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| 1 | 在动态血压得到控制的老年高血压患者中非杓型血压和晨峰的预后价值显示文摘动态血压已控制的高血压患者中非杓型血压和晨峰的独立预后意义还不清楚。研究者在接受治疗且动态血压正常的老年高血压患者中调查动态血压参数与心血管病风险之间的关系。 | Pierdomenico SD Pierdomenico AM Coccina F Lapenna D Porreca E 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，10： | 9 |
| 2 | Oligodendroglioma: CD44 as a possible prognostic opportunity显示文摘CD44, in its standard form as well in its isoforms, is a cell surface adhesion glycoprotein which occurs in a widevariety of non-neoplastic and neoplastic ceils. CD44 has been considered to be implicated in tumoral growth andin metastatic potential. We studied the immunohistochemical expression of CD44 standard in 30 oligodendrogliomas(19 primary lesions and 11 recurrences) in order to verify its possible prognostic role. Twelve primary oligoden- | Buccoliero AM Caldarella A Arganini L Mennonna P Ammanati F Taddei A Taddei GL | 2003 | 中国神经肿瘤杂志2003，1，3： | 8 |
| 3 | 母亲妊娠期焦虑抑郁对孩子应激性心率及血压的影响显示文摘心理障碍,包括焦虑和抑郁在妊娠期间十分常见。该研究目的在于确定母亲的这些心理障碍是否会对后代的心血管反应产生影响。方法:对231名孕妇的心理状态进行评定,在其后代(n=216)7~9岁时进行视频压力反应测试。测定静息时、观看压力视频时和恢复期的心率及血压水平。 | 刘莉 叶鹏 Fan F Zou Y Tian H Zhang Y Zhang J Ma X Meng Y Yue Y Liu K Dart AM | 2015 | 中华高血压杂志2015，23，6： | 5 |
| 4 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 5 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 6 | In situ liver transection with portal vein ligation for rapid growth of the future liver remnant in two‐stage liver resection显示文摘 | W. T. Knoefel I. Gabor A. Rehders A. Alexander M. Krausch J. Schulte am Esch G. Fürst S. A. Topp | 2012 | Br J Surg2012，，3： | 2 |
| 7 | Identification of mycobacteria and other acid fast organisms associated with pulmonary disease显示文摘 | AE Ani B Diarra UR Dahle C Lekuk F Yetunde AM Somboro Tounkara Anatole J Idoko | 2011 | Asian Pacific Journal of Tropical Disease2011，，4： | 2 |
| 8 | Interactions between triazoles andamphotericin B against cryprococcus neoformans显示文摘 | Barchiesi F Schimizzi AM Caselli F | 2000 | Antimierob Agents Chemother2000，44，9： | 1 |
| 9 | Assessment of hepatic perfusion parameters with dynamic MRI显示文摘 | Mateme B Smith AM Peelers F | 2002 | Mngn Rason Med2002，47，： | 1 |
| 10 | Laparoscopic cholecystectomy and common bile duct exploration are safe for older patients 显示文摘 | Paganini AM Feliciotti F Guerrieri M | 2002 | Surg Endosc2002，16，9： | 1 |
| 11 | Magnetic resonance imaging of cartilaginous tumors:a retrospective study of 79 patients显示文摘 | De Beuckeleer LH De Schepper AM Ramon F | 1995 | Eur J Radiol1995，21，1： | 1 |
| 12 | Laparoscopic vs openhemicolectomy for colon cancer显示文摘 | Lezoche E Feliciotti F Paganini AM | 2002 | Surg Endosc2002，16，59： | 1 |
| 13 | Importance of a reliable admission Glasgow coma scale for determining the need of evacuation of posttraumatic subdural hematomas: a prospective study of 65 patients显示文摘 | Servadei F Nasi MT Cremonini AM | 1998 | J Trauma1998，44，： | 1 |
| 14 | Adipocyte differentiation of multipotent cells established from human adipose tissue显示文摘 | Elabd C Delteil F | 2004 | Biochem Biophys Res Commun2004，315，2： | 1 |
| 15 | Effinacy of hepatitis C core antigen detection during the preneroconversion window 显示文摘 | Courouce AM Le Marrec N Bouehardeau F | 2000 | Tranfusion2000，40，： | 1 |
| 16 | I'm still waiting:Barriers to accessing cardiac rehabilitation services显示文摘 | Tod AM Lacey EA McNeill F | 2002 | J Adv Nurs2002，40，4： | 1 |
| 17 | Predictors of prolonged me-chanical ventilation in a cohort of 3,269 CABG patients 显示文摘 | Cislaghi F Condemi AM Corona A | 2007 | Mi- nerva Anestesiol2007，73，12： | 1 |
| 18 | Mutagen sensitive and cancer susceptibility in patients with multiple primary cancers 显示文摘 | Cianciulli AM Venture I Leonado F | 1995 | Oncol REP1995，2，： | 1 |
| 19 | GIMEMA-AIEOP AIDA protocol for the treatment of newly diagnosed promyelocytic leukemia in children显示文摘 | Testi AM Lo-Coco F Biondi A | 2005 | Blood2005，106，2： | 1 |
| 20 | Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor显示文摘 | Ramesh R Mhashilkar AM Tanaka F | 2003 | Cancer Res2003，63，16： | 1 |
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