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| 1 | Bio-inspired adhesive porous particles with human MSCs encapsulation for systemic lupus erythematosus treatment显示文摘Mesenchymal stem cells(MSCs)therapy is a promising treatment for Systemic lupus erythematosus(SLE)patients.However,this method is encumbered by suboptimal phenotype of MSCs used in clinical settings,and a short in vivo persistence time.Herein,inspired by the natural microstructure of the sand tower worm nest,we proposed novel adhesive porous particles with human MSCs encapsulation via microfluidic electrospray technology for SLE treatment.The porous microparticles were formed by immediate gelation reaction between sodium alginate(ALG)and poly-D-lysine(PDL),and then sacrificed polyethylene oxide(PEO)to form the pores.The resultant microparticles could protect MSCs from immune cells while maintain their immune modulating functions,and achieve rapid exchange of nutrients from the body.In addition,owing to the electrostatic adsorption and covalent bonding between PDL and tissues,the porous microparticles could adhere to the bowel surfaces tightly after intraperitoneal injection.Through in vivo imaging system(IVIS)methods and in vivo study,it was demonstrated that the MSCs-encapsulated porous adhesive microparticles could significantly increase the cellular half-life,turn activated inflammatory macrophages into an anti-inflammatory profile,and ameliorate disease progression in MRL/lpr mice.Thus,the MSCs-encapsulated porous microparticles showed distinctive functions in chronic SLE treatment,with additional potential to be used in a variety of biomedical applications. | Min Nie Guopu Chen Cheng Zhao Jingjing Gan Mihribangvl Alip Yuanjin Zhao Lingyun Sun | 2021 | Bioactive Materials2021，6，1： | 2 |
| 2 | Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease显示文摘 | Kausik Das Kshaunish Das Partha S. Mukherjee Alip Ghosh Sumantra Ghosh Asit R. Mridha Tapan Dhibar Bhaskar Bhattacharya Dilip Bhattacharya Byomkesh Manna Gopal K. Dhali Amal Santra Abhijit Chowdhury | 2010 | Hepatology2010，，： | 2 |
| 3 | Genetics and epigenetics of aging and longevity显示文摘 | Moskalev AA Aliper AM Smit-Mc Bride Z | 2014 | Cell Cycle2014，13，7： | 1 |
| 4 | Isolated noncompaction of the ventricular myocardium:contemporary diagnosis and management显示文摘 | Chrissoheris MP Alip R Vivas Y | 2007 | Clic cardiol2007，30，4： | 1 |
| 5 | Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans 显示文摘 | Tripathi G Wiltshire C Macaskill S Tournu H Budge S Brown ALIp | 2002 | EMBO J2002，21，20： | 1 |
| 6 | Signaling pathway activation profiles make better markers of cancer than expression of individual genes显示文摘 | Borisov N M Terekhanova N V Aliper A Mv Venkova L Sv Smirnov P Y Roumiantsev Sv | 2014 | Oncotarget2014，5，10： | 1 |
| 7 | A method for predicting target drug efficiency in cancer based on the analysis of signaling pathway activation显示文摘 | Artemov A Aliper A Korzinkin M | 2015 | Oncotarget2015，6，29： | 1 |
| 8 | Isolated noncompaction of the ventricular myocardlium:contemporary diagnosis and manasemerit显示文摘 | Chrissoheris M P Alip R Vivas Y | | 0，，04： | 1 |
| 9 | Potential of a mixture of eugenol and garlic tincture to improve performance and intestinal health in broilers under necrotic enteritis challenge显示文摘Plant extracts(PE)are gaining increased attention as potential alternatives to in-feed antimicrobials(AM)due to their known antimicrobial activities.This study was conducted to examine the potential of PE,a microencapsulated product composed of eugenol and garlic tincture as an alternative to AM-agent on performance and intestinal health in broilers under necrotic enteritis(NE)challenge.A total of 960 dayold mixed-sex Cobb 500 chicks were randomly distributed to 48-floor pens with 6 treatments replicated 8 times with 20 birds each.The 6 treatments were as follows:UC,unchallenged control;CC,challenged control;PE,challenged group plus PE;AM,challenged group plus AM;FAP,challenged group plus a full dose of AM with PE;HAP,challenged group plus a half dose of AM with PE in starter,grower and finisher phases.Birds in the challenged groups were inoculated with Eimeria spp.on d 9 and Clostridium perfringens on d 14.The body weight gain(BWG),feed intake(FI),feed conversion ratio(FCR),and livability of birds were compromised,and intestinal lesions and mortality were increased(P<0.05)by NE challenge,illustrating a successful clinical NE challenge.Birds fed AM had higher BWG and FI,and lower FCR,mortality,and intestinal lesions compared to the CC group(P<0.05).Birds fed PE had improved FCR(P<0.05)and livability(5.8%)in an overall period compared to the CC group.On d 16,PE supplementation reduced ileal lesion scores in only male birds(P<0.05).Birds fed PE had decreased Eimeria maxima and Eimeria acervulina oocyst counts in caecal content(P<0.05).Birds fed PE had decreased Eimeria brunetti and total oocyst counts in caecal content,and E.acervulina oocyst counts in ileal content in only female birds(P<0.05).On d 35,PE supplementation reduced variation of BW in both male and female birds and increased yellowness(b*value,14.4%)in the thigh.These findings suggest the potential of PE supplementation in diets to improve the performance and intestinal health of birds under clinical NE as indicated by improved FCR,livability,uniformity,reduced ileal lesions,oocyst counts and increased skin yellowness.However,the protective effect of PE may not be apparent in the presence of AM in the feed. | Alip Kumar Nishchal K.Sharma Sarbast K.Kheravii Chake Keerqin Catherine Ionescu Alexandra Blanchard Shu-Biao Wu | 2022 | Animal Nutrition2022，，1： | 1 |
| 10 | Isolation of peplomer glycoprotein E2 of transmissible gastroenteritis virus and application in enzyme-linked immunosoebent assay显示文摘 | Rukhadze G G Aliper T I Sergeer V A | 1989 | J Clin Microbiol1989，27，8： | 1 |
| 11 | Organic acid blends improve intestinal integrity,modulate short-chain fatty acids profiles and alter microbiota of broilers under necrotic enteritis challenge显示文摘Controlling enteric diseases of broilers is crucial.Among many additives,organic acids(OA)and their blends are gaining attention to combat diseases in the post-antibiotic era.The current study evaluated the potentials of short-chain fatty acids(SCFA)and medium-chain fatty acids(MCFA)blends and/or phenolic compounds on intestinal integrity,intestinal pH,caecal microbiota,and caecal SCFA profiles of broilers under necrotic enteritis(NE)challenge.The additives used were:(A)a blend of SCFA,MCFA,and a phenolic compound(SMP),(B)a blend of free and buffered SCFA with MCFA(SMF),and(C)a blend of free and buffered SCFA with a high concentration of MCFA(SHM).A total of 1,404 male parental chicks of Ross 308 broilers were randomly allocated to 78 floor pens on hatching day with 6 treatments replicated 13 times with 18 birds per pen.The treatments were:UCC,unchallenged control;CHC,challenged control;BAC,challenged group plus zinc bacitracin;SMP,challenged group plus additive SMP;SMF,challenged group plus additive SMF;SHM,challenged group plus additive SHM.Birds were challenged with field-strain Eimeria spp.on d 9 and Clostridium perfringens on d 14.Birds challenged with NE increased fluorescein isothiocyanate dextran(FITC-d)concentration in serum,reduced acetate and butyrate concentrations,and increased Bacteroides and C.perfringens load in the caeca(P<0.05).Birds fed additives decreased FITC-d from gut to serum,reduced Bacteroides(d 16,P<0.05)and numerically reduced C.perfringens load compared to CHC group.Birds fed additive SHM had higher concentrations of acetate and butyrate(d 21,P<0.05)than CHC group but were not different from SMP and SMF groups.All the additives exhibited similar intestinal protection against NE compared to the BAC group indicated by FITC-d concentration in serum,acetate,propionate and butyrate concentrations in the caeca,and caecal bacterial loads except for the C.perfringens(P>0.05).The SMP group had a higher load compared to BAC(P<0.05).These findings suggest the promising effects of OA blends as alternatives to BAC to ameliorate the impact of NE challenge of broilers as indicated by improved intestinal health. | Alip Kumar Mehdi Toghyani Sarbast K.Kheravii Lane Pineda Yanming Han Robert A.Swick Shu-Biao Wu | 2022 | Animal Nutrition2022，，1： | 1 |
| 12 | Assessing the impact of massive out-migration on Albanian agriculture显示文摘 | Nancy M Calogero C Alip K | 2009 | European Journal of Development Research2009，21，： | 1 |
| 13 | Carrageenan induces interleukin-8 production through distinct Bcll0 pathway in normal human colonic epithelial cells 显示文摘 | Alip Borthakur Sumit Bhattacharyya Pradeep K Dudeja | 2006 | AJP Castrointest Liver Physiol2006，9，1： | 1 |
| 14 | Prognostic factors in pa- tients with non' small cell lung carcinoma and brain metasta- ses :a malaysian perspective 显示文摘 | TANG W H ALIP A SAAD M | 2015 | Asian Pac J Cancer Prey2015，16，5： | 1 |
| 15 | How mesenchymal stem cells transform into adipocytes:Overview of the current understanding of adipogenic differentiation显示文摘Mesenchymal stem cells(MSCs)are stem/progenitor cells capable of self-renewal and differentiation into osteoblasts,chondrocytes and adipocytes.The transformation of multipotent MSCs to adipocytes mainly involves two subsequent steps from MSCs to preadipocytes and further preadipocytes into adipocytes,in which the process MSCs are precisely controlled to commit to the adipogenic lineage and then mature into adipocytes.Previous studies have shown that the master transcription factors C/enhancer-binding protein alpha and peroxisome proliferation activator receptor gamma play vital roles in adipogenesis.However,the mechanism underlying the adipogenic differentiation of MSCs is not fully understood.Here,the current knowledge of adipogenic differentiation in MSCs is reviewed,focusing on signaling pathways,noncoding RNAs and epigenetic effects on DNA methylation and acetylation during MSC differentiation.Finally,the relationship between maladipogenic differentiation and diseases is briefly discussed.We hope that this review can broaden and deepen our understanding of how MSCs turn into adipocytes. | Shan-Shan Liu Xiang Fang Xin Wen Ji-Shan Liu Miribangvl Alip Tian Sun Yuan-Yuan Wang Hong-Wei Chen | 2024 | World Journal of Stem Cells2024，16，3： | 0 |
| 16 | RENORMALIZED SOLUTIONS OF ELLIPTIC EQUATIONS WITH ROBIN BOUNDARY CONDITIONS显示文摘In the present paper, we consider elliptic equations with nonlinear and nonhomogeneous Robin boundary conditions of the type{-div(B(x, u)▽u) = f in ?,u = 0 on Γ_0,B(x, u)▽u·n→+γ(x)h(u) =g on Γ_1,where f and g are the element of L^1(?) and L^1(Γ_1), respectively. We define a notion of renormalized solution and we prove the existence of a solution. Under additional assumptions on the matrix field B we show that the renormalized solution is unique. | Olivier GUIBE Alip OROPEZA | 2017 | Acta Mathematica Scientia2017，37，4： | 0 |
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