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| 1 | Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected. | Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena | 2007 | World Journal of Gastroenterology2007，13，3： | 18 |
| 2 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 3 | Gastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers显示文摘 | Marcia V. Galván-Portillo Alejandra Cantoral Luis F. O?ate-Oca?a Jia Chen Roberto Herrera-Goepfert Luisa Torres-Sanchez Raul U. Hernandez-Ramirez Oswaldo Palma-Coca Lizbeth López-Carrillo | 2009 | European Journal of Nutrition2009，，5： | 3 |
| 4 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 5 | Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease显示文摘 | María Inés Vargas-Rojas Alejandra Ramírez-Venegas Leonardo Limón-Camacho Leticia Ochoa Rafael Hernández-Zenteno Raúl H. Sansores | 2011 | Respiratory Medicine2011，，11： | 2 |
| 6 | 1H and DOSY NMR spectroscopy analysis of Ligusticum porteri rhizome extracts 显示文摘 | Alejandra L Maria Isabel C Guillermo D | 2011 | Magn Reson Chem2011，49，8： | 1 |
| 7 | National natural capital accounting with the ecological footprint concept显示文摘 | Wackernagel Mathis Onisto Larry Bello Patricia Callejas Linares Alejandra Susana López Falf ón Ina | 1999 | Ecological Economics1999，，3： | 1 |
| 8 | Increased accumulation of anthocyanins in Fragaria chiloensis fruits by transient suppression of FcMYB1 gene显示文摘 | Ariel Salvatierra Paula Pimentel María Alejandra Moya-León Raúl Herrera | 2013 | Phytochemistry2013，，： | 1 |
| 9 | Probiotics: An alternative strategy for combating salmonellosis Immune mechanisms involved 显示文摘 | Natalia A C Alejandra M L Galdeano C M | 2012 | Food Res Int2012，45，2： | 1 |
| 10 | Ontogeny of the digestive tract and enzymatic activity in white seabass, Atractoscion nobilis, larvae显示文摘 | Mario A. Galaviz Alejandra García-Gasca Mark Drawbridge Carlos Alfonso álvarez-González Lus M. López | 2011 | Aquaculture2011，，1： | 1 |
| 11 | The opening of maitotoxin-sensitive calcium channels induces the acrosome reaction in human spermatozoa: differences from the zona pellucida显示文摘acrosome 反应(AR ) ,为精子的一个绝对要求和卵熔化,通过电压依赖者 Ca2+ 隧道和操作店的隧道要求 Ca2+ 的流入进精子。Maitotoxin (MTx ) ,一个动员 Ca2+ 代理人,被显示了是老鼠精子 AR 的有势力 inducer 与类似于带 pellucida (ZP ) 的药理学,可能为两 inducers 建议一条普通小径。使用的 recombinant 人 ZP3 (rhZP3 ) ,老鼠 ZP 和二 MTx 隧道 blockers (U73122 和 U73343 ) ,我们在人和老鼠精子调查了并且比较导致 MTx 、导致 ZP 的艺术。此处,我们报导 MTx 导致了 AR 并且提高了细胞内部的 Ca2+([Ca2+] 我) 在人的精子,哪个被 U73122 和 U73343 堵住。这二混合物也在老鼠精子禁止了导致 MTx 的 AR。在有我们的以前的建议的争论, AR 由 rhZP3 被触发或老鼠 ZP 没被 U73343 堵住,显示在人和老鼠精子,由生理的 ligands 或由 MTx 的 AR 正式就职通过不同小径发生了。U73122,然而并非 U73343 (不活跃的类似物) ,能堵住 phospholipase C (PLC ) 。另一个 PLC 禁止者, edelfosine,也堵住了导致 rhZP3 、导致 ZP 的艺术。这些调查结果在人和老鼠带证实了一条 PLC 依赖的发信号小径的参予导致蛋白质的 AR。尤其是, edelfosine 也禁止了导致 MTx 的老鼠精子 AR 然而并非人的,建议导致毒素的 AR 在老鼠是 PLC 依赖的并且在人 PLC 独立。 | lulio C Chaivez Gerardo A de Blas Josd L de la Vega-Beltran Takuya Nishigaki Mayel Chirinos Maria Elena Gonzaez-Gonzalez Fernando Larrea Alejandra Soiis Alberto Darszon Claudia L Trevino | 2011 | Asian Journal of Andrology2011，13，1： | 1 |
| 12 | Cadmium,zinc and copper biosorption mediated by Pseudomonas veronii 2E显示文摘 | VULLO DIANA L CERETTI HELENA M DANIEL ALEJANDRA | 2008 | Bioresource Technology2008，99，： | 1 |
| 13 | Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria显示文摘 | Sarkissian CN Alejandra G Wang L | 2008 | Proceedings of the National Academy of Sciences of the United States of America2008，105，20： | 1 |
| 14 | Structural and biochemical characterization of the therapeutic Anabaena variabilis phenylalanine ammonia lyase显示文摘 | Wang L Alejandra G Archer H | 2008 | Journal of Molecular Biology2008，380，4： | 1 |
| 15 | Hepatitis C virus core protein regulates p300/CBP co-activation function. Possible role in the regulation of NF-AT1 transcriptional activity显示文摘 | Marta Gómez-Gonzalo Ignacio Benedicto Marta Carretero Enrique Lara-Pezzi Alejandra Maldonado-Rodríguez Ricardo Moreno-Otero Michael M.C. Lai Manuel López-Cabrera | 2004 | Virology2004，，1： | 1 |
| 16 | Protein kinase C inhibits amyloid β peptide neurotoxicity by acting on members of the Wnt pathway显示文摘 | Garrido J L Jodoy J A Alejandra A | 2002 | Faseb J2002，16，14： | 1 |
| 17 | Pharamacodynamic assessment of amoxicillin/sulbactam against Acinetobacter baumannii:searching the optimal dose and infusion time through a human ex-vivo model显示文摘 | Bantar C Fernandez Canigia L Alejandra Berger M | 2009 | Braz J Infect Dis2009，13，5： | 1 |
| 18 | Antioxidant effects of water-and lipid-soluble nitroxide radicals in liposomes显示文摘 | Alejandra N C Lidia L P Graciela B | 2004 | Free Radical Biology and Medicine2004，37，12： | 1 |
| 19 | Bacillus thuringiensis : A story of a successful bioinsecticide显示文摘 | ALEJANDRA B SUPAPORN L SARJEET S G | 2011 | Insect Biochemistry and Molecular Biology2011，41，： | 1 |
| 20 | Transforming Growth Factor-β1 gene polymorphisms are associated with disease progression in idiopathic pulmonary fibrosis显示文摘 | Antoni X Alejandra M Sergio L | 2003 | American Journal of Respiratory and Critical Gare Medicine2003，168，： | 1 |
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