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| 1 | Primary hepatic carcinoid:A case report and literature review显示文摘Carcinoids are tumors derived from neuroendocrine cells and often produce functional peptide hormones.Approximately 54.5% arise in the gastrointestinal tract and frequently metastasize to the liver.Primary hepatic carcinoid tumors(PHCT) are extremely rare;only 95 cases have been reported.A 65-year-old man came to our attention due to occasional ultrasound findings in absence of clinical manifestations.His previous medical history,since 2003,included an echotomography of the dishomogeneous parenchymal area but no focal lesions.A computed tomography scan performed in 2005 showed an enhanced pseudonodular-like lesion of about 2 cm.Cholangio-magnetic resonance imaging identified the lesion as a possible cholangiocarcinoma.No positive findings were obtained with positron emission tomography.Histology suggested a secondary localization in the liver caused by a low-grade malignant neuroendocrine tumor.Immunohistochemistry was positive for anti chromogranin antibodies,Ki67 antibodies and synaptophysin.Octreoscan scintigraphy indicated intense activity in the lesion.Endoscopic investigations were performed to exclude the presence of extrahepatic neoplasms.Diagnosis of PHCT was established.The patient underwent left hepatectomy,followed by hormone therapy with sandostatine LAR.Two months after surgery he had a lymph nodal relapse along the celiac trunk and caudate lobe,which was histologically confirmed.The postoperative clinical course was uneventful,with a negative follow-up for hematochemical,clinical and radiological investigations at 18 mo post-surgery.Diagnosis of PHCT is based principally on the histopathological confi rmation of a carcinoid tumor and the exclusion of a non-hepatic primary tumor.Surgical resection is the recommended primary treatment for PHCT.Recurrence rate and survival rate in patients treated with resection were 18% and 74%,respectively. | Luigi Maria Fenoglio Sara Severini Domenico Ferrigno Giovanni Gollè Cristina Serraino Christian Bracco Elisabetta Castagna Chiara Brignone Fulvio Pomero Elena Migliore Ezio David Mauro Salizzoni | 2009 | World Journal of Gastroenterology2009，15，19： | 14 |
| 2 | Chemical modification of carbon fiber surfaces显示文摘 | Febo Severini Leonardo Formaro Mario Pegoraro Luca Posca | 2002 | Carbon2002，，5： | 2 |
| 3 | Neither hereditary periodic fever nor periodic fever, aphthae, pharingitis, adenitis: Undifferentiated periodic fever in a tertiary pediatric center显示文摘AIM To describe the frequency and clinical characteristics of patients with undifferentiated periodic fever(UPF) and to investigate whether a clinical classification of UPF based on the PRINTO-Eurofever score can help predicting the response to treatment and the outcome at follow-up.METHODS Clinical and therapeutic information of patients with recurrent fever who presented at a single pediatric rheumatology center from January 2006 through April 2016 were retrospectively collected. Patients with a clinical suspicion of hereditary periodic fever(HPF) syndrome and patients with clinical picture of periodic fever, aphthae, pharingitis, adenitis(PFAPA) who were refractory to tonsillectomy underwent molecular analysis of five HPF-related genes: MEFV(NM_000243.2), MVK(NM_000431.3), TNFRSF1 A(NM_001065.3), NLRP3(NM_001079821.2), NLRP12(NM_001277126.1). All patients who had a negative genetic result were defined as UPF and further investigated. PRINTO-Eurofever score for clinical diagnosis of HPF was calculated in all cases. RESULTS Of the 221 patients evaluated for periodic fever, twelve subjects with a clinical picture of PFAPA who were refractory to tonsillectomy and 22 subjects with a clinical suspicion of HPF underwent genetic analysis. Twenty-three patients(10.4%) resulted negative and were classified as UPF. The median age at presentation of patients with UPF was 9.5 mo(IQR 4-24). Patients with UPF had a higher frequency of aphthae(52.2% vs 0%, P = 0.0026) and musculoskeletal pain(65.2% vs 18.2%, P = 0.0255) than patients with genetic confirmed HPF. Also, patients with UPF had a higher frequency of aphthous stomatitis(52.2% vs 10.7%, P < 0.0001), musculoskeletal pain(65.2% vs 8,0%, P < 0.0001), and abdominal pain(52.2% vs 4.8%, P < 0.0001) and a lower frequency of pharyngitis(56.6% vs 81.3%, P = 0.0127) compared with typical PFAPA in the same cohort. Twenty-one of 23 patients with UPF(91.3%) received steroids, being effective in 16; 13(56.2%) were given colchicine, which was effective in 6. Symptoms resolution occurred in 2 patients with UPF at last follow-up. Classification according to the PRINTOEurofever score did not correlate with treatment response and prognosis. CONCLUSION UPF is not a rare diagnosis among patients with periodic fever. Clinical presentation place UPF half way on a clinical spectrum between PFAPA and HPF. The PRINTOEurofever score is not useful to predict clinical outcome and treatment response in these patients. | Silvia De Pauli Sara Lega Serena Pastore Domenico Leonardo Grasso Anna Monica Rosaria Bianco Giovanni Maria Severini Alberto Tommasini Andrea Taddio | 2018 | World Journal of Clinical Pediatrics2018，7，1： | 2 |
| 4 | Entanglement and discord assisted entropic uncertainty relations under decoherence显示文摘The uncertainty principle is a crucial aspect of quantum mechanics.It has been shown that quantum entanglement as well as more general notions of correlations,such as quantum discord,can relax or tighten the entropic uncertainty relation in the presence of an ancillary system.We explored the behaviour of entropic uncertainty relations for system of two qubits—one of which subjects to several forms of independent quantum noise,in both Markovian and non-Markovian regimes.The uncertainties and their lower bounds,identified by the entropic uncertainty relations,increase under independent local unital Markovian noisy channels,but they may decrease under non-unital channels.The behaviour of the uncertainties(and lower bounds)exhibit periodical oscillations due to correlation dynamics under independent non-Markovian reservoirs.In addition,we compare different entropic uncertainty relations in several special cases and find that discord-tightened entropic uncertainty relations offer in general a better estimate of the uncertainties in play. | YAO ChunMei CHEN ZhiHua MA ZhiHao SEVERINI Simone SERAFINI Alessio | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，9： | 2 |
| 5 | Percutaneous transhepatic biliary drainage in the management of postsurgical biliary leaks in patients with nondilated intrahepatic bile ducts显示文摘 | Cozzi G Severini A Civelli E | 2006 | Cardiovasc In- tervent Radiol2006，29，3： | 1 |
| 6 | Parameters of Integral Circulant Graphs and Periodic Quantum Dynamics显示文摘 | Saxena N Severini S Shparlinski I E | 2007 | International Journal of Quantum Information2007，5，3： | 1 |
| 7 | Familial dilated cardiomyopathy 显示文摘 | Mestroni L Krajinovic M Severini GM | 1994 | Br Heart J1994，72，： | 1 |
| 8 | Lorentz beams and symmetry properties in paraxial optics显示文摘 | Oawhary O E Severini S | 2006 | J Opt A : PureAppl Opt2006，8，5： | 1 |
| 9 | Application of vacuum impregnation techniques to improve the pH reduction of vegetables : study on carrots and eggplants 显示文摘 | Derossi A Pilli T D Severini C | 2013 | Food and Bioprocess Technology2013，6，11： | 1 |
| 10 | Chemical modification of carbon fiber surfaces显示文摘 | Febo Severini Leonardo Formaro Mario Pegoraro | 2002 | Carbon2002，40，5： | 1 |
| 11 | Nested polymerase chain reaction for high-sensitivity detection of enteroviral RNA in biological samples 显示文摘 | Severini GM Mestroni L Falaschi A | 1993 | J Clin Microbiol1993，31，5： | 1 |
| 12 | In situ hybridization analysis of preprotachykinin-A mRNA levels in young and old rats显示文摘 | Pompei P Severini R Costa G | 1999 | Mol Brain Res1999，64，： | 1 |
| 13 | Grafting reaction of methylmethacrylate onto EPR and EPDM rubbers toughening effects of graft copolymers on polycarbonate and poly (methyl methacrylate) 显示文摘 | Severini F Pegoraro M Landro L D | 1991 | Angewandte Makro- molekulare Chemie1991，190，： | 1 |
| 14 | Glutathione S-transferase activity in patients with cancer of digestive tract显示文摘 | Severini G | 1993 | J Cancer Res Clin Oncol1993，120，： | 1 |
| 15 | Spatial and temporal distribution of cadmium and copper in water and zooplankton in the Bahia Blanea estuary, Argentina显示文摘 | FERNANDEZ SEVERINI Yl D BoTFE S E HOFFMEYERM S | 2009 | Estuarine Coastal and Shelf Science2009，85，1： | 1 |
| 16 | TLQP-21,a neuroendocrine VGF-derived peptide, prevents cerebellar granule cells death induced by serum and potassium deprivation 显示文摘 | Severini C Ciotti M T Biondini L | 2008 | Neurochem2008，104，： | 1 |
| 17 | Prevention of enzymatic browning in sliced potatoes by blanching in boiling saline solutions显示文摘 | C Severini A Baiano T De Pilli | 2003 | LWT-Food Science and Technology2003，36，7： | 1 |
| 18 | A randomized, controlled study of thymosin-alpha therapy in patients with anti-HBe, HBV-DNA -positive chronic hepatitis B显示文摘 | Zavaglia C Severini R Tinelli C | 2000 | Dig Dis Sci2000，45，4： | 1 |
| 19 | Chemical modification of carbon fiber surfaces 显示文摘 | Severini Febo Formaro Leonardo Pegoraro Mario | 2002 | Carbon2002，40，4： | 1 |
| 20 | Polymer显示文摘 | Severini F Pegoraro M Yuan L | 1999 | 40:7 0591999，40，： | 1 |
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