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| 1 | Increased ALK Gene Copy Number and Amplification are Frequent in Non-small Cell Lung Cancer显示文摘 | Marta Salido Lara Pijuan Luz Martínez-Avilés Ana B. Galván Israel Ca?adas Ana Rovira Montserrat Zanui Alejandro Martínez Raquel Longarón Francisco Sole Sergio Serrano Beatriz Bellosillo Murry W. Wynes Joan Albanell Fred R. Hirsch Edurne Arriola | 2011 | Journal of Thoracic Oncology2011，，1： | 1 |
| 2 | Postoperative radiotherapy in resected non-small cell lung cancer:The never-ending story显示文摘This manuscript collects in a joint and orderly manner the existing evidence at the present time about postoperative treatment with radiotherapy in non-small cell lung cancer.It also systematically reviews the current evidence,the international recommendations in the most relevant guidelines,the most controversial aspects in clinical and pathological staging,the specific technical aspects of radiotherapy treatment,and also collects all the potential risk factors that have been postulated as significant in the prognosis of these patients,evaluating the possibility of segmenting a particularly sensitive subpopulation with a high risk of relapse on which an adjuvant treatment with radiotherapy could have an impact on their clinical evolution.Finally,currently active trials that aspire to provide more evidence on this topic are reviewed. | Javier Serrano Patricia Calvo Crespo Begoña Taboada Ana Alvarez Gonzalez Rafael Garcia García Antonio Gomez Caamaño Juan Carlos Trujillo Reyes Xabier Mielgo-Rubio Felipe Couñago | 2021 | World Journal of Clinical Oncology2021，12，10： | 1 |
| 3 | Interventional radiology treatment for pulmonary embolism显示文摘Venous thromboembolism(VTE) is an illness that has a potentially life-threatening condition that affects a large percentage of the global population. VTE with pulmonary embolism(PE) is the third leading cause of death after myocardial infarction and stroke. In the first three months after an acute PE, there is an estimated 15% mortality among submassive PE, and 68% mortality in massive PE. Current guidelines suggest fibrinolytic therapy regarding the clinical severity, however some studies suggest a more aggressive treatment approach. This review will summarize the available endovascular treatments and the different techniques with its indications and outcomes. | Miguel A De Gregorio Jose A Guirola Celia Lahuerta Carolina Serrano Ana L Figueredo William T Kuo | 2017 | World Journal of Radiology2017，9，7： | 1 |
| 4 | Alternative Raw Materials and Pulping Process Using Clean Technologies 显示文摘 | Jimenez L Rodriguez Alcjandro Perez A Moral Ana Serrano Luis | 2008 | Ind Crop Prod2008，28，1： | 1 |
| 5 | Looking backward to look forward: water use and economic growth from a long-term perspective显示文摘 | Rosa Duarte Vicente Pinilla Ana Serrano | 2014 | Applied Economics2014，，2： | 1 |
| 6 | Design and implementation of synchronization and AGC for OFDM-based WLAN receivers 显示文摘 | Victor P Gil Jimenez M Julia Femandez-Getino Garcia Francisco J Gonzaez Serrano and Ana Garcia Amada | 2004 | IEEE Transaction on Consumer Electronics2004，50，4： | 1 |
| 7 | Is there an environmental Kuznets curve for water use?A panel smooth transition regression approach显示文摘 | ROSA DUARTE VICENTE PINILLA ANA SERRANO | 2013 | Economic Modelling2013，31，1： | 1 |
| 8 | Quality fruit improvement in sweet pepper culture by bumblebee pollination显示文摘 | Ana Roldán Serrano José M. Guerra-Sanz | 2006 | Scientia Horticulturae2006，，2： | 1 |
| 9 | GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK显示文摘 | Beiroa Daniel Imbernon Monica Gallego Rosalía Senra Ana Herranz Daniel Villarroya Francesc Serrano Manuel Fern? Johan Salvador Javier Escalada Javier Dieguez Carlos Lopez Miguel Frühbeck Gema Nogueiras Ruben | 2014 | Diabetes2014，，10： | 1 |
| 10 | The FOXO1 -miR27 Tandem Regulates Myometrial Invasion in Endometrioid Endometrial Adenocarcinoma显示文摘 | Ana Mozos Lluis Catasús Emanuela D’Angelo Elena Serrano I?igo Espinosa Irene Ferrer Cristina Pons Jaime Prat | 2013 | Human Pathology2013，，： | 1 |
| 11 | Isotretinoin was not associated with depression or anxiety:A twelve-week study显示文摘AIM: To investigate the frequency and severity of depression and/or anxiety in isotretinoin(ITT)-treated subjects and in a non-ITT control group. METHODS: Sixty consecutively-admitted non-psychiatric outpatients with acne were assigned to either ITT at a fixed dose of 30 mg/d(n = 36) or 'other treatment' group(OT; n = 24). The Zung depression or anxiety scales(with cut-off points), two locally developed scales for depression(Ge Depr) and anxiety(Ansilet)(without cut-off points) and clinical global impression scales of acne severity were administered at baseline and at weeks 6 and 12 of treatment. Data was analyzed with the chi-squared test and covariance analysis. RESULTS: Gender distribution, age, marital status and education level did not differ between both treatment groups. The frequency of depression, as defined by the Zung scale cut-off points was similar in the ITT and in the non-ITT groups: Weeks 6 and 12: 8.3% in both groups, P = 0.9. The frequency of anxiety was similar in the groups as well: Week 6: ITT = 8.3%; OT = 0.0%, P > 0.05; week 12: ITT = 11.1%, OT = 4.2%, P > 0.05. The scores in both scales' sets did not differ between the treatment groups at any evaluation time point(P> 0.05). Five ITT-treated subjects(13.8%) and two from the OT-treated group(8.3%) developed clinically significant anxiety and/or depression during treatment(P > 0.05). CONCLUSION: Our study confirms the safety of ITT regarding psychological side effects in regular dermatological patients. Susceptible subjects may exist but their identification requires additional strategies. | Bella Suarez Ana Serrano Yves Cova Trino Baptista | 2016 | World Journal of Psychiatry2016，6，1： | 0 |
| 12 | 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases显示文摘We describe the development of quinolylnitrones(QNs)as multifunctional ligands inhibiting cholinesterases(ChEs:acetylcholinesterase and butyrylcholinesterase—h BChE)and monoamine oxidases(hMAO-A/B)for the therapy of neurodegenerative diseases.We identified QN 19,a simple,low molecular weight nitrone,that is readily synthesized from commercially available 8-hydroxyquinoline-2-carbaldehyde.Quinolylnitrone 19 has no typical pharmacophoric element to suggest ChE or MAO inhibition,yet unexpectedly showed potent inhibition of h BChE(IC50=1.06±0.31 nmol/L)and h MAO-B(IC_(50)=4.46±0.18μmol/L).The crystal structures of 19 with hBChE and hMAO-B provided the structural basis for potent binding,which was further studied by enzyme kinetics.Compound 19 acted as a free radical scavenger and biometal chelator,crossed the blood—brain barrier,was not cytotoxic,and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's disease.In addition,in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and coordination.Importantly,chronic treatment of double transgenic APPswe-PS1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice,underscoring the disease-modifying effect of QN 19. | Damijan Knez Daniel Diez-Iriepa Mourad Chioua Andrea Gottinger Milica Denic Fabien Chantegreil Florian Nachon Xavier Brazzolotto Anna Skrzypczak-Wiercioch Ane Meden Anja Pilar Janko Kos Simon akelj Jure Stojan Kinga Saat Julia Serrano Ana Patricia Fernández Aitana Sánchez-García Ricardo Martínez-Murillo Claudia Binda Francisco López-Muoz Stanislav Gobec JoséMarco-Contelles | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 0 |
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