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| 1 | Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis显示文摘AIM: Pancreatic regenerating protein (regⅠ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal andβ-cells. This suggests that regⅠand its receptor may play a role in recovery after pancreatic injury. We hypothesized that regⅠand its receptor are induced in acute pancreatitis. METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). RegⅠreceptor mRNA, serum regⅠprotein, and tissue regⅠprotein levels were determined by Northern analysis, enzyme-linked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in regⅠand its receptor. RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum regⅠconcentrations from controls. However, Western blot demonstrated increased tissue levels of regⅠat 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in regⅠreceptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION: Acute pancreatitis results in increased tissue regⅠprotein levels localized to the acinar and ductal cells, and a parallel threefold induction of regⅠreceptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg I and its receptor may be important for recovery from acute pancreatitis. | Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，28： | 19 |
| 2 | Knockdown of RNA Binding Protein Musashi-1 Leads to Tumor Regression In Vivo显示文摘 | Sripathi M. Sureban Randal May Robert J. George Brian K. Dieckgraefe Howard L. McLeod Satish Ramalingam Kumar S. Bishnupuri Gopalan Natarajan Shrikant Anant Courtney W. Houchen | 2008 | Gastroenterology2008，，5： | 1 |
| 3 | Characterization of cecal gene expression in a differentially susceptible mouse model of bacterial - induced inflammatory bowel disease 显示文摘 | Myles MH Dieckgraefe BK Criley JM | 2007 | Inflamm Bowel Dis2007，13，7： | 1 |
| 4 | Reg4‐induced mitogenesis involves Akt‐GSK3β‐β‐Catenin‐TCF‐4 signaling in human colorectal cancer显示文摘 | Kumar S Bishnupuri Satheesh K Sainathan Kislay Bishnupuri Devon R Leahy Qizhi Luo Shrikant Anant Courtney W Houchen Brian K Dieckgraefe | 2014 | Mol Carcinog2014，，1： | 1 |
| 5 | Immune stimulation in Crohn's disease:safty and efficacy of rhuGM-CSF for the treatment of active Crohn's disease显示文摘 | Korzenik J Dieckgraefe B | 2001 | Gastroenenterology2001，1120，： | 1 |
| 6 | ERK and p38 MAP kinase pathways are mediators of intestinal epithelial wound-induced signal transduction显示文摘 | Dieckgraefe BK Weems DM Santoro SA | 1997 | Biochem Biophys Res Commun1997，233，2： | 1 |
| 7 | ERK and p38 MAP kinase pathways are mediators of intestinal epithelial wound-induced signal transduction显示文摘 | Dieckgraefe BK Wessms DM Santoro SA | 1997 | Biochem Biophys Res Commun1997，233，： | 1 |
| 8 | Is Crohn’s Disease an Immunodeficiency?显示文摘 | Joshua R. Korzenik Brian K. Dieckgraefe | 2000 | Digestive Diseases and Sciences2000，，6： | 1 |
| 9 | Growth factors as treatment options for intestinal inflammation显示文摘 | Dieckgraefe B K Korzenik J R Anant S | 2006 | Ann N Y Acad Sci2006，1072，： | 1 |
| 10 | Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues显示文摘 | McDonald KG McDonough JS Dieckgraefe BK | 2010 | Am J Pathol2010，176，5： | 1 |
| 11 | Expression of the regenerating gene family in inflammatory bowel disease mucosa: Reg Iot lpha upregulation, processing, and antiapoptotic activity显示文摘 | Dieckgraefe BK Crimmins DL Landt V | 2002 | J Investig Med2002，50，： | 1 |
| 12 | Molecular biology of the small intestine显示文摘 | Ahuja V Dieckgraefe BK Anant S | 2006 | Curr Opin Gastroenterol2006，22，2： | 1 |
| 13 | Growth factors as treatment options for intestinal inflammation 显示文摘 | Dieckgraefe BK Korzenik JR Anant S | 2006 | Ann N Y Acad Sci2006，1072，： | 1 |
| 14 | Sargramostim for active Crohn's disease显示文摘 | Korzenik JR Dieckgraefe BK Valentine JF | 2005 | N Engl J Med2005，352，： | 1 |
| 15 | Molecular biology of the small intestine显示文摘 | Vineet Ahuja Brian K Dieckgraefe Shrikant Anant | 2006 | Current Opinion in Gastroenterology2006，，2： | 1 |
| 16 | Analysis of mucosal gene expression in inflammatory bowel disease by parallel oligonucleotide arrays 显示文摘 | DIECKGRAEFE B K STENSON W F KORZENIK J R | 2000 | Physiol Genomics2000，4，1： | 1 |
| 17 | Analy- sis of mucosal gene expression in inflammatory bowel dis- ease by parallel oligonucleotide arrays 显示文摘 | Dieckgraefe BK Stenson WF Korzenik JR | 2000 | Physiol Ge- nomics2000，，4： | 1 |
| 18 | Growth factors as treatment options for intestinal inflammation显示文摘 | Dieckgraefe BK Korzenik JR Anant S | 2006 | Ann N Y Acad Sci2006，1072，： | 1 |
| 19 | 沙莫司亭治疗活动性克罗恩病 | Korzenik J.R. Dieckgraefe B.K. Valentine J.F. 刘丽娜 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，9： | 0 |
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