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| 1 | Anti-pancreatic antibody in Turkish patients with inflammatory bowel disease and first-degree relatives显示文摘AIM: To identify the role of anti-pancreatic antibody (PAB) in the diagnosis of inflammatory bowel diseases (IBD) among Turkish patients, and its frequency in firstdegree relatives.METHODS: PAB and anti-Saccharomyces cerevisiae (ASCA) were examined in serum samples of 214 subjects including patients with Crohn's disease (CD, n = 64), ulcerative colitis (UC, n = 63), first-degree relatives of patients with CD (n = 25), first-degree relatives of patients with UC (n = 28),and a control group with gastrointestinal symptoms other than (IBD) (n = 34) by indirect immunofluorescence Positivity of PAB and ASCA was compared in terms of Vienna classification, disease activity and medications used.RESULTS: In terms of PAB positivity, no difference was found between patients with CD (14.1%) and UC (7.9%) however, significant difference was observed between patients with CD and subjects in the control group (P < 0.05). No difference was found between patients with CD and their relatives in terms of ASCA positivity, whereas a significant difference was found between other groups (P < 0.001). Compared to ASCA, the sensitivity of the PAB was 19% (7/37), its specificity was 93% (25/27), positive predictive value was 77% (7/9) and negative predictive value was 45% (25/55). ASCA was found with significantly higher prevalence in patients with CD activity index > 150 (P < 0.05).CONCLUSION: PAB is valuable in the diagnosis of IBD rather than CD, but cannot be used alone for diagnostic purposes. PAB is not superior to ASCA in CD diagnosis and in detecting CD among relatives of patients with CD. | Huseyin Demirsoy Kamil Ozdil Ozdal Ersoy Besir Kesici Cetin Karaca Canan Alkim Nihat Akbayir Levent Kamil Erdem Mehmet Derya Onuk Hulya Tugrul Beyzadeoglu | 2010 | World Journal of Gastroenterology2010，16，45： | 3 |
| 2 | A fast and adaptive automateddisease diagnosis method with an innovative neural network model显示文摘 | ALKIM E GURBOZ E KILIQ E | 2012 | Neural Netw2012，33，： | 1 |
| 3 | Infliximab- and azathioprine-related severe neutropenia and thrombocytopenia in a case with Crohn's disease 显示文摘 | Kuksal AR Alkim C Altinkaya E | 2011 | Turk J Gastroenterol2011，22，5： | 1 |
| 4 | A case report of doxycycline induced esophageal and gastric ulcer显示文摘 | Akbayir N Alkim C Erdem L | 2002 | Turk J Gastroenterol2002，13，4： | 1 |
| 5 | Infliximab- and azathioprine-related severe neutropenia and thrombocytopenia in a case with Crohn's disease 显示文摘 | Koksal A R Alkim C Altinkaya E | 2011 | Turk J Gastroenterol2011，22，5： | 1 |
| 6 | Continuous active state of coagula- tion system in patients with nonthrombotic inflammatory bowel disease显示文摘 | Alkim H Ayaz S Alkim C | 2011 | Clin Appl Thromb Hemost2011，17，： | 1 |
| 7 | Hemodynamic changes during gaseous and gasless laparoscopic cholecystectomy 显示文摘 | KorkmazA AlkiM HamamciO a al | 2002 | Surg Today2002，32，8： | 1 |
| 8 | Thrombospondin-1 and VEGF in inflammatory bowel disease 显示文摘 | Alkim C Sakiz D Alkim H | 2012 | Libyan J Med2012，7，： | 1 |
| 9 | Omeprazole inhibits natural killer cell functions 显示文摘 | Alkim H Unal S Okur H | 2008 | Dig Dis Sci2008，53，： | 1 |
| 10 | Is There Any Relationship Between Hepatitis C Virus and Vitiligo?显示文摘 | Nihat Akbayir Gonca G?kdemir Tülin Mansur Mehmet S?kmen Sevil Gündüz Canan Alkim Burcu Barutcuoglu Levent Erdem | 2004 | Journal of Clinical Gastroenterology2004，，9： | 1 |
| 11 | Infliximab-and azathioprine-related severe neutropenia and thrombocytopenia in a case with Crohn's disease显示文摘 | Koksal AR Alkim C Altinkaya E | 2011 | Turk J Gastroenterol2011，22，5： | 1 |
| 12 | Hemostatic abnormalities in cirrhosis and tumor-related portal vein thrombosis 显示文摘 | Alkim H Ayaz S Zhu HL | 2012 | Clinical and Applied Thrombosis-Hemostasis2012，18，4： | 1 |
| 13 | Serum complement C4 in chronic hepatitis C:correlation with histopathologic findings and disease activity显示文摘 | Bu(g)daci MS Karaca C Alkim C | | 0，，01： | 1 |
| 14 | Heterotopic gastric mucosa in the cervical esophagus (inlet patch): endoscopic prevalence, histological and clinical characteristics 显示文摘 | AKBAYIR N ALKIM C ERDEM L | 2004 | J Gas-troenteml Hepatol2004，19，8： | 1 |
| 15 | Continuous active state of coagulation system in patients with nonthrombotic inflammatory bowel diseases 显示文摘 | Alkim H Ayaz S | 2011 | J Clin Appl Thromb Hemost2011，56，9： | 1 |
| 16 | Could complement C4 be an alternative to biopsy for chronic hepatitis B histopathologic findings显示文摘 | Bugdaci MS Alkim C Karaca C | | 0，，05： | 1 |
| 17 | Expression of p53, VEGF, Microvessel Density, and Cyclin-D1 in Noncancerous Tissue of Inflammatory Bowel Disease显示文摘 | Canan Alkim Berna Savas Arzu Ensari Huseyin Alkim Ulku Dagli Erkan Parlak Aysel Ulker Burhan Sahin | 2009 | Digestive Diseases and Sciences2009，，9： | 1 |
| 18 | Isolation of cobalt hyperresistant mutants of Saccharomyces cerevisiae by in vivo evolutionary engineering approach显示文摘 | Cakar Z P Alkim C Turanh B Tokmen N Akman S Sankaya M Tamerler C Benbadis L Fran(c)ois J M | | 0，，02： | 1 |
| 19 | Effectiveness of ranitidine bismuth citrate and proton pump inhibitor based triple therapies of Helicobacter pylori in Turkey显示文摘 | Alkim H Iscan M Oz F | 2011 | Libyan J Med2011，，： | 1 |
| 20 | Acute phase protein levels in pregnancy and oestrus cycle in bitches显示文摘 | Pinar Alkim Ulutas Bayazit Musal Funda Kiral | 2009 | Research Veterinary Science2009，86，3： | 1 |
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