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| 1 | Invited review:Remediation strategies for mycotoxin control in feed显示文摘Mycotoxins are secondary metabolites of different species of fungi.Aflatoxin B1(AFB1),deoxynivalenol(DON),zearalenone(ZEN)and fumonisin B1(FB1)are the main mycotoxins contaminating animal feedstuffs.These mycotoxins can primarily induce hepatotoxicity,immunotoxicity,neurotoxicity and nephrotoxicity,consequently cause adverse effects on the health and performance of animals.Therefore,physical,chemical,biological and nutritional regulation approaches have been developed as primary strategies for the decontamination and detoxification of these mycotoxins in the feed industry.Meanwhile,each of these techniques has its drawbacks,including inefficient,costly,or impractically applied on large scale.This review summarized the advantages and disadvantages of the different remediation strategies,as well as updates of the research progress of these strategies for AFB1,DON,ZEN and FB1 control in the feed industry. | Meng Liu Ling Zhao Guoxin Gong Lei Zhang Lei Shi Jiefan Dai Yanming Han Yuanyuan Wu Mahmoud Mohamed Khalil Lvhui Sun | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 8 |
| 2 | Establishment of safety evidence for Xingxue~ Shuxuening injection显示文摘OBJECTIVE: To systematically investigate the safety of Xingxue~ Shuxuening injection(SXN) in preand post-marketing, and to ensure clinical drug safety.METHODS: Strict quality control in raw herb selection and production processes was adopted and pharmacology research on SXN was performed by the drug manufacturing company, Heilongjiang ZBD Pharmaceutical Co., Ltd. We systematically reviewed the safety literature of Xingxue~ SXN. Adverse drug reaction(ADR) data of the drug, extracted from Spontaneous Reporting System(SRS), and clinical characters based on 20 hospital information systems(HIS) in China, were analyzed. Large-scale prospective safety monitoring and Risk Minimization Action Plans(Risk MAPs) of Xingxue~SXN were carried out.RESULTS: The quality of SXN was stable and controllable when it was produced. Drug toxicology studies found no effect on rabbits with hemolytic or condensed, local stimulation and muscle stimulation, and no allergic reactions in guinea pigs. The ADRs of Xingxue~ SXN were dizziness, phlebitis,and vomiting based on SRS data. The injection did not conform to instructions in clinical practice when we analyzed HIS database, and patient’s abnormal blood urea nitrogen levels may be related to the drug, when analyzed using the propensity score method. A nested case-control study was designed and performed to analyze the influencing factors of suspected allergic reactions to SXN. The study showed that patients with an allergy history were more prone to allergic reactions(P<0.001),and some medicine combinations could cause allergic reactions.CONCLUSION: These studies have established a body of evidence on Xingxue~ SXN safety, and provide a good model for Chinese medicine injection for clinical safety. The Xingxue~ SXN production process and toxicology research indicate the safety of the injection. However, the use of the injection is not consistent with instructed clinical practice.Xingxue~ SXN causes ADRs perhaps from inappropriate usage or its pharmacological action. This injection needs better Risk MAPs to ensure its clinical safety. | Wei Yang Wen Zhang Yanming Xie Bing Han | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 3 |
| 3 | Contrasting effects of nitrogen addition on litter decomposition in forests and grasslands in China显示文摘Nitrogen(N)addition has profound impacts on litter-mediated nutrient cycling.Numerous studies have reported different effects of N addition on litter decomposition,exhibiting positive,negative,or neutral effects.Previous meta-analysis of litter decomposition under N addition was mainly based on a small number of samples to allow comparisons among ecosystem types.This study presents the results of a meta-analysis incorporating data from 53 published studies(including 617 observations)across forests,grasslands,wetlands,and croplands in China,to investigate how environmental and experimental factors impact the effects of N addition on litter decomposition.Averaged across all of the studies,N addition significantly slows litter decomposition by 7.02%.Considering ecosystem types,N addition significantly accelerates litter decomposition by 3.70%and 11.22%in grasslands and wetlands,respectively,clearly inhibits litter decomposition by 14.53%in forests,and has no significant effects on litter decomposition in croplands.Regarding the accelerated litter decomposition rate in grasslands due to N addition,litter decomposition rate increases slightly with increasing rates of N addition.However,N addition slows litter decomposition in forests,but litter decomposition is at a significantly increasing rate with increasing amounts of N addition.The responses of litter decomposition to N addition are also influenced by the forms of N addition,experiential duration of N addition,humidity index,litter quality,and soil pH.In summary,N addition alters litter decomposition rate,but the direction and magnitude of the response are affected by the forms of N addition,the rate of N addition,ambient N deposition,experimental duration,and climate factors.Our study highlights the contrasting effects of N addition on litter decomposition in forests and grasslands.This finding could be used in biogeochemical models to better evaluate ecosystem carbon cycling under increasing N deposition due to the differential responses of litter decomposition to N addition rates and ecosystem types. | SU Yuan MA Xiaofei GONG Yanming LI Kaihui HAN Wenxuan LIU Xuejun | 2021 | Journal of Arid Land2021，13，7： | 2 |
| 4 | Heteroatom substitution-induced asymmetric A–D–A type non-fullerene acceptor for efficient organic solar cells显示文摘Research on asymmetric A–D–A structured non-fullerene acceptors has lagged far behind the development of symmetric counterpart.In this contribution,by simply replacing one sulfur atom in indacenodithiophene unit with a selenium atom,an asymmetric building block Se PT and a corresponding asymmetric non-fullerene acceptor Se PT-IN have been developed.Asymmetric Se PT-IN achieved a high efficiency of 10.20% in organic solar cells when blended with PBT1-C,much higher than that of symmetric TPT-IN counterpart(8.91%).Our results demonstrated an effective heteroatom substitution strategy to develop asymmetric A–D–A structured non-fullerene acceptors. | Chao Lia Jiali Song Yunhao Cai Guangchao Han Wenyu Zheng Yuanping Yi Hwa Sook Ryu Han Young Woo Yanming Sun | 2020 | Journal of Energy Chemistry2020，29，1： | 2 |
| 5 | Dietary organic acids ameliorate high stocking density stress-induced intestinal inflammation through the restoration of intestinal microbiota in broilers显示文摘Background:High stocking density(HSD)stress has detrimental effects on growth performance,intestinal barrier function,and intestinal microbiota in intensive animal production.Organic acids(OA)are widely used as feed addi-tives for their ability to improve growth performance and intestinal health in poultry.However,whether dietary OA can ameliorate HSD stress-induced impaired intestinal barrier in broilers remains elusive.In this study,a total of 528 one-day-old male Arbor Acres broilers were randomly allocated into 3 treatments with 12 replicates per treatment including 10 birds for normal stocking density and 17 birds for HSD.The dietary treatments were as follows:1)Normal stocking density+basal diet;2)HSD+basal diets;3)HSD+OA.Results:HSD stress can induce increased levels of serum corticosterone,lipopolysaccharides,interleukin-1β,tumor necrosis factor-α,and down-regulated mRNA expression of ZO-1,resulting in compromised growth performance of broilers(P<0.05).Dietary OA could significantly reduce levels of serum corticosterone,lipopolysaccharides,interleukin-1β,and tumor necrosis factor-α,which were accompanied by up-regulated interleukin-10,mRNA expres-sion of ZO-1,and growth performance(P<0.05).Moreover,OA could down-regulate the mRNA expression of TLR4 and MyD88 to inhibit the NF-κB signaling pathway(P<0.05).Additionally,HSD stress significantly decreased the abundance of Bacteroidetes and disturbed the balance of microbial ecosystems,whereas OA significantly increased the abundance of Bacteroidetes and restored the disordered gut microbiota by reducing competitive and exploita-tive interactions in microbial communities(P<0.05).Meanwhile,OA significantly increased the content of acetic and butyric acids,which showed significant correlations with intestinal inflammation indicators(P<0.05).Conclusions:Dietary OA ameliorated intestinal inflammation and growth performance of broilers through restor-ing the disordered gut microbial compositions and interactions induced by HSD and elevating short-chain fatty acid production to inhibit the TLR4/NF-κB signaling pathway.These findings demonstrated the critical role of intestinal microbiota in mediating the HSD-induced inflammatory responses,contributing to exploring nutritional strategies to alleviate HSD-induced stress in animals. | Dong Dai Guanghai Qi Jing Wang Haijun Zhang Kai Qiu Yanming Han Yuanyuan Wu Shugeng Wu | 2023 | Journal of Animal Science and Biotechnology2023，14，2： | 1 |
| 6 | Differentiated cells derived from fetal neural stem cells improve motor deficits in a rat model of Parkinson's disease显示文摘Objective: Parkinson's disease(PD), which is one of the most common neuro‐degenerative disorders, is characterized by the loss of dopamine(DA) neurons in the substantia nigra in the midbrain. Experimental and clinical studies have shown that fetal neural stem cells(NSCs) have therapeutic effects in neurological disorders. The aim of this study was to examine whether cells that were differentiated from NSCs had therapeutic effects in a rat model of PD. Methods: NSCs were isolated from 14‐week‐old embryos and induced to differentiate into neurons, DA neurons, and glial cells, and these cells were characterized by their expression of the following markers: βⅢ‐tubulin and microtubule‐associated protein 2(neurons), tyrosine hydroxylase(DA neurons), and glial fibrillary acidic protein(glial cells). After a 6‐hydroxydopamine(6‐OHDA)‐lesioned rat model of PD was generated, the differentiated cells were transplanted into the striata of the 6‐OHDA‐lesioned PD rats. Results: The motor behaviors of the PD rats were assessed by the number of apomorphine‐induced rotation turns. The results showed that the NSCs differentiated in vitro into neurons and DA neurons with high efficiencies. After transplantation into the striata of the PD rats, the differentiated cells significantly improved the motor deficits of the transplanted PD rats compared to those of the control nontransplanted PD rats by decreasing the apomorphine‐induced turn cycles as early as 4 weeks after transplantation. Immunofluorescence analyses showed that the differentiated DA neurons survived more than 16 weeks. Conclusions: Our results showed that cells that were differentiated from NSCs had therapeutic effects in a rat PD model, which suggests that differentiated cells may be an effective treatment for patients with PD. | Wei Wang Hao Song Aifang Shen Chao Chen Yanming Liu Yabing Dong Fabin Han | 2015 | Translational Neuroscience and Clinics2015，1，2： | 1 |
| 7 | Role of glycosylation in the function express ion of an aspergillus niger phytase in pichia pastoris显示文摘 | LEI Xingen | 1999 | Archieve of Bioche mistry and Biophysics1999，，364： | 1 |
| 8 | Organic acid blends improve intestinal integrity,modulate short-chain fatty acids profiles and alter microbiota of broilers under necrotic enteritis challenge显示文摘Controlling enteric diseases of broilers is crucial.Among many additives,organic acids(OA)and their blends are gaining attention to combat diseases in the post-antibiotic era.The current study evaluated the potentials of short-chain fatty acids(SCFA)and medium-chain fatty acids(MCFA)blends and/or phenolic compounds on intestinal integrity,intestinal pH,caecal microbiota,and caecal SCFA profiles of broilers under necrotic enteritis(NE)challenge.The additives used were:(A)a blend of SCFA,MCFA,and a phenolic compound(SMP),(B)a blend of free and buffered SCFA with MCFA(SMF),and(C)a blend of free and buffered SCFA with a high concentration of MCFA(SHM).A total of 1,404 male parental chicks of Ross 308 broilers were randomly allocated to 78 floor pens on hatching day with 6 treatments replicated 13 times with 18 birds per pen.The treatments were:UCC,unchallenged control;CHC,challenged control;BAC,challenged group plus zinc bacitracin;SMP,challenged group plus additive SMP;SMF,challenged group plus additive SMF;SHM,challenged group plus additive SHM.Birds were challenged with field-strain Eimeria spp.on d 9 and Clostridium perfringens on d 14.Birds challenged with NE increased fluorescein isothiocyanate dextran(FITC-d)concentration in serum,reduced acetate and butyrate concentrations,and increased Bacteroides and C.perfringens load in the caeca(P<0.05).Birds fed additives decreased FITC-d from gut to serum,reduced Bacteroides(d 16,P<0.05)and numerically reduced C.perfringens load compared to CHC group.Birds fed additive SHM had higher concentrations of acetate and butyrate(d 21,P<0.05)than CHC group but were not different from SMP and SMF groups.All the additives exhibited similar intestinal protection against NE compared to the BAC group indicated by FITC-d concentration in serum,acetate,propionate and butyrate concentrations in the caeca,and caecal bacterial loads except for the C.perfringens(P>0.05).The SMP group had a higher load compared to BAC(P<0.05).These findings suggest the promising effects of OA blends as alternatives to BAC to ameliorate the impact of NE challenge of broilers as indicated by improved intestinal health. | Alip Kumar Mehdi Toghyani Sarbast K.Kheravii Lane Pineda Yanming Han Robert A.Swick Shu-Biao Wu | 2022 | Animal Nutrition2022，，1： | 1 |
| 9 | 显示文摘 | Han Yanming Zhang Junying Yang Qiaoyun | 2008 | Journal of Applied Polymer Science2008，107，： | 1 |
| 10 | Alcohol use and HIV risk taking among Chinese MSM in Beijing显示文摘 | Hongyan Lu Yang Han Xiong He Yanming Sun Guiying Li Xuefeng Li Willi McFarland Yan Xiao Yiming Shao Yuhua Ruan H. Fisher Raymond | 2013 | Drug and Alcohol Dependence2013，，： | 1 |
| 11 | Expression of an aspergillus niger phytase gene(phyA) in saccharomyces显示文摘 | YANMING HAN DARID B WLISON | 1999 | Applied and Environmental Microbiology1999，65，5： | 1 |
| 12 | Ageing of soft thermoplastic starch with high glycerol content 显示文摘 | SHI Rui LIU Quanyong HAN Yanming | 2007 | J Appl Polym Sci2007，103，1： | 1 |
| 13 | Expression of an Aspergillus niger phytase gene (phyA) in Saccharomyces cerevisiae显示文摘 | Han Yanming Wilson D Xin Genlei | 1999 | Appl Environ Microbiol1999，1915，： | 1 |
| 14 | 显示文摘 | Han Yanming Zhang Junying Yang Qiaoyun Shi Ling Qi Shicheng Jin Riguang | 2008 | Journal of Applied Polymer Science2008，107，： | 1 |
| 15 | Hydroxychloride trace minerals have a positive effect on growth performance,carcass quality and impact ileal and cecal microbiota in broiler chickens显示文摘Background:The objective was to study the effect of hydroxychloride trace minerals(HTM)on growth performance,carcass quality and gut microbiota of broiler chickens in comparison to sulphate trace minerals(STM).In total 1440 male Ross 308 day-old chicks were divided into 12 replicate pens with 30 birds each per treatment.Four different treatments were tested according to a 2×2 factorial study design,where the animals received a three phase diet containing either inorganic Zn from sulphates or Zn from HTM in high(80 mg/kg Zn)or low Zn dosage(20 mg/kg Zn).In all treatments 15 mg/kg Cu was added from the same mineral source as the Zn.Body weight and feed intake were measured on day 0,10,27 and 34,while carcass and breast meat yields were measured at the end of the study(day 34).In addition,high-throughput sequencing analysis was performed in digesta samples from ileum and cecum to study the gut microbiome(day 34).Results:The results showed an improved(P<0.05)body weight of broiler chickens fed HTM,regardless of Zn level,on day 27,while on day 34 this effect remained as a tendency(P=0.0542).In the overall study period,birds fed HTM had a higher(P<0.05)average daily gain and average daily feed intake when compared to birds fed STM.The mineral source did not affect the carcass characteristics,however,feeding 80 mg/kg Zn resulted in a significantly higher(P=0.0171)breast meat yield,regardless of source.High-throughput sequencing analysis of the microbiota revealed a higher microbial diversity in the ileum and cecum of HTM fed birds compared to STM fed birds.Taxonomical differences were mainly found in the cecum,specifically between the group fed high and low Zn levels from HTM.This correlated with the mineral contents observed in the cecal digesta.Comparing both groups fed 80 mg/kg Zn,the HTM group had more Streptococcaceae,Streptococcus,Clostridia,Weissella and Leuconostocaceae compared to the STM group.Conclusions:HTM improved growth performance of broiler chickens;and the source and level of Zn modulated the gut microbiota communities in broilers differentially. | Sandra J.A.van Kuijk Yanming Han Ana Isabel Garcia-Ruiz Ana Rodiles | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 1 |
| 16 | The reduction of polysiloxane thermal degradation by the hybridization with novel polymethoxylsiloxane显示文摘 | Yanming Han Junying Zhang Ling Shi | 2008 | Polymer Degradation and Stability2008，93，1： | 1 |
| 17 | Novel polymethoxylsiloxane based crosslinking reagent and its in-situ improvement for thermal and mechanical properties of siloxane elastomer显示文摘 | Han Yanming Zhang Junying Yang Qiaoyun | 2007 | Journal of Applied Polymer Science2007，107，6： | 1 |
| 18 | High-efficiency organic solar cells enabled by an alcohol-washable solid additive显示文摘The solvent additive strategy has been widely utilized to boost the power conversion efficiency(PCE)of organic solar cells(OSCs).However,the residual solvent additive in the active layer tends to induce a gradual morphology degradation and further influences the long-term stability of OSCs.Here,a solid additive,1,4-diiodobenzene(DIB),was introduced to fabricate efficient OSCs.We found that the treatment of DIB can lead to optimized morphology to form a bicontinuous network with intensified intermolecular packing in the donor and acceptor phases.Notably,DIB can be easily removed from the active layer via a simple alcohol washing process and no further post-thermal annealing is needed,which is desirable for large-scale manufacturing of OSCs.As a result,high efficiencies of 17.47%for PM6:Y6 and 18.13%(certified as 17.7%)for PM6:BTP-eC9 binary OSCs are achieved,which are among the highest efficiencies reported for binary OSCs thus far.Moreover,OSCs fabricated with DIB also exhibit superior stability compared with the as-cast and traditional solvent additive processed devices.Additionally,DIB was successfully applied in different active layers,manifesting its general applicability.This work provides a feasible approach to enhance both the efficiency and stability of OSCs. | Yuanpeng Xie Hwa Sook Ryu Lili Han Yunhao Cai Xiaopeng Duan Donghui Wei Han Young Woo Yanming Sun | 2021 | Science China Chemistry2021，64，12： | 0 |
| 19 | Organic solar cells based on chlorine functionalized benzo[1,2-b:4,5-b′]difuran-benzo[1,2-c:4,5-c′]dithiophene-4,8-dione copolymer with efficiency exceeding 13%显示文摘Benzo[1,2-b:4,5-b′]dithiophene(BDT) has been widely used to construct donor-acceptor(D-A) copolymers in organic solar cells(OSCs). However, benzo[1,2-b:4,5-b′]difuran(BDF), an analogue of BDT, has received less attention than BDT. The photovoltaic performance of BDF copolymers has lagged behind that of BDT copolymers. Here, we designed and synthesized two BDF copolymers, PBF1-C and PBF1-C-2Cl. PBF1-C-2Cl, which is composed of BDF and benzo[1,2-c:4,5-c′]dithiophene-4,8-dione connected by a chlorinated thiophene π-bridge, displays a low-lying highest occupied molecular orbital energy level,which helps in yielding a high open-circuit voltage(Voc) in OSCs. As a result, when blended with Y6, PBF1-C-2Cl-based devices showed a high Voc of 0.83 V and a power conversion efficiency(PCE) of 13.10%. To the best of our knowledge, the PCE of 13.10% is among the highest efficiency values for OSCs based on BDF copolymers. | Linglong Ye Xueshan Li Yunhao Cai Hwa Sook Ryu Guangkai Lu Donghui Wei Xiaobo Sun Han Young Woo Songting Tan Yanming Sun | 2020 | Science China Chemistry2020，63，4： | 0 |
| 20 | Status of transjugular intrahepatic portosystemic shunt for portal hypertension in China:A national survey analysis显示文摘Aim:The transjugular intrahepatic portosystemic shunt(TIPS)procedure has been performed in China for 30 years,but our understanding of the status and difficulties associated with the use of TIPS for portal hypertension is incomplete.This study aims to investigate the current situation of the use of TIPS for portal hypertension,which should aid the development of TIPS in China.Methods:This study involved a questionnaire survey,initiated by the China Portal Hypertension Alliance(CHESS)to investigate the use of TIPS for portal hypertension in China.Questionnaires were released on the Internet between August 16,2022 and September 16,2022.Detailed information was collected from 545 hospitals contracted by the CHESS in China,which performed TIPS surgery in 2021.Results:The 545 hospitals covers the majority of hospitals in China that conduct TIPS intervention.In the survey,a total of 13,527 TIPS interventions were carried out with 94.1%(498/545)of them had a system of routine follow‐up after TIPS.The majority(42.6%[232/545])believed that the main indication of TIPS was the control of acute bleeding.Overall,48.1%(262/545)carried out early or pre‐emptive TIPS,53.0%(289/545)carried out TIPS for cavernous transformation of the portal vein,and 81.0%(441/545)chose routine embolization of collateral circulation during operation.Most used coils(97.0%[475/490])and biological glue(72.0%[353/490])as embolic materials,and 78.5%(428/545)routinely performed intraoperative portal pressure gradient measurements.When selecting TIPS stents,57.1%(311/545)chose viator‐specific stents,and 57.2%(312/545)chose conventional anticoagulation after TIPS.Conventional anticoagulation after TIPS is over a time interval of 3–6 months(55.4%[173/312]).The limitation of TIPS surgery is mainly its cost(72.3%[394/545])and insufficient understanding of the procedure by doctors in other related departments(77.4%[422/545]).Most of the hospital teams accept the use of domestic instruments in TIPS surgery(92.7%[505/545]).Conclusions:This survey shows that TIPS is an essential part of the treatment of portal hypertension in China.TIPS is widely used in Chinese patients with portal hypertension,and this survey presents a more comprehensive picture of the options and difficulties encountered in the implementation of TIPS.In the future,it is necessary to promote TIPS technology and further standardize surgical indications,routine operations,and instrument application. | Haibo Shao Xinwei Han Jianbo Zhao Junhui Sun Zhuting Fang Bin Xiong Xiaoli Zhu Weixin Ren Min Yuan Shiping Yu Meng Niu Weifu Lv Xueqiang Zhang Chunqing Zhang Lei Li Xuefeng Luo Yusheng Song Yilong Ma Tong Dang Hua Xiang Yun Jin Hui Xue Guiyun Jin Xiao Li Jiarui Li Shi Zhou Changlu Yu Song He Lei Yu Hongmei Zu Jun Ma Yanming Lei Ke Xu Xiaolong Qi | 2023 | Portal Hypertension & Cirrhosis2023，2，1： | 0 |
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