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| 1 | Helicobacter pylori in human health and disease:Mechanisms for local gastric and systemic effects显示文摘Helicobacter pylori(H. pylori) is present in roughly 50% of the human population worldwide and infection levels reach over 70% in developing countries. The infection has classically been associated with different gastro-intestinal diseases, but also with extra gastric diseases. Despite such associations, the bacterium frequently persists in the human host without inducing disease, and it has been suggested that H. pylori may also play a beneficial role in health. To understand how H. pylori can produce such diverse effects in the human host, several studies have focused on understanding the local and systemic effects triggered by this bacterium. One of the main mechanisms by which H. pylori is thought to damage the host is by inducing local and systemic inflammation. However, more recently, studies are beginning to focus on the effects of H. pylori and its metabolism on the gastric and intestinal microbiome. The objective of this review is to discuss how H. pylori has co-evolved with humans, how H. pylori presence is associated with positive and negative effects in human health and how inflammation and/or changes in the microbiome are associated with the observed outcomes. | Denisse Bravo Anilei Hoare Cristopher Soto Manuel A Valenzuela Andrew FG Quest | 2018 | World Journal of Gastroenterology2018，24，28： | 32 |
| 2 | Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis显示文摘The sequence of events associated with the development of gastric cancer has been described as 'the gastric precancerous cascade'. This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori(H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the mostrelevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and mi RNAs in this context. | Manuel A Valenzuela Jimena Canales Alejandro H Corvalán Andrew FG Quest | 2015 | World Journal of Gastroenterology2015，21，45： | 33 |
| 3 | 柑桔同源及异源四倍体花粉育性研究显示文摘对8个柑桔同源四倍体及通过原生质体融合得到的2个异源四倍体的花粉育性和花粉粒大小进行了测定。结果显示,同源四倍体柑桔花粉育性平均为36%,约为二倍体(62%)的60%。‘伏今夏’甜橙由于是异质结合的染色体易位突变体,其同源四倍体花粉育性比二倍体(23%)高出50%。权(Poncirustrifoliata)与甜橙(Citrussinensis)属间以及来檬(C.aurantifolia)与甜橙种间四倍体体细胞杂种花粉育性介于其双亲之间,花粉育性分别为各自高值亲本的99%和75%。同源及异源四倍体花粉粒体积平均为二倍体的2倍或双亲之和。本结果说明,柑桔体细胞杂种可作为杂交亲本进一步被利用。 | 邓秀新 Gmit.,FG | 1995 | 园艺学报1995，22，1： | 28 |
| 4 | Label-free detection of single nanoparticles and biological molecules using microtoroid optical resonators显示文摘Single-molecule detection is one of the fundamental challenges of modern biology.Such experiments often use labels that can be expensive,difficult to produce,and for small analytes,might perturb the molecular events being studied.Analyte size plays an important role in determining detectability.Here we use laser-frequency locking in the context of sensing to improve the signal-to-noise ratio of microtoroid optical resonators to the extent that single nanoparticles 2.5 nm in radius,and 15.5 kDa molecules are detected in aqueous solution,thereby bringing these detectors to the size limits needed for detecting the key macromolecules of the cell.Our results,covering several orders of magnitude of particle radius(100 nm to 2 nm),agree with the‘reactive’model prediction for the frequency shift of the resonator upon particle binding.This confirms that the main contribution of the frequency shift for the resonator upon particle binding is an increase in the effective path length due to part of the evanescent field coupling into the adsorbed particle.We anticipate that our results will enable many applications,including more sensitive medical diagnostics and fundamental studies of single receptor–ligand and protein–protein interactions in real time. | Judith Su Alexander FG Goldberg Brian M Stoltz | 2016 | Light(Science & Applications)2016，5，1： | 20 |
| 5 | Improving the outcomes in gastric cancer surgery显示文摘Gastric cancer remains a significant health problem worldwide and surgery is currently the only potentially curative treatment option. Gastric cancer surgery is generally considered to be high risk surgery and fiveyear survival rates are poor,therefore a continuous strive to improve outcomes for these patients is warranted. Fortunately,in the last decades several potential advances have been introduced that intervene at various stages of the treatment process. This review provides an overview of methods implemented in pre-,intra- and postoperative stage of gastric cancer surgery to improve outcome. Better preoperative risk assessment using comorbidity index(e.g.,Charlson comorbidity index),assessment of nutritional status(e.g.,short nutritional assessment questionnaire,nutritional risk screening- 2002) and frailty assessment(Groningen frailty indicator,Edmonton frail scale,Hopkins frailty) was introduced. Also preoperative optimization of patients using prehabilitation has future potential.Implementation of fast-track or enhanced recovery after surgery programs is showing promising results,although future studies have to determine what the exact optimal strategy is.Introduction of laparoscopic surgery has shown improvement of results as well as optimization of lymph node dissection.Hyperthermic intraperitoneal chemotherapy has not shown to be beneficial in peritoneal metastatic disease thus far.Advances in postoperative care include optimal timing of oral diet,which has been shown to reduce hospital stay.In general,hospital volume,i.e.,centralization,and clinical audits might further improve the outcome in gastric cancer surgery.In conclusion,progress has been made in improving the surgical treatment of gastric cancer.However,gastric cancer treatment is high risk surgery and many areas for future research remain. | Juul JW Tegels Michiel FG De Maat Karel WE Hulsewé Anton GM Hoofwijk Jan HMB Stoot | 2014 | World Journal of Gastroenterology2014，20，38： | 16 |
| 6 | Effect of fatty acids on poly-amine contents and Na^+/H^+ antiport activity in PM vesicles isolated from roots of barley under salt stress显示文摘With 200 mmol/L NaCl treatment on barley cultivar 'Jian 4' (Hordeum vulgare L. cv. J4) seedlings for 6 d, the contents of covalently and noncovalently conjugated polyamines (PAs) and activities of H+-ATPase in plasma membrane (PM) vesicles isolated from the roots decreased remarkably. Moreover, the activity of Na+/H+ antiport was detected first in PM vesicles. The results showed that the decrease in the contents of membrane phospholipid, noncovalently conjugated PAs and activity of H+-ATPase caused by NaCl could be restored partially by application of 1 mmol/L stearic acid (C16:0) and linoleic acid (C18:2), and C18:2 was more effective than C16:0. In addition, a reduction in the contents of covalently conjugated PAs was only reversed partially in the presence of C18:2. Furthermore, Na+/H+ antiport activity was strengthened by exogenous C16:0 and C18:2, and C18:2 was more effective than C16:0. The correlative analysis suggested that, after application of C16:0 and C18:2 under salt stress, there was a | Zhao, FG Shu, HR | 2002 | Chinese Science Bulletin2002，47，14： | 3 |
| 7 | Comparative evaluation of the prognostic value of MUC1,MUC2,sialyl-Lewis(a) and sialyl-Lewis(x) antigens in colorectal adenocarcinoma显示文摘 | Baldus SE Monig SP Hanisch FG | 2002 | Histopathology2002，40，5： | 2 |
| 8 | Integrin signaling显示文摘 | Giancotti FG Ruoslahti E | | 0，，： | 2 |
| 9 | Integrin signaling显示文摘 | Giancotti FG Ruoslahti E | 1999 | Science1999，285，5430： | 2 |
| 10 | The NF-kappa B/Rel and I Kappa B gene families:Mediators of immune response and inflammation显示文摘 | Wulczyn FG Krappmann D | 1996 | J Mol Med1996，74，： | 2 |
| 11 | 绿色经营战略管理和平衡记分卡构建方法显示文摘本文主要探讨绿色经营战略管理愿景、战略实施、平衡记分卡制定的程序化方法和基本内容,以及面向信任度策略的企业战略地图,试图通过绿色经营战略管理平衡计分卡的构建为可持续管理对经济成功贡献之间所暗含的依存关系提供依据,正面推动绿色经营。 | 谢琨 刘思峰 FG Liang | 2006 | 企业经济2006，25，9： | 2 |
| 12 | Evidence-based medicine:watching out for its friends显示文摘 | Brody H Miller FG Bogdan LE | 2005 | Perspect Biol Med2005，48，4： | 1 |
| 13 | Indirubin-3'- monoxime, a CDK inhibitor induces growth inhibition and apoptosis-independent up-regulation of survivin in transitional cell cancer显示文摘 | Perabo FG Frssler C Landwehrs G | 2006 | Anticancer Res2006，26，3： | 1 |
| 14 | Lovastatin and phenylacetate inhibit the induction ofnitric oxide synthase and eytokines in rat primary astrocytes, microglia and macrophages 显示文摘 | Pahan K Sheikh FG Namboodiri AM | 1997 | ] Clin Invest1997，100，11： | 1 |
| 15 | The rate of visual loss in Behcet's disease显示文摘 | Mamo FG | 1970 | Arch Ophthalmol1970，84，： | 1 |
| 16 | Identification of wrist and metacarpophalangeal joint erosions using a portable magnetic resonance imaging system compared to conventional radiographs显示文摘 | Shellock FG Dardashti S | 2004 | J Rheumatol2004，31，4： | 1 |
| 17 | PKD1 interacts with PKD2 through aprobable coiled-coil domain显示文摘 | GERMINO FG CAI Y | 1997 | Nature1997，16，2： | 1 |
| 18 | Avascular necrosis of the femoral head after femoral neck fracture显示文摘 | Caballer AP Portal L F | 2002 | Clin Orthop2002，39，9： | 1 |
| 19 | 显示文摘 | da-Costa JL Tonin FG Zanolli LA | 2009 | Electrophoresis2009，30，12： | 1 |
| 20 | Soy isoflavone genistein in prevention and treatment of prostate cancer 显示文摘 | Perabo FG Von EC Ellinger J | 2008 | Prostate Cancer Prostatic Dis2008，11，： | 1 |
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