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| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | COPD heterogeneity: gender differences in the multidimensional BODE index 显示文摘 | de Torres JP Casanova C de Gareini AM | 2007 | International Journal of Chronic Obstructive Pulmonary Disease2007，2，2： | 1 |
| 3 | Genetic relations- hips among Orobanche pecies as revealed by PAPD analysis显示文摘 | Roman B Alfaro C Torres AM | 2003 | Ann Bot(Lond)2003，91，6： | 1 |
| 4 | Malrotation of the intestine显示文摘 | Torres AM Ziegler MM | 1993 | World J Surg1993，17，3： | 1 |
| 5 | Rhabdomyolysis: Pathogenesis ,Diagnosis ,and Treatment 显示文摘 | Torres PA Helmstetter JA Kaye AM | 2015 | OchSner J2015，15，1： | 1 |
| 6 | Rhabdomyoly- sis: pathogenesis, diagnosis, and treatment显示文摘 | Torres PA Helmstetter JA Kaye AM | 2015 | Ochsner J2015，15，： | 1 |
| 7 | Quantitative risk assessment of foot-and-mouth disease introduction into Spain via importation of live animals 显示文摘 | Martinez-L6pez B Perez AM De la Torre A | 2008 | Preventive Veterinary Medicine2008，86，： | 1 |
| 8 | P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis显示文摘 | Matute C Torre I Perez-Cerda F Perez-Samartin A Alberdi E Etxebar-ria E Arranz AM Ravid R Rodriguez-Antiguedad A Sanchez-Go-mez M Domercq M | | 0，，： | 1 |
| 9 | A report of three patients with an interstitial deletion of chromosome 15q24显示文摘 | Cushman LJ Torres MW Cherry AM | 2005 | Am J Med Genet2005，137，1： | 1 |
| 10 | Three dimensional distribution of gas hydrate beneath Southern Hydrate Ridge: Constraints from ODP Leg 204显示文摘 | Trehu AM Long P E Torres M | 2004 | Earth Planet Science Let ters2004，222，： | 1 |
| 11 | Pain management after major or- thopaedic surgery: current strategies and new concepts 显示文摘 | Sinatra RS Torres J Bustos AM | 2002 | J Am Acad Orthop Surg2002，10，2： | 1 |
| 12 | Clinical use of enteral nutrition显示文摘 | Hemandez A Torres NP Jimenez AM | 2006 | Nutr HOSP2006，21，2： | 1 |
| 13 | Nutrient uptake rates by the alien alga Undaria pinnatifida (Phaeophyta) (Nuevo Gulf, Patagonia, Argentina) when exposed to diluted sewage effluent显示文摘 | Américo I. Torres Mónica N. Gil José L. Esteves | 2004 | Hydrobiologia (-)2004，，1： | 1 |
| 14 | Potentiation bynitric oxide of cyclosporine A and FK506-induded aptosis in renal proximal tubule cells显示文摘 | Horlano S Castilla M Torres AM | | 0，，： | 1 |
| 15 | The role of intraoperative parathyroid hormone assay in the surgical management of hyperparathyroidism显示文摘 | Romani AM Panarese A La Torre V | 2007 | Ann Ital Chir2007，78，2： | 1 |
| 16 | Passive immunization during pregnancy for congenitalcytomegalovirus infection显示文摘 | Nigro G Adler SP La Torre R Best AM Congenital Cytomegalovirus Collaborating Group | | 0，，： | 1 |
| 17 | Double-blind,randomized,placebo-controlled Phase I Clinical Trial of the therapeutical antituberculous vaccine RUTI显示文摘 | Vilaplana C Montané E Pinto S Barriocanal AM Domenech G Torres F Cardona PJ Costa J | 2009 | Vaccine2009，28，4： | 1 |
| 18 | Malrotation of the intestine 显示文摘 | Torre s AM Ziegler MM | 1993 | World J Surg1993，17，3： | 1 |
| 19 | Rat kidney function related to tissue glutathione levels显示文摘 | Torres AM Rodriguez JV Ochoa JE | 1986 | Biochem Pharmacol1986，35，： | 1 |
| 20 | Translation and validation of the breastfeeding self-efficacy scale into Spanish: data from a Puerto Rican population 显示文摘 | Molina Tortes M Davila Torres RR Parrilla Rodriguez AM | 2003 | J Hum Lact2003，19，1： | 1 |
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