|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 肾素血管紧张素系统与动脉粥样硬化显示文摘动脉粥样硬化是脂质在血管壁的异常堆积而引起的慢性血管炎症,据估计,90%的心肌梗死,60%的缺血性脑卒中以及大多数的心力衰竭均可由其引起。经典的肾素血管紧张素系统(renin-angiotensin system,RAS)作为调节机体血压的关键内分泌系统,目前认为它是调节动脉粥样硬化发生发展的重要因子。 | 徐银川 陈晓锋 Alan Daugherty 吕红 王建安 | 2017 | 中华高血压杂志2017，25，6： | 6 |
| 2 | Complex pathologies of angiotensin Ⅱ-induced abdominal aortic aneurysms显示文摘Angiotensin Ⅱ (AngⅡ) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases.Sub-cutaneous infusion of AngⅡ into mice induces the development of abdominal aortic aneurysms (AAAs).Like human AAAs,AngⅡ-induced AAA tissues exhibit progressive changes and considerable heterogeneity.This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques.Therefore,while the mouse model of AngⅡ-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans,meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue. | Alan DAUGHERTY Lisa A. CASSIS Hong LU | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，8： | 3 |
| 3 | Differential effects of doxycycline,a Broad-Spectrum matrix metalloproteinase Inhibitor,on Angiotensin Ⅱ-Induced atherosclerosis and abdominal aortic aneurysms显示文摘 | Michael W Manning Lisa A Cassis Alan Daugherty | 2003 | Arteriosclerosis Thrombosis and Vascular Biology2003，23，6： | 1 |
| 4 | Myeliperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions显示文摘 | Alan Daugherty Dunn Rateri | 1994 | J Clin Invest1994，94，： | 1 |
| 5 | Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms显示文摘 | Jian-an Wang Wen-ai Chen Yifan Wang Songzhao Zhang Honghao Bi Bo Hong Yueqiu Luo Alan Daugherty Xiaojie Xie | 2011 | Atherosclerosis2011，，： | 1 |
| 6 | Interleukin-18 Enhances Atherosclerosis in Apolipoprotein E?/? Mice Through Release of Interferon-γ显示文摘 | Stewart C. Whitman Punnaivanam Ravisankar Alan Daugherty | 2002 | Circulation Research: Journal of the American Heart Association2002，，2： | 1 |
| 7 | Angiotensin II-Mediated Development of Vascular Diseases显示文摘 | Alan Daugherty Lisa Cassis | 2004 | Trends in Cardiovascular Medicine2004，，3： | 1 |
| 8 | Use of Nonsteroidal Antiinflammatory Drugs: An Update for Clinicians: A Scientific Statement From the American Heart Association显示文摘 | Elliott M. Antman Joel S. Bennett Alan Daugherty Curt Furberg Harold Roberts Kathryn A. Taubert | 2007 | Circulation2007，，12： | 1 |
| 9 | Urokinase-Type Plasminogen Activator Deficiency in Bone Marrow–Derived Cells Augments Rupture of Angiotensin II–Induced Abdominal Aortic Aneurysms显示文摘 | Haruhito A. Uchida Aruna Poduri Venkateswaran Subramanian Lisa A. Cassis Alan Daugherty | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，12： | 1 |
| 10 | Prominent Roles of the Renin Angiotensin System in Atherosclerosis显示文摘The renin angiotensin system (RAS) is emerging as a prominent factor in the development of experimental atherosclerosis. We have previously demonstrated that the RAS is profoundly activated in hypercholesterolemia. This was demonstrated in LDLR-/-mice fed a saturated fat enriched diet and manifested as increased plasma concentrations of angiotensinogen and angiotensin peptides; especially angiotensin Ⅱ (AngⅡ). | Debra L. Rateri Alan Daugherty | 2009 | 中国动脉硬化杂志2009，17，7： | 0 |
| 11 | Ginkgo biloba extracts prevent aortic rupture in angiotensin II-infused hypercholesterolemic mice显示文摘Abdominal aortic aneurysms (AAAs) are a chronic vascular disease characterized by pathological luminal dilation. Aortic rupture is the fatal consequence of AAAs. Ginkgo biloba extracts (GBEs), a natural herb extract widely used as food supplements, drugs, and cosmetics, has been reported to suppress development of calcium chloride-induced AAAs in mice. Calcium chloride-induced AAAs do not rupture, while angiotensin II (AngII)-induced AAAs in mice have high rate of aortic rupture, implicating potentially different mechanisms from calcium chloride-induced AAAs. This study aimed to determine whether GBE would improve aortic dilation and rupture rate of AngII-induced AAAs. Male apolipoprotein E (apoE) -/- mice were infused with AngII and administered either GBE or its major active ingredients, flavonoids and ginkgolides, individually or in combination. To determine the effects of GBE in mice with established AAAs, male apoE-/- mice were flrstly infused with AngII for 28 days to develop AAAs, and then administered either GBE or vehicle in mice with established AAAs, which were continuously infused with AngII for another 56 days. GBE, but not the two major active components separately or synergistically, prevented aortic rupture, but not aortic dilation. The protection of GBE from aortic rupture was independent of systolic blood pressure, lipid, and inflammation. GBE also did not attenuate either aortic rupture or progressive aortic dilation in mice with established AAAs. GBE did not reduce the atherosclerotic lesion areas, either. In conclusion, GBE prevents aortic rupture in AngII-infused hypercholesterolemic mice, but only in the early phase of the disease development. | Xiao-fang Huang Song-zhao Zhang Ya-yu You Na Zhang Hong Lu Alan Daugherty Xiao-jie Xie | 2019 | Acta Pharmacologica Sinica2019，40，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员