4篇
您的检索式：作者名="Alexander FG"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Label-free detection of single nanoparticles and biological molecules using microtoroid optical resonators显示文摘Single-molecule detection is one of the fundamental challenges of modern biology.Such experiments often use labels that can be expensive,difficult to produce,and for small analytes,might perturb the molecular events being studied.Analyte size plays an important role in determining detectability.Here we use laser-frequency locking in the context of sensing to improve the signal-to-noise ratio of microtoroid optical resonators to the extent that single nanoparticles 2.5 nm in radius,and 15.5 kDa molecules are detected in aqueous solution,thereby bringing these detectors to the size limits needed for detecting the key macromolecules of the cell.Our results,covering several orders of magnitude of particle radius(100 nm to 2 nm),agree with the‘reactive’model prediction for the frequency shift of the resonator upon particle binding.This confirms that the main contribution of the frequency shift for the resonator upon particle binding is an increase in the effective path length due to part of the evanescent field coupling into the adsorbed particle.We anticipate that our results will enable many applications,including more sensitive medical diagnostics and fundamental studies of single receptor–ligand and protein–protein interactions in real time. | Judith Su Alexander FG Goldberg Brian M Stoltz | 2016 | Light(Science & Applications)2016，5，1： | 20 |
| 2 | High rate of failure of impaction grafting in large acetabular defeets显示文摘 | van Haaren EH Heyligers IC Alexander FG | 2007 | J Bone Joint Surg Br2007，89，3： | 1 |
| 3 | Deaths of children during an outbreak of hand,foot,and mouth disease in Sarawak,Malaysia:clinical and pathological characteristics of the disease显示文摘 | Chan LG Parashar UD Lye MS Ong FG Zaki SR Alexander JP | | 0，，： | 1 |
| 4 | Inhibition of NK cellinduced cytolysis by thiocarbamide antithyroid drugs 显示文摘 | Ferguson MM McDonald FG Alexander WD | 1985 | Immunol Lett1985，11，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员