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3篇 您的检索式：作者名="Mercedes Robles"

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		题名	作者	年代	出处	被引量
	1	Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected.	Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena	2007	World Journal of Gastroenterology2007，13，3：	18
	2	Toxicidad hepática inducida por los nuevos fármacos inmunosupresores显示文摘	Elena Toscano Judit Cotta Mercedes Robles M a Isabel Lucena Raúl J. Andrade	2009	Gastroenterologia y Hepatologia2009，，1：	1
	3	Phenotypic characterization of idiosyncratic drug‐induced liver injury: The influence of age and sex显示文摘	M. Isabel Lucena Raúl J. Andrade Neil Kaplowitz Miren García‐Cortes M. Carmen Fernández Manuel Romero‐Gomez Miguel Bruguera Hacibe Hallal Mercedes Robles‐Diaz Jose F. Rodriguez‐González Jose Maria Navarro Javier Salmeron Pedro Martinez‐Odriozola Ramón Pér	2009	Hepatology2009，，：	1

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