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| 1 | Alcoholic hepatitis 2010:A clinician's guide to diagnosis and therapy显示文摘Alcoholic hepatitis(AH)remains a common and life threatening cause of liver failure,especially when it is severe.Although the adjective'acute'is frequently used to describe this form of liver injury,it is usually subacute and has been developing for weeks to months before it becomes clinically apparent.Patients with this form of alcoholic liver disease usually have a history of drinking heavily for many years.While certain aspects of therapy,mainly nutritional support and abstinence are well established,significant debate has surrounded the pharmacologic treatment of AH,and many institutions practice widely varying treatment protocols. In recent years a significant amount of literature has helped focus on the details of treatment,and more data have accumulated regarding risks and benefits of pharmacologic treatment.In particular,the efficacy of pentoxifylline has become increasingly apparent,and when compared with the risks associated with prednisolone,has brought this drug to the forefront of therapy for severe AH.This review will focus on the clinical and laboratory diagnosis and pharmacologic therapies that should be applied during hospitalization and continued into outpatient management.We conclude that the routine use of glucocorticoids for severe AH poses significant risk with equivocal benefit,and that pentoxifylline is a better,safer and cheaper alternative.While the full details of nutritional support lie beyond the scope of this article,nutrition is a cornerstone of therapy and must be addressed in every patient diagnosed with AH. Finally,while traditional psychosocial techniques play a major role in post-hospitalization care of alcoholics, we hope to make the medical clinician realize his or her role in reducing recidivism rates with early and frequent outpatient visits and with the use of baclofen to reduce alcohol craving. | Maziyar Amini Bruce A Runyon | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 2 | Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with, firsthand examples显示文摘纳米技术在药交货广泛地被使用了改进各种各样的疾病的治疗学的结果。巨大的努力在与他们的生物命运和函数的关系集中于 nanoparticles 的物理化学的性质的新奇 nanoparticles 和描述的开发。然而在这些基于纳米技术的药交货系统的设计和评估,交付的药的药理学并且(patho-) 主人的生理学收到了更少的注意。在这评论,我们讨论集成于使纳米技术能的药交货系统和治疗的设计的重要药理学机制,生理的特征,和病理学的因素。第一手的例子被举由利用 1 为癌症治疗说明如此的综合设计策略的原则和优点)到克服的multidrug抵抗的癌症的药药和 drug-nanomaterial 联合的细胞内部的 synergistic 相互作用, 2 )循环系统到的血流动方向为肺转移最大化药交货到肿瘤 neovasculature 和房间 overexpressing integrin 受体, 3 )装饰 nanocarriers 和 t 的内长的脂蛋白关于在糖尿病管理的申请,一个使纳米技术能的靠近环的胰岛素交货系统被设计在生理地相关的时间规模和葡萄糖层次提供动态胰岛素版本。和另外的研究结果,这些例子建议药理学的相互影响的那利用,(patho-) 生理学和纳米技术是一条灵巧的途径与高效率和翻译潜力开发创新的药交货系统和治疗。 | Rui Xue ZHANG Jason LI Tian ZHANG Mohammad A AMINI Chunsheng HE Brian LU Taksim AHMED HoYin LIP Andrew M RAUTH Xiao Yu WU | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 3 | Enantioseparation of local ananesthetic drugs by capillary zone electrophoresis with cyclodextrins as chiral selectors using a partial filling technique显示文摘 | Amini A Paulsen-Sorman U | 1997 | Electrophoresis1997，18，： | 2 |
| 4 | Photophobia in a blind patient : an alternate visual pathway : case report 显示文摘 | Amini A Digre K Couldwell WT | 2006 | J Neurosurg2006，105，： | 1 |
| 5 | Anatomical ibject volumes from deformable B-spline surface models显示文摘 | Huang Jiantao Amir A Amini | 1998 | IEEE Trans on Image Processing1998，7，2： | 1 |
| 6 | Using dynamic programming for solving variational problems in version显示文摘 | AMINI A A WEYMOUTH T E JAIN R C | 1990 | Pattern Analysis and Machine Intelligence1990，12，9： | 1 |
| 7 | Dynamic interspinous process stabilization:Review of complications associated with the X-STOP device显示文摘 | Bowers C Amini A Dailey AT | | 0，，06： | 1 |
| 8 | The Role of the Psychological Capital on Quality of Work Life and Organi- zation Performance显示文摘 | Mortazavi S Yazdi S V S & Amini A | 2012 | Interdisciplinary Journal of Con- temporary Research in Business2012，4，2： | 1 |
| 9 | Syndrome of inappropriate secretion of antidiuretic hormone and hyponatremia after spinal surgery显示文摘 | Amini A Schmidt MH | 2004 | Neurosurg Focus2004，16，4： | 1 |
| 10 | Factor Ⅸ complex for the correction of traumatic coagulopathy 显示文摘 | Joseph B Amini A Friese RS | 2012 | J Trauma Acute Care Surg2012，72，4： | 1 |
| 11 | Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer显示文摘 | Welsh JW Komaki R Amini A | 2013 | J Clin Oncol2013，31，7： | 1 |
| 12 | Using dynamic programming for solring variational problems in vision 显示文摘 | Amini A A Weymouth T E Jain T C | 1990 | IEEE Trans on Patten analysis and machine intelligence1990，12，9： | 1 |
| 13 | N-acetylcysteine does not preventcontrast-induced nephropathy after cardiac catheterization in patientswith diabe-tesmellitus and chronic kidney disease:a randomized clinical trial显示文摘 | Amini M Salarifar M Amirbaigloo A | 2009 | Trials2009，，10： | 1 |
| 14 | Clinical efficacy of sublin- gual captopril in the treatment of hypertensi-e urgency 显示文摘 | Kazerani H Hajimoradi B Amini A | 2009 | Singapore Med J2009，50，4： | 1 |
| 15 | Accelerated hypofractionated radia-tion therapy compared to conventionally fractionated radiation therapyfor the treatment of inoperable non-small cell lung cancer 显示文摘 | Amini A Lin SH Wei C | 2012 | RadiatOncol2012，7，： | 1 |
| 16 | The effects of LIF and EGF on mouse oocyte maturation, fertilization and development in vitro显示文摘 | Amiri I Mirahadi N Amini A | 2009 | IranJ Reprod Med2009，7，4： | 1 |
| 17 | Evaluation of eating habits in dys-peptic patients with or without helicobacter pylori infection显示文摘 | Amini M Karbasi A Khedmat H | 2009 | Trop-ical Gastroenterology2009，30，3： | 1 |
| 18 | Rings over which flat covers of finitely generated modules are projective显示文摘 | Amini A Ershad M Sharif H | | 0，，： | 1 |
| 19 | Influence of different cryotreatments on tribological behavior of 80CrMo12 5 cold work tool steel显示文摘 | Amini K Nategh S Shafyei A | 2010 | Materials and Design2010，31，： | 1 |
| 20 | Surgical management of hepatic hemangiomas: a multi-institutional experience 显示文摘 | Miura J T Amini A Schmocker R et at | 2014 | HPB (Oxford)2014，16，10： | 1 |
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