellular processes in the gastric epithelium including proliferation, apoptosis, migration, invasion, tissue remodelling and angiogenesis. Elevated serum concentrations of this hormone are caused by many conditions, particularly hypochlorhydria (as a result of autoimmune or Helicobacter pylori (H pylori)-induced chronic atrophic gastritis or acid suppressing drugs) and gastrin producing tumors (gastrinomas). There is now accumulating evidence that altered local and plasma concentrations of gastrin may play a role during the development of various gastric tumors. In the absence of H pylori infection, marked hypergastrinemia frequently results in the development of gastric enterochromaffi n cell-like neuroendocrine tumors and surgery to remove the cause of hypergastrinemia may lead to tumor resolution in this condition. In animal models such as transgenic INS-GAS mice, hypergastrinemia has also been shown to act as a cofactor with Helicobacter infection during gastric adenocarcinoma development. However, it is currently unclear as to what extent gastrin also modulates human gastric adenocarcinoma development. Therapeutic approaches targeting hypergastrinemia,such as immunization with G17DT, have been evaluated for the treatment of gastric adenocarcinoma, with some promising results. Although the mild hypergastrinemia associated with proton pump inhibitor drug use has been shown to cause ECL-cell hyperplasia and to increase H pylori-induced gastric atrophy, there is currently no convincing evidence that this class of agents contributes towards the development of gastric neuroendocrine tumors or gastric adenocarcinomas in human subjects. | Michael D Burkitt Andrea Varro D Mark Pritchard | 2009 | World Journal of Gastroenterology2009，15，1： | 36 |
| 2 | Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth显示文摘 | Michael Quante Shui Ping Tu Hiroyuki Tomita Tamas Gonda Sophie S.W. Wang Shigeo Takashi Gwang Ho Baik Wataru Shibata Bethany DiPrete Kelly S. Betz Richard Friedman Andrea Varro Benjamin Tycko Timothy C. Wang | 2011 | Cancer Cell2011，，2： | 4 |
| 3 | The Role of Matrix Metalloproteinase-7 in Redefining the Gastric Microenvironment in Response to Helicobacter pylori显示文摘 | Catherine McCaig Cedric Duval Elaine Hemers Islay Steele D. Mark Pritchard Sabine Przemeck Rod Dimaline Suhail Ahmed Keith Bodger David D. Kerrigan Timothy C. Wang Graham J. Dockray Andrea Varro | 2006 | Gastroenterology2006，，6： | 2 |
| 4 | Comparison of the cellular electrophysiological characteristics of canine left ventricular epicardium,M cells,endocardium and Purkinje fibers显示文摘 | Balati B Varro A Papp JC | 1998 | Acta Physiol Scand1998，164，： | 1 |
| 5 | Electrophysiological effects of dronedarone ( SR 33589) , a noniodinated amiodarone derivative in the canine heart: comparison with amiodarone 显示文摘 | Varro A Takacs J Nemeth M | 2001 | Br J Pharma- col2001，133，5： | 1 |
| 6 | The role of the delayed rectifier component Iks in dog ventricular muscle and Purkinje fibre repolarization显示文摘 | Varro A Balati B lost N | 2000 | J Physiol Lond2000，523，1： | 1 |
| 7 | Cytometric bead array:a multiplexed assay platform with applications in various areas of biology显示文摘 | Morgan E Varro R Sepulveda H | 2004 | Clin Immunol2004，110，3： | 1 |
| 8 | Flow cytometric immunobead assay for fast and easy detection of PML-RARA fusion proteins for the diagnosis of acute promyelocytic leukemia显示文摘 | Dekking EH van der Velden VH Varro R | 2012 | Leukemia2012，26，9： | 1 |
| 9 | Increased gastric expression of MMP-7 in hypergastrinemia and signif- icance for epithelial-mesenchymal signalin显示文摘 | Varro A Kenny S Hemers E | 2007 | Am J Physiol Gastrointest Liver Physiol2007，292，4： | 1 |
| 10 | Hypergastrinemiaincreases gastric epithelial susceptibility to apoptosis显示文摘 | Przemeck SM Varro A Berry D | 2008 | Regul Pept2008，14，6： | 1 |
| 11 | Potassium currents in isolated human atrial and ventricular cardiocytes显示文摘 | Varro A | 1993 | Acta Physiol Scand1993，149，2： | 1 |
| 12 | Percutaneous alcohol sclerotherapy of a hepatic hydatid cyst after balloon occlusion of a large biliary communication显示文摘 | Varro J Mathew L Athyal RP et aL | 2011 | Med Princ Pract2011，20，5： | 1 |
| 13 | Increased gastric expression of MMP-7 in hypergastrlnemia and significance for epithelial-mesenchymal signaling 显示文摘 | Varro A Kenny S Hemers E | 2007 | Am J Physiol Gastrointest Liver Physiol2007，292，4： | 1 |
| 14 | Gastrin: old hormone, new functions 显示文摘 | Dockray G Dimaline R Varro A | 2005 | Pflugers Arch2005，449，4： | 1 |
| 15 | Molecular biology of canc- er-associated fibroblasts: can these cells be targeted in anti-cancer therapy显示文摘 | Gonda T A Varro A Wang T C | 2010 | Semin Cell Dev Biol2010，21，1： | 1 |
| 16 | Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts显示文摘 | Nathalie Gaborit Andras Varro Sabrina Le Bouter Viktoria Szuts Denis Escande Stanley Nattel Sophie Demolombe | 2010 | Journal of Molecular and Cellular Cardiology2010，，： | 1 |
| 17 | Cytometric bead array:a multiplexed aseay platform with applieatious in various areas of biology显示文摘 | VARRO R SEPMLVEDA H | 2004 | Clin lmmunol2004，110，3： | 1 |
| 18 | Calcitonin gene-related peptide in visceral afferent nerve fibres: quantification by radioimmunoassay and determination of axonal transport rates显示文摘 | Varro A | 1998 | Neuro Ssc1998，26，： | 1 |
| 19 | Bead - based multianalyte flow immunoassays : the cytometric bead array system 显示文摘 | Varro R Chen R Sepulveda H | 2007 | Meth- ods Mol Bio12007，378，： | 1 |
| 20 | Cytometric bead array:a multiplexed assay platform with applications in various areas of biology显示文摘 | Morgan E Varro R Sepulveda H | | 0，，03： | 1 |
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