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| 1 | Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin显示文摘AIM:To examine the influence of ghrelin on the regenerative potential of gastrointestinal(GI)epithelium.METHODS:Damage to GI epithelium was induced in mice by two intravenous injections of doxorubicin(10 and 6 mg/kg).Some of the doxorubicin-treated mice received a continuous subcutaneous infusion of ghrelin(1.25μg/h)for 10 d via implanted mini-osmotic pumps.To label dividing stem cells in the S-phase of the cell cycle,all mice received a single intraperitoneal injection of 5'-bromo-2'-deoxyuridine(BrdU)one hour before sacrifice.The stomach along with the duodenum were then removed and processed for histological examination and immunohistochemistry using anti-BrdU antibody.RESULTS:The results showed dramatic damage to the GI epithelium 3 d after administration of chemotherapy which began to recover by day 10.In ghrelintreated mice,attenuation of GI mucosal damage was evident in the tissues examined postchemotherapy.Immunohistochemical analysis showed an increase in the number of BrdUlabeled cells and an alteration in their distribution along the epithelial lining in response to damage by doxorubicin.In mice treated with both doxorubicin and ghrelin,the number of BrdUlabeled cells was reduced when compared with mice treated with doxorubicin alone.CONCLUSION:The present study suggests that ghrelin enhances the regenerative potential of the GI epithelium in doxorubicintreated mice,at least in part,by modulating cell proliferation. | Mohamed A Fahim Hazem Kataya Rkia El-Kharrag Dena AM Amer Basel al-Ramadi Sherif M Karam | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 2 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 3 | The required number of treatment imaging days for an effective off-line correction of syst- ematic errors in conformal radiotherapy of prostatecancer a radiobiological analysis显示文摘 | Amer AM Mackay RI Roberts SA | 2001 | Radiother Oncol2001，61，2： | 1 |
| 4 | Oxidative stress during erythropoietin hyporesponsiveness anemia at end stage renal disease:Molecular and biochemical studies显示文摘 | Khalil SK Amer HA El Behairy AM | 2016 | J Adv Res2016，7，3： | 1 |
| 5 | Cervical tracheal resec- tion with cricotracheal anastomosis: experience in adults with grade III-IV tracheal stenosis显示文摘 | El-Fattah AM Kamal E Amer HE | 2011 | J Laryngol Otol2011，125，6： | 1 |
| 6 | Correlation be- tween ankle brachial index and coronary artery disease severity in elderly egyptians显示文摘 | Amer MS Tawfik HM Elmoteleb AM | 2014 | Angiology2014，65，10： | 1 |
| 7 | Relationship betweenankle brachial index and ejection fraction in elderly Egyptians withischemic heart disease显示文摘 | Amer MS Tawfik HM Abd Elmotteleb AM | 2015 | Geriatr Gerontol Int2015，15，4： | 1 |
| 8 | Cancer chemopreventive and anti-inflammatory activities of chemically modifled guar gum显示文摘 | Gamal-Eldeen AM Amer H Helmy WA | 2006 | Chem Biol Interact2006，161，3： | 1 |
| 9 | The required number oftreatment imaging days for an effective off-line correction of systematicerrors in conformal radiotherapy of prostate cancer^a radiobiological a-nalysis显示文摘 | Amer AM Mackay RI Roberts SA | 2001 | Badiother Oncol2001，61，2： | 1 |
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